Q8TE54 (S26A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anion exchange transporter

Alternative name(s):
Solute carrier family 26 member 7

Gene names

Name:	SLC26A7
Synonyms:	SUT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Ref.2 Ref.5 UniProtKB Q8R2Z3
Subcellular location	Recycling endosome membrane; Multi-pass membrane protein. Note: Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. Ref.7
Tissue specificity	Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. Ref.1 Ref.2 Ref.6 Ref.8
Miscellaneous	Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Ref.5
Sequence similarities	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification] Contains 1 STAS domain.

Ontologies

Keywords
Biological process	Anion exchange Ion transport Transport
Cellular component	Endosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gastric acid secretion Inferred from electronic annotation. Source: Compara sulfate transport Inferred from direct assay PubMed 1183472. Source: UniProtKB
Cellular_component	basolateral plasma membrane Inferred from mutant phenotype Ref.7. Source: UniProtKB endosome Inferred from direct assay Ref.7. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW recycling endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	anion:anion antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW bicarbonate transmembrane transporter activity Inferred from sequence or structural similarity Ref.5. Source: UniProtKB chloride channel activity Inferred from direct assay PubMed 1183472. Source: UniProtKB oxalate transmembrane transporter activity Inferred from direct assay PubMed 1183472. Source: UniProtKB sulfate transmembrane transporter activity Inferred from direct assay PubMed 1183472. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.3 (identifier: Q8TE54-1)

Also known as: 1A; 1B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 Ref.3 Ref.4 (identifier: Q8TE54-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 656	656	Anion exchange transporter		PRO_0000320681
Regions
	Topological domain	1 – 75	75	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Potential
	Topological domain	97 – 144	48	Extracellular Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Topological domain	166	1	Cytoplasmic Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Topological domain	188 – 202	15	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Topological domain	224 – 227	4	Cytoplasmic Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Topological domain	249 – 254	6	Extracellular Potential
	Transmembrane	255 – 275	21	Helical; Potential
	Topological domain	276 – 306	31	Cytoplasmic Potential
	Transmembrane	307 – 327	21	Helical; Potential
	Topological domain	328 – 343	16	Extracellular Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Topological domain	365 – 383	19	Cytoplasmic Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Transmembrane	405 – 425	21	Helical; Potential
	Topological domain	426 – 448	23	Extracellular Potential
	Transmembrane	449 – 469	21	Helical; Potential
	Topological domain	470 – 656	187	Cytoplasmic Potential
	Domain	492 – 641	150	STAS
	Region	641 – 656	16	Membrane targeting Ref.7
Natural variations
	Alternative sequence	646 – 656	11	NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. Ref.1 Ref.2 Ref.4		VSP_052689
	Natural variant	215	1	I → V. Corresponds to variant rs16912250 [ dbSNP | Ensembl ].		VAR_053666
	Natural variant	381	1	V → G. Corresponds to variant rs34921316 [ dbSNP | Ensembl ].		VAR_053667
Experimental info
	Sequence conflict	132	1	T → A in CAC88371. Ref.1
	Sequence conflict	521	1	T → A in AAI14475. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (1A) (1B) [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 9F8D2E140E5C00CB	FASTA	656	72,213
	10 20 30 40 50 60 MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ 70 80 90 100 110 120 QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP 130 140 150 160 170 180 QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS 190 200 210 220 230 240 AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV 250 260 270 280 290 300 LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 310 320 330 340 350 360 PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI 370 380 390 400 410 420 PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 430 440 450 460 470 480 LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI 490 500 510 520 530 540 KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI 550 560 570 580 590 600 SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 610 620 630 640 650 SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV
	Isoform 2 (B) [UniParc]. Checksum: 1F8967404F54DC9F	FASTA	663	73,033
	10 20 30 40 50 60 MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ 70 80 90 100 110 120 QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP 130 140 150 160 170 180 QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS 190 200 210 220 230 240 AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV 250 260 270 280 290 300 LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 310 320 330 340 350 360 PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI 370 380 390 400 410 420 PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 430 440 450 460 470 480 LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI 490 500 510 520 530 540 KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI 550 560 570 580 590 600 SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 610 620 630 640 650 660 SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKASYKL LFDNLDLPTM PPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney." Vincourt J.-B., Jullien D., Kossida S., Amalric F., Girard J.-P. Genomics 79:249-256(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Endothelial cell and Kidney.
[2]	"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9." Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J. J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta.
[5]	"Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells." Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M. Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, FUNCTION, INHIBITION.
[6]	"SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney." Kujala M., Tienari J., Lohi H., Elomaa O., Sariola H., Lehtonen E., Kere J. Nephron Exp. Nephrol. 101:E50-E58(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion." Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M. J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[8]	"Expression of ion transport-associated proteins in human efferent and epididymal ducts." Kujala M., Hihnala S., Tienari J., Kaunisto K., Hastbacka J., Holmberg C., Kere J., Hoglund P. Reproduction 133:775-784(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ413228 mRNA. Translation: CAC88370.1. AJ413229 mRNA. Translation: CAC88371.1. AJ413230 mRNA. Translation: CAC88372.1. AF331521 mRNA. Translation: AAK95665.1. CH471060 Genomic DNA. Translation: EAW91680.1. CH471060 Genomic DNA. Translation: EAW91679.1. BC094730 mRNA. Translation: AAH94730.1. BC113866 mRNA. Translation: AAI13867.1. BC114474 mRNA. Translation: AAI14475.1.
IPI	IPI00150366. IPI00152632.
RefSeq	NP_439897.1. NM_052832.2. NP_599028.1. NM_134266.1.
UniGene	Hs.354013.
3D structure databases
ProteinModelPortal	Q8TE54.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000309504.
Protein family/group databases
TCDB	2.A.53.2.6. sulfate permease (SulP) family.
PTM databases
PhosphoSite	Q8TE54.
Polymorphism databases
DMDM	172045817.
Proteomic databases
PaxDb	Q8TE54.
PRIDE	Q8TE54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276609; ENSP00000276609; ENSG00000147606. ENST00000309536; ENSP00000309504; ENSG00000147606. ENST00000523719; ENSP00000428849; ENSG00000147606.
GeneID	115111.
KEGG	hsa:115111.
UCSC	uc003yex.3. human. uc003yez.3. human.
Organism-specific databases
CTD	115111.
GeneCards	GC08P092221.
HGNC	HGNC:14467. SLC26A7.
MIM	608479. gene.
neXtProt	NX_Q8TE54.
PharmGKB	PA37884.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0659.
HOGENOM	HOG000049231.
HOVERGEN	HBG108442.
KO	K13962.
OMA	NAKKFYT.
OrthoDB	EOG45HRWX.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q8TE54.
Bgee	Q8TE54.
CleanEx	HS_SLC26A7.
Genevestigator	Q8TE54.
Family and domain databases
Gene3D	3.30.750.24. 2 hits.
InterPro	IPR002645. STAS_dom. IPR011547. Sulph_transpt. [Graphical view]
Pfam	PF01740. STAS. 1 hit. PF00916. Sulfate_transp. 1 hit. [Graphical view]
SUPFAM	SSF52091. STAS. 1 hit.
PROSITE	PS01130. SLC26A. False negative. PS50801. STAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC26A7. human.
GenomeRNAi	115111.
NextBio	79513.
SOURCE	Search...

Entry information

Entry name

S26A7_HUMAN

Accession

Primary (citable) accession number: Q8TE54
Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.