Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

OTU domain-containing protein 7A

Gene

OTUD7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.2 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei207By similarity1
Active sitei210NucleophileBy similarity1
Active sitei367Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri884 – 919A20-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169918-MONOMER.
ReactomeiR-HSA-5689896. Ovarian tumor domain proteases.

Protein family/group databases

MEROPSiC64.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 7A (EC:3.4.19.12)
Alternative name(s):
Zinc finger protein Cezanne 2
Gene namesi
Name:OTUD7A
Synonyms:C15orf16, CEZANNE2, OTUD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20718. OTUD7A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi161725.
OpenTargetsiENSG00000169918.
PharmGKBiPA134877572.

Polymorphism and mutation databases

BioMutaiOTUD7A.
DMDMi51701344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001887891 – 926OTU domain-containing protein 7AAdd BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineBy similarity1
Modified residuei880Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8TE49.
MaxQBiQ8TE49.
PaxDbiQ8TE49.
PeptideAtlasiQ8TE49.
PRIDEiQ8TE49.

PTM databases

iPTMnetiQ8TE49.
PhosphoSitePlusiQ8TE49.

Expressioni

Gene expression databases

BgeeiENSG00000169918.
CleanExiHS_OTUD7A.
ExpressionAtlasiQ8TE49. baseline and differential.
GenevisibleiQ8TE49. HS.

Organism-specific databases

HPAiHPA044554.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127799. 2 interactors.
STRINGi9606.ENSP00000305926.

Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi22 – 24Combined sources3
Helixi27 – 38Combined sources12
Helixi42 – 51Combined sources10
Turni52 – 54Combined sources3
Helixi56 – 68Combined sources13
Beta strandi71 – 75Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L2DNMR-A11-83[»]
ProteinModelPortaliQ8TE49.
SMRiQ8TE49.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TE49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 374OTUPROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 410TRAF-bindingBy similarityAdd BLAST243
Regioni183 – 449CatalyticBy similarityAdd BLAST267

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi494 – 509Nuclear localization signalSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the peptidase C64 family.Curated
Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 OTU domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri884 – 919A20-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4345. Eukaryota.
ENOG410XT8E. LUCA.
GeneTreeiENSGT00530000062989.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
InParanoidiQ8TE49.
KOiK11860.
OMAiHTANLPQ.
OrthoDBiEOG091G03R0.
PhylomeDBiQ8TE49.
TreeFamiTF323312.

Family and domain databases

InterProiIPR033477. Cezanne-2.
IPR003323. OTU_dom.
IPR002653. Znf_A20.
[Graphical view]
PANTHERiPTHR13367:SF9. PTHR13367:SF9. 1 hit.
PfamiPF02338. OTU. 1 hit.
PF01754. zf-A20. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE
60 70 80 90 100
GKNWDLTAAL SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP
110 120 130 140 150
CLQRQDDIAQ EKRLSRGISH ASSAIVSLAR SHVASECNNE QFPLEMPIYT
160 170 180 190 200
FQLPDLSVYS EDFRSFIERD LIEQATMVAL EQAGRLNWWS TVCTSCKRLL
210 220 230 240 250
PLATTGDGNC LLHAASLGMW GFHDRDLVLR KALYTMMRTG AEREALKRRW
260 270 280 290 300
RWQQTQQNKE EEWEREWTEL LKLASSEPRT HFSKNGGTGG GVDNSEDPVY
310 320 330 340 350
ESLEEFHVFV LAHILRRPIV VVADTMLRDS GGEAFAPIPF GGIYLPLEVP
360 370 380 390 400
PNRCHCSPLV LAYDQAHFSA LVSMEQRDQQ REQAVIPLTD SEHKLLPLHF
410 420 430 440 450
AVDPGKDWEW GKDDNDNARL AHLILSLEAK LNLLHSYMNV TWIRIPSETR
460 470 480 490 500
APLAQPESPT ASAGEDVQSL ADSLDSDRDS VCSNSNSNNG KNGKDKEKEK
510 520 530 540 550
QRKEKDKTRA DSVANKLGSF SKTLGIKLKK NMGGLGGLVH GKMGRANSAN
560 570 580 590 600
GKNGDSAERG KEKKAKSRKG SKEESGASAS TSPSEKTTPS PTDKAAGASP
610 620 630 640 650
AEKGGGPRGD AWKYSTDVKL SLNILRAAMQ GERKFIFAGL LLTSHRHQFH
660 670 680 690 700
EEMIGYYLTS AQERFSAEQE QRRRDAATAA AAAAAAAAAT AKRPPRRPET
710 720 730 740 750
EGVPVPERAS PGPPTQLVLK LKERPSPGPA AGRAARAAAG GTASPGGGAR
760 770 780 790 800
RASASGPVPG RSPPAPARQS VIHVQASGAR DEACAPAVGA LRPCATYPQQ
810 820 830 840 850
NRSLSSQSYS PARAAALRTV NTVESLARAV PGALPGAAGT AGAAEHKSQT
860 870 880 890 900
YTNGFGALRD GLEFADADAP TARSNGECGR GGPGPVQRRC QRENCAFYGR
910 920
AETEHYCSYC YREELRRRRE ARGARP
Length:926
Mass (Da):100,677
Last modified:June 1, 2002 - v1
Checksum:i6E4623C2EB2C8058
GO
Isoform 2 (identifier: Q8TE49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-260: E → ESGLVYTE

