Taste receptor type 1 member 2 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q8TE23 (TS1R2_HUMAN)

Last modified January 19, 2010. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Taste receptor type 1 member 2
Alternative name(s):
    Sweet taste receptor T1R2
    G-protein coupled receptor 71

Gene names

Name:	TAS1R2
Synonyms:	GPR71, T1R2, TR2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
Subunit structure	Forms heterodimers with TAS1R3.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred by curator. Source: HGNC detection of chemical stimulus involved in sensory perception of sweet taste Inferred from direct assay. Source: HGNC
Cellular component	integral to membrane Ref.1 Inferred by curator. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein heterodimerization activity Ref.1 Non-traceable author statement. Source: UniProtKB taste receptor activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

19

Potential

Chain

820

Taste receptor type 1 member 2

PRO_0000012957

Regions

Topological domain

547

Extracellular Potential

Transmembrane

21

1 Potential

Topological domain

15

Cytoplasmic Potential

Transmembrane

21

2 Potential

Topological domain

12

Extracellular Potential

Transmembrane

21

3 Potential

Topological domain

25

Cytoplasmic Potential

Transmembrane

21

4 Potential

Topological domain

25

Extracellular Potential

Transmembrane

21

5 Potential

Topological domain

12

Cytoplasmic Potential

Transmembrane

21

6 Potential

Topological domain

3

Extracellular Potential

Transmembrane

21

7 Potential

Topological domain

34

Cytoplasmic Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

1

S → C: dbSNP rs9701796. Ref.1

VAR_027901

Natural variant

1

I → V: dbSNP rs35874116. Ref.1

VAR_061199

Natural variant

1

R → G: dbSNP rs34447754. Ref.1

VAR_061200

Natural variant

1

I → V: dbSNP rs28374389. Ref.1

VAR_061201

Natural variant

1

A → T: dbSNP rs6662276.

VAR_020787

Natural variant

1

I → T: dbSNP rs41273167.

VAR_061202

Natural variant

1

R → K: dbSNP rs9988418.

VAR_027902

Sequences

Sequence

Length

Mass (Da)

Tools

Q8TE23-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: A7F73516489A05F9
Show »

839

95,183

        10         20         30         40         50         60 
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK 

        70         80         90        100        110        120 
EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD VCYISNNVQP VLYFLAHEDN 

       130        140        150        160        170        180 
LLPIQEDYSN YISRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL 

       190        200        210        220        230        240 
LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL 

       250        260        270        280        290        300 
PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA 

       310        320        330        340        350        360 
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL SRTSQSYTCN 

       370        380        390        400        410        420 
QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDKSTC TKRVVYPWQL 

       430        440        450        460        470        480 
LEEIWKVNFT LLDHQIFFDP QGDVALHLEI VQWQWDRSQN PFQSVASYYP LQRQLKNIQD 

       490        500        510        520        530        540 
ISWHTINNTI PMSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN 

       550        560        570        580        590        600 
NEWSYQSETS CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG 

       610        620        630        640        650        660 
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIVCAFK 

       670        680        690        700        710        720 
MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLSPTTRTDP DDPKITIVSC 

       730        740        750        760        770        780 
NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM 

       790        800        810        820        830 
SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human receptors for sweet and umami taste." Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E. Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002) [PubMed: 11917125] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-9; VAL-191; GLY-317 AND VAL-486.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Protein Spotlight

The taste experience - Issue 55 of February 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF458154 AF458151 Genomic DNA. Translation: AAM12239.1. BX537160, AL831755 Genomic DNA. Translation: CAH69954.1. AL831755, BX537160 Genomic DNA. Translation: CAI17299.1. BK000151 Genomic DNA. Translation: DAA00019.1.
IPI	IPI00152592.
RefSeq	NP_689418.2.
UniGene	Hs.553548
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TE23.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8TE23.
Genome annotation databases
Ensembl	ENST00000375371; ENSP00000364520; ENSG00000179002; Homo sapiens. [Genome view]
GeneID	80834.
KEGG	hsa:80834.
NMPDR	fig\|9606.3.peg.430.
UCSC	uc001bba.1. human.
Organism-specific databases
CTD	80834.
GeneCards	GC01M019038.
H-InvDB	HIX0028889.
HGNC	HGNC:14905. TAS1R2.
MIM	606226. gene.
PharmGKB	PA37919.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08735.
HOGENOM	HBG446995.
HOVERGEN	Q8TE23.
InParanoid	Q8TE23.
OMA	PRATTIC.
OrthoDB	EOG95B41N.
PhylomeDB	Q8TE23.
Gene expression databases
ArrayExpress	Q8TE23.
CleanEx	HS_TAS1R2.
Genevestigator	Q8TE23.
GermOnline	ENSG00000179002. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig_bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. False negative. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. False negative. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00168. Aspartame.
NextBio	71270.
SOURCE	Search...

Entry information

Entry name

TS1R2_HUMAN

Accession

Primary (citable) accession number: Q8TE23
Secondary accession number(s): Q5TZ19

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 17, 2006
Last modified:	January 19, 2010
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents