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Protein

Taste receptor type 1 member 2

Gene

TAS1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
  • G-protein coupled receptor signaling pathway Source: Reactome
  • positive regulation of cytokinesis Source: UniProtKB
  • sensory perception of sweet taste Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Protein family/group databases

TCDBi9.A.14.7.4 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:TAS1R2
Synonyms:GPR71, T1R2, TR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179002.5
HGNCiHGNC:14905 TAS1R2
MIMi606226 gene
neXtProtiNX_Q8TE23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 566ExtracellularSequence analysisAdd BLAST547
Transmembranei567 – 587Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini588 – 602CytoplasmicSequence analysisAdd BLAST15
Transmembranei603 – 623Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini624 – 635ExtracellularSequence analysisAdd BLAST12
Transmembranei636 – 656Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini657 – 681CytoplasmicSequence analysisAdd BLAST25
Transmembranei682 – 702Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini703 – 727ExtracellularSequence analysisAdd BLAST25
Transmembranei728 – 748Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini749 – 760CytoplasmicSequence analysisAdd BLAST12
Transmembranei761 – 781Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini782 – 784ExtracellularSequence analysis3
Transmembranei785 – 805Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini806 – 839CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80834
OpenTargetsiENSG00000179002
PharmGKBiPA37919

Chemistry databases

ChEMBLiCHEMBL1613741
DrugBankiDB00168 Aspartame

Polymorphism and mutation databases

BioMutaiTAS1R2
DMDMi116242831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001295720 – 839Taste receptor type 1 member 2Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TE23
PeptideAtlasiQ8TE23
PRIDEiQ8TE23

PTM databases

iPTMnetiQ8TE23
PhosphoSitePlusiQ8TE23

Expressioni

Gene expression databases

BgeeiENSG00000179002
CleanExiHS_TAS1R2
GenevisibleiQ8TE23 HS

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi123327, 1 interactor
STRINGi9606.ENSP00000364520

Chemistry databases

BindingDBiQ8TE23

Structurei

3D structure databases

ProteinModelPortaliQ8TE23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000038047
HOVERGENiHBG108601
InParanoidiQ8TE23
KOiK04625
OMAiFITLSMT
OrthoDBiEOG091G035J
PhylomeDBiQ8TE23
TreeFamiTF331269

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TE23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH
60 70 80 90 100
LNFLQVPMCK EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD
110 120 130 140 150
VCYISNNVQP VLYFLAHEDN LLPIQEDYSN YISRVVAVIG PDNSESVMTV
160 170 180 190 200
ANFLSLFLLP QITYSAISDE LRDKVRFPAL LRTTPSADHH IEAMVQLMLH
210 220 230 240 250
FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL PTLQPNQNMT
260 270 280 290 300
SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA
310 320 330 340 350
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL
360 370 380 390 400
SRTSQSYTCN QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH
410 420 430 440 450
SLLGCDKSTC TKRVVYPWQL LEEIWKVNFT LLDHQIFFDP QGDVALHLEI
460 470 480 490 500
VQWQWDRSQN PFQSVASYYP LQRQLKNIQD ISWHTINNTI PMSMCSKRCQ
510 520 530 540 550
SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN NEWSYQSETS
560 570 580 590 600
CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG
610 620 630 640 650
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV
660 670 680 690 700
RSFQIVCAFK MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT
710 720 730 740 750
GLSPTTRTDP DDPKITIVSC NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK
760 770 780 790 800
ELPTNYNEAK FITLSMTFYF TSSVSLCTFM SAYSGVLVTI VDLLVTVLNL
810 820 830
LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
Length:839
Mass (Da):95,183
Last modified:October 17, 2006 - v2
Checksum:iA7F73516489A05F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0279019S → C1 PublicationCorresponds to variant dbSNP:rs9701796Ensembl.1
Natural variantiVAR_061199191I → V1 PublicationCorresponds to variant dbSNP:rs35874116Ensembl.1
Natural variantiVAR_061200317R → G1 PublicationCorresponds to variant dbSNP:rs34447754Ensembl.1
Natural variantiVAR_061201486I → V1 PublicationCorresponds to variant dbSNP:rs28374389Ensembl.1
Natural variantiVAR_020787574A → T. Corresponds to variant dbSNP:rs6662276Ensembl.1
Natural variantiVAR_061202595I → T. Corresponds to variant dbSNP:rs41273167Ensembl.1
Natural variantiVAR_027902838R → K. Corresponds to variant dbSNP:rs9988418Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458154
, AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA Translation: AAM12239.1
BX537160 Genomic DNA No translation available.
AL831755 Genomic DNA No translation available.
BK000151 Genomic DNA Translation: DAA00019.1
CCDSiCCDS187.1
RefSeqiNP_689418.2, NM_152232.2
UniGeneiHs.553548

Genome annotation databases

EnsembliENST00000375371; ENSP00000364520; ENSG00000179002
GeneIDi80834
KEGGihsa:80834
UCSCiuc001bba.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTS1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8TE23
Secondary accession number(s): Q5TZ19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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