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Q8TE23 (TS1R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene names
Name:TAS1R2
Synonyms:GPR71, T1R2, TR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

Subunit structure

Forms heterodimers with TAS1R3.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 839820Taste receptor type 1 member 2
PRO_0000012957

Regions

Topological domain20 – 566547Extracellular Potential
Transmembrane567 – 58721Helical; Name=1; Potential
Topological domain588 – 60215Cytoplasmic Potential
Transmembrane603 – 62321Helical; Name=2; Potential
Topological domain624 – 63512Extracellular Potential
Transmembrane636 – 65621Helical; Name=3; Potential
Topological domain657 – 68125Cytoplasmic Potential
Transmembrane682 – 70221Helical; Name=4; Potential
Topological domain703 – 72725Extracellular Potential
Transmembrane728 – 74821Helical; Name=5; Potential
Topological domain749 – 76012Cytoplasmic Potential
Transmembrane761 – 78121Helical; Name=6; Potential
Topological domain782 – 7843Extracellular Potential
Transmembrane785 – 80521Helical; Name=7; Potential
Topological domain806 – 83934Cytoplasmic Potential

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2921N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Glycosylation5271N-linked (GlcNAc...) Potential

Natural variations

Natural variant91S → C. Ref.1
Corresponds to variant rs9701796 [ dbSNP | Ensembl ].
VAR_027901
Natural variant1911I → V. Ref.1
Corresponds to variant rs35874116 [ dbSNP | Ensembl ].
VAR_061199
Natural variant3171R → G. Ref.1
Corresponds to variant rs34447754 [ dbSNP | Ensembl ].
VAR_061200
Natural variant4861I → V. Ref.1
Corresponds to variant rs28374389 [ dbSNP | Ensembl ].
VAR_061201
Natural variant5741A → T.
Corresponds to variant rs6662276 [ dbSNP | Ensembl ].
VAR_020787
Natural variant5951I → T.
Corresponds to variant rs41273167 [ dbSNP | Ensembl ].
VAR_061202
Natural variant8381R → K.
Corresponds to variant rs9988418 [ dbSNP | Ensembl ].
VAR_027902

Sequences

Sequence LengthMass (Da)Tools
Q8TE23 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: A7F73516489A05F9

FASTA83995,183
        10         20         30         40         50         60 
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK 

        70         80         90        100        110        120 
EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD VCYISNNVQP VLYFLAHEDN 

       130        140        150        160        170        180 
LLPIQEDYSN YISRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL 

       190        200        210        220        230        240 
LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL 

       250        260        270        280        290        300 
PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA 

       310        320        330        340        350        360 
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL SRTSQSYTCN 

       370        380        390        400        410        420 
QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDKSTC TKRVVYPWQL 

       430        440        450        460        470        480 
LEEIWKVNFT LLDHQIFFDP QGDVALHLEI VQWQWDRSQN PFQSVASYYP LQRQLKNIQD 

       490        500        510        520        530        540 
ISWHTINNTI PMSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN 

       550        560        570        580        590        600 
NEWSYQSETS CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG 

       610        620        630        640        650        660 
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIVCAFK 

       670        680        690        700        710        720 
MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLSPTTRTDP DDPKITIVSC 

       730        740        750        760        770        780 
NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM 

       790        800        810        820        830 
SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD

« Hide

References

« Hide 'large scale' references
[1]"Human receptors for sweet and umami taste."
Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.
Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-9; VAL-191; GLY-317 AND VAL-486.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Web resources

Protein Spotlight

The taste experience - Issue 55 of February 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF458154 expand/collapse EMBL AC list , AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA. Translation: AAM12239.1.
BX537160, AL831755 Genomic DNA. Translation: CAH69954.1.
AL831755, BX537160 Genomic DNA. Translation: CAI17299.1.
BK000151 Genomic DNA. Translation: DAA00019.1.
IPIIPI00152592.
RefSeqNP_689418.2. NM_152232.2.
UniGeneHs.553548.

3D structure databases

ProteinModelPortalQ8TE23.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000364520.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8TE23.

Polymorphism databases

DMDM116242831.

Proteomic databases

PaxDbQ8TE23.
PRIDEQ8TE23.

Protocols and materials databases

DNASU80834.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375371; ENSP00000364520; ENSG00000179002.
GeneID80834.
KEGGhsa:80834.
UCSCuc001bba.1. human.

Organism-specific databases

CTD80834.
GeneCardsGC01M019166.
HGNCHGNC:14905. TAS1R2.
MIM606226. gene.
neXtProtNX_Q8TE23.
PharmGKBPA37919.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278413.
HOGENOMHOG000038047.
HOVERGENHBG108601.
InParanoidQ8TE23.
KOK04625.
OMAGYTMRRD.
OrthoDBEOG48SGSM.
PhylomeDBQ8TE23.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_TAS1R2.
GenevestigatorQ8TE23.
GermOnlineENSG00000179002. Homo sapiens.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. False negative.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL1613741.
DrugBankDB00168. Aspartame.
GenomeRNAi80834.
NextBio71270.
SOURCESearch...

Entry information

Entry nameTS1R2_HUMAN
AccessionPrimary (citable) accession number: Q8TE23
Secondary accession number(s): Q5TZ19
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 17, 2006
Last modified: May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents