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Reviewed, UniProtKB/Swiss-Prot Q8TE56 (ATS17_HUMAN)

Last modified November 24, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 17
      Short name=ADAMTS-17
      Short name=ADAM-TS 17
      Short name=ADAM-TS17
    EC=3.4.24.-
Gene names
Name: ADAMTS17
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1095 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Secreted › extracellular space › extracellular matrix By similarity.

Tissue specificity

Expressed in fetal lung, in adult brain, prostate, and liver.

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Post-translational modification

The precursor is cleaved by a furin endopeptidase By similarity.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 peptidase M12B domain.

Contains 1 PLAC domain.

Contains 5 TSP type-1 domains.

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Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 223196 By similarity
PRO_0000029198
Chain224 – 1095872A disintegrin and metalloproteinase with thrombospondin motifs 17
PRO_0000029199

Regions

Domain232 – 452221Peptidase M12B
Domain453 – 54290Disintegrin
Domain543 – 59856TSP type-1 1
Domain800 – 86061TSP type-1 2
Domain861 – 92262TSP type-1 3
Domain925 – 96844TSP type-1 4
Domain972 – 102958TSP type-1 5
Domain1045 – 108440PLAC
Region702 – 77978Spacer
Motif199 – 2068Cysteine switch By similarity
Compositional bias60 – 12061Arg-rich
Compositional bias599 – 701103Cys-rich

Sites

Active site3901 By similarity
Metal binding2011Zinc; in inhibited form By similarity
Metal binding3891Zinc; catalytic By similarity
Metal binding3931Zinc; catalytic By similarity
Metal binding3991Zinc; catalytic By similarity

Amino acid modifications

Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Glycosylation7851N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8321N-linked (GlcNAc...) Potential
Glycosylation8391N-linked (GlcNAc...) Potential
Glycosylation8941N-linked (GlcNAc...) Potential
Disulfide bond367 ↔ 447 By similarity
Disulfide bond406 ↔ 431 By similarity
Disulfide bond555 ↔ 592 By similarity
Disulfide bond559 ↔ 597 By similarity
Disulfide bond570 ↔ 582 By similarity
Disulfide bond873 ↔ 916 By similarity
Disulfide bond877 ↔ 921 By similarity
Disulfide bond888 ↔ 905 By similarity

Natural variations

Natural variant2161S → L: dbSNP rs7496668.
VAR_057081
Natural variant4821M → T: dbSNP rs28567966.
VAR_057082
Natural variant10941S → N: dbSNP rs2573652.
VAR_060317

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Sequences

Sequence LengthMass (Da)Tools
Q8TE56-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A5C6540484754D5D

FASTA1,095121,100
        10         20         30         40         50         60 
MCDGALLPPL VLPVLLLLVW GLDPGTAVGD AAADVEVVLP WRVRPDDVHL PPLPAAPGPR 

        70         80         90        100        110        120 
RRRRPRTPPA APRARPGERA LLLHLPAFGR DLYLQLRRDL RFLSRGFEVE EAGAARRRGR 

       130        140        150        160        170        180 
PAELCFYSGR VLGHPGSLVS LSACGAAGGL VGLIQLGQEQ VLIQPLNNSQ GPFSGREHLI 

       190        200        210        220        230        240 
RRKWSLTPSP SAEAQRPEQL CKVLTEKKKP TWGRPSRDWR ERRNAIRLTS EHTVETLVVA 

       250        260        270        280        290        300 
DADMVQYHGA EAAQRFILTV MNMVYNMFQH QSLGIKINIQ VTKLVLLRQR PAKLSIGHHG 

       310        320        330        340        350        360 
ERSLESFCHW QNEEYGGARY LGNNQVPGGK DDPPLVDAAV FVTRTDFCVH KDEPCDTVGI 

       370        380        390        400        410        420 
AYLGGVCSAK RKCVLAEDNG LNLAFTIAHE LGHNLGMNHD DDHSSCAGRS HIMSGEWVKG 

