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Q8TE58

- ATS15_HUMAN

UniProt

Q8TE58 - ATS15_HUMAN

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 15

Gene
ADAMTS15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi174 – 1741Zinc; in inhibited form By similarity
Metal bindingi361 – 3611Zinc; catalytic By similarity
Active sitei362 – 3621 By similarity
Metal bindingi365 – 3651Zinc; catalytic By similarity
Metal bindingi371 – 3711Zinc; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.025.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 15 (EC:3.4.24.-)
Short name:
ADAM-TS 15
Short name:
ADAM-TS15
Short name:
ADAMTS-15
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16305. ADAMTS15.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 212195 By similarityPRO_0000029192Add
BLAST
Chaini213 – 950738A disintegrin and metalloproteinase with thrombospondin motifs 15PRO_0000029193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi293 ↔ 345 By similarity
Disulfide bondi322 ↔ 327 By similarity
Disulfide bondi339 ↔ 422 By similarity
Disulfide bondi377 ↔ 406 By similarity
Disulfide bondi448 ↔ 470 By similarity
Disulfide bondi459 ↔ 480 By similarity
Disulfide bondi465 ↔ 499 By similarity
Disulfide bondi493 ↔ 504 By similarity
Disulfide bondi528 ↔ 565 By similarity
Disulfide bondi532 ↔ 570 By similarity
Disulfide bondi543 ↔ 555 By similarity
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi623 – 6231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi679 – 6791N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8TE58.
PRIDEiQ8TE58.

PTM databases

PhosphoSiteiQ8TE58.

Expressioni

Tissue specificityi

Expressed in fetal liver and kidney, but not in any of the adult tissues examined.

Gene expression databases

BgeeiQ8TE58.
CleanExiHS_ADAMTS15.
GenevestigatoriQ8TE58.

Organism-specific databases

HPAiHPA042867.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299164.

Structurei

3D structure databases

ProteinModelPortaliQ8TE58.
SMRiQ8TE58. Positions 218-690.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 427210Peptidase M12BAdd
BLAST
Domaini428 – 51588DisintegrinAdd
BLAST
Domaini516 – 57156TSP type-1 1Add
BLAST
Domaini839 – 89557TSP type-1 2Add
BLAST
Domaini896 – 94954TSP type-1 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni701 – 838138SpacerAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi172 – 1798Cysteine switch By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi572 – 700129Cys-richAdd
BLAST

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix By similarity.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 3 TSP type-1 domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG240910.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
InParanoidiQ8TE58.
KOiK08629.
OMAiRGFKRRP.
OrthoDBiEOG7WDN1M.
PhylomeDBiQ8TE58.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR013277. Pept_M12B_ADAM-TS8.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01861. ADAMTS8.
PR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 3 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TE58-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLGILTLA FAGRTAGGSE PEREVVVPIR LDPDINGRRY YWRGPEDSGD    50
QGLIFQITAF QEDFYLHLTP DAQFLAPAFS TEHLGVPLQG LTGGSSDLRR 100
CFYSGDVNAE PDSFAAVSLC GGLRGAFGYR GAEYVISPLP NASAPAAQRN 150
SQGAHLLQRR GVPGGPSGDP TSRCGVASGW NPAILRALDP YKPRRAGFGE 200
SRSRRRSGRA KRFVSIPRYV ETLVVADESM VKFHGADLEH YLLTLLATAA 250
RLYRHPSILN PINIVVVKVL LLRDRDSGPK VTGNAALTLR NFCAWQKKLN 300
KVSDKHPEYW DTAILFTRQD LCGATTCDTL GMADVGTMCD PKRSCSVIED 350
DGLPSAFTTA HELGHVFNMP HDNVKVCEEV FGKLRANHMM SPTLIQIDRA 400
NPWSACSAAI ITDFLDSGHG DCLLDQPSKP ISLPEDLPGA SYTLSQQCEL 450
AFGVGSKPCP YMQYCTKLWC TGKAKGQMVC QTRHFPWADG TSCGEGKLCL 500
KGACVERHNL NKHRVDGSWA KWDPYGPCSR TCGGGVQLAR RQCTNPTPAN 550
GGKYCEGVRV KYRSCNLEPC PSSASGKSFR EEQCEAFNGY NHSTNRLTLA 600
VAWVPKYSGV SPRDKCKLIC RANGTGYFYV LAPKVVDGTL CSPDSTSVCV 650
QGKCIKAGCD GNLGSKKRFD KCGVCGGDNK SCKKVTGLFT KPMHGYNFVV 700
AIPAGASSID IRQRGYKGLI GDDNYLALKN SQGKYLLNGH FVVSAVERDL 750
VVKGSLLRYS GTGTAVESLQ ASRPILEPLT VEVLSVGKMT PPRVRYSFYL 800
PKEPREDKSS HPKDPRGPSV LHNSVLSLSN QVEQPDDRPP ARWVAGSWGP 850
CSASCGSGLQ KRAVDCRGSA GQRTVPACDA AHRPVETQAC GEPCPTWELS 900
AWSPCSKSCG RGFQRRSLKC VGHGGRLLAR DQCNLHRKPQ ELDFCVLRPC 950
Length:950
Mass (Da):103,287
Last modified:June 1, 2002 - v1
Checksum:i5DFBE18285CCCC3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti623 – 6231N → S.
Corresponds to variant rs11222114 [ dbSNP | Ensembl ].
VAR_051594
Natural varianti770 – 7701Q → R in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036150
Natural varianti878 – 8781C → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036151

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315733 mRNA. Translation: CAC86014.1.
BC109114 mRNA. Translation: AAI09115.1.
CCDSiCCDS8488.1.
RefSeqiNP_620686.1. NM_139055.2.
UniGeneiHs.534221.

Genome annotation databases

EnsembliENST00000299164; ENSP00000299164; ENSG00000166106.
GeneIDi170689.
KEGGihsa:170689.
UCSCiuc010scd.2. human.

Polymorphism databases

DMDMi48474504.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315733 mRNA. Translation: CAC86014.1 .
BC109114 mRNA. Translation: AAI09115.1 .
CCDSi CCDS8488.1.
RefSeqi NP_620686.1. NM_139055.2.
UniGenei Hs.534221.

3D structure databases

ProteinModelPortali Q8TE58.
SMRi Q8TE58. Positions 218-690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000299164.

Protein family/group databases

MEROPSi M12.025.

PTM databases

PhosphoSitei Q8TE58.

Polymorphism databases

DMDMi 48474504.

Proteomic databases

PaxDbi Q8TE58.
PRIDEi Q8TE58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299164 ; ENSP00000299164 ; ENSG00000166106 .
GeneIDi 170689.
KEGGi hsa:170689.
UCSCi uc010scd.2. human.

Organism-specific databases

CTDi 170689.
GeneCardsi GC11P130318.
HGNCi HGNC:16305. ADAMTS15.
HPAi HPA042867.
MIMi 607509. gene.
neXtProti NX_Q8TE58.
PharmGKBi PA24541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240910.
HOGENOMi HOG000004799.
HOVERGENi HBG004313.
InParanoidi Q8TE58.
KOi K08629.
OMAi RGFKRRP.
OrthoDBi EOG7WDN1M.
PhylomeDBi Q8TE58.
TreeFami TF331949.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 170689.
NextBioi 89098.
PROi Q8TE58.
SOURCEi Search...

Gene expression databases

Bgeei Q8TE58.
CleanExi HS_ADAMTS15.
Genevestigatori Q8TE58.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR013277. Pept_M12B_ADAM-TS8.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view ]
PRINTSi PR01861. ADAMTS8.
PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 3 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 3 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
    Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
    Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-770 AND GLY-878.

Entry informationi

Entry nameiATS15_HUMAN
AccessioniPrimary (citable) accession number: Q8TE58
Secondary accession number(s): Q32MI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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