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Q8TE57

- ATS16_HUMAN

UniProt

Q8TE57 - ATS16_HUMAN

Protein

A disintegrin and metalloproteinase with thrombospondin motifs 16

Gene

ADAMTS16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi249 – 2491Zinc; in inhibited formBy similarity
    Metal bindingi433 – 4331Zinc; catalyticPROSITE-ProRule annotation
    Active sitei434 – 4341PROSITE-ProRule annotation
    Metal bindingi437 – 4371Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi443 – 4431Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.
    REACT_201925. Degradation of the extracellular matrix.

    Protein family/group databases

    MEROPSiM12.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 16 (EC:3.4.24.-)
    Short name:
    ADAM-TS 16
    Short name:
    ADAM-TS16
    Short name:
    ADAMTS-16
    Gene namesi
    Name:ADAMTS16
    Synonyms:KIAA2029
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17108. ADAMTS16.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24542.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 279255By similarityPRO_0000029194Add
    BLAST
    Chaini280 – 1224945A disintegrin and metalloproteinase with thrombospondin motifs 16PRO_0000029195Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi366 ↔ 417By similarity
    Disulfide bondi392 ↔ 399By similarity
    Disulfide bondi411 ↔ 490By similarity
    Disulfide bondi450 ↔ 474By similarity
    Disulfide bondi518 ↔ 543By similarity
    Disulfide bondi529 ↔ 550By similarity
    Disulfide bondi538 ↔ 569By similarity
    Disulfide bondi563 ↔ 574By similarity
    Disulfide bondi598 ↔ 635By similarity
    Disulfide bondi602 ↔ 640By similarity
    Disulfide bondi613 ↔ 625By similarity
    Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi905 – 9051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi935 – 9351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi939 ↔ 981By similarity
    Disulfide bondi943 ↔ 986By similarity
    Disulfide bondi954 ↔ 970By similarity

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity
    Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ8TE57.
    PRIDEiQ8TE57.

    PTM databases

    PhosphoSiteiQ8TE57.

    Expressioni

    Tissue specificityi

    Expressed in fetal lung and kidney and in adult prostate and ovary.

    Gene expression databases

    ArrayExpressiQ8TE57.
    BgeeiQ8TE57.
    CleanExiHS_ADAMTS16.
    GenevestigatoriQ8TE57.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE57.
    SMRiQ8TE57. Positions 292-789.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 495206Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 58590DisintegrinAdd
    BLAST
    Domaini586 – 64156TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini874 – 92249TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini927 – 98761TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini988 – 104861TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1051 – 111565TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1127 – 118155TSP type-1 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1186 – 122338PLACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni747 – 873127SpacerAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi247 – 2548Cysteine switchBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi642 – 746105Cys-richAdd
    BLAST

    Domaini

    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Contains 1 disintegrin domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
    Contains 1 PLAC domain.PROSITE-ProRule annotation
    Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG237764.
    HOGENOMiHOG000004800.
    HOVERGENiHBG004315.
    InParanoidiQ8TE57.
    KOiK08630.
    OMAiEDQDLCK.
    PhylomeDBiQ8TE57.
    TreeFamiTF313537.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 6 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 5 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TE57-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPRARGWRG LAALWMLLAQ VAEQAPACAM GPAAAAPGSP SVPRPPPPAE     50
    RPGWMEKGEY DLVSAYEVDH RGDYVSHEIM HHQRRRRAVP VSEVESLHLR 100
    LKGSRHDFHM DLRTSSSLVA PGFIVQTLGK TGTKSVQTLP PEDFCFYQGS 150
    LRSHRNSSVA LSTCQGLSGM IRTEEADYFL RPLPSHLSWK LGRAAQGSSP 200
    SHVLYKRSTE PHAPGASEVL VTSRTWELAH QPLHSSDLRL GLPQKQHFCG 250
    RRKKYMPQPP KEDLFILPDE YKSCLRHKRS LLRSHRNEEL NVETLVVVDK 300
    KMMQNHGHEN ITTYVLTILN MVSALFKDGT IGGNINIAIV GLILLEDEQP 350
    GLVISHHADH TLSSFCQWQS GLMGKDGTRH DHAILLTGLD ICSWKNEPCD 400
    TLGFAPISGM CSKYRSCTIN EDTGLGLAFT IAHESGHNFG MIHDGEGNMC 450
    KKSEGNIMSP TLAGRNGVFS WSPCSRQYLH KFLSTAQAIC LADQPKPVKE 500
    YKYPEKLPGE LYDANTQCKW QFGEKAKLCM LDFKKDICKA LWCHRIGRKC 550
    ETKFMPAAEG TICGHDMWCR GGQCVKYGDE GPKPTHGHWS DWSSWSPCSR 600
    TCGGGVSHRS RLCTNPKPSH GGKFCEGSTR TLKLCNSQKC PRDSVDFRAA 650
    QCAEHNSRRF RGRHYKWKPY TQVEDQDLCK LYCIAEGFDF FFSLSNKVKD 700
    GTPCSEDSRN VCIDGICERV GCDNVLGSDA VEDVCGVCNG NNSACTIHRG 750
    LYTKHHHTNQ YYHMVTIPSG ARSIRIYEMN VSTSYISVRN ALRRYYLNGH 800
    WTVDWPGRYK FSGTTFDYRR SYNEPENLIA TGPTNETLIV ELLFQGRNPG 850
    VAWEYSMPRL GTEKQPPAQP SYTWAIVRSE CSVSCGGGQM TVREGCYRDL 900
    KFQVNMSFCN PKTRPVTGLV PCKVSACPPS WSVGNWSACS RTCGGGAQSR 950
    PVQCTRRVHY DSEPVPASLC PQPAPSSRQA CNSQSCPPAW SAGPWAECSH 1000
    TCGKGWRKRA VACKSTNPSA RAQLLPDAVC TSEPKPRMHE ACLLQRCHKP 1050
    KKLQWLVSAW SQCSVTCERG TQKRFLKCAE KYVSGKYREL ASKKCSHLPK 1100
    PSLELERACA PLPCPRHPPF AAAGPSRGSW FASPWSQCTA SCGGGVQTRS 1150
    VQCLAGGRPA SGCLLHQKPS ASLACNTHFC PIAEKKDAFC KDYFHWCYLV 1200
    PQHGMCSHKF YGKQCCKTCS KSNL 1224
    Length:1,224
    Mass (Da):136,203
    Last modified:May 18, 2010 - v3
    Checksum:iFB6115E6C97A9683
    GO
    Isoform 2 (identifier: Q8TE57-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1063-1072: CSVTCERGTQ → VGALVSRERG
         1073-1224: Missing.

    Show »
    Length:1,072
    Mass (Da):119,507
    Checksum:i3E2C0FF34194E631
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901P → A in CAC86015. (PubMed:11867212)Curated
    Sequence conflicti104 – 1041S → P in CAC86015. (PubMed:11867212)Curated
    Sequence conflicti284 – 2841S → Y in BAC23125. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101M → V.
    Corresponds to variant rs1863968 [ dbSNP | Ensembl ].
    VAR_057076
    Natural varianti486 – 4861A → T.
    Corresponds to variant rs16875054 [ dbSNP | Ensembl ].
    VAR_057077
    Natural varianti789 – 7891R → C.
    Corresponds to variant rs9313105 [ dbSNP | Ensembl ].
    VAR_057078
    Natural varianti859 – 8591R → L.
    Corresponds to variant rs16875122 [ dbSNP | Ensembl ].
    VAR_057079
    Natural varianti863 – 8631E → K.
    Corresponds to variant rs35394775 [ dbSNP | Ensembl ].
    VAR_057080

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1063 – 107210CSVTCERGTQ → VGALVSRERG in isoform 2. 1 PublicationVSP_007664
    Alternative sequencei1073 – 1224152Missing in isoform 2. 1 PublicationVSP_007665Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315734 mRNA. Translation: CAC86015.1.
    FJ515844 Genomic DNA. Translation: ACS13738.1.
    AC010269 Genomic DNA. No translation available.
    AC022424 Genomic DNA. No translation available.
    AC091978 Genomic DNA. No translation available.
    AB095949 mRNA. Translation: BAC23125.1.
    CCDSiCCDS43299.1. [Q8TE57-1]
    RefSeqiNP_620687.2. NM_139056.2. [Q8TE57-1]
    UniGeneiHs.661915.

    Genome annotation databases

    EnsembliENST00000274181; ENSP00000274181; ENSG00000145536. [Q8TE57-1]
    GeneIDi170690.
    KEGGihsa:170690.
    UCSCiuc003jdk.1. human. [Q8TE57-2]
    uc003jdl.3. human. [Q8TE57-1]

    Polymorphism databases

    DMDMi296439429.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315734 mRNA. Translation: CAC86015.1 .
    FJ515844 Genomic DNA. Translation: ACS13738.1 .
    AC010269 Genomic DNA. No translation available.
    AC022424 Genomic DNA. No translation available.
    AC091978 Genomic DNA. No translation available.
    AB095949 mRNA. Translation: BAC23125.1 .
    CCDSi CCDS43299.1. [Q8TE57-1 ]
    RefSeqi NP_620687.2. NM_139056.2. [Q8TE57-1 ]
    UniGenei Hs.661915.

    3D structure databases

    ProteinModelPortali Q8TE57.
    SMRi Q8TE57. Positions 292-789.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M12.026.

    PTM databases

    PhosphoSitei Q8TE57.

    Polymorphism databases

    DMDMi 296439429.

    Proteomic databases

    PaxDbi Q8TE57.
    PRIDEi Q8TE57.

    Protocols and materials databases

    DNASUi 170690.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274181 ; ENSP00000274181 ; ENSG00000145536 . [Q8TE57-1 ]
    GeneIDi 170690.
    KEGGi hsa:170690.
    UCSCi uc003jdk.1. human. [Q8TE57-2 ]
    uc003jdl.3. human. [Q8TE57-1 ]

    Organism-specific databases

    CTDi 170690.
    GeneCardsi GC05P005140.
    HGNCi HGNC:17108. ADAMTS16.
    MIMi 607510. gene.
    neXtProti NX_Q8TE57.
    PharmGKBi PA24542.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237764.
    HOGENOMi HOG000004800.
    HOVERGENi HBG004315.
    InParanoidi Q8TE57.
    KOi K08630.
    OMAi EDQDLCK.
    PhylomeDBi Q8TE57.
    TreeFami TF313537.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_200626. O-glycosylation of TSR domain-containing proteins.
    REACT_201925. Degradation of the extracellular matrix.

    Miscellaneous databases

    GenomeRNAii 170690.
    NextBioi 89102.
    PROi Q8TE57.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TE57.
    Bgeei Q8TE57.
    CleanExi HS_ADAMTS16.
    Genevestigatori Q8TE57.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 6 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 5 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
      Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
      Gene 283:49-62(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-1224 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiATS16_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE57
    Secondary accession number(s): C6G490, Q8IVE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3