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Q8TDY3 (ACTT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein T2
Short name=ARP-T2
Alternative name(s):
Actin-related protein M2
Gene names
Name:ACTRT2
Synonyms:ARPM2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Sequence similarities

Belongs to the actin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Actin-related protein T2
PRO_0000089144

Natural variations

Natural variant2471G → R.
Corresponds to variant rs3795263 [ dbSNP | Ensembl ].
VAR_020416

Experimental info

Sequence conflict551Missing in AAH29499. Ref.5
Sequence conflict2241A → P in BAB85862. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TDY3 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 73272DE854B48FEB

FASTA37741,702
        10         20         30         40         50         60 
MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE 

        70         80         90        100        110        120 
EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR 

       130        140        150        160        170        180 
EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT 

       190        200        210        220        230        240 
KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR 

       250        260        270        280        290        300 
EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV 

       310        320        330        340        350        360 
LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT 

       370 
AADFKEFGTS VVQRRCF

« Hide

References

« Hide 'large scale' references
[1]"Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin."
Harata M., Nishimori K., Hatta S.
Biochim. Biophys. Acta 1522:130-133(2001) [PubMed: 11750065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head."
Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.
Exp. Cell Res. 279:177-187(2002) [PubMed: 12243744] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB057364 mRNA. Translation: BAB85862.1.
AF440740 mRNA. Translation: AAM00433.1.
AL356984 Genomic DNA. Translation: CAH72587.1.
CH471248 Genomic DNA. Translation: EAW61142.1.
BC029499 mRNA. Translation: AAH29499.1.
IPIIPI00154776.
RefSeqNP_536356.3. NM_080431.4.
UniGeneHs.236635.

3D structure databases

ProteinModelPortalQ8TDY3.
SMRQ8TDY3. Positions 7-377.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8TDY3.

Polymorphism databases

DMDM47115879.

Proteomic databases

PRIDEQ8TDY3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378404; ENSP00000367658; ENSG00000169717.
GeneID140625.
KEGGhsa:140625.
UCSCuc001ajz.1. human.

Organism-specific databases

CTD140625.
GeneCardsGC01P002962.
H-InvDBHIX0000062.
HGNCHGNC:24026. ACTRT2.
HPAHPA006480.
HPA025079.
MIM608535. gene.
neXtProtNX_Q8TDY3.
PharmGKBPA142672647.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07382.
HOGENOMHBG559892.
HOVERGENHBG003771.
InParanoidQ8TDY3.
OMAFYLSDQA.
OrthoDBEOG4NVZKF.
PhylomeDBQ8TDY3.

Gene expression databases

ArrayExpressQ8TDY3.
BgeeQ8TDY3.
CleanExHS_ACTRT2.
GenevestigatorQ8TDY3.
GermOnlineENSG00000169717. Homo sapiens.

Family and domain databases

InterProIPR004000. Actin-like.
IPR020902. Actin/actin-like_CS.
[Graphical view]
PANTHERPTHR11937. Actin_like. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio84197.
SOURCESearch...

Entry information

Entry nameACTT2_HUMAN
AccessionPrimary (citable) accession number: Q8TDY3
Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: January 25, 2012
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents