Q8TDY3 (ACTT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Actin-related protein T2 Short name=ARP-T2 Alternative name(s): Actin-related protein M2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 377 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Sequence similarities | Belongs to the actin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletonInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 377 | 377 | Actin-related protein T2 | PRO_0000089144 | |||||
Natural variations | |||||||||
| Natural variant | 247 | 1 | G → R. Corresponds to variant rs3795263 [ dbSNP | Ensembl ]. | VAR_020416 | |||||
Experimental info | |||||||||
| Sequence conflict | 55 | 1 | Missing in AAH29499. Ref.5 | ||||||
| Sequence conflict | 224 | 1 | A → P in BAB85862. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin." Harata M., Nishimori K., Hatta S. Biochim. Biophys. Acta 1522:130-133(2001) [PubMed: 11750065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head." Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W. Exp. Cell Res. 279:177-187(2002) [PubMed: 12243744] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB057364 mRNA. Translation: BAB85862.1. AF440740 mRNA. Translation: AAM00433.1. AL356984 Genomic DNA. Translation: CAH72587.1. CH471248 Genomic DNA. Translation: EAW61142.1. BC029499 mRNA. Translation: AAH29499.1. |
| IPI | IPI00154776. |
| RefSeq | NP_536356.3. NM_080431.4. |
| UniGene | Hs.236635. |
3D structure databases | |
| ProteinModelPortal | Q8TDY3. |
| SMR | Q8TDY3. Positions 7-377. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8TDY3. |
Polymorphism databases | |
| DMDM | 47115879. |
Proteomic databases | |
| PRIDE | Q8TDY3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000378404; ENSP00000367658; ENSG00000169717. |
| GeneID | 140625. |
| KEGG | hsa:140625. |
| UCSC | uc001ajz.1. human. |
Organism-specific databases | |
| CTD | 140625. |
| GeneCards | GC01P002962. |
| H-InvDB | HIX0000062. |
| HGNC | HGNC:24026. ACTRT2. |
| HPA | HPA006480. HPA025079. |
| MIM | 608535. gene. |
| neXtProt | NX_Q8TDY3. |
| PharmGKB | PA142672647. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG07382. |
| HOGENOM | HBG559892. |
| HOVERGEN | HBG003771