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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 15

Gene

ADAMTS15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi174Zinc; in inhibited formBy similarity1
Metal bindingi361Zinc; catalyticBy similarity1
Active sitei362PROSITE-ProRule annotation1
Metal bindingi365Zinc; catalyticBy similarity1
Metal bindingi371Zinc; catalyticBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166106-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.025.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 15 (EC:3.4.24.-)
Short name:
ADAM-TS 15
Short name:
ADAM-TS15
Short name:
ADAMTS-15
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16305. ADAMTS15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi170689.
OpenTargetsiENSG00000166106.
PharmGKBiPA24541.

Polymorphism and mutation databases

BioMutaiADAMTS15.
DMDMi48474504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002919218 – 212By similarityAdd BLAST195
ChainiPRO_0000029193213 – 950A disintegrin and metalloproteinase with thrombospondin motifs 15Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi293 ↔ 345By similarity
Disulfide bondi322 ↔ 327By similarity
Disulfide bondi339 ↔ 422By similarity
Disulfide bondi377 ↔ 406By similarity
Disulfide bondi448 ↔ 470By similarity
Disulfide bondi459 ↔ 480By similarity
Disulfide bondi465 ↔ 499By similarity
Disulfide bondi493 ↔ 504By similarity
Disulfide bondi528 ↔ 565By similarity
Disulfide bondi532 ↔ 570By similarity
Disulfide bondi543 ↔ 555By similarity
Glycosylationi591N-linked (GlcNAc...)Sequence analysis1
Glycosylationi623N-linked (GlcNAc...)Sequence analysis1
Glycosylationi679N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ8TE58.
PaxDbiQ8TE58.
PeptideAtlasiQ8TE58.
PRIDEiQ8TE58.

PTM databases

iPTMnetiQ8TE58.
PhosphoSitePlusiQ8TE58.

Expressioni

Tissue specificityi

Expressed in fetal liver and kidney, but not in any of the adult tissues examined.

Gene expression databases

BgeeiENSG00000166106.
CleanExiHS_ADAMTS15.
GenevisibleiQ8TE58. HS.

Organism-specific databases

HPAiHPA042867.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299164.

Structurei

3D structure databases

ProteinModelPortaliQ8TE58.
SMRiQ8TE58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 427Peptidase M12BPROSITE-ProRule annotationAdd BLAST210
Domaini428 – 515DisintegrinAdd BLAST88
Domaini516 – 571TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini839 – 895TSP type-1 2PROSITE-ProRule annotationAdd BLAST57
Domaini896 – 949TSP type-1 3PROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni701 – 838SpacerAdd BLAST138

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 179Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi572 – 700Cys-richAdd BLAST129

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
InParanoidiQ8TE58.
KOiK08629.
OMAiFQEDFYL.
OrthoDBiEOG091G00AX.
PhylomeDBiQ8TE58.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR013277. Pept_M12B_ADAM-TS8.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01861. ADAMTS8.
PR01857. ADAMTSFAMILY.
SMARTiSM00608. ACR. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 3 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TE58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLGILTLA FAGRTAGGSE PEREVVVPIR LDPDINGRRY YWRGPEDSGD
60 70 80 90 100
QGLIFQITAF QEDFYLHLTP DAQFLAPAFS TEHLGVPLQG LTGGSSDLRR
110 120 130 140 150
CFYSGDVNAE PDSFAAVSLC GGLRGAFGYR GAEYVISPLP NASAPAAQRN
160 170 180 190 200
SQGAHLLQRR GVPGGPSGDP TSRCGVASGW NPAILRALDP YKPRRAGFGE
210 220 230 240 250
SRSRRRSGRA KRFVSIPRYV ETLVVADESM VKFHGADLEH YLLTLLATAA
260 270 280 290 300
RLYRHPSILN PINIVVVKVL LLRDRDSGPK VTGNAALTLR NFCAWQKKLN
310 320 330 340 350
KVSDKHPEYW DTAILFTRQD LCGATTCDTL GMADVGTMCD PKRSCSVIED
360 370 380 390 400
DGLPSAFTTA HELGHVFNMP HDNVKVCEEV FGKLRANHMM SPTLIQIDRA
410 420 430 440 450
NPWSACSAAI ITDFLDSGHG DCLLDQPSKP ISLPEDLPGA SYTLSQQCEL
460 470 480 490 500
AFGVGSKPCP YMQYCTKLWC TGKAKGQMVC QTRHFPWADG TSCGEGKLCL
510 520 530 540 550
KGACVERHNL NKHRVDGSWA KWDPYGPCSR TCGGGVQLAR RQCTNPTPAN
560 570 580 590 600
GGKYCEGVRV KYRSCNLEPC PSSASGKSFR EEQCEAFNGY NHSTNRLTLA
610 620 630 640 650
VAWVPKYSGV SPRDKCKLIC RANGTGYFYV LAPKVVDGTL CSPDSTSVCV
660 670 680 690 700
QGKCIKAGCD GNLGSKKRFD KCGVCGGDNK SCKKVTGLFT KPMHGYNFVV
710 720 730 740 750
AIPAGASSID IRQRGYKGLI GDDNYLALKN SQGKYLLNGH FVVSAVERDL
760 770 780 790 800
VVKGSLLRYS GTGTAVESLQ ASRPILEPLT VEVLSVGKMT PPRVRYSFYL
810 820 830 840 850
PKEPREDKSS HPKDPRGPSV LHNSVLSLSN QVEQPDDRPP ARWVAGSWGP
860 870 880 890 900
CSASCGSGLQ KRAVDCRGSA GQRTVPACDA AHRPVETQAC GEPCPTWELS
910 920 930 940 950
AWSPCSKSCG RGFQRRSLKC VGHGGRLLAR DQCNLHRKPQ ELDFCVLRPC
Length:950
Mass (Da):103,287
Last modified:June 1, 2002 - v1
Checksum:i5DFBE18285CCCC3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051594623N → S.Corresponds to variant rs11222114dbSNPEnsembl.1
Natural variantiVAR_036150770Q → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs776537988dbSNPEnsembl.1
Natural variantiVAR_036151878C → G in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315733 mRNA. Translation: CAC86014.1.
BC109114 mRNA. Translation: AAI09115.1.
CCDSiCCDS8488.1.
RefSeqiNP_620686.1. NM_139055.3.
UniGeneiHs.534221.

Genome annotation databases

EnsembliENST00000299164; ENSP00000299164; ENSG00000166106.
GeneIDi170689.
KEGGihsa:170689.
UCSCiuc010scd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315733 mRNA. Translation: CAC86014.1.
BC109114 mRNA. Translation: AAI09115.1.
CCDSiCCDS8488.1.
RefSeqiNP_620686.1. NM_139055.3.
UniGeneiHs.534221.

3D structure databases

ProteinModelPortaliQ8TE58.
SMRiQ8TE58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299164.

Protein family/group databases

MEROPSiM12.025.

PTM databases

iPTMnetiQ8TE58.
PhosphoSitePlusiQ8TE58.

Polymorphism and mutation databases

BioMutaiADAMTS15.
DMDMi48474504.

Proteomic databases

MaxQBiQ8TE58.
PaxDbiQ8TE58.
PeptideAtlasiQ8TE58.
PRIDEiQ8TE58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299164; ENSP00000299164; ENSG00000166106.
GeneIDi170689.
KEGGihsa:170689.
UCSCiuc010scd.3. human.

Organism-specific databases

CTDi170689.
DisGeNETi170689.
GeneCardsiADAMTS15.
HGNCiHGNC:16305. ADAMTS15.
HPAiHPA042867.
MIMi607509. gene.
neXtProtiNX_Q8TE58.
OpenTargetsiENSG00000166106.
PharmGKBiPA24541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
InParanoidiQ8TE58.
KOiK08629.
OMAiFQEDFYL.
OrthoDBiEOG091G00AX.
PhylomeDBiQ8TE58.
TreeFamiTF331949.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166106-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii170689.
PROiQ8TE58.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166106.
CleanExiHS_ADAMTS15.
GenevisibleiQ8TE58. HS.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR013277. Pept_M12B_ADAM-TS8.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01861. ADAMTS8.
PR01857. ADAMTSFAMILY.
SMARTiSM00608. ACR. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 3 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATS15_HUMAN
AccessioniPrimary (citable) accession number: Q8TE58
Secondary accession number(s): Q32MI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.