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Protein

[F-actin]-methionine sulfoxide oxidase MICAL1

Gene

MICAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of sectrory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.By similarityCurated2 Publications

Catalytic activityi

[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O.By similarity

Cofactori

FAD1 Publication

Kineticsi

  1. KM=4.7 µM for F-actin (at saturing NADPH concentration)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei95FADBy similarity1
    Binding sitei114FADBy similarity1
    Binding sitei116FADBy similarity1
    Binding sitei121FADBy similarity1
    Binding sitei123FADBy similarity1
    Binding sitei393FADBy similarity1
    Metal bindingi697Zinc 1Combined sources1
    Metal bindingi700Zinc 1Combined sources1
    Metal bindingi718Zinc 1; via pros nitrogenCombined sources1
    Metal bindingi721Zinc 1Combined sources1
    Metal bindingi724Zinc 2Combined sources1
    Metal bindingi727Zinc 2Combined sources1
    Metal bindingi747Zinc 2Combined sources1
    Metal bindingi750Zinc 2; via pros nitrogenCombined sources1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi95 – 123FADBy similarityAdd BLAST29

    GO - Molecular functioni

    • actin binding Source: UniProtKB
    • FAD binding Source: UniProtKB
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: UniProtKB
    • protein kinase binding Source: Ensembl
    • Rab GTPase binding Source: Ensembl
    • SH3 domain binding Source: UniProtKB
    • zinc ion binding Source: InterPro

    GO - Biological processi

    • actin filament depolymerization Source: UniProtKB
    • cytoskeleton organization Source: UniProtKB
    • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    • negative regulation of protein phosphorylation Source: Ensembl
    • oxidation-reduction process Source: UniProtKB
    • regulation of regulated secretory pathway Source: Ensembl
    • signal transduction Source: UniProtKB
    • sulfur oxidation Source: UniProtKB

    Keywordsi

    Molecular functionActin-binding, Monooxygenase, Oxidoreductase
    LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

    Enzyme and pathway databases

    ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ8TDZ2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [F-actin]-methionine sulfoxide oxidase MICAL1 (EC:1.14.13.225By similarity)
    Alternative name(s):
    Molecule interacting with CasL protein 1
    Short name:
    MICAL-1
    NEDD9-interacting protein with calponin homology and LIM domains
    Gene namesi
    Name:MICAL1
    Synonyms:MICAL, NICAL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20619. MICAL1.

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: UniProtKB
    • hippocampal mossy fiber expansion Source: Ensembl
    • intermediate filament Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi64780.
    OpenTargetsiENSG00000135596.
    PharmGKBiPA134900249.

    Polymorphism and mutation databases

    BioMutaiMICAL1.
    DMDMi45593495.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000758421 – 1067[F-actin]-methionine sulfoxide oxidase MICAL1Add BLAST1067

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei475PhosphothreonineBy similarity1
    Modified residuei617PhosphoserineCombined sources1
    Modified residuei872PhosphoserineCombined sources1
    Modified residuei875PhosphoserineCombined sources1
    Modified residuei876PhosphoserineCombined sources1
    Modified residuei1057PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiQ8TDZ2.
    MaxQBiQ8TDZ2.
    PaxDbiQ8TDZ2.
    PeptideAtlasiQ8TDZ2.
    PRIDEiQ8TDZ2.

    PTM databases

    iPTMnetiQ8TDZ2.
    PhosphoSitePlusiQ8TDZ2.

    Expressioni

    Tissue specificityi

    Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.1 Publication

    Gene expression databases

    BgeeiENSG00000135596.
    CleanExiHS_MICAL1.
    ExpressionAtlasiQ8TDZ2. baseline and differential.
    GenevisibleiQ8TDZ2. HS.

    Organism-specific databases

    HPAiHPA030175.
    HPA030176.
    HPA030178.

    Interactioni

    Subunit structurei

    Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.By similarity5 Publications

    GO - Molecular functioni

    • actin binding Source: UniProtKB
    • protein kinase binding Source: Ensembl
    • Rab GTPase binding Source: Ensembl
    • SH3 domain binding Source: UniProtKB

    Protein-protein interaction databases

    BioGridi122290. 25 interactors.
    IntActiQ8TDZ2. 8 interactors.
    MINTiMINT-1343875.
    STRINGi9606.ENSP00000351664.

