Reviewed, UniProtKB/Swiss-Prot Q8TE02 (DERP6_HUMAN)

Names and origin

Protein names

Recommended name:
    Dermal papilla-derived protein 6
Alternative name(s):
    S-phase 2 protein

Gene names

Name:	DERP6
Synonyms:	C17orf81
ORF Names:	HSPC002, MSTP071

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in TP53-mediated transcriptional regulation. Ref.1
Subcellular location	Cytoplasm. Ref.1
Tissue specificity	Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
Sequence similarities	Belongs to the ELP5 family.
Caution	It is uncertain whether Met-1 or Met-17 is the initiator.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	1	EBI-946189,EBI-930964

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TE02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TE02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-316: DPTTHLTFNL...QEDPDDDLDI → SKNAKARTRKCSLVSGQGRENKSCRGWGWGQGF

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TE02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     154-179: DSSSVGKVSVLGLLHEELHGPGPVGA → ETPPSLFPLIHLPLPRSVPLFLSTLE
     180-316: Missing.

Isoform 4 (identifier: Q8TE02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: V → VHPLYLQV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Dermal papilla-derived protein 6		PRO_0000280817
Natural variations
	Alternative sequence	154 – 179	26	DSSSV…GPVGA → ETPPSLFPLIHLPLPRSVPL FLSTLE in isoform 3.		VSP_023920
	Alternative sequence	180 – 316	137	Missing in isoform 3.		VSP_023921
	Alternative sequence	246	1	V → VHPLYLQV in isoform 4.		VSP_023922
	Alternative sequence	247 – 316	70	DPTTH…DDLDI → SKNAKARTRKCSLVSGQGRE NKSCRGWGWGQGF in isoform 2.		VSP_023923
	Natural variant	14	1	E → K: dbSNP rs2521988. Ref.2		VAR_053882
	Natural variant	303	1	D → Y: dbSNP rs17849664. Ref.3		VAR_031205
Experimental info
	Sequence conflict	151	1	C → R in AAM10496. Ref.1
	Sequence conflict	175	1	G → S in AAM10496. Ref.1
	Sequence conflict	181	1	S → N in AAM10496. Ref.1
	Sequence conflict	228	1	Q → K in AAM10496. Ref.1
	Sequence conflict	245	1	P → R in AAM10496. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: C96F86C6B99CE7CE	FASTA	316	34,841
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 280 290 300 PHIPPVDPTT HLTFNLHLSK KEREARDSLI LPFQFSSEKQ QALLRPRPGQ ATSHIFYEPD 310 AYDDLDQEDP DDDLDI
	Isoform 2. Checksum: 93CF241F211E8004	FASTA	279	30,340
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 PHIPPVSKNA KARTRKCSLV SGQGRENKSC RGWGWGQGF
	Isoform 3. Checksum: D4FD6EDBB859EF3C	FASTA	179	19,719
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGETPPSLF PLIHLPLPRS VPLFLSTLE
	Isoform 4. Checksum: 085D33C458297F9A	FASTA	323	35,692
	10 20 30 40 50 60 MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 70 80 90 100 110 120 CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 130 140 150 160 170 180 IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 190 200 210 220 230 240 SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 250 260 270 280 290 300 PHIPPVHPLY LQVDPTTHLT FNLHLSKKER EARDSLILPF QFSSEKQQAL LRPRPGQATS 310 320 HIFYEPDAYD DLDQEDPDDD LDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53." Yuan J., Tang W., Luo K., Chen X., Gu X., Wan B., Yu L. Mol. Biol. Rep. 33:151-158(2006) [PubMed: 16850183] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
[2]	"Molecular cloning of a dermal papilla derived gene." Ikeda A., Yoshimoto M. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-14. Tissue: Hair follicle dermal papilla.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-303. Tissue: Placenta.
[4]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-316 (ISOFORM 3). Tissue: Umbilical cord blood.
[5]	Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Liu B., Sheng H., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Gao R.L., Wu Q.Y., Hui R.T. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-316 (ISOFORM 2). Tissue: Aorta.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-316 (ISOFORM 4). Tissue: Amygdala.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF087868 mRNA. Translation: AAM10496.1. AB013910 mRNA. Translation: BAB87800.1. BC002762 mRNA. Translation: AAH02762.2. AF070658 mRNA. Translation: AAD20964.1. Different initiation. AF163262 mRNA. Translation: AAQ13591.1. Different initiation. AL713741 mRNA. Translation: CAH56280.1.
IPI	IPI00328185. IPI00383650. IPI00402148. IPI00829707.
RefSeq	NP_056177.3. NP_981958.1. NP_981959.1. NP_981960.1.
UniGene	Hs.417029
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TE02. 1 interaction.
Proteomic databases
PRIDE	Q8TE02.
Genome annotation databases
Ensembl	ENST00000354429; ENSP00000346412; ENSG00000170291; Homo sapiens. [Genome view] ENST00000356683; ENSP00000349111; ENSG00000170291; Homo sapiens. [Genome view] ENST00000396627; ENSP00000379868; ENSG00000170291; Homo sapiens. [Genome view] ENST00000396628; ENSP00000379869; ENSG00000170291; Homo sapiens. [Genome view]
GeneID	23587.
KEGG	hsa:23587.
UCSC	uc002gfg.1. human. uc002gfk.1. human. uc002gfl.1. human.
Organism-specific databases
CTD	23587.
GeneCards	GC17P007097.
HGNC	HGNC:30617. C17orf81.
HPA	HPA023279.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TE02.
OMA	NSRLVYH.
Gene expression databases
ArrayExpress	Q8TE02.
Bgee	Q8TE02.
CleanEx	HS_C17orf81.
Genevestigator	Q8TE02.
Family and domain databases
InterPro	IPR019519. Histone_acetylation_protein_2. [Graphical view]
Pfam	PF10483. Hap2_elong. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	46212.

Entry information

Entry name

DERP6_HUMAN

Accession

Primary (citable) accession number: Q8TE02
Secondary accession number(s): Q659B6 , Q7Z2T4, Q8TDR9, Q9BUB2, Q9Y2Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	November 3, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.