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Q8TE54

- S26A7_HUMAN

UniProt

Q8TE54 - S26A7_HUMAN

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Protein

Anion exchange transporter

Gene

SLC26A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.By similarity2 Publications

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB-KW
  2. bicarbonate transmembrane transporter activity Source: UniProtKB
  3. chloride channel activity Source: UniProtKB
  4. oxalate transmembrane transporter activity Source: UniProtKB
  5. sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. anion transport Source: UniProtKB
  2. bicarbonate transport Source: UniProtKB
  3. chloride transport Source: UniProtKB
  4. gastric acid secretion Source: Ensembl
  5. ion transport Source: Reactome
  6. oxalate transport Source: UniProtKB
  7. sulfate transmembrane transport Source: GOC
  8. sulfate transport Source: UniProtKB
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19357. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.6. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene namesi
Name:SLC26A7Imported
Synonyms:SUT2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:14467. SLC26A7.

Subcellular locationi

Recycling endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.1 Publication

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endosome Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Anion exchange transporterPRO_0000320681Add
BLAST

Proteomic databases

PaxDbiQ8TE54.
PRIDEiQ8TE54.

PTM databases

PhosphoSiteiQ8TE54.

Expressioni

Tissue specificityi

Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.4 Publications

Gene expression databases

BgeeiQ8TE54.
CleanExiHS_SLC26A7.
ExpressionAtlasiQ8TE54. baseline and differential.
GenevestigatoriQ8TE54.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309504.

Structurei

3D structure databases

ProteinModelPortaliQ8TE54.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini97 – 14448ExtracellularSequence AnalysisAdd
BLAST
Topological domaini166 – 1661CytoplasmicSequence Analysis
Topological domaini188 – 20215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 2274CytoplasmicSequence Analysis
Topological domaini249 – 2546ExtracellularSequence Analysis
Topological domaini276 – 30631CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini328 – 34316ExtracellularSequence AnalysisAdd
BLAST
Topological domaini365 – 38319CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini426 – 44823ExtracellularSequence AnalysisAdd
BLAST
Topological domaini470 – 656187CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei449 – 46921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini492 – 641150STASPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 65616Membrane targeting1 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000049231.
HOVERGENiHBG108442.
InParanoidiQ8TE54.
KOiK13962.
OMAiCLISCIF.
OrthoDBiEOG76T9QT.
PhylomeDBiQ8TE54.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8TE54-1) [UniParc]FASTAAdd to Basket

Also known as: 1A1 Publication

, 1B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD
60 70 80 90 100
TVSGIMLAVQ QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA
110 120 130 140 150
TGTFALTSLI SANAVERIVP QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA
160 170 180 190 200
VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS AMTTGAATHV VTSQVKYLLG
210 220 230 240 250
MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV LVLVKELNEQ
260 270 280 290 300
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP
310 320 330 340 350
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS
360 370 380 390 400
NIVSSFFFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL
410 420 430 440 450
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC
460 470 480 490 500
FAANVGLLFG VVCTIAIVIG RFPRAMTVSI KNMKEMEFKV KTEMDSETLQ
510 520 530 540 550
QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI SKCEQNTLLN
560 570 580 590 600
SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR
610 620 630 640 650
SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL

SDHSEV
Length:656
Mass (Da):72,213
Last modified:February 26, 2008 - v2
Checksum:i9F8D2E140E5C00CB
GO
Isoform 22 Publications (identifier: Q8TE54-2) [UniParc]FASTAAdd to Basket

Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

Show »
Length:663
Mass (Da):73,033
Checksum:i1F8967404F54DC9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321T → A in CAC88371. (PubMed:11829495)Curated
Sequence conflicti521 – 5211T → A in AAI14475. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151I → V.
Corresponds to variant rs16912250 [ dbSNP | Ensembl ].
VAR_053666
Natural varianti381 – 3811V → G.
Corresponds to variant rs34921316 [ dbSNP | Ensembl ].
VAR_053667

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei646 – 65611NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. 3 PublicationsVSP_052689Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ413228 mRNA. Translation: CAC88370.1.
AJ413229 mRNA. Translation: CAC88371.1.
AJ413230 mRNA. Translation: CAC88372.1.
AF331521 mRNA. Translation: AAK95665.1.
CH471060 Genomic DNA. Translation: EAW91680.1.
CH471060 Genomic DNA. Translation: EAW91679.1.
BC094730 mRNA. Translation: AAH94730.1.
BC113866 mRNA. Translation: AAI13867.1.
BC114474 mRNA. Translation: AAI14475.1.
CCDSiCCDS6254.1. [Q8TE54-1]
CCDS6255.1. [Q8TE54-2]
RefSeqiNP_001269285.1. NM_001282356.1. [Q8TE54-1]
NP_001269286.1. NM_001282357.1.
NP_439897.1. NM_052832.3. [Q8TE54-1]
NP_599028.1. NM_134266.1. [Q8TE54-2]
UniGeneiHs.354013.