       430        440        450        460        470        480 
RNPSDLSWSS CSRDDLENFL KSKVSTCLLV TDPRSQHTVR LPHKLPGMHY SANEQCQILF 

       490        500        510        520        530        540 
GMNATFCRNM EHLMCAGLWC LVEGDTSCKT KLDPPLDGTE CGADKWCRAG ECVSKTPIPE 

       550        560        570        580        590        600 
HVDGDWSPWG AWSMCSRTCG TGARFRQRKC DNPPPGPGGT HCPGASVEHA VCENLPCPKG 

       610        620        630        640        650        660 
LPSFRDQQCQ AHDRLSPKKK GLLTAVVVDD KPCELYCSPL GKESPLLVAD RVLDGTPCGP 

       670        680        690        700        710        720 
YETDLCVHGK CQKIGCDGII GSAAKEDRCG VCSGDGKTCH LVKGDFSHAR GTALKDSGKG 

       730        740        750        760        770        780 
SINSDWKIEL PGEFQIAGTT VRYVRRGLWE KISAKGPTKL PLHLMVLLFH DQDYGIHYEY 

       790        800        810        820        830        840 
TVPVNRTAEN QSEPEKPQDS LFIWTHSGWE GCSVQCGGGE RRTIVSCTRI VNKTTTLVND 

       850        860        870        880        890        900 
SDCPQASRPE PQVRRCNLHP CQSRWVAGPW SPCSATCEKG FQHREVTCVY QLQNGTHVAT 

       910        920        930        940        950        960 
RPLYCPGPRP AAVQSCEGQD CLSIWEASEW SQCSASCGKG VWKRTVACTN SQGKCDASTR 

       970        980        990       1000       1010       1020 
PRAEEACEDY SGCYEWKTGD WSTCSSTCGK GLQSRVVQCM HKVTGRHGSE CPALSKPAPY 

      1030       1040       1050       1060       1070       1080 
RQCYQEVCND RINANTITSP RLAALTYKCT RDQWTVYCRV IREKNLCQDM RWYQRCCQTC 

      1090 
RDFYANKMRQ PPPSS

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References

[1]"Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains."
Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.
Gene 283:49-62(2002) [PubMed: 11867212] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

AJ315735 mRNA. Translation: CAC86016.1.
IPIIPI00152635.
RefSeqNP_620688.2.
UniGeneHs.513200

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ8TE56.

Protein family/group databases

MEROPSM12.027.

Proteomic databases

PRIDEQ8TE56.

Genome annotation databases

EnsemblENST00000268070; ENSP00000268070; ENSG00000140470; Homo sapiens. [Genome view]
GeneID170691.
KEGGhsa:170691.

Organism-specific databases

CTD170691.
GeneCardsGC15M098332.
H-InvDBHIX0012615.
HGNCHGNC:17109. ADAMTS17.
MIM607511. gene.
PharmGKBPA24543.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8TE56.
HOVERGENQ8TE56.

Gene expression databases

ArrayExpressQ8TE56.
BgeeQ8TE56.
CleanExHS_ADAMTS17.
GenevestigatorQ8TE56.
GermOnlineENSG00000140470. Homo sapiens.

Family and domain databases

InterProIPR010294. ADAM_spacer1.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
IPR007087. Znf_C2H2.
[Graphical view]
PfamPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF08686. PLAC. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
SMARTSM00209. TSP1. 5 hits.
[Graphical view]
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00546. CYSTEINE_SWITCH. False negative.
PS00427. DISINTEGRIN_1. False negative.
PS50214. DISINTEGRIN_2. False negative.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio89106.
SOURCESearch...

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Entry information

Entry nameATS17_HUMAN
AccessionPrimary (citable) accession number: Q8TE56
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2002
Last modified: November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

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Human chromosome 15: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents