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Q8TE58

- ATS15_HUMAN

UniProt

Q8TE58 - ATS15_HUMAN

Protein

A disintegrin and metalloproteinase with thrombospondin motifs 15

Gene

ADAMTS15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi174 – 1741Zinc; in inhibited formBy similarity
    Metal bindingi361 – 3611Zinc; catalyticBy similarity
    Active sitei362 – 3621PROSITE-ProRule annotation
    Metal bindingi365 – 3651Zinc; catalyticBy similarity
    Metal bindingi371 – 3711Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

    Protein family/group databases

    MEROPSiM12.025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 15 (EC:3.4.24.-)
    Short name:
    ADAM-TS 15
    Short name:
    ADAM-TS15
    Short name:
    ADAMTS-15
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16305. ADAMTS15.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24541.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 212195By similarityPRO_0000029192Add
    BLAST
    Chaini213 – 950738A disintegrin and metalloproteinase with thrombospondin motifs 15PRO_0000029193Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi293 ↔ 345By similarity
    Disulfide bondi322 ↔ 327By similarity
    Disulfide bondi339 ↔ 422By similarity
    Disulfide bondi377 ↔ 406By similarity
    Disulfide bondi448 ↔ 470By similarity
    Disulfide bondi459 ↔ 480By similarity
    Disulfide bondi465 ↔ 499By similarity
    Disulfide bondi493 ↔ 504By similarity
    Disulfide bondi528 ↔ 565By similarity
    Disulfide bondi532 ↔ 570By similarity
    Disulfide bondi543 ↔ 555By similarity
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi623 – 6231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity
    Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ8TE58.
    PRIDEiQ8TE58.

    PTM databases

    PhosphoSiteiQ8TE58.

    Expressioni

    Tissue specificityi

    Expressed in fetal liver and kidney, but not in any of the adult tissues examined.

    Gene expression databases

    BgeeiQ8TE58.
    CleanExiHS_ADAMTS15.
    GenevestigatoriQ8TE58.

    Organism-specific databases

    HPAiHPA042867.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000299164.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE58.
    SMRiQ8TE58. Positions 218-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini218 – 427210Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini428 – 51588DisintegrinAdd
    BLAST
    Domaini516 – 57156TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini839 – 89557TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini896 – 94954TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni701 – 838138SpacerAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi172 – 1798Cysteine switchBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi572 – 700129Cys-richAdd
    BLAST

    Domaini

    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Contains 1 disintegrin domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
    Contains 3 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG240910.
    HOGENOMiHOG000004799.
    HOVERGENiHBG004313.
    InParanoidiQ8TE58.
    KOiK08629.
    OMAiRGFKRRP.
    OrthoDBiEOG7WDN1M.
    PhylomeDBiQ8TE58.
    TreeFamiTF331949.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR013277. Pept_M12B_ADAM-TS8.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 3 hits.
    [Graphical view]
    PRINTSiPR01861. ADAMTS8.
    PR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 3 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 3 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 3 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TE58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGILTLA FAGRTAGGSE PEREVVVPIR LDPDINGRRY YWRGPEDSGD    50
    QGLIFQITAF QEDFYLHLTP DAQFLAPAFS TEHLGVPLQG LTGGSSDLRR 100
    CFYSGDVNAE PDSFAAVSLC GGLRGAFGYR GAEYVISPLP NASAPAAQRN 150
    SQGAHLLQRR GVPGGPSGDP TSRCGVASGW NPAILRALDP YKPRRAGFGE 200
    SRSRRRSGRA KRFVSIPRYV ETLVVADESM VKFHGADLEH YLLTLLATAA 250
    RLYRHPSILN PINIVVVKVL LLRDRDSGPK VTGNAALTLR NFCAWQKKLN 300
    KVSDKHPEYW DTAILFTRQD LCGATTCDTL GMADVGTMCD PKRSCSVIED 350
    DGLPSAFTTA HELGHVFNMP HDNVKVCEEV FGKLRANHMM SPTLIQIDRA 400
    NPWSACSAAI ITDFLDSGHG DCLLDQPSKP ISLPEDLPGA SYTLSQQCEL 450
    AFGVGSKPCP YMQYCTKLWC TGKAKGQMVC QTRHFPWADG TSCGEGKLCL 500
    KGACVERHNL NKHRVDGSWA KWDPYGPCSR TCGGGVQLAR RQCTNPTPAN 550
    GGKYCEGVRV KYRSCNLEPC PSSASGKSFR EEQCEAFNGY NHSTNRLTLA 600
    VAWVPKYSGV SPRDKCKLIC RANGTGYFYV LAPKVVDGTL CSPDSTSVCV 650
    QGKCIKAGCD GNLGSKKRFD KCGVCGGDNK SCKKVTGLFT KPMHGYNFVV 700
    AIPAGASSID IRQRGYKGLI GDDNYLALKN SQGKYLLNGH FVVSAVERDL 750
    VVKGSLLRYS GTGTAVESLQ ASRPILEPLT VEVLSVGKMT PPRVRYSFYL 800
    PKEPREDKSS HPKDPRGPSV LHNSVLSLSN QVEQPDDRPP ARWVAGSWGP 850
    CSASCGSGLQ KRAVDCRGSA GQRTVPACDA AHRPVETQAC GEPCPTWELS 900
    AWSPCSKSCG RGFQRRSLKC VGHGGRLLAR DQCNLHRKPQ ELDFCVLRPC 950
    Length:950
    Mass (Da):103,287
    Last modified:June 1, 2002 - v1
    Checksum:i5DFBE18285CCCC3B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti623 – 6231N → S.
    Corresponds to variant rs11222114 [ dbSNP | Ensembl ].
    VAR_051594
    Natural varianti770 – 7701Q → R in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036150
    Natural varianti878 – 8781C → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036151

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315733 mRNA. Translation: CAC86014.1.
    BC109114 mRNA. Translation: AAI09115.1.
    CCDSiCCDS8488.1.
    RefSeqiNP_620686.1. NM_139055.2.
    UniGeneiHs.534221.

    Genome annotation databases

    EnsembliENST00000299164; ENSP00000299164; ENSG00000166106.
    GeneIDi170689.
    KEGGihsa:170689.
    UCSCiuc010scd.2. human.

    Polymorphism databases

    DMDMi48474504.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315733 mRNA. Translation: CAC86014.1 .
    BC109114 mRNA. Translation: AAI09115.1 .
    CCDSi CCDS8488.1.
    RefSeqi NP_620686.1. NM_139055.2.
    UniGenei Hs.534221.

    3D structure databases

    ProteinModelPortali Q8TE58.
    SMRi Q8TE58. Positions 218-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000299164.

    Protein family/group databases

    MEROPSi M12.025.

    PTM databases

    PhosphoSitei Q8TE58.

    Polymorphism databases

    DMDMi 48474504.

    Proteomic databases

    PaxDbi Q8TE58.
    PRIDEi Q8TE58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299164 ; ENSP00000299164 ; ENSG00000166106 .
    GeneIDi 170689.
    KEGGi hsa:170689.
    UCSCi uc010scd.2. human.

    Organism-specific databases

    CTDi 170689.
    GeneCardsi GC11P130318.
    HGNCi HGNC:16305. ADAMTS15.
    HPAi HPA042867.
    MIMi 607509. gene.
    neXtProti NX_Q8TE58.
    PharmGKBi PA24541.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240910.
    HOGENOMi HOG000004799.
    HOVERGENi HBG004313.
    InParanoidi Q8TE58.
    KOi K08629.
    OMAi RGFKRRP.
    OrthoDBi EOG7WDN1M.
    PhylomeDBi Q8TE58.
    TreeFami TF331949.

    Enzyme and pathway databases

    Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    GenomeRNAii 170689.
    NextBioi 89098.
    PROi Q8TE58.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TE58.
    CleanExi HS_ADAMTS15.
    Genevestigatori Q8TE58.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR013277. Pept_M12B_ADAM-TS8.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 3 hits.
    [Graphical view ]
    PRINTSi PR01861. ADAMTS8.
    PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 3 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 3 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
      Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
      Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-770 AND GLY-878.

    Entry informationi

    Entry nameiATS15_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE58
    Secondary accession number(s): Q32MI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3