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Q8TE49

- OTU7A_HUMAN

UniProt

Q8TE49 - OTU7A_HUMAN

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Protein
OTU domain-containing protein 7A
Gene
OTUD7A, C15orf16, CEZANNE2, OTUD7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.2 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071 By similarity
Active sitei210 – 2101Nucleophile By similarity
Active sitei367 – 3671Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri884 – 91936A20-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC64.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 7A (EC:3.4.19.12)
Alternative name(s):
Zinc finger protein Cezanne 2
Gene namesi
Name:OTUD7A
Synonyms:C15orf16, CEZANNE2, OTUD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:20718. OTUD7A.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926OTU domain-containing protein 7A
PRO_0000188789Add
BLAST

Proteomic databases

MaxQBiQ8TE49.
PaxDbiQ8TE49.
PRIDEiQ8TE49.

PTM databases

PhosphoSiteiQ8TE49.

Expressioni

Gene expression databases

ArrayExpressiQ8TE49.
BgeeiQ8TE49.
CleanExiHS_OTUD7A.
GenevestigatoriQ8TE49.

Organism-specific databases

HPAiHPA044554.

Interactioni

Protein-protein interaction databases

BioGridi127799. 1 interaction.
STRINGi9606.ENSP00000305926.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 153
Beta strandi22 – 243
Helixi27 – 3812
Helixi42 – 5110
Turni52 – 543
Helixi56 – 6813
Beta strandi71 – 755

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2DNMR-A11-83[»]
ProteinModelPortaliQ8TE49.
SMRiQ8TE49. Positions 11-83, 146-404.

Miscellaneous databases

EvolutionaryTraceiQ8TE49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 374176OTU
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 410243TRAF-binding By similarity
Add
BLAST
Regioni183 – 449267Catalytic By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi494 – 50916Nuclear localization signal Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C64 family.
Contains 1 OTU domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282016.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
KOiK11860.
OMAiKQPEREP.
OrthoDBiEOG7JHM57.
PhylomeDBiQ8TE49.
TreeFamiTF323312.

Family and domain databases

InterProiIPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TE49-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE    50
GKNWDLTAAL SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP 100
CLQRQDDIAQ EKRLSRGISH ASSAIVSLAR SHVASECNNE QFPLEMPIYT 150
FQLPDLSVYS EDFRSFIERD LIEQATMVAL EQAGRLNWWS TVCTSCKRLL 200
PLATTGDGNC LLHAASLGMW GFHDRDLVLR KALYTMMRTG AEREALKRRW 250
RWQQTQQNKE EEWEREWTEL LKLASSEPRT HFSKNGGTGG GVDNSEDPVY 300
ESLEEFHVFV LAHILRRPIV VVADTMLRDS GGEAFAPIPF GGIYLPLEVP 350
PNRCHCSPLV LAYDQAHFSA LVSMEQRDQQ REQAVIPLTD SEHKLLPLHF 400
AVDPGKDWEW GKDDNDNARL AHLILSLEAK LNLLHSYMNV TWIRIPSETR 450
APLAQPESPT ASAGEDVQSL ADSLDSDRDS VCSNSNSNNG KNGKDKEKEK 500
QRKEKDKTRA DSVANKLGSF SKTLGIKLKK NMGGLGGLVH GKMGRANSAN 550
GKNGDSAERG KEKKAKSRKG SKEESGASAS TSPSEKTTPS PTDKAAGASP 600
AEKGGGPRGD AWKYSTDVKL SLNILRAAMQ GERKFIFAGL LLTSHRHQFH 650
EEMIGYYLTS AQERFSAEQE QRRRDAATAA AAAAAAAAAT AKRPPRRPET 700
EGVPVPERAS PGPPTQLVLK LKERPSPGPA AGRAARAAAG GTASPGGGAR 750
RASASGPVPG RSPPAPARQS VIHVQASGAR DEACAPAVGA LRPCATYPQQ 800
NRSLSSQSYS PARAAALRTV NTVESLARAV PGALPGAAGT AGAAEHKSQT 850
YTNGFGALRD GLEFADADAP TARSNGECGR GGPGPVQRRC QRENCAFYGR 900
AETEHYCSYC YREELRRRRE ARGARP 926
Length:926
Mass (Da):100,677
Last modified:June 1, 2002 - v1
Checksum:i6E4623C2EB2C8058
GO
Isoform 2 (identifier: Q8TE49-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-260: E → ESGLVYTE

Note: No experimental confirmation available.

