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Q8TE54

- S26A7_HUMAN

UniProt

Q8TE54 - S26A7_HUMAN

Protein

Anion exchange transporter

Gene

SLC26A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.By similarity2 Publications

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB-KW
    2. bicarbonate transmembrane transporter activity Source: UniProtKB
    3. chloride channel activity Source: UniProtKB
    4. oxalate transmembrane transporter activity Source: UniProtKB
    5. sulfate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. anion transport Source: UniProtKB
    2. bicarbonate transport Source: UniProtKB
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: UniProtKB
    5. gastric acid secretion Source: Ensembl
    6. ion transport Source: Reactome
    7. oxalate transport Source: UniProtKB
    8. sulfate transmembrane transport Source: GOC
    9. sulfate transport Source: UniProtKB
    10. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Anion exchange, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19357. Multifunctional anion exchangers.

    Protein family/group databases

    TCDBi2.A.53.2.6. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange transporter
    Alternative name(s):
    Solute carrier family 26 member 7
    Gene namesi
    Name:SLC26A7Imported
    Synonyms:SUT2Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14467. SLC26A7.

    Subcellular locationi

    Recycling endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.1 Publication

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. endosome Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: Reactome
    6. recycling endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Anion exchange transporterPRO_0000320681Add
    BLAST

    Proteomic databases

    PaxDbiQ8TE54.
    PRIDEiQ8TE54.

    PTM databases

    PhosphoSiteiQ8TE54.

    Expressioni

    Tissue specificityi

    Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.4 Publications

    Gene expression databases

    ArrayExpressiQ8TE54.
    BgeeiQ8TE54.
    CleanExiHS_SLC26A7.
    GenevestigatoriQ8TE54.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000309504.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE54.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 14448ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 1661CytoplasmicSequence Analysis
    Topological domaini188 – 20215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 2274CytoplasmicSequence Analysis
    Topological domaini249 – 2546ExtracellularSequence Analysis
    Topological domaini276 – 30631CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini328 – 34316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini365 – 38319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini426 – 44823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini470 – 656187CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini492 – 641150STASPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni641 – 65616Membrane targeting1 PublicationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000049231.
    HOVERGENiHBG108442.
    KOiK13962.
    OMAiCLISCIF.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ8TE54.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8TE54-1) [UniParc]FASTAAdd to Basket

    Also known as: 1A1 Publication

    , 1B1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD    50
    TVSGIMLAVQ QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA 100
    TGTFALTSLI SANAVERIVP QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA 150
    VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS AMTTGAATHV VTSQVKYLLG 200
    MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV LVLVKELNEQ 250
    FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 300
    PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS 350
    NIVSSFFFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL 400
    LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC 450
    FAANVGLLFG VVCTIAIVIG RFPRAMTVSI KNMKEMEFKV KTEMDSETLQ 500
    QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI SKCEQNTLLN 550
    SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 600
    SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL 650
    SDHSEV 656
    Length:656
    Mass (Da):72,213
    Last modified:February 26, 2008 - v2
    Checksum:i9F8D2E140E5C00CB
    GO
    Isoform 22 Publications (identifier: Q8TE54-2) [UniParc]FASTAAdd to Basket

    Also known as: B1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

    Show »
    Length:663
    Mass (Da):73,033
    Checksum:i1F8967404F54DC9F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321T → A in CAC88371. (PubMed:11829495)Curated
    Sequence conflicti521 – 5211T → A in AAI14475. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti215 – 2151I → V.
    Corresponds to variant rs16912250 [ dbSNP | Ensembl ].
    VAR_053666
    Natural varianti381 – 3811V → G.
    Corresponds to variant rs34921316 [ dbSNP | Ensembl ].
    VAR_053667

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei646 – 65611NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. 3 PublicationsVSP_052689Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ413228 mRNA. Translation: CAC88370.1.
    AJ413229 mRNA. Translation: CAC88371.1.
    AJ413230 mRNA. Translation: CAC88372.1.
    AF331521 mRNA. Translation: AAK95665.1.
    CH471060 Genomic DNA. Translation: EAW91680.1.
    CH471060 Genomic DNA. Translation: EAW91679.1.
    BC094730 mRNA. Translation: AAH94730.1.
    BC113866 mRNA. Translation: AAI13867.1.
    BC114474 mRNA. Translation: AAI14475.1.
    CCDSiCCDS6254.1. [Q8TE54-1]
    CCDS6255.1. [Q8TE54-2]
    RefSeqiNP_001269285.1. NM_001282356.1. [Q8TE54-1]
    NP_001269286.1. NM_001282357.1.
    NP_439897.1. NM_052832.3. [Q8TE54-1]
    NP_599028.1. NM_134266.1. [Q8TE54-2]
    UniGeneiHs.354013.

    Genome annotation databases

    EnsembliENST00000276609; ENSP00000276609; ENSG00000147606. [Q8TE54-1]
    ENST00000309536; ENSP00000309504; ENSG00000147606. [Q8TE54-2]
    ENST00000523719; ENSP00000428849; ENSG00000147606. [Q8TE54-1]
    GeneIDi115111.
    KEGGihsa:115111.
    UCSCiuc003yex.3. human. [Q8TE54-1]
    uc003yez.3. human. [Q8TE54-2]

    Polymorphism databases

    DMDMi172045817.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ413228 mRNA. Translation: CAC88370.1 .
    AJ413229 mRNA. Translation: CAC88371.1 .
    AJ413230 mRNA. Translation: CAC88372.1 .
    AF331521 mRNA. Translation: AAK95665.1 .
    CH471060 Genomic DNA. Translation: EAW91680.1 .
    CH471060 Genomic DNA. Translation: EAW91679.1 .
    BC094730 mRNA. Translation: AAH94730.1 .
    BC113866 mRNA. Translation: AAI13867.1 .
    BC114474 mRNA. Translation: AAI14475.1 .
    CCDSi CCDS6254.1. [Q8TE54-1 ]
    CCDS6255.1. [Q8TE54-2 ]
    RefSeqi NP_001269285.1. NM_001282356.1. [Q8TE54-1 ]
    NP_001269286.1. NM_001282357.1.
    NP_439897.1. NM_052832.3. [Q8TE54-1 ]
    NP_599028.1. NM_134266.1. [Q8TE54-2 ]
    UniGenei Hs.354013.

    3D structure databases

    ProteinModelPortali Q8TE54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000309504.

    Protein family/group databases

    TCDBi 2.A.53.2.6. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q8TE54.

    Polymorphism databases

    DMDMi 172045817.

    Proteomic databases

    PaxDbi Q8TE54.
    PRIDEi Q8TE54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276609 ; ENSP00000276609 ; ENSG00000147606 . [Q8TE54-1 ]
    ENST00000309536 ; ENSP00000309504 ; ENSG00000147606 . [Q8TE54-2 ]
    ENST00000523719 ; ENSP00000428849 ; ENSG00000147606 . [Q8TE54-1 ]
    GeneIDi 115111.
    KEGGi hsa:115111.
    UCSCi uc003yex.3. human. [Q8TE54-1 ]
    uc003yez.3. human. [Q8TE54-2 ]

    Organism-specific databases

    CTDi 115111.
    GeneCardsi GC08P092221.
    HGNCi HGNC:14467. SLC26A7.
    MIMi 608479. gene.
    neXtProti NX_Q8TE54.
    PharmGKBi PA37884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000049231.
    HOVERGENi HBG108442.
    KOi K13962.
    OMAi CLISCIF.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q8TE54.
    TreeFami TF313784.

    Enzyme and pathway databases

    Reactomei REACT_19357. Multifunctional anion exchangers.

    Miscellaneous databases

    ChiTaRSi SLC26A7. human.
    GeneWikii SLC26A7.
    GenomeRNAii 115111.
    NextBioi 79513.
    PROi Q8TE54.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TE54.
    Bgeei Q8TE54.
    CleanExi HS_SLC26A7.
    Genevestigatori Q8TE54.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney."
      Vincourt J.-B., Jullien D., Kossida S., Amalric F., Girard J.-P.
      Genomics 79:249-256(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Endothelial cellImported and KidneyImported.
    2. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
      Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
      J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: PlacentaImported.
    5. "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
      Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
      Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, INHIBITION.
    6. "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney."
      Kujala M., Tienari J., Lohi H., Elomaa O., Sariola H., Lehtonen E., Kere J.
      Nephron Exp. Nephrol. 101:E50-E58(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
      Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
      J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Expression of ion transport-associated proteins in human efferent and epididymal ducts."
      Kujala M., Hihnala S., Tienari J., Kaunisto K., Hastbacka J., Holmberg C., Kere J., Hoglund P.
      Reproduction 133:775-784(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS26A7_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE54
    Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3