    Structurei

    Secondary structure

    11067
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi511 – 524Combined sources14
    Turni533 – 538Combined sources6
    Helixi541 – 550Combined sources10
    Helixi552 – 554Combined sources3
    Helixi560 – 562Combined sources3
    Helixi565 – 578Combined sources14
    Helixi588 – 593Combined sources6
    Helixi597 – 610Combined sources14
    Beta strandi698 – 700Combined sources3
    Turni706 – 708Combined sources3
    Turni719 – 721Combined sources3
    Beta strandi725 – 727Combined sources3
    Beta strandi735 – 737Combined sources3
    Turni740 – 742Combined sources3
    Turni748 – 750Combined sources3
    Helixi919 – 959Combined sources41
    Helixi963 – 972Combined sources10
    Helixi974 – 1013Combined sources40
    Helixi1027 – 1059Combined sources33

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1WYLNMR-A510-612[»]
    2CO8NMR-A687-755[»]
    2DK9NMR-A506-614[»]
    5LE0X-ray3.30B918-1067[»]
    5LPNX-ray2.80B918-1067[»]
    ProteinModelPortaliQ8TDZ2.
    SMRiQ8TDZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TDZ2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini508 – 609CHPROSITE-ProRule annotationAdd BLAST102
    Domaini695 – 757LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1 – 489Monooxygenase domainBy similarityAdd BLAST489
    Regioni919 – 1061RAB-binding domain (RBD)1 PublicationAdd BLAST143

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Coiled coili646 – 666Sequence analysisAdd BLAST21
    Coiled coili919 – 962Sequence analysisAdd BLAST44
    Coiled coili999 – 1027Sequence analysisAdd BLAST29

    Domaini

    The C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).1 Publication
    The C-terminal coiled coil part contains the plexin-interacting region.

    Sequence similaritiesi

    Belongs to the Mical family.Curated

    Keywords - Domaini

    Coiled coil, LIM domain

    Phylogenomic databases

    eggNOGiKOG1700. Eukaryota.
    COG5069. LUCA.
    GeneTreeiENSGT00760000118856.
    HOGENOMiHOG000047263.
    HOVERGENiHBG052474.
    InParanoidiQ8TDZ2.
    KOiK19947.
    OMAiFYCLQHL.
    OrthoDBiEOG091G009H.
    PhylomeDBiQ8TDZ2.
    TreeFamiTF324129.

    Family and domain databases

    CDDicd00014. CH. 1 hit.
    Gene3Di1.10.418.10. 1 hit.
    3.50.50.60. 1 hit.
    InterProiView protein in InterPro
    IPR001715. CH-domain.
    IPR022735. DUF3585.
    IPR002938. FAD-bd.
    IPR023753. FAD/NAD-binding_dom.
    IPR029937. MICAL1.
    IPR001781. Znf_LIM.
    PANTHERiPTHR11915:SF387. PTHR11915:SF387. 1 hit.
    PfamiView protein in Pfam
    PF00307. CH. 1 hit.
    PF12130. DUF3585. 1 hit.
    PF01494. FAD_binding_3. 1 hit.
    PF00412. LIM. 1 hit.
    SMARTiView protein in SMART
    SM00033. CH. 1 hit.
    SM00132. LIM. 1 hit.
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF51905. SSF51905. 2 hits.
    PROSITEiView protein in PROSITE
    PS50021. CH. 1 hit.
    PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8TDZ2-1) [UniParc]FASTAAdd to basket
    Also known as: MICAL-1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MASPTSTNPA HAHFESFLQA QLCQDVLSSF QELCGALGLE PGGGLPQYHK
    60 70 80 90 100
    IKDQLNYWSA KSLWTKLDKR AGQPVYQQGR ACTSTKCLVV GAGPCGLRVA
    110 120 130 140 150
    VELALLGARV VLVEKRTKFS RHNVLHLWPF TIHDLRALGA KKFYGRFCTG
    160 170 180 190 200
    TLDHISIRQL QLLLLKVALL LGVEIHWGVT FTGLQPPPRK GSGWRAQLQP
    210 220 230 240 250
    NPPAQLANYE FDVLISAAGG KFVPEGFKVR EMRGKLAIGI TANFVNGRTV
    260 270 280 290 300
    EETQVPEISG VARIYNQSFF QSLLKATGID LENIVYYKDD THYFVMTAKK
    310 320 330 340 350
    QCLLRLGVLR QDWPDTNRLL GSANVVPEAL QRFTRAAADF ATHGKLGKLE
    360 370 380 390 400
    FAQDAHGQPD VSAFDFTSMM RAESSARVQE KHGARLLLGL VGDCLVEPFW
    410 420 430 440 450
    PLGTGVARGF LAAFDAAWMV KRWAEGAESL EVLAERESLY QLLSQTSPEN
    460 470 480 490 500
    MHRNVAQYGL DPATRYPNLN LRAVTPNQVR DLYDVLAKEP VQRNNDKTDT
    510 520 530 540 550
    GMPATGSAGT QEELLRWCQE QTAGYPGVHV SDLSSSWADG LALCALVYRL
    560 570 580 590 600
    QPGLLEPSEL QGLGALEATA WALKVAENEL GITPVVSAQA VVAGSDPLGL
    610 620 630 640 650
    IAYLSHFHSA FKSMAHSPGP VSQASPGTSS AVLFLSKLQR TLQRSRAKEN
    660 670 680 690 700
    AEDAGGKKLR LEMEAETPST EVPPDPEPGV PLTPPSQHQE AGAGDLCALC
    710 720 730 740 750
    GEHLYVLERL CVNGHFFHRS CFRCHTCEAT LWPGGYEQHP GDGHFYCLQH
    760 770 780 790 800
    LPQTDHKAEG SDRGPESPEL PTPSENSMPP GLSTPTASQE GAGPVPDPSQ
    810 820 830 840 850
    PTRRQIRLSS PERQRLSSLN LTPDPEMEPP PKPPRSCSAL ARHALESSFV
    860 870 880 890 900
    GWGLPVQSPQ ALVAMEKEEK ESPFSSEEEE EDVPLDSDVE QALQTFAKTS
    910 920 930 940 950
    GTMNNYPTWR RTLLRRAKEE EMKRFCKAQT IQRRLNEIEA ALRELEAEGV
    960 970 980 990 1000
    KLELALRRQS SSPEQQKKLW VGQLLQLVDK KNSLVAEEAE LMITVQELNL
    1010 1020 1030 1040 1050
    EEKQWQLDQE LRGYMNREEN LKTAADRQAE DQVLRKLVDL VNQRDALIRF
    1060
    QEERRLSELA LGTGAQG
    Length:1,067
    Mass (Da):117,875
    Last modified:March 15, 2004 - v2
    Checksum:i78C1BBF3E3CCD56B
    GO
    Isoform 2 (identifier: Q8TDZ2-2) [UniParc]FASTAAdd to basket
    Also known as: MICAL-1b

    The sequence of this isoform differs from the canonical sequence as follows:
         312-397: Missing.

    Show »
    Length:981
    Mass (Da):108,552
    Checksum:i8EC7E9C12989C1E9
    GO
    Isoform 3 (identifier: Q8TDZ2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-735: Missing.
         736-768: YEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESP → MPRLTFAPKGWPHPPTSLHPGQVTDQTTWWLFQ

    Note: No experimental confirmation available.
    Show »
    Length:332
    Mass (Da):37,715
    Checksum:i7FF1E955AE2204DB
    GO
    Isoform 4 (identifier: Q8TDZ2-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSCLSHSSLPSCCPPQEASM

