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Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

ASAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell proliferation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri441 – 46424C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell migration Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of stress fiber assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Development and differentiation-enhancing factor-like 1
Protein up-regulated in liver cancer 1
Gene namesi
Name:ASAP3
Synonyms:DDEFL1, UPLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14987. ASAP3.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
  • ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716179.

Polymorphism and mutation databases

BioMutaiASAP3.
DMDMi74751433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3PRO_0000232887Add
BLAST

Proteomic databases

MaxQBiQ8TDY4.
PaxDbiQ8TDY4.
PeptideAtlasiQ8TDY4.
PRIDEiQ8TDY4.

PTM databases

PhosphoSiteiQ8TDY4.

Expressioni

Tissue specificityi

Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.1 Publication

Gene expression databases

BgeeiQ8TDY4.
CleanExiHS_ASAP3.
ExpressionAtlasiQ8TDY4. baseline and differential.
GenevestigatoriQ8TDY4.

Organism-specific databases

HPAiHPA020537.
HPA020546.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDZD3Q86UT53EBI-2609717,EBI-8744528
RELQ048643EBI-2609717,EBI-307352
TFCP2Q128003EBI-2609717,EBI-717422
UBE3AQ05086-23EBI-2609717,EBI-10175863

Protein-protein interaction databases

BioGridi120756. 11 interactions.
IntActiQ8TDY4. 5 interactions.
STRINGi9606.ENSP00000338769.

Structurei

Secondary structure

1
903
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi424 – 43310Combined sources
Turni436 – 4394Combined sources
Turni442 – 4443Combined sources
Beta strandi451 – 4533Combined sources
Turni454 – 4563Combined sources
Helixi462 – 47110Combined sources
Turni473 – 4753Combined sources
Beta strandi478 – 4803Combined sources
Turni481 – 4833Combined sources
Helixi488 – 4969Combined sources
Helixi499 – 5068Combined sources
Turni507 – 5093Combined sources
Beta strandi512 – 5143Combined sources
Helixi524 – 53512Combined sources
Helixi548 – 5569Combined sources
Helixi560 – 5689Combined sources
Beta strandi573 – 5753Combined sources
Beta strandi580 – 5823Combined sources
Helixi589 – 5957Combined sources
Turni599 – 6013Combined sources
Helixi602 – 61110Combined sources
Beta strandi620 – 6223Combined sources
Helixi625 – 6317Combined sources
Helixi635 – 6439Combined sources
Helixi658 – 6658Combined sources
Helixi668 – 68013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B0OX-ray2.06E/F/G/H416-697[»]
3LVQX-ray3.38E416-697[»]
3LVRX-ray3.38E416-697[»]
ProteinModelPortaliQ8TDY4.
SMRiQ8TDY4. Positions 128-408, 423-687.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDY4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 39493PHPROSITE-ProRule annotationAdd
BLAST
Domaini426 – 551126Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati585 – 61733ANK 1Add
BLAST
Repeati621 – 65030ANK 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili141 – 17232Sequence AnalysisAdd
BLAST
Coiled coili248 – 27528Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi798 – 8014Poly-Ser

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri441 – 46424C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000230570.
HOVERGENiHBG051327.
InParanoidiQ8TDY4.
KOiK12488.
OMAiEHECEAW.
OrthoDBiEOG7WQ7RJ.
PhylomeDBiQ8TDY4.
TreeFamiTF325156.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR028775. ASAP3.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23180:SF211. PTHR23180:SF211. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA
60 70 80 90 100
ILQRIKKAVR AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL
110 120 130 140 150
NLAVFTREVA ALFKNLIQNL NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA
160 170 180 190 200
WKDYEAKMAK LEKERDRARV TGGIPGEVAQ DMQRERRIFQ LHMCEYLLKA
210 220 230 240 250
GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI EKLAASVHAL
260 270 280 290 300
HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
310 320 330 340 350
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT
360 370 380 390 400
CQVRPNPEEK KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA
410 420 430 440 450
FLGEPSAGPG SWGSAGHDGE PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT
460 470 480 490 500
WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS LTLDLLGPSE LLLALNMGNT
510 520 530 540 550
SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF ARRCTPEPQR
560 570 580 590 600
LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
610 620 630 640 650
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT
660 670 680 690 700
VNEAGETALD IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS
710 720 730 740 750
DSEEDEEEKR CLLKLPAQAH WASGRLDISN KTYETVASLG AATPQGESED
760 770 780 790 800
CPPPLPVKNS SRTLVQGCAR HASGDRSEVS SLSSEAPETP ESLGSPASSS
810 820 830 840 850
SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS EMYLPVRFSS
860 870 880 890 900
ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL

LQD
Length:903
Mass (Da):99,155
Last modified:June 1, 2002 - v1
Checksum:iD5E89518AFC86656
GO
Isoform 2 (identifier: Q8TDY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.

Note: No experimental confirmation available.

Show »
Length:407
Mass (Da):43,695
Checksum:i563CCA514252A27A
GO
Isoform 3 (identifier: Q8TDY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: DSKKQLEKAWKDYEAKM → ASLSLGSR

Note: No experimental confirmation available.

Show »
Length:894
Mass (Da):97,847
Checksum:i124043E01A5F8C85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191V → A in AAH60786 (PubMed:15489334).Curated
Sequence conflicti521 – 5211E → G in BAA91008 (PubMed:14702039).Curated
Sequence conflicti596 – 5961V → D in BAA91008 (PubMed:14702039).Curated
Sequence conflicti802 – 8021L → V in BAA91008 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti377 – 3771E → A.
Corresponds to variant rs16828486 [ dbSNP | Ensembl ].
VAR_048295
Natural varianti617 – 6171A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035612

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 496496Missing in isoform 2. 1 PublicationVSP_018013Add
BLAST
Alternative sequencei142 – 15817DSKKQ…YEAKM → ASLSLGSR in isoform 3. 1 PublicationVSP_039827Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056749 mRNA. Translation: BAB85677.1.
AK000206 mRNA. Translation: BAA91008.1.
AK092291 mRNA. Translation: BAG52522.1.
AK295100 mRNA. Translation: BAG58136.1.
AL021154, AL357134 Genomic DNA. Translation: CAI19596.1.
AL357134, AL021154 Genomic DNA. Translation: CAI22177.1.
CH471134 Genomic DNA. Translation: EAW95050.1.
BC052305 mRNA. Translation: AAH52305.1.
BC060786 mRNA. Translation: AAH60786.1.
CCDSiCCDS235.1. [Q8TDY4-1]
CCDS44087.1. [Q8TDY4-3]
RefSeqiNP_001137250.1. NM_001143778.1. [Q8TDY4-3]
NP_060177.2. NM_017707.3. [Q8TDY4-1]
UniGeneiHs.437379.

Genome annotation databases

EnsembliENST00000336689; ENSP00000338769; ENSG00000088280. [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280. [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280. [Q8TDY4-2]
GeneIDi55616.
KEGGihsa:55616.
UCSCiuc001bgy.1. human. [Q8TDY4-2]
uc001bha.2. human. [Q8TDY4-1]
uc010oea.1. human. [Q8TDY4-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056749 mRNA. Translation: BAB85677.1.
AK000206 mRNA. Translation: BAA91008.1.
AK092291 mRNA. Translation: BAG52522.1.
AK295100 mRNA. Translation: BAG58136.1.
AL021154, AL357134 Genomic DNA. Translation: CAI19596.1.
AL357134, AL021154 Genomic DNA. Translation: CAI22177.1.
CH471134 Genomic DNA. Translation: EAW95050.1.
BC052305 mRNA. Translation: AAH52305.1.
BC060786 mRNA. Translation: AAH60786.1.
CCDSiCCDS235.1. [Q8TDY4-1]
CCDS44087.1. [Q8TDY4-3]
RefSeqiNP_001137250.1. NM_001143778.1. [Q8TDY4-3]
NP_060177.2. NM_017707.3. [Q8TDY4-1]
UniGeneiHs.437379.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B0OX-ray2.06E/F/G/H416-697[»]
3LVQX-ray3.38E416-697[»]
3LVRX-ray3.38E416-697[»]
ProteinModelPortaliQ8TDY4.
SMRiQ8TDY4. Positions 128-408, 423-687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120756. 11 interactions.
IntActiQ8TDY4. 5 interactions.
STRINGi9606.ENSP00000338769.

PTM databases

PhosphoSiteiQ8TDY4.

Polymorphism and mutation databases

BioMutaiASAP3.
DMDMi74751433.

Proteomic databases

MaxQBiQ8TDY4.
PaxDbiQ8TDY4.
PeptideAtlasiQ8TDY4.
PRIDEiQ8TDY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336689; ENSP00000338769; ENSG00000088280. [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280. [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280. [Q8TDY4-2]
GeneIDi55616.
KEGGihsa:55616.
UCSCiuc001bgy.1. human. [Q8TDY4-2]
uc001bha.2. human. [Q8TDY4-1]
uc010oea.1. human. [Q8TDY4-3]

Organism-specific databases

CTDi55616.
GeneCardsiGC01M023755.
H-InvDBHIX0000247.
HGNCiHGNC:14987. ASAP3.
HPAiHPA020537.
HPA020546.
neXtProtiNX_Q8TDY4.
PharmGKBiPA164716179.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000230570.
HOVERGENiHBG051327.
InParanoidiQ8TDY4.
KOiK12488.
OMAiEHECEAW.
OrthoDBiEOG7WQ7RJ.
PhylomeDBiQ8TDY4.
TreeFamiTF325156.

Miscellaneous databases

ChiTaRSiASAP3. human.
EvolutionaryTraceiQ8TDY4.
GenomeRNAii55616.
NextBioi60208.
PROiQ8TDY4.

Gene expression databases

BgeeiQ8TDY4.
CleanExiHS_ASAP3.
ExpressionAtlasiQ8TDY4. baseline and differential.
GenevestigatoriQ8TDY4.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR028775. ASAP3.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23180:SF211. PTHR23180:SF211. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas."
    Okabe H., Furukawa Y., Kato T., Hasegawa S., Yamaoka Y., Nakamura Y.
    Int. J. Oncol. 24:43-48(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain, Colon mucosa and Tongue.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  6. "Structural analysis of gap and ankyrin domains of UPLC1."
    Structural genomics consortium (SGC)
    Submitted (SEP-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 416-697 IN COMPLEX WITH ZINC IONS.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-617.

Entry informationi

Entry nameiASAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDY4
Secondary accession number(s): B3KRW0
, B4DHH4, Q6P9F4, Q86UY1, Q9NXK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: May 27, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.