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Protein

Anion exchange transporter

Gene

SLC26A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.By similarity2 Publications

Miscellaneous

Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

GO - Molecular functioni

  • anion:anion antiporter activity Source: GO_Central
  • bicarbonate transmembrane transporter activity Source: UniProtKB
  • chloride channel activity Source: UniProtKB
  • oxalate transmembrane transporter activity Source: UniProtKB
  • secondary active sulfate transmembrane transporter activity Source: InterPro
  • sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • anion transport Source: UniProtKB
  • bicarbonate transport Source: UniProtKB
  • chloride transport Source: UniProtKB
  • gastric acid secretion Source: Ensembl
  • ion transport Source: Reactome
  • oxalate transport Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: UniProtKB

Keywordsi

Biological processAnion exchange, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.6. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene namesi
Name:SLC26A7Imported
Synonyms:SUT2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147606.8.
HGNCiHGNC:14467. SLC26A7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 144ExtracellularSequence analysisAdd BLAST48
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166CytoplasmicSequence analysis1
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 202ExtracellularSequence analysisAdd BLAST15
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 227CytoplasmicSequence analysis4
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 254ExtracellularSequence analysis6
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 306CytoplasmicSequence analysisAdd BLAST31
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 343ExtracellularSequence analysisAdd BLAST16
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 383CytoplasmicSequence analysisAdd BLAST19
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 448ExtracellularSequence analysisAdd BLAST23
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 656CytoplasmicSequence analysisAdd BLAST187

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi115111.
OpenTargetsiENSG00000147606.
PharmGKBiPA37884.

Polymorphism and mutation databases

BioMutaiSLC26A7.
DMDMi172045817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206811 – 656Anion exchange transporterAdd BLAST656

Proteomic databases

PaxDbiQ8TE54.
PeptideAtlasiQ8TE54.
PRIDEiQ8TE54.

PTM databases

iPTMnetiQ8TE54.
PhosphoSitePlusiQ8TE54.

Expressioni

Tissue specificityi

Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.4 Publications

Gene expression databases

BgeeiENSG00000147606.
CleanExiHS_SLC26A7.
ExpressionAtlasiQ8TE54. baseline and differential.
GenevisibleiQ8TE54. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309504.

Structurei

3D structure databases

ProteinModelPortaliQ8TE54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini492 – 641STASPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni641 – 656Membrane targeting1 PublicationAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000049231.
HOVERGENiHBG108442.
InParanoidiQ8TE54.
KOiK13962.
OMAiDYSGVSM.
OrthoDBiEOG091G07RT.
PhylomeDBiQ8TE54.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiView protein in InterPro
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030329. SLC26A7.
IPR002645. STAS_dom.
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF142. PTHR11814:SF142. 1 hit.
PfamiView protein in Pfam
PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiView protein in PROSITE
PS50801. STAS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8TE54-1) [UniParc]FASTAAdd to basket
Also known as: 1A1 Publication, 1B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD
60 70 80 90 100
TVSGIMLAVQ QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA
110 120 130 140 150
TGTFALTSLI SANAVERIVP QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA
160 170 180 190 200
VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS AMTTGAATHV VTSQVKYLLG
210 220 230 240 250
MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV LVLVKELNEQ
260 270 280 290 300
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP
310 320 330 340 350
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS
360 370 380 390 400
NIVSSFFFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL
410 420 430 440 450
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC
460 470 480 490 500
FAANVGLLFG VVCTIAIVIG RFPRAMTVSI KNMKEMEFKV KTEMDSETLQ
510 520 530 540 550
QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI SKCEQNTLLN
560 570 580 590 600
SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR
610 620 630 640 650
SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL

SDHSEV
Length:656
Mass (Da):72,213
Last modified:February 26, 2008 - v2
Checksum:i9F8D2E140E5C00CB
GO
Isoform 22 Publications (identifier: Q8TE54-2) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

Show »
Length:663
Mass (Da):73,033
Checksum:i1F8967404F54DC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132T → A in CAC88371 (PubMed:11829495).Curated1
Sequence conflicti521T → A in AAI14475 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053666215I → V. Corresponds to variant dbSNP:rs16912250Ensembl.1
Natural variantiVAR_053667381V → G. Corresponds to variant dbSNP:rs34921316Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052689646 – 656NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ413228 mRNA. Translation: CAC88370.1.
AJ413229 mRNA. Translation: CAC88371.1.
AJ413230 mRNA. Translation: CAC88372.1.
AF331521 mRNA. Translation: AAK95665.1.
CH471060 Genomic DNA. Translation: EAW91680.1.
CH471060 Genomic DNA. Translation: EAW91679.1.
BC094730 mRNA. Translation: AAH94730.1.
BC113866 mRNA. Translation: AAI13867.1.
BC114474 mRNA. Translation: AAI14475.1.
CCDSiCCDS6254.1. [Q8TE54-1]
CCDS6255.1. [Q8TE54-2]
RefSeqiNP_001269285.1. NM_001282356.1. [Q8TE54-1]
NP_001269286.1. NM_001282357.1.
NP_439897.1. NM_052832.3. [Q8TE54-1]
NP_599028.1. NM_134266.1. [Q8TE54-2]
UniGeneiHs.354013.

Genome annotation databases

EnsembliENST00000276609; ENSP00000276609; ENSG00000147606. [Q8TE54-1]
ENST00000309536; ENSP00000309504; ENSG00000147606. [Q8TE54-2]
ENST00000523719; ENSP00000428849; ENSG00000147606. [Q8TE54-1]
ENST00000617233; ENSP00000482549; ENSG00000147606. [Q8TE54-1]
GeneIDi115111.
KEGGihsa:115111.
UCSCiuc003yex.5. human. [Q8TE54-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS26A7_HUMAN
AccessioniPrimary (citable) accession number: Q8TE54
Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families