    Note: No experimental confirmation available.
    Show »
    Length:1,086
    Mass (Da):119,821
    Checksum:i947094500071E091
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti767S → C in BAB15124 (PubMed:14702039).Curated1
    Sequence conflicti816L → S in BAH12301 (PubMed:14702039).Curated1
    Sequence conflicti877E → V in BAH12301 (PubMed:14702039).Curated1
    Sequence conflicti887S → L in CAB59266 (PubMed:17974005).Curated1
    Sequence conflicti981K → N in BAB13949 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06706312A → S. Corresponds to variant dbSNP:rs4946977Ensembl.1
    Natural variantiVAR_05015312A → T. Corresponds to variant dbSNP:rs4946977Ensembl.1
    Natural variantiVAR_050154153D → A. Corresponds to variant dbSNP:rs34726911Ensembl.1
    Natural variantiVAR_067064195R → H. Corresponds to variant dbSNP:rs34699467Ensembl.1
    Natural variantiVAR_036191309L → M in a breast cancer sample; somatic mutation. 1 Publication1
    Natural variantiVAR_067065453R → C1 PublicationCorresponds to variant dbSNP:rs17854785Ensembl.1
    Natural variantiVAR_067066624A → T1 PublicationCorresponds to variant dbSNP:rs17850590Ensembl.1
    Natural variantiVAR_017903758A → E. Corresponds to variant dbSNP:rs9320288Ensembl.1
    Natural variantiVAR_067067758A → K Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs35260632Ensembl.1
    Natural variantiVAR_067068758A → S. Corresponds to variant dbSNP:rs59056467Ensembl.1
    Natural variantiVAR_061355758A → T. Corresponds to variant dbSNP:rs59056467Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0096371 – 735Missing in isoform 3. 1 PublicationAdd BLAST735
    Alternative sequenceiVSP_0425901M → MSCLSHSSLPSCCPPQEASM in isoform 4. 1 Publication1
    Alternative sequenceiVSP_009639312 – 397Missing in isoform 2. 1 PublicationAdd BLAST86
    Alternative sequenceiVSP_009638736 – 768YEQHP…GPESP → MPRLTFAPKGWPHPPTSLHP GQVTDQTTWWLFQ in isoform 3. 1 PublicationAdd BLAST33

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB048948 mRNA. Translation: BAB86289.1.
    AK024500 mRNA. Translation: BAB15790.1.
    AK021999 mRNA. Translation: BAB13949.1.
    AK025392 mRNA. Translation: BAB15124.1.
    AK296284 mRNA. Translation: BAH12301.1.
    AL109947 Genomic DNA. Translation: CAI23343.1.
    CH471051 Genomic DNA. Translation: EAW48344.1.
    CH471051 Genomic DNA. Translation: EAW48345.1.
    BC009972 mRNA. Translation: AAH09972.2.
    BC042144 mRNA. Translation: AAH42144.1.
    BC052983 mRNA. Translation: AAH52983.1.
    AL122098 mRNA. Translation: CAB59266.1.
    CCDSiCCDS5076.1. [Q8TDZ2-1]
    CCDS55047.1. [Q8TDZ2-2]
    CCDS69170.1. [Q8TDZ2-4]
    PIRiT34532.
    RefSeqiNP_001152763.1. NM_001159291.1. [Q8TDZ2-2]
    NP_001273542.1. NM_001286613.1. [Q8TDZ2-4]
    NP_073602.3. NM_022765.3. [Q8TDZ2-1]
    UniGeneiHs.33476.

    Genome annotation databases

    EnsembliENST00000358577; ENSP00000351385; ENSG00000135596. [Q8TDZ2-2]
    ENST00000358807; ENSP00000351664; ENSG00000135596. [Q8TDZ2-1]
    ENST00000630715; ENSP00000486901; ENSG00000135596. [Q8TDZ2-4]
    GeneIDi64780.
    KEGGihsa:64780.
    UCSCiuc003ptk.4. human. [Q8TDZ2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB048948 mRNA. Translation: BAB86289.1.
    AK024500 mRNA. Translation: BAB15790.1.
    AK021999 mRNA. Translation: BAB13949.1.
    AK025392 mRNA. Translation: BAB15124.1.
    AK296284 mRNA. Translation: BAH12301.1.
    AL109947 Genomic DNA. Translation: CAI23343.1.
    CH471051 Genomic DNA. Translation: EAW48344.1.
    CH471051 Genomic DNA. Translation: EAW48345.1.
    BC009972 mRNA. Translation: AAH09972.2.
    BC042144 mRNA. Translation: AAH42144.1.
    BC052983 mRNA. Translation: AAH52983.1.
    AL122098 mRNA. Translation: CAB59266.1.
    CCDSiCCDS5076.1. [Q8TDZ2-1]
    CCDS55047.1. [Q8TDZ2-2]
    CCDS69170.1. [Q8TDZ2-4]
    PIRiT34532.
    RefSeqiNP_001152763.1. NM_001159291.1. [Q8TDZ2-2]
    NP_001273542.1. NM_001286613.1. [Q8TDZ2-4]
    NP_073602.3. NM_022765.3. [Q8TDZ2-1]
    UniGeneiHs.33476.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1WYLNMR-A510-612[»]
    2CO8NMR-A687-755[»]
    2DK9NMR-A506-614[»]
    5LE0X-ray3.30B918-1067[»]
    5LPNX-ray2.80B918-1067[»]
    ProteinModelPortaliQ8TDZ2.
    SMRiQ8TDZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi122290. 25 interactors.
    IntActiQ8TDZ2. 8 interactors.
    MINTiMINT-1343875.
    STRINGi9606.ENSP00000351664.

    PTM databases

    iPTMnetiQ8TDZ2.
    PhosphoSitePlusiQ8TDZ2.

    Polymorphism and mutation databases

    BioMutaiMICAL1.
    DMDMi45593495.

    Proteomic databases

    EPDiQ8TDZ2.
    MaxQBiQ8TDZ2.
    PaxDbiQ8TDZ2.
    PeptideAtlasiQ8TDZ2.
    PRIDEiQ8TDZ2.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000358577; ENSP00000351385; ENSG00000135596. [Q8TDZ2-2]
    ENST00000358807; ENSP00000351664; ENSG00000135596. [Q8TDZ2-1]
    ENST00000630715; ENSP00000486901; ENSG00000135596. [Q8TDZ2-4]
    GeneIDi64780.
    KEGGihsa:64780.
    UCSCiuc003ptk.4. human. [Q8TDZ2-1]

    Organism-specific databases

    CTDi64780.
    DisGeNETi64780.
    GeneCardsiMICAL1.
    HGNCiHGNC:20619. MICAL1.
    HPAiHPA030175.
    HPA030176.
    HPA030178.
    MIMi607129. gene.
    neXtProtiNX_Q8TDZ2.
    OpenTargetsiENSG00000135596.
    PharmGKBiPA134900249.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1700. Eukaryota.
    COG5069. LUCA.
    GeneTreeiENSGT00760000118856.
    HOGENOMiHOG000047263.
    HOVERGENiHBG052474.
    InParanoidiQ8TDZ2.
    KOiK19947.
    OMAiFYCLQHL.
    OrthoDBiEOG091G009H.
    PhylomeDBiQ8TDZ2.
    TreeFamiTF324129.

    Enzyme and pathway databases

    ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ8TDZ2.

    Miscellaneous databases

    ChiTaRSiMICAL1. human.
    EvolutionaryTraceiQ8TDZ2.
    GeneWikiiMICAL1.
    GenomeRNAii64780.
    PROiPR:Q8TDZ2.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000135596.
    CleanExiHS_MICAL1.
    ExpressionAtlasiQ8TDZ2. baseline and differential.
    GenevisibleiQ8TDZ2. HS.

    Family and domain databases

    CDDicd00014. CH. 1 hit.
    Gene3Di1.10.418.10. 1 hit.
    3.50.50.60. 1 hit.
    InterProiView protein in InterPro
    IPR001715. CH-domain.
    IPR022735. DUF3585.
    IPR002938. FAD-bd.
    IPR023753. FAD/NAD-binding_dom.
    IPR029937. MICAL1.
    IPR001781. Znf_LIM.
    PANTHERiPTHR11915:SF387. PTHR11915:SF387. 1 hit.
    PfamiView protein in Pfam
    PF00307. CH. 1 hit.
    PF12130. DUF3585. 1 hit.
    PF01494. FAD_binding_3. 1 hit.
    PF00412. LIM. 1 hit.
    SMARTiView protein in SMART
    SM00033. CH. 1 hit.
    SM00132. LIM. 1 hit.
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF51905. SSF51905. 2 hits.
    PROSITEiView protein in PROSITE
    PS50021. CH. 1 hit.
    PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiMICA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDZ2
    Secondary accession number(s): B7Z3R5
    , E1P5F0, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 15, 2004
    Last modified: June 7, 2017
    This is version 157 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.