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Protein

Immunoglobulin superfamily DCC subclass member 4

Gene

IGDCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily DCC subclass member 4
Alternative name(s):
Neighbor of punc e11
Protein DDM36
Short name:
hDDM36
Gene namesi
Name:IGDCC4
Synonyms:DDM36, KIAA1628, NOPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:13770. IGDCC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 957ExtracellularSequence analysisAdd BLAST933
Transmembranei958 – 978HelicalSequence analysisAdd BLAST21
Topological domaini979 – 1250CytoplasmicSequence analysisAdd BLAST272

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57722.
OpenTargetsiENSG00000103742.
PharmGKBiPA164720914.

Polymorphism and mutation databases

BioMutaiIGDCC4.
DMDMi74760490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000030462225 – 1250Immunoglobulin superfamily DCC subclass member 4Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 121PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 212PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi265 ↔ 312PROSITE-ProRule annotation
Disulfide bondi356 ↔ 405PROSITE-ProRule annotation
Glycosylationi582N-linked (GlcNAc...)Sequence analysis1
Modified residuei995PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TDY8.
PeptideAtlasiQ8TDY8.
PRIDEiQ8TDY8.

PTM databases

iPTMnetiQ8TDY8.
PhosphoSitePlusiQ8TDY8.

Expressioni

Gene expression databases

BgeeiENSG00000103742.
GenevisibleiQ8TDY8. HS.

Organism-specific databases

HPAiHPA008576.

Interactioni

Protein-protein interaction databases

BioGridi121745. 3 interactors.
IntActiQ8TDY8. 1 interactor.
STRINGi9606.ENSP00000319623.

Structurei

3D structure databases

ProteinModelPortaliQ8TDY8.
SMRiQ8TDY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 137Ig-like C2-type 1Add BLAST109
Domaini143 – 229Ig-like C2-type 2Add BLAST87
Domaini242 – 330Ig-like C2-type 3Add BLAST89
Domaini335 – 421Ig-like C2-type 4Add BLAST87
Domaini431 – 525Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini527 – 623Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini632 – 741Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST110
Domaini752 – 845Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini850 – 945Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 64Poly-Ala4
Compositional biasi385 – 388Poly-Gly4

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113009.
InParanoidiQ8TDY8.
OMAiGAPSQWM.
OrthoDBiEOG091G02TN.
PhylomeDBiQ8TDY8.
TreeFamiTF321506.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGDAGRGR GLLALTFCLL AARGELLLPQ ETTVELSCGV GPLQVILGPE
60 70 80 90 100
QAAVLNCSLG AAAAGPPTRV TWSKDGDTLL EHDHLHLLPN GSLWLSQPLA
110 120 130 140 150
PNGSDESVPE AVGVIEGNYS CLAHGPLGVL ASQTAVVKLA TLADFSLHPE
160 170 180 190 200
SQTVEENGTA RFECHIEGLP APIITWEKDQ VTLPEEPRLI VLPNGVLQIL
210 220 230 240 250
DVQESDAGPY RCVATNSARQ HFSQEALLSV AHRGSLASTR GQDVVIVAAP
260 270 280 290 300
ENTTVVSGQS VVMECVASAD PTPFVSWVRQ DGKPISTDVI VLGRTNLLIA
310 320 330 340 350
NAQPWHSGVY VCRANKPRTR DFATAAAELR VLAAPAITQA PEALSRTRAS
360 370 380 390 400
TARFVCRASG EPRPALRWLH NGAPLRPNGR VKVQGGGGSL VITQIGLQDA
410 420 430 440 450
GYYQCVAENS AGMACAAASL AVVVREGLPS APTRVTATPL SSSAVLVAWE
460 470 480 490 500
RPEMHSEQII GFSLHYQKAR GMDNVEYQFA VNNDTTELQV RDLEPNTDYE
510 520 530 540 550
FYVVAYSQLG ASRTSTPALV HTLDDVPSAA PQLSLSSPNP SDIRVAWLPL
560 570 580 590 600
PPSLSNGQVV KYKIEYGLGK EDQIFSTEVR GNETQLMLNS LQPNKVYRVR
610 620 630 640 650
ISAGTAAGFG APSQWMHHRT PSMHNQSHVP FAPAELKVQA KMESLVVSWQ
660 670 680 690 700
PPPHPTQISG YKLYWREVGA EEEANGDRLP GGRGDQAWDV GPVRLKKKVK
710 720 730 740 750
QYELTQLVPG RLYEVKLVAF NKHEDGYAAV WKGKTEKAPA PDMPIQRGPP
760 770 780 790 800
LPPAHVHAES NSSTSIWLRW KKPDFTTVKI VNYTVRFSPW GLRNASLVTY
810 820 830 840 850
YTSSGEDILI GGLKPFTKYE FAVQSHGVDM DGPFGSVVER STLPDRPSTP
860 870 880 890 900
PSDLRLSPLT PSTVRLHWCP PTEPNGEIVE YLILYSSNHT QPEHQWTLLT
910 920 930 940 950
TQGNIFSAEV HGLESDTRYF FKMGARTEVG PGPFSRLQDV ITLQEKLSDS
960 970 980 990 1000
LDMHSVTGII VGVCLGLLCL LACMCAGLRR SPHRESLPGL SSTATPGNPA
1010 1020 1030 1040 1050
LYSRARLGPP SPPAAHELES LVHPHPQDWS PPPSDVEDRA EVHSLMGGGV
1060 1070 1080 1090 1100
SEGRSHSKRK ISWAQPSGLS WAGSWAGCEL PQAGPRPALT RALLPPAGTG
1110 1120 1130 1140 1150
QTLLLQALVY DAIKGNGRKK SPPACRNQVE AEVIVHSDFS ASNGNPDLHL
1160 1170 1180 1190 1200
QDLEPEDPLP PEAPDLISGV GDPGQGAAWL DRELGGCELA APGPDRLTCL
1210 1220 1230 1240 1250
PEAASASCSY PDLQPGEVLE ETPGDSCQLK SPCPLGASPG LPRSPVSSSA
Length:1,250
Mass (Da):134,210
Last modified:June 1, 2002 - v1
Checksum:i181CA412E935F977
GO
Isoform 2 (identifier: Q8TDY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: MARGDAGRGR...FATAAAELRV → MGRRKGRSAL...IPRSASPLAP

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):105,361
Checksum:iA0636C95D4EE951E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04996652A → P.Corresponds to variant rs34355056dbSNPEnsembl.1
Natural variantiVAR_049967301N → S.Corresponds to variant rs12442757dbSNPEnsembl.1
Natural variantiVAR_059391803S → C.Corresponds to variant rs1469778dbSNPEnsembl.1
Natural variantiVAR_0499681102T → A.Corresponds to variant rs33918653dbSNPEnsembl.1
Natural variantiVAR_0499691125C → Y.Corresponds to variant rs33918653dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0280461 – 331MARGD…AELRV → MGRRKGRSALSRSSLERVNQ GEVKVIGRGAREGGGGQAWG TGGGGRDLSCGIPRSASPLA P in isoform 2. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052622 mRNA. Translation: BAB86306.1.
AB046848 mRNA. Translation: BAB13454.1.
CCDSiCCDS10206.1. [Q8TDY8-1]
RefSeqiNP_066013.1. NM_020962.2. [Q8TDY8-1]
UniGeneiHs.458607.

Genome annotation databases

EnsembliENST00000352385; ENSP00000319623; ENSG00000103742. [Q8TDY8-1]
GeneIDi57722.
KEGGihsa:57722.
UCSCiuc002aou.2. human. [Q8TDY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052622 mRNA. Translation: BAB86306.1.
AB046848 mRNA. Translation: BAB13454.1.
CCDSiCCDS10206.1. [Q8TDY8-1]
RefSeqiNP_066013.1. NM_020962.2. [Q8TDY8-1]
UniGeneiHs.458607.

3D structure databases

ProteinModelPortaliQ8TDY8.
SMRiQ8TDY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121745. 3 interactors.
IntActiQ8TDY8. 1 interactor.
STRINGi9606.ENSP00000319623.

PTM databases

iPTMnetiQ8TDY8.
PhosphoSitePlusiQ8TDY8.

Polymorphism and mutation databases

BioMutaiIGDCC4.
DMDMi74760490.

Proteomic databases

PaxDbiQ8TDY8.
PeptideAtlasiQ8TDY8.
PRIDEiQ8TDY8.

Protocols and materials databases

DNASUi57722.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352385; ENSP00000319623; ENSG00000103742. [Q8TDY8-1]
GeneIDi57722.
KEGGihsa:57722.
UCSCiuc002aou.2. human. [Q8TDY8-1]

Organism-specific databases

CTDi57722.
DisGeNETi57722.
GeneCardsiIGDCC4.
HGNCiHGNC:13770. IGDCC4.
HPAiHPA008576.
neXtProtiNX_Q8TDY8.
OpenTargetsiENSG00000103742.
PharmGKBiPA164720914.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113009.
InParanoidiQ8TDY8.
OMAiGAPSQWM.
OrthoDBiEOG091G02TN.
PhylomeDBiQ8TDY8.
TreeFamiTF321506.

Miscellaneous databases

ChiTaRSiIGDCC4. human.
GenomeRNAii57722.
PROiQ8TDY8.

Gene expression databases

BgeeiENSG00000103742.
GenevisibleiQ8TDY8. HS.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGDC4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDY8
Secondary accession number(s): Q9HCE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.