Show »
Length:933
Mass (Da):101,427
Checksum:iD35018A59F8747FE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei260 – 2601E → ESGLVYTE in isoform 2.
VSP_011430

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ430383 mRNA. Translation: CAD23047.1.
BC035668 mRNA. Translation: AAH35668.1.
CCDSiCCDS10026.1. [Q8TE49-1]
RefSeqiNP_570971.1. NM_130901.1. [Q8TE49-1]
XP_006720476.1. XM_006720413.1. [Q8TE49-2]
UniGeneiHs.355236.

Genome annotation databases

EnsembliENST00000307050; ENSP00000305926; ENSG00000169918. [Q8TE49-1]
ENST00000382902; ENSP00000372358; ENSG00000169918. [Q8TE49-2]
GeneIDi161725.
KEGGihsa:161725.
UCSCiuc001zfq.3. human. [Q8TE49-1]
uc001zfr.3. human. [Q8TE49-2]

Polymorphism databases

DMDMi51701344.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ430383 mRNA. Translation: CAD23047.1 .
BC035668 mRNA. Translation: AAH35668.1 .
CCDSi CCDS10026.1. [Q8TE49-1 ]
RefSeqi NP_570971.1. NM_130901.1. [Q8TE49-1 ]
XP_006720476.1. XM_006720413.1. [Q8TE49-2 ]
UniGenei Hs.355236.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L2D NMR - A 11-83 [» ]
ProteinModelPortali Q8TE49.
SMRi Q8TE49. Positions 11-83, 146-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127799. 1 interaction.
STRINGi 9606.ENSP00000305926.

Protein family/group databases

MEROPSi C64.002.

PTM databases

PhosphoSitei Q8TE49.

Polymorphism databases

DMDMi 51701344.

Proteomic databases

MaxQBi Q8TE49.
PaxDbi Q8TE49.
PRIDEi Q8TE49.

Protocols and materials databases

DNASUi 161725.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307050 ; ENSP00000305926 ; ENSG00000169918 . [Q8TE49-1 ]
ENST00000382902 ; ENSP00000372358 ; ENSG00000169918 . [Q8TE49-2 ]
GeneIDi 161725.
KEGGi hsa:161725.
UCSCi uc001zfq.3. human. [Q8TE49-1 ]
uc001zfr.3. human. [Q8TE49-2 ]

Organism-specific databases

CTDi 161725.
GeneCardsi GC15M031773.
HGNCi HGNC:20718. OTUD7A.
HPAi HPA044554.
MIMi 612024. gene.
neXtProti NX_Q8TE49.
PharmGKBi PA134877572.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282016.
HOGENOMi HOG000048103.
HOVERGENi HBG050904.
KOi K11860.
OMAi KQPEREP.
OrthoDBi EOG7JHM57.
PhylomeDBi Q8TE49.
TreeFami TF323312.

Miscellaneous databases

EvolutionaryTracei Q8TE49.
GenomeRNAii 161725.
NextBioi 88096.
PROi Q8TE49.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TE49.
Bgeei Q8TE49.
CleanExi HS_OTUD7A.
Genevestigatori Q8TE49.

Family and domain databases

InterProi IPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel human gene, Cezanne 2."
    Evans P.C., Coadwell W.J., Kilshaw P.J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-678 (ISOFORM 2).
    Tissue: Brain.
  3. "Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne."
    Bremm A., Freund S.M., Komander D.
    Nat. Struct. Mol. Biol. 17:939-947(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
    Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
    Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  5. "The amino-terminal UBA domain of OTUD7A."
    Structural genomics consortium (SGC)
    Submitted (FEB-2012) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 11-83.

Entry informationi

Entry nameiOTU7A_HUMAN
AccessioniPrimary (citable) accession number: Q8TE49
Secondary accession number(s): Q8IWK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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