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Q8TE23

- TS1R2_HUMAN

UniProt

Q8TE23 - TS1R2_HUMAN

Protein

Taste receptor type 1 member 2

Gene

TAS1R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

    GO - Molecular functioni

    1. protein heterodimerization activity Source: UniProtKB
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
    2. G-protein coupled receptor signaling pathway Source: HGNC
    3. positive regulation of cytokinesis Source: UniProt
    4. sensory perception of sweet taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

    Protein family/group databases

    TCDBi9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 1 member 2
    Alternative name(s):
    G-protein coupled receptor 71
    Sweet taste receptor T1R2
    Gene namesi
    Name:TAS1R2
    Synonyms:GPR71, T1R2, TR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14905. TAS1R2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 839820Taste receptor type 1 member 2PRO_0000012957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8TE23.
    PRIDEiQ8TE23.

    PTM databases

    PhosphoSiteiQ8TE23.

    Expressioni

    Gene expression databases

    CleanExiHS_TAS1R2.
    GenevestigatoriQ8TE23.

    Interactioni

    Subunit structurei

    Forms heterodimers with TAS1R3.

    Protein-protein interaction databases

    BioGridi123327. 1 interaction.
    STRINGi9606.ENSP00000364520.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TE23.
    SMRiQ8TE23. Positions 29-481, 558-822.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 566547ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini588 – 60215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini624 – 63512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini657 – 68125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini703 – 72725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini749 – 76012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini782 – 7843ExtracellularSequence Analysis
    Topological domaini806 – 83934CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei567 – 58721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei603 – 62321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei636 – 65621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei682 – 70221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei728 – 74821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei761 – 78121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei785 – 80521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278413.
    HOGENOMiHOG000038047.
    HOVERGENiHBG108601.
    InParanoidiQ8TE23.
    KOiK04625.
    OMAiCKEYEMK.
    OrthoDBiEOG7H791N.
    PhylomeDBiQ8TE23.
    TreeFamiTF331269.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TE23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH    50
    LNFLQVPMCK EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD 100
    VCYISNNVQP VLYFLAHEDN LLPIQEDYSN YISRVVAVIG PDNSESVMTV 150
    ANFLSLFLLP QITYSAISDE LRDKVRFPAL LRTTPSADHH IEAMVQLMLH 200
    FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL PTLQPNQNMT 250
    SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA 300
    SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL 350
    SRTSQSYTCN QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH 400
    SLLGCDKSTC TKRVVYPWQL LEEIWKVNFT LLDHQIFFDP QGDVALHLEI 450
    VQWQWDRSQN PFQSVASYYP LQRQLKNIQD ISWHTINNTI PMSMCSKRCQ 500
    SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN NEWSYQSETS 550
    CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG 600
    GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV 650
    RSFQIVCAFK MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT 700
    GLSPTTRTDP DDPKITIVSC NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK 750
    ELPTNYNEAK FITLSMTFYF TSSVSLCTFM SAYSGVLVTI VDLLVTVLNL 800
    LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD 839
    Length:839
    Mass (Da):95,183
    Last modified:October 17, 2006 - v2
    Checksum:iA7F73516489A05F9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → C.1 Publication
    Corresponds to variant rs9701796 [ dbSNP | Ensembl ].
    VAR_027901
    Natural varianti191 – 1911I → V.1 Publication
    Corresponds to variant rs35874116 [ dbSNP | Ensembl ].
    VAR_061199
    Natural varianti317 – 3171R → G.1 Publication
    Corresponds to variant rs34447754 [ dbSNP | Ensembl ].
    VAR_061200
    Natural varianti486 – 4861I → V.1 Publication
    Corresponds to variant rs28374389 [ dbSNP | Ensembl ].
    VAR_061201
    Natural varianti574 – 5741A → T.
    Corresponds to variant rs6662276 [ dbSNP | Ensembl ].
    VAR_020787
    Natural varianti595 – 5951I → T.
    Corresponds to variant rs41273167 [ dbSNP | Ensembl ].
    VAR_061202
    Natural varianti838 – 8381R → K.
    Corresponds to variant rs9988418 [ dbSNP | Ensembl ].
    VAR_027902

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458154
    , AF458149, AF458150, AF458152, AF458153, AF458151 Genomic DNA. Translation: AAM12239.1.
    BX537160, AL831755 Genomic DNA. Translation: CAH69954.1.
    AL831755, BX537160 Genomic DNA. Translation: CAI17299.1.
    BK000151 Genomic DNA. Translation: DAA00019.1.
    CCDSiCCDS187.1.
    RefSeqiNP_689418.2. NM_152232.2.
    UniGeneiHs.553548.

    Genome annotation databases

    EnsembliENST00000375371; ENSP00000364520; ENSG00000179002.
    GeneIDi80834.
    KEGGihsa:80834.
    UCSCiuc001bba.1. human.

    Polymorphism databases

    DMDMi116242831.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The taste experience - Issue 55 of February 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458154
    , AF458149 , AF458150 , AF458152 , AF458153 , AF458151 Genomic DNA. Translation: AAM12239.1 .
    BX537160 , AL831755 Genomic DNA. Translation: CAH69954.1 .
    AL831755 , BX537160 Genomic DNA. Translation: CAI17299.1 .
    BK000151 Genomic DNA. Translation: DAA00019.1 .
    CCDSi CCDS187.1.
    RefSeqi NP_689418.2. NM_152232.2.
    UniGenei Hs.553548.

    3D structure databases

    ProteinModelPortali Q8TE23.
    SMRi Q8TE23. Positions 29-481, 558-822.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123327. 1 interaction.
    STRINGi 9606.ENSP00000364520.

    Chemistry

    DrugBanki DB00168. Aspartame.

    Protein family/group databases

    TCDBi 9.A.14.7.4. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8TE23.

    Polymorphism databases

    DMDMi 116242831.

    Proteomic databases

    PaxDbi Q8TE23.
    PRIDEi Q8TE23.

    Protocols and materials databases

    DNASUi 80834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375371 ; ENSP00000364520 ; ENSG00000179002 .
    GeneIDi 80834.
    KEGGi hsa:80834.
    UCSCi uc001bba.1. human.

    Organism-specific databases

    CTDi 80834.
    GeneCardsi GC01M019166.
    HGNCi HGNC:14905. TAS1R2.
    MIMi 606226. gene.
    neXtProti NX_Q8TE23.
    PharmGKBi PA37919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278413.
    HOGENOMi HOG000038047.
    HOVERGENi HBG108601.
    InParanoidi Q8TE23.
    KOi K04625.
    OMAi CKEYEMK.
    OrthoDBi EOG7H791N.
    PhylomeDBi Q8TE23.
    TreeFami TF331269.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

    Miscellaneous databases

    GeneWikii TAS1R2.
    GenomeRNAii 80834.
    NextBioi 71270.
    PROi Q8TE23.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS1R2.
    Genevestigatori Q8TE23.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-9; VAL-191; GLY-317 AND VAL-486.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTS1R2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TE23
    Secondary accession number(s): Q5TZ19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3