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Q8TE54 (S26A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene names
Name:SLC26A7
Synonyms:SUT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Ref.2 Ref.5 UniProtKB Q8R2Z3

Subcellular location

Recycling endosome membrane; Multi-pass membrane protein. Note: Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. Ref.7

Tissue specificity

Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. Ref.1 Ref.2 Ref.6 Ref.8

Miscellaneous

Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Ref.5

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Ontologies

Keywords
   Biological processAnion exchange
Ion transport
Transport
   Cellular componentEndosome
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanion transport

Inferred from direct assay Ref.2. Source: UniProtKB

bicarbonate transport

Inferred from sequence or structural similarity Ref.5. Source: UniProtKB

chloride transmembrane transport

Inferred from direct assay PubMed 1183472. Source: GOC

chloride transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

ion transport

Traceable author statement. Source: Reactome

oxalate transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

sulfate transmembrane transport

Inferred from direct assay PubMed 1183472. Source: GOC

sulfate transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentbasolateral plasma membrane

Inferred from mutant phenotype Ref.7. Source: UniProtKB

cytoplasm

Inferred from direct assay Ref.7. Source: UniProtKB

endosome

Inferred from direct assay Ref.7. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

recycling endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionanion:anion antiporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

bicarbonate transmembrane transporter activity

Inferred from sequence or structural similarity Ref.5. Source: UniProtKB

chloride channel activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

oxalate transmembrane transporter activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

sulfate transmembrane transporter activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.3 (identifier: Q8TE54-1)

Also known as: 1A; 1B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 Ref.3 Ref.4 (identifier: Q8TE54-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 656656Anion exchange transporter
PRO_0000320681

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 14448Extracellular Potential
Transmembrane145 – 16521Helical; Potential
Topological domain1661Cytoplasmic Potential
Transmembrane167 – 18721Helical; Potential
Topological domain188 – 20215Extracellular Potential
Transmembrane203 – 22321Helical; Potential
Topological domain224 – 2274Cytoplasmic Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 2546Extracellular Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 30631Cytoplasmic Potential
Transmembrane307 – 32721Helical; Potential
Topological domain328 – 34316Extracellular Potential
Transmembrane344 – 36421Helical; Potential
Topological domain365 – 38319Cytoplasmic Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane405 – 42521Helical; Potential
Topological domain426 – 44823Extracellular Potential
Transmembrane449 – 46921Helical; Potential
Topological domain470 – 656187Cytoplasmic Potential
Domain492 – 641150STAS
Region641 – 65616Membrane targeting Ref.7

Natural variations

Alternative sequence646 – 65611NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. Ref.1 Ref.2 Ref.4
VSP_052689
Natural variant2151I → V.
Corresponds to variant rs16912250 [ dbSNP | Ensembl ].
VAR_053666
Natural variant3811V → G.
Corresponds to variant rs34921316 [ dbSNP | Ensembl ].
VAR_053667

Experimental info

Sequence conflict1321T → A in CAC88371. Ref.1
Sequence conflict5211T → A in AAI14475. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1A) (1B) [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 9F8D2E140E5C00CB

FASTA65672,213
        10         20         30         40         50         60 
MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ 

        70         80         90        100        110        120 
QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP 

       130        140        150        160        170        180 
QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS 

       190        200        210        220        230        240 
AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV 

       250        260        270        280        290        300 
LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP 

       310        320        330        340        350        360 
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI 

       370        380        390        400        410        420 
PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 

       430        440        450        460        470        480 
LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI 

       490        500        510        520        530        540 
KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI 

       550        560        570        580        590        600 
SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR 

       610        620        630        640        650 
SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 1F8967404F54DC9F
Show »

FASTA66373,033

References

« Hide 'large scale' references
[1]"Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney."
Vincourt J.-B., Jullien D., Kossida S., Amalric F., Girard J.-P.
Genomics 79:249-256(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Tissue: Endothelial cell and Kidney.
[2]"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta.
[5]"Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, INHIBITION.
[6]"SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney."
Kujala M., Tienari J., Lohi H., Elomaa O., Sariola H., Lehtonen E., Kere J.
Nephron Exp. Nephrol. 101:E50-E58(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Expression of ion transport-associated proteins in human efferent and epididymal ducts."
Kujala M., Hihnala S., Tienari J., Kaunisto K., Hastbacka J., Holmberg C., Kere J., Hoglund P.
Reproduction 133:775-784(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ413228 mRNA. Translation: CAC88370.1.
AJ413229 mRNA. Translation: CAC88371.1.
AJ413230 mRNA. Translation: CAC88372.1.
AF331521 mRNA. Translation: AAK95665.1.
CH471060 Genomic DNA. Translation: EAW91680.1.
CH471060 Genomic DNA. Translation: EAW91679.1.
BC094730 mRNA. Translation: AAH94730.1.
BC113866 mRNA. Translation: AAI13867.1.
BC114474 mRNA. Translation: AAI14475.1.
CCDSCCDS6254.1. [Q8TE54-1]
CCDS6255.1. [Q8TE54-2]
RefSeqNP_001269285.1. NM_001282356.1. [Q8TE54-1]
NP_001269286.1. NM_001282357.1.
NP_439897.1. NM_052832.3. [Q8TE54-1]
NP_599028.1. NM_134266.1. [Q8TE54-2]
UniGeneHs.354013.

3D structure databases

ProteinModelPortalQ8TE54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000309504.

Protein family/group databases

TCDB2.A.53.2.6. the sulfate permease (sulp) family.

PTM databases

PhosphoSiteQ8TE54.

Polymorphism databases

DMDM172045817.

Proteomic databases

PaxDbQ8TE54.
PRIDEQ8TE54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276609; ENSP00000276609; ENSG00000147606. [Q8TE54-1]
ENST00000309536; ENSP00000309504; ENSG00000147606. [Q8TE54-2]
ENST00000523719; ENSP00000428849; ENSG00000147606. [Q8TE54-1]
GeneID115111.
KEGGhsa:115111.
UCSCuc003yex.3. human. [Q8TE54-1]
uc003yez.3. human. [Q8TE54-2]

Organism-specific databases

CTD115111.
GeneCardsGC08P092221.
HGNCHGNC:14467. SLC26A7.
MIM608479. gene.
neXtProtNX_Q8TE54.
PharmGKBPA37884.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0659.
HOGENOMHOG000049231.
HOVERGENHBG108442.
KOK13962.
OMACLISCIF.
OrthoDBEOG76T9QT.
PhylomeDBQ8TE54.
TreeFamTF313784.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ8TE54.
BgeeQ8TE54.
CleanExHS_SLC26A7.
GenevestigatorQ8TE54.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
PROSITEPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC26A7. human.
GeneWikiSLC26A7.
GenomeRNAi115111.
NextBio79513.
PROQ8TE54.
SOURCESearch...

Entry information

Entry nameS26A7_HUMAN
AccessionPrimary (citable) accession number: Q8TE54
Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM