Q8TE02 (ELP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongator complex protein 5

Alternative name(s):
Dermal papilla-derived protein 6
S-phase 2 protein

Gene names

Name:	ELP5
Synonyms:	C17orf81, DERP6
ORF Names:	HSPC002, MSTP071

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration By similarity. May be involved in TP53-mediated transcriptional regulation. Ref.1
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4. Ref.10
Subcellular location	Nucleus. Cytoplasm Ref.1 Ref.10.
Tissue specificity	Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
Sequence similarities	Belongs to the ELP5 family.
Caution	It is uncertain whether Met-1 or Met-17 is the initiator.
Sequence caution	The sequence AAD20964.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAQ13591.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Elongator holoenzyme complex Inferred from direct assay Ref.10. Source: UniProtKB cytoplasm Inferred from direct assay Ref.10. Source: UniProtKB nucleus Inferred from direct assay Ref.10. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	2	EBI-946189,EBI-930964

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TE02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TE02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-316: DPTTHLTFNL...QEDPDDDLDI → SKNAKARTRKCSLVSGHGRENKSCRGWGWGQGF

Isoform 3 (identifier: Q8TE02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     154-179: DSSSVGKVSVLGLLHEELHGPGPVGA → ETPPSLFPLIHLPLPRSVPLFLSTLE
     180-316: Missing.

Isoform 4 (identifier: Q8TE02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: V → VHPLYLQV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Elongator complex protein 5		PRO_0000280817
Natural variations
	Alternative sequence	154 – 179	26	DSSSV…GPVGA → ETPPSLFPLIHLPLPRSVPL FLSTLE in isoform 3.		VSP_023920
	Alternative sequence	180 – 316	137	Missing in isoform 3.		VSP_023921
	Alternative sequence	246	1	V → VHPLYLQV in isoform 4.		VSP_023922
	Alternative sequence	247 – 316	70	DPTTH…DDLDI → SKNAKARTRKCSLVSGHGRE NKSCRGWGWGQGF in isoform 2.		VSP_023923
	Natural variant	14	1	E → K. Ref.2 Corresponds to variant rs2521988 [ dbSNP | Ensembl ].		VAR_053882
	Natural variant	303	1	D → Y. Ref.6 Corresponds to variant rs17849664 [ dbSNP | Ensembl ].		VAR_031205
Experimental info
	Sequence conflict	151	1	C → R in AAM10496. Ref.1
	Sequence conflict	175	1	G → S in AAM10496. Ref.1
	Sequence conflict	181	1	S → N in AAM10496. Ref.1
	Sequence conflict	228	1	Q → K in AAM10496. Ref.1
	Sequence conflict	245	1	P → R in AAM10496. Ref.1
Isoform 2:
	Sequence conflict	263	1	H → Q in AAQ13591. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: C96F86C6B99CE7CE	FASTA	316	34,841
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 280 290 300 PHIPPVDPTT HLTFNLHLSK KEREARDSLI LPFQFSSEKQ QALLRPRPGQ ATSHIFYEPD 310 AYDDLDQEDP DDDLDI
	Isoform 2 [UniParc]. Checksum: 8178D41F211E8004	FASTA	279	30,349
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 PHIPPVSKNA KARTRKCSLV SGHGRENKSC RGWGWGQGF
	Isoform 3 [UniParc]. Checksum: D4FD6EDBB859EF3C	FASTA	179	19,719
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGETPPSLF PLIHLPLPRS VPLFLSTLE
	Isoform 4 [UniParc]. Checksum: 085D33C458297F9A	FASTA	323	35,692
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 280 290 300 PHIPPVHPLY LQVDPTTHLT FNLHLSKKER EARDSLILPF QFSSEKQQAL LRPRPGQATS 310 320 HIFYEPDAYD DLDQEDPDDD LDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53." Yuan J., Tang W., Luo K., Chen X., Gu X., Wan B., Yu L. Mol. Biol. Rep. 33:151-158(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
[2]	"Molecular cloning of a dermal papilla derived gene." Ikeda A., Yoshimoto M. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-14. Tissue: Hair follicle dermal papilla.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hippocampus.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-303. Tissue: Placenta.
[7]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-316 (ISOFORM 3). Tissue: Umbilical cord blood.
[8]	Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Liu B., Sheng H., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Gao R.L., Wu Q.Y., Hui R.T. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-316 (ISOFORM 2). Tissue: Aorta.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-316 (ISOFORM 4). Tissue: Amygdala.
[10]	"DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator." Close P., Gillard M., Ladang A., Jiang Z., Papuga J., Hawkes N., Nguyen L., Chapelle J.P., Bouillenne F., Svejstrup J., Fillet M., Chariot A. J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE RNA POLYMERASE II ELONGATOR COMPLEX, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087868 mRNA. Translation: AAM10496.1. AB013910 mRNA. Translation: BAB87800.1. AK289940 mRNA. Translation: BAF82629.1. AC003688 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90230.1. CH471108 Genomic DNA. Translation: EAW90231.1. BC002762 mRNA. Translation: AAH02762.2. AF070658 mRNA. Translation: AAD20964.1. Different initiation. AF163262 mRNA. Translation: AAQ13591.1. Different initiation. AL713741 mRNA. Translation: CAH56280.1.
IPI	IPI00328185. IPI00383650. IPI00402148. IPI00829707. IPI00877109.
RefSeq	NP_056177.3. NM_015362.3. NP_981958.1. NM_203413.1. NP_981959.1. NM_203414.1. NP_981960.1. NM_203415.1.
UniGene	Hs.417029.
3D structure databases
ProteinModelPortal	Q8TE02.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TE02. 1 interaction.
MINT	MINT-2856032.
STRING	9606.ENSP00000346412.
PTM databases
PhosphoSite	Q8TE02.
Polymorphism databases
DMDM	134034093.
Proteomic databases
PaxDb	Q8TE02.
PRIDE	Q8TE02.
Protocols and materials databases
DNASU	23587.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354429; ENSP00000346412; ENSG00000170291. ENST00000356683; ENSP00000349111; ENSG00000170291. ENST00000396627; ENSP00000379868; ENSG00000170291. ENST00000396628; ENSP00000379869; ENSG00000170291. ENST00000573657; ENSP00000459633; ENSG00000170291. ENST00000574255; ENSP00000461489; ENSG00000170291. ENST00000574993; ENSP00000459835; ENSG00000170291.
GeneID	23587.
KEGG	hsa:23587.
UCSC	uc002gfg.1. human. uc002gfk.1. human.
Organism-specific databases
CTD	23587.
GeneCards	GC17P007154.
HGNC	HGNC:30617. ELP5.
HPA	HPA023279.
MIM	615019. gene.
neXtProt	NX_Q8TE02.
PharmGKB	PA143485405.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41404.
HOGENOM	HOG000013029.
HOVERGEN	HBG081433.
InParanoid	Q8TE02.
OMA	NSRLVYH.
OrthoDB	EOG4D26QP.
PhylomeDB	Q8TE02.
Gene expression databases
ArrayExpress	Q8TE02.
Bgee	Q8TE02.
CleanEx	HS_C17orf81.
Genevestigator	Q8TE02.
Family and domain databases
InterPro	IPR019519. Histone_acetylation_protein_2. [Graphical view]
Pfam	PF10483. Hap2_elong. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23587.
NextBio	46212.
SOURCE	Search...

Entry information

Entry name

ELP5_HUMAN

Accession

Primary (citable) accession number: Q8TE02
Secondary accession number(s): A8K1M5 , D3DTN9, Q659B6, Q7Z2T4, Q8TDR9, Q9BUB2, Q9Y2Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.