Reviewed,
UniProtKB/Swiss-Prot Q8TE59 (ATS19_HUMAN)
Last modified
November 24, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: A disintegrin and metalloproteinase with thrombospondin motifs 19 Short name=ADAMTS-19 Short name=ADAM-TS 19 Short name=ADAM-TS19 EC=3.4.24.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1207 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subcellular location | Secreted › extracellular space › extracellular matrix By similarity. |
| Tissue specificity | Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library. |
| Domain | The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. |
| Post-translational modification | The precursor is cleaved by a furin endopeptidase By similarity. |
| Sequence similarities | Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 PLAC domain. Contains 5 TSP type-1 domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Extracellular matrix Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Metalloprotease Protease |
| PTM | Cleavage on pair of basic residues Disulfide bond Glycoprotein Phosphoprotein Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Propeptide | 22 – 316 | 295 | By similarity | PRO_0000029202 | |||||||
| Chain | 317 – 1207 | 891 | A disintegrin and metalloproteinase with thrombospondin motifs 19 | PRO_0000029203 | |||||||
Regions | |||||||||||
| Domain | 325 – 545 | 221 | Peptidase M12B | ||||||||
| Domain | 546 – 633 | 88 | Disintegrin | ||||||||
| Domain | 634 – 686 | 53 | TSP type-1 1 | ||||||||
| Domain | 915 – 975 | 61 | TSP type-1 2 | ||||||||
| Domain | 976 – 1037 | 62 | TSP type-1 3 | ||||||||
| Domain | 1039 – 1083 | 45 | TSP type-1 4 | ||||||||
| Domain | 1087 – 1144 | 58 | TSP type-1 5 | ||||||||
| Domain | 1160 – 1199 | 40 | PLAC | ||||||||
| Region | 791 – 914 | 124 | Spacer | ||||||||
| Motif | 292 – 299 | 8 | Cysteine switch By similarity | ||||||||
| Compositional bias | 88 – 216 | 129 | Pro-rich | ||||||||
| Compositional bias | 687 – 790 | 104 | Cys-rich | ||||||||
Sites | |||||||||||
| Active site | 483 | 1 | By similarity | ||||||||
| Metal binding | 294 | 1 | Zinc; in inhibited form By similarity | ||||||||
| Metal binding | 482 | 1 | Zinc; catalytic By similarity | ||||||||
| Metal binding | 486 | 1 | Zinc; catalytic By similarity | ||||||||
| Metal binding | 492 | 1 | Zinc; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 728 | 1 | Phosphoserine Ref.2 | ||||||||
| Glycosylation | 260 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 797 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 907 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 949 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1009 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 460 ↔ 540 | By similarity | |||||||||
| Disulfide bond | 499 ↔ 524 | By similarity | |||||||||
| Disulfide bond | 645 ↔ 680 | By similarity | |||||||||
| Disulfide bond | 649 ↔ 685 | By similarity | |||||||||
| Disulfide bond | 660 ↔ 670 | By similarity | |||||||||
| Disulfide bond | 988 ↔ 1031 | By similarity | |||||||||
| Disulfide bond | 992 ↔ 1036 | By similarity | |||||||||
| Disulfide bond | 1003 ↔ 1020 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 360 | 1 | L → I in a breast cancer sample; somatic mutation. Ref.3 | VAR_036154 | |||||||
| Natural variant | 582 | 1 | E → G: dbSNP rs10062501. | VAR_057087 | |||||||
| Natural variant | 1089 | 1 | Y → F: dbSNP rs11749126. | VAR_024599 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains." Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C. Gene 283:49-62(2002) [PubMed: 11867212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-728, MASS SPECTROMETRY. Tissue: Epithelium. |
| [3] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-360. |
Cross-references
Sequence databases | |
|---|---|
| AJ311904 mRNA. Translation: CAC84565.1. | |
| IPI | IPI00152639. |
| RefSeq | NP_598377.3. |
| UniGene | Hs.23751 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8TE59. |
Genome annotation databases | |
| Ensembl | ENST00000274487; ENSP00000274487; ENSG00000145808; Homo sapiens. [Genome view] |
| GeneID | 171019. |
| KEGG | hsa:171019. |
| UCSC | uc003kvb.1. human. |
Organism-specific databases | |
| CTD | 171019. |
| GeneCards | GC05P128824. |
| HGNC | HGNC:17111. ADAMTS19. |
| MIM | 607513. gene. |
| PharmGKB | PA24545. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8TE59. |
| HOVERGEN | Q8TE59. |
Gene expression databases | |
| ArrayExpress | Q8TE59. |
| Bgee | Q8TE59. |
| CleanEx | HS_ADAMTS19. |
| Genevestigator | Q8TE59. |
| GermOnline | ENSG00000145808. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR010294. ADAM_spacer1. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR010909. PLAC. IPR000884. Thrombospondin_1_rpt. [Graphical view] |
| Pfam | PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF08686. PLAC. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 5 hits. [Graphical view] |
| PRINTS | PR01857. ADAMTSFAMILY. |
| SMART | SM00209. TSP1. 5 hits. [Graphical view] |
| PROSITE | PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS50900. PLAC. 1 hit. PS50092. TSP1. 5 hits. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 89186. |
| SOURCE | Search... |
Entry information
| Entry name | ATS19_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TE59 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


