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Q8TE23

- TS1R2_HUMAN

UniProt

Q8TE23 - TS1R2_HUMAN

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Protein

Taste receptor type 1 member 2

Gene

TAS1R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

  1. protein heterodimerization activity Source: UniProtKB
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
  2. G-protein coupled receptor signaling pathway Source: HGNC
  3. positive regulation of cytokinesis Source: UniProt
  4. sensory perception of sweet taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

Protein family/group databases

TCDBi9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:TAS1R2
Synonyms:GPR71, T1R2, TR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14905. TAS1R2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 839820Taste receptor type 1 member 2PRO_0000012957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TE23.
PRIDEiQ8TE23.

PTM databases

PhosphoSiteiQ8TE23.

Expressioni

Gene expression databases

CleanExiHS_TAS1R2.
GenevestigatoriQ8TE23.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

BioGridi123327. 1 interaction.
STRINGi9606.ENSP00000364520.

Structurei

3D structure databases

ProteinModelPortaliQ8TE23.
SMRiQ8TE23. Positions 29-481, 558-822.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 566547ExtracellularSequence AnalysisAdd
BLAST
Topological domaini588 – 60215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini624 – 63512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini657 – 68125CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini703 – 72725ExtracellularSequence AnalysisAdd
BLAST
Topological domaini749 – 76012CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini782 – 7843ExtracellularSequence Analysis
Topological domaini806 – 83934CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei567 – 58721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei603 – 62321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei636 – 65621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei682 – 70221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei728 – 74821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei761 – 78121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei785 – 80521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278413.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ8TE23.
KOiK04625.
OMAiCKEYEMK.
OrthoDBiEOG7H791N.
PhylomeDBiQ8TE23.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TE23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH
60 70 80 90 100
LNFLQVPMCK EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD
110 120 130 140 150
VCYISNNVQP VLYFLAHEDN LLPIQEDYSN YISRVVAVIG PDNSESVMTV
160 170 180 190 200
ANFLSLFLLP QITYSAISDE LRDKVRFPAL LRTTPSADHH IEAMVQLMLH
210 220 230 240 250
FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL PTLQPNQNMT
260 270 280 290 300
SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA
310 320 330 340 350
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL
360 370 380 390 400
SRTSQSYTCN QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH
410 420 430 440 450
SLLGCDKSTC TKRVVYPWQL LEEIWKVNFT LLDHQIFFDP QGDVALHLEI
460 470 480 490 500
VQWQWDRSQN PFQSVASYYP LQRQLKNIQD ISWHTINNTI PMSMCSKRCQ
510 520 530 540 550
SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN NEWSYQSETS
560 570 580 590 600
CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG
610 620 630 640 650
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV
660 670 680 690 700
RSFQIVCAFK MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT
710 720 730 740 750
GLSPTTRTDP DDPKITIVSC NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK
760 770 780 790 800
ELPTNYNEAK FITLSMTFYF TSSVSLCTFM SAYSGVLVTI VDLLVTVLNL
810 820 830
LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
Length:839
Mass (Da):95,183
Last modified:October 17, 2006 - v2
Checksum:iA7F73516489A05F9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → C.1 Publication
Corresponds to variant rs9701796 [ dbSNP | Ensembl ].
VAR_027901
Natural varianti191 – 1911I → V.1 Publication
Corresponds to variant rs35874116 [ dbSNP | Ensembl ].
VAR_061199
Natural varianti317 – 3171R → G.1 Publication
Corresponds to variant rs34447754 [ dbSNP | Ensembl ].
VAR_061200
Natural varianti486 – 4861I → V.1 Publication
Corresponds to variant rs28374389 [ dbSNP | Ensembl ].
VAR_061201
Natural varianti574 – 5741A → T.
Corresponds to variant rs6662276 [ dbSNP | Ensembl ].
VAR_020787
Natural varianti595 – 5951I → T.
Corresponds to variant rs41273167 [ dbSNP | Ensembl ].
VAR_061202
Natural varianti838 – 8381R → K.
Corresponds to variant rs9988418 [ dbSNP | Ensembl ].
VAR_027902

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458154
, AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA. Translation: AAM12239.1.
BX537160, AL831755 Genomic DNA. Translation: CAH69954.1.
AL831755, BX537160 Genomic DNA. Translation: CAI17299.1.
BK000151 Genomic DNA. Translation: DAA00019.1.
CCDSiCCDS187.1.
RefSeqiNP_689418.2. NM_152232.2.
UniGeneiHs.553548.

Genome annotation databases

EnsembliENST00000375371; ENSP00000364520; ENSG00000179002.
GeneIDi80834.
KEGGihsa:80834.
UCSCiuc001bba.1. human.

Polymorphism databases

DMDMi116242831.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458154
, AF458149 , AF458150 , AF458152 , AF458153 , AF458151 Genomic DNA. Translation: AAM12239.1 .
BX537160 , AL831755 Genomic DNA. Translation: CAH69954.1 .
AL831755 , BX537160 Genomic DNA. Translation: CAI17299.1 .
BK000151 Genomic DNA. Translation: DAA00019.1 .
CCDSi CCDS187.1.
RefSeqi NP_689418.2. NM_152232.2.
UniGenei Hs.553548.

3D structure databases

ProteinModelPortali Q8TE23.
SMRi Q8TE23. Positions 29-481, 558-822.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123327. 1 interaction.
STRINGi 9606.ENSP00000364520.

Chemistry

DrugBanki DB00168. Aspartame.

Protein family/group databases

TCDBi 9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8TE23.

Polymorphism databases

DMDMi 116242831.

Proteomic databases

PaxDbi Q8TE23.
PRIDEi Q8TE23.

Protocols and materials databases

DNASUi 80834.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375371 ; ENSP00000364520 ; ENSG00000179002 .
GeneIDi 80834.
KEGGi hsa:80834.
UCSCi uc001bba.1. human.

Organism-specific databases

CTDi 80834.
GeneCardsi GC01M019166.
HGNCi HGNC:14905. TAS1R2.
MIMi 606226. gene.
neXtProti NX_Q8TE23.
PharmGKBi PA37919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278413.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000038047.
HOVERGENi HBG108601.
InParanoidi Q8TE23.
KOi K04625.
OMAi CKEYEMK.
OrthoDBi EOG7H791N.
PhylomeDBi Q8TE23.
TreeFami TF331269.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikii TAS1R2.
GenomeRNAii 80834.
NextBioi 71270.
PROi Q8TE23.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAS1R2.
Genevestigatori Q8TE23.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-9; VAL-191; GLY-317 AND VAL-486.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTS1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8TE23
Secondary accession number(s): Q5TZ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3