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Protein

Taste receptor type 1 member 2

Gene

TAS1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
  • G-protein coupled receptor signaling pathway Source: HGNC
  • positive regulation of cytokinesis Source: UniProtKB
  • sensory perception of sweet taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179002-MONOMER.
ReactomeiR-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Protein family/group databases

TCDBi9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:TAS1R2
Synonyms:GPR71, T1R2, TR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14905. TAS1R2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 566ExtracellularSequence analysisAdd BLAST547
Transmembranei567 – 587Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini588 – 602CytoplasmicSequence analysisAdd BLAST15
Transmembranei603 – 623Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini624 – 635ExtracellularSequence analysisAdd BLAST12
Transmembranei636 – 656Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini657 – 681CytoplasmicSequence analysisAdd BLAST25
Transmembranei682 – 702Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini703 – 727ExtracellularSequence analysisAdd BLAST25
Transmembranei728 – 748Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini749 – 760CytoplasmicSequence analysisAdd BLAST12
Transmembranei761 – 781Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini782 – 784ExtracellularSequence analysis3
Transmembranei785 – 805Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini806 – 839CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
  • sweet taste receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80834.
OpenTargetsiENSG00000179002.
PharmGKBiPA37919.

Chemistry databases

DrugBankiDB00168. Aspartame.

Polymorphism and mutation databases

BioMutaiTAS1R2.
DMDMi116242831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001295720 – 839Taste receptor type 1 member 2Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1
Glycosylationi527N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TE23.
PaxDbiQ8TE23.
PeptideAtlasiQ8TE23.
PRIDEiQ8TE23.

PTM databases

iPTMnetiQ8TE23.
PhosphoSitePlusiQ8TE23.

Expressioni

Gene expression databases

CleanExiHS_TAS1R2.
GenevisibleiQ8TE23. HS.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi123327. 1 interactor.
STRINGi9606.ENSP00000364520.

Structurei

3D structure databases

ProteinModelPortaliQ8TE23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ8TE23.
KOiK04625.
OMAiQVPMCKE.
OrthoDBiEOG091G035J.
PhylomeDBiQ8TE23.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TE23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH
60 70 80 90 100
LNFLQVPMCK EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD
110 120 130 140 150
VCYISNNVQP VLYFLAHEDN LLPIQEDYSN YISRVVAVIG PDNSESVMTV
160 170 180 190 200
ANFLSLFLLP QITYSAISDE LRDKVRFPAL LRTTPSADHH IEAMVQLMLH
210 220 230 240 250
FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL PTLQPNQNMT
260 270 280 290 300
SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA
310 320 330 340 350
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL
360 370 380 390 400
SRTSQSYTCN QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH
410 420 430 440 450
SLLGCDKSTC TKRVVYPWQL LEEIWKVNFT LLDHQIFFDP QGDVALHLEI
460 470 480 490 500
VQWQWDRSQN PFQSVASYYP LQRQLKNIQD ISWHTINNTI PMSMCSKRCQ
510 520 530 540 550
SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN NEWSYQSETS
560 570 580 590 600
CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG
610 620 630 640 650
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV
660 670 680 690 700
RSFQIVCAFK MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT
710 720 730 740 750
GLSPTTRTDP DDPKITIVSC NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK
760 770 780 790 800
ELPTNYNEAK FITLSMTFYF TSSVSLCTFM SAYSGVLVTI VDLLVTVLNL
810 820 830
LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
Length:839
Mass (Da):95,183
Last modified:October 17, 2006 - v2
Checksum:iA7F73516489A05F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0279019S → C.1 PublicationCorresponds to variant rs9701796dbSNPEnsembl.1
Natural variantiVAR_061199191I → V.1 PublicationCorresponds to variant rs35874116dbSNPEnsembl.1
Natural variantiVAR_061200317R → G.1 PublicationCorresponds to variant rs34447754dbSNPEnsembl.1
Natural variantiVAR_061201486I → V.1 PublicationCorresponds to variant rs28374389dbSNPEnsembl.1
Natural variantiVAR_020787574A → T.Corresponds to variant rs6662276dbSNPEnsembl.1
Natural variantiVAR_061202595I → T.Corresponds to variant rs41273167dbSNPEnsembl.1
Natural variantiVAR_027902838R → K.Corresponds to variant rs9988418dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458154
, AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA. Translation: AAM12239.1.
BX537160, AL831755 Genomic DNA. Translation: CAH69954.1.
AL831755, BX537160 Genomic DNA. Translation: CAI17299.1.
BK000151 Genomic DNA. Translation: DAA00019.1.
CCDSiCCDS187.1.
RefSeqiNP_689418.2. NM_152232.2.
UniGeneiHs.553548.

Genome annotation databases

EnsembliENST00000375371; ENSP00000364520; ENSG00000179002.
GeneIDi80834.
KEGGihsa:80834.
UCSCiuc001bba.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458154
, AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA. Translation: AAM12239.1.
BX537160, AL831755 Genomic DNA. Translation: CAH69954.1.
AL831755, BX537160 Genomic DNA. Translation: CAI17299.1.
BK000151 Genomic DNA. Translation: DAA00019.1.
CCDSiCCDS187.1.
RefSeqiNP_689418.2. NM_152232.2.
UniGeneiHs.553548.

3D structure databases

ProteinModelPortaliQ8TE23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123327. 1 interactor.
STRINGi9606.ENSP00000364520.

Chemistry databases

DrugBankiDB00168. Aspartame.

Protein family/group databases

TCDBi9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8TE23.
PhosphoSitePlusiQ8TE23.

Polymorphism and mutation databases

BioMutaiTAS1R2.
DMDMi116242831.

Proteomic databases

EPDiQ8TE23.
PaxDbiQ8TE23.
PeptideAtlasiQ8TE23.
PRIDEiQ8TE23.

Protocols and materials databases

DNASUi80834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375371; ENSP00000364520; ENSG00000179002.
GeneIDi80834.
KEGGihsa:80834.
UCSCiuc001bba.2. human.

Organism-specific databases

CTDi80834.
DisGeNETi80834.
GeneCardsiTAS1R2.
HGNCiHGNC:14905. TAS1R2.
MIMi606226. gene.
neXtProtiNX_Q8TE23.
OpenTargetsiENSG00000179002.
PharmGKBiPA37919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ8TE23.
KOiK04625.
OMAiQVPMCKE.
OrthoDBiEOG091G035J.
PhylomeDBiQ8TE23.
TreeFamiTF331269.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179002-MONOMER.
ReactomeiR-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS1R2.
GenomeRNAii80834.
PROiQ8TE23.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAS1R2.
GenevisibleiQ8TE23. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTS1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8TE23
Secondary accession number(s): Q5TZ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.