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):101,427
Checksum:iD35018A59F8747FE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011430260E → ESGLVYTE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430383 mRNA. Translation: CAD23047.1.
BC035668 mRNA. Translation: AAH35668.1.
CCDSiCCDS10026.1. [Q8TE49-1]
RefSeqiNP_570971.1. NM_130901.2. [Q8TE49-1]
UniGeneiHs.355236.
Hs.668950.

Genome annotation databases

EnsembliENST00000307050; ENSP00000305926; ENSG00000169918. [Q8TE49-1]
GeneIDi161725.
KEGGihsa:161725.
UCSCiuc001zfq.4. human. [Q8TE49-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430383 mRNA. Translation: CAD23047.1.
BC035668 mRNA. Translation: AAH35668.1.
CCDSiCCDS10026.1. [Q8TE49-1]
RefSeqiNP_570971.1. NM_130901.2. [Q8TE49-1]
UniGeneiHs.355236.
Hs.668950.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L2DNMR-A11-83[»]
ProteinModelPortaliQ8TE49.
SMRiQ8TE49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127799. 2 interactors.
STRINGi9606.ENSP00000305926.

Protein family/group databases

MEROPSiC64.002.

PTM databases

iPTMnetiQ8TE49.
PhosphoSitePlusiQ8TE49.

Polymorphism and mutation databases

BioMutaiOTUD7A.
DMDMi51701344.

Proteomic databases

EPDiQ8TE49.
MaxQBiQ8TE49.
PaxDbiQ8TE49.
PeptideAtlasiQ8TE49.
PRIDEiQ8TE49.

Protocols and materials databases

DNASUi161725.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307050; ENSP00000305926; ENSG00000169918. [Q8TE49-1]
GeneIDi161725.
KEGGihsa:161725.
UCSCiuc001zfq.4. human. [Q8TE49-1]

Organism-specific databases

CTDi161725.
DisGeNETi161725.
GeneCardsiOTUD7A.
HGNCiHGNC:20718. OTUD7A.
HPAiHPA044554.
MIMi612024. gene.
neXtProtiNX_Q8TE49.
OpenTargetsiENSG00000169918.
PharmGKBiPA134877572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4345. Eukaryota.
ENOG410XT8E. LUCA.
GeneTreeiENSGT00530000062989.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
InParanoidiQ8TE49.
KOiK11860.
OMAiHTANLPQ.
OrthoDBiEOG091G03R0.
PhylomeDBiQ8TE49.
TreeFamiTF323312.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169918-MONOMER.
ReactomeiR-HSA-5689896. Ovarian tumor domain proteases.

Miscellaneous databases

ChiTaRSiOTUD7A. human.
EvolutionaryTraceiQ8TE49.
GenomeRNAii161725.
PROiQ8TE49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169918.
CleanExiHS_OTUD7A.
ExpressionAtlasiQ8TE49. baseline and differential.
GenevisibleiQ8TE49. HS.

Family and domain databases

InterProiIPR033477. Cezanne-2.
IPR003323. OTU_dom.
IPR002653. Znf_A20.
[Graphical view]
PANTHERiPTHR13367:SF9. PTHR13367:SF9. 1 hit.
PfamiPF02338. OTU. 1 hit.
PF01754. zf-A20. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTU7A_HUMAN
AccessioniPrimary (citable) accession number: Q8TE49
Secondary accession number(s): Q8IWK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.