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Q8TDY4

- ASAP3_HUMAN

UniProt

Q8TDY4 - ASAP3_HUMAN

Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

ASAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Promotes cell proliferation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri441 – 46424C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. positive regulation of ARF GTPase activity Source: UniProtKB
    3. regulation of stress fiber assembly Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
    Alternative name(s):
    Development and differentiation-enhancing factor-like 1
    Protein up-regulated in liver cancer 1
    Gene namesi
    Name:ASAP3
    Synonyms:DDEFL1, UPLC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14987. ASAP3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. focal adhesion Source: UniProtKB
    3. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164716179.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 903903Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3PRO_0000232887Add
    BLAST

    Proteomic databases

    MaxQBiQ8TDY4.
    PaxDbiQ8TDY4.
    PeptideAtlasiQ8TDY4.
    PRIDEiQ8TDY4.

    PTM databases

    PhosphoSiteiQ8TDY4.

    Expressioni

    Tissue specificityi

    Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ8TDY4.
    BgeeiQ8TDY4.
    CleanExiHS_ASAP3.
    GenevestigatoriQ8TDY4.

    Organism-specific databases

    HPAiHPA020537.
    HPA020546.

    Interactioni

    Protein-protein interaction databases

    BioGridi120756. 2 interactions.
    IntActiQ8TDY4. 1 interaction.
    STRINGi9606.ENSP00000338769.

    Structurei

    Secondary structure

    1
    903
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi424 – 43310
    Turni436 – 4394
    Turni442 – 4443
    Beta strandi451 – 4533
    Turni454 – 4563
    Helixi462 – 47110
    Turni473 – 4753
    Beta strandi478 – 4803
    Turni481 – 4833
    Helixi488 – 4969
    Helixi499 – 5068
    Turni507 – 5093
    Beta strandi512 – 5143
    Helixi524 – 53512
    Helixi548 – 5569
    Helixi560 – 5689
    Beta strandi573 – 5753
    Beta strandi580 – 5823
    Helixi589 – 5957
    Turni599 – 6013
    Helixi602 – 61110
    Beta strandi620 – 6223
    Helixi625 – 6317
    Helixi635 – 6439
    Helixi658 – 6658
    Helixi668 – 68013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B0OX-ray2.06E/F/G/H416-697[»]
    3LVQX-ray3.38E416-697[»]
    3LVRX-ray3.38E416-697[»]
    ProteinModelPortaliQ8TDY4.
    SMRiQ8TDY4. Positions 304-408, 423-687.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TDY4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini302 – 39493PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini426 – 551126Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati585 – 61733ANK 1Add
    BLAST
    Repeati621 – 65030ANK 2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili141 – 17232Sequence AnalysisAdd
    BLAST
    Coiled coili248 – 27528Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi798 – 8014Poly-Ser

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri441 – 46424C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000230570.
    HOVERGENiHBG051327.
    InParanoidiQ8TDY4.
    KOiK12488.
    OMAiEHECEAW.
    OrthoDBiEOG7WQ7RJ.
    PhylomeDBiQ8TDY4.
    TreeFamiTF325156.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    1.25.40.20. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR028775. ASAP3.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR23180:SF211. PTHR23180:SF211. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDY4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA    50
    ILQRIKKAVR AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL 100
    NLAVFTREVA ALFKNLIQNL NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA 150
    WKDYEAKMAK LEKERDRARV TGGIPGEVAQ DMQRERRIFQ LHMCEYLLKA 200
    GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI EKLAASVHAL 250
    HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ 300
    FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT 350
    CQVRPNPEEK KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA 400
    FLGEPSAGPG SWGSAGHDGE PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT 450
    WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS LTLDLLGPSE LLLALNMGNT 500
    SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF ARRCTPEPQR 550
    LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA 600
    SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT 650
    VNEAGETALD IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS 700
    DSEEDEEEKR CLLKLPAQAH WASGRLDISN KTYETVASLG AATPQGESED 750
    CPPPLPVKNS SRTLVQGCAR HASGDRSEVS SLSSEAPETP ESLGSPASSS 800
    SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS EMYLPVRFSS 850
    ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL 900
    LQD 903
    Length:903
    Mass (Da):99,155
    Last modified:June 1, 2002 - v1
    Checksum:iD5E89518AFC86656
    GO
    Isoform 2 (identifier: Q8TDY4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-496: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:407
    Mass (Da):43,695
    Checksum:i563CCA514252A27A
    GO
    Isoform 3 (identifier: Q8TDY4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-158: DSKKQLEKAWKDYEAKM → ASLSLGSR

    Note: No experimental confirmation available.

    Show »
    Length:894
    Mass (Da):97,847
    Checksum:i124043E01A5F8C85
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191V → A in AAH60786. (PubMed:15489334)Curated
    Sequence conflicti521 – 5211E → G in BAA91008. (PubMed:14702039)Curated
    Sequence conflicti596 – 5961V → D in BAA91008. (PubMed:14702039)Curated
    Sequence conflicti802 – 8021L → V in BAA91008. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti377 – 3771E → A.
    Corresponds to variant rs16828486 [ dbSNP | Ensembl ].
    VAR_048295
    Natural varianti617 – 6171A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035612

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 496496Missing in isoform 2. 1 PublicationVSP_018013Add
    BLAST
    Alternative sequencei142 – 15817DSKKQ…YEAKM → ASLSLGSR in isoform 3. 1 PublicationVSP_039827Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056749 mRNA. Translation: BAB85677.1.
    AK000206 mRNA. Translation: BAA91008.1.
    AK092291 mRNA. Translation: BAG52522.1.
    AK295100 mRNA. Translation: BAG58136.1.
    AL021154, AL357134 Genomic DNA. Translation: CAI19596.1.
    AL357134, AL021154 Genomic DNA. Translation: CAI22177.1.
    CH471134 Genomic DNA. Translation: EAW95050.1.
    BC052305 mRNA. Translation: AAH52305.1.
    BC060786 mRNA. Translation: AAH60786.1.
    CCDSiCCDS235.1. [Q8TDY4-1]
    CCDS44087.1. [Q8TDY4-3]
    RefSeqiNP_001137250.1. NM_001143778.1. [Q8TDY4-3]
    NP_060177.2. NM_017707.3. [Q8TDY4-1]
    UniGeneiHs.437379.

    Genome annotation databases

    EnsembliENST00000336689; ENSP00000338769; ENSG00000088280. [Q8TDY4-1]
    ENST00000437606; ENSP00000408826; ENSG00000088280. [Q8TDY4-3]
    ENST00000495646; ENSP00000436150; ENSG00000088280. [Q8TDY4-2]
    GeneIDi55616.
    KEGGihsa:55616.
    UCSCiuc001bgy.1. human. [Q8TDY4-2]
    uc001bha.2. human. [Q8TDY4-1]
    uc010oea.1. human. [Q8TDY4-3]

    Polymorphism databases

    DMDMi74751433.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056749 mRNA. Translation: BAB85677.1 .
    AK000206 mRNA. Translation: BAA91008.1 .
    AK092291 mRNA. Translation: BAG52522.1 .
    AK295100 mRNA. Translation: BAG58136.1 .
    AL021154 , AL357134 Genomic DNA. Translation: CAI19596.1 .
    AL357134 , AL021154 Genomic DNA. Translation: CAI22177.1 .
    CH471134 Genomic DNA. Translation: EAW95050.1 .
    BC052305 mRNA. Translation: AAH52305.1 .
    BC060786 mRNA. Translation: AAH60786.1 .
    CCDSi CCDS235.1. [Q8TDY4-1 ]
    CCDS44087.1. [Q8TDY4-3 ]
    RefSeqi NP_001137250.1. NM_001143778.1. [Q8TDY4-3 ]
    NP_060177.2. NM_017707.3. [Q8TDY4-1 ]
    UniGenei Hs.437379.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B0O X-ray 2.06 E/F/G/H 416-697 [» ]
    3LVQ X-ray 3.38 E 416-697 [» ]
    3LVR X-ray 3.38 E 416-697 [» ]
    ProteinModelPortali Q8TDY4.
    SMRi Q8TDY4. Positions 304-408, 423-687.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120756. 2 interactions.
    IntActi Q8TDY4. 1 interaction.
    STRINGi 9606.ENSP00000338769.

    PTM databases

    PhosphoSitei Q8TDY4.

    Polymorphism databases

    DMDMi 74751433.

    Proteomic databases

    MaxQBi Q8TDY4.
    PaxDbi Q8TDY4.
    PeptideAtlasi Q8TDY4.
    PRIDEi Q8TDY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336689 ; ENSP00000338769 ; ENSG00000088280 . [Q8TDY4-1 ]
    ENST00000437606 ; ENSP00000408826 ; ENSG00000088280 . [Q8TDY4-3 ]
    ENST00000495646 ; ENSP00000436150 ; ENSG00000088280 . [Q8TDY4-2 ]
    GeneIDi 55616.
    KEGGi hsa:55616.
    UCSCi uc001bgy.1. human. [Q8TDY4-2 ]
    uc001bha.2. human. [Q8TDY4-1 ]
    uc010oea.1. human. [Q8TDY4-3 ]

    Organism-specific databases

    CTDi 55616.
    GeneCardsi GC01M023755.
    H-InvDB HIX0000247.
    HGNCi HGNC:14987. ASAP3.
    HPAi HPA020537.
    HPA020546.
    neXtProti NX_Q8TDY4.
    PharmGKBi PA164716179.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000230570.
    HOVERGENi HBG051327.
    InParanoidi Q8TDY4.
    KOi K12488.
    OMAi EHECEAW.
    OrthoDBi EOG7WQ7RJ.
    PhylomeDBi Q8TDY4.
    TreeFami TF325156.

    Miscellaneous databases

    ChiTaRSi ASAP3. human.
    EvolutionaryTracei Q8TDY4.
    GenomeRNAii 55616.
    NextBioi 60208.
    PROi Q8TDY4.

    Gene expression databases

    ArrayExpressi Q8TDY4.
    Bgeei Q8TDY4.
    CleanExi HS_ASAP3.
    Genevestigatori Q8TDY4.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    1.25.40.20. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR028775. ASAP3.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR23180:SF211. PTHR23180:SF211. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas."
      Okabe H., Furukawa Y., Kato T., Hasegawa S., Yamaoka Y., Nakamura Y.
      Int. J. Oncol. 24:43-48(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain, Colon mucosa and Tongue.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Testis.
    6. "Structural analysis of gap and ankyrin domains of UPLC1."
      Structural genomics consortium (SGC)
      Submitted (SEP-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 416-697 IN COMPLEX WITH ZINC IONS.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-617.

    Entry informationi

    Entry nameiASAP3_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDY4
    Secondary accession number(s): B3KRW0
    , B4DHH4, Q6P9F4, Q86UY1, Q9NXK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3