Genome annotation databases

EnsembliENST00000276609; ENSP00000276609; ENSG00000147606. [Q8TE54-1]
ENST00000309536; ENSP00000309504; ENSG00000147606. [Q8TE54-2]
ENST00000523719; ENSP00000428849; ENSG00000147606. [Q8TE54-1]
ENST00000617233; ENSP00000482549; ENSG00000147606. [Q8TE54-1]
GeneIDi115111.
KEGGihsa:115111.
UCSCiuc003yex.3. human. [Q8TE54-1]
uc003yez.3. human. [Q8TE54-2]

Polymorphism databases

DMDMi172045817.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ413228 mRNA. Translation: CAC88370.1 .
AJ413229 mRNA. Translation: CAC88371.1 .
AJ413230 mRNA. Translation: CAC88372.1 .
AF331521 mRNA. Translation: AAK95665.1 .
CH471060 Genomic DNA. Translation: EAW91680.1 .
CH471060 Genomic DNA. Translation: EAW91679.1 .
BC094730 mRNA. Translation: AAH94730.1 .
BC113866 mRNA. Translation: AAI13867.1 .
BC114474 mRNA. Translation: AAI14475.1 .
CCDSi CCDS6254.1. [Q8TE54-1 ]
CCDS6255.1. [Q8TE54-2 ]
RefSeqi NP_001269285.1. NM_001282356.1. [Q8TE54-1 ]
NP_001269286.1. NM_001282357.1.
NP_439897.1. NM_052832.3. [Q8TE54-1 ]
NP_599028.1. NM_134266.1. [Q8TE54-2 ]
UniGenei Hs.354013.

3D structure databases

ProteinModelPortali Q8TE54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000309504.

Protein family/group databases

TCDBi 2.A.53.2.6. the sulfate permease (sulp) family.

PTM databases

PhosphoSitei Q8TE54.

Polymorphism databases

DMDMi 172045817.

Proteomic databases

PaxDbi Q8TE54.
PRIDEi Q8TE54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276609 ; ENSP00000276609 ; ENSG00000147606 . [Q8TE54-1 ]
ENST00000309536 ; ENSP00000309504 ; ENSG00000147606 . [Q8TE54-2 ]
ENST00000523719 ; ENSP00000428849 ; ENSG00000147606 . [Q8TE54-1 ]
ENST00000617233 ; ENSP00000482549 ; ENSG00000147606 . [Q8TE54-1 ]
GeneIDi 115111.
KEGGi hsa:115111.
UCSCi uc003yex.3. human. [Q8TE54-1 ]
uc003yez.3. human. [Q8TE54-2 ]

Organism-specific databases

CTDi 115111.
GeneCardsi GC08P092221.
HGNCi HGNC:14467. SLC26A7.
MIMi 608479. gene.
neXtProti NX_Q8TE54.
PharmGKBi PA37884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00760000119026.
HOGENOMi HOG000049231.
HOVERGENi HBG108442.
InParanoidi Q8TE54.
KOi K13962.
OMAi CLISCIF.
OrthoDBi EOG76T9QT.
PhylomeDBi Q8TE54.
TreeFami TF313784.

Enzyme and pathway databases

Reactomei REACT_19357. Multifunctional anion exchangers.

Miscellaneous databases

ChiTaRSi SLC26A7. human.
GeneWikii SLC26A7.
GenomeRNAii 115111.
NextBioi 79513.
PROi Q8TE54.
SOURCEi Search...

Gene expression databases

Bgeei Q8TE54.
CleanExi HS_SLC26A7.
ExpressionAtlasi Q8TE54. baseline and differential.
Genevestigatori Q8TE54.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney."
    Vincourt J.-B., Jullien D., Kossida S., Amalric F., Girard J.-P.
    Genomics 79:249-256(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Endothelial cellImported and KidneyImported.
  2. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
    Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
    J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: PlacentaImported.
  5. "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
    Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
    Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, INHIBITION.
  6. "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney."
    Kujala M., Tienari J., Lohi H., Elomaa O., Sariola H., Lehtonen E., Kere J.
    Nephron Exp. Nephrol. 101:E50-E58(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
    Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
    J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Expression of ion transport-associated proteins in human efferent and epididymal ducts."
    Kujala M., Hihnala S., Tienari J., Kaunisto K., Hastbacka J., Holmberg C., Kere J., Hoglund P.
    Reproduction 133:775-784(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS26A7_HUMAN
AccessioniPrimary (citable) accession number: Q8TE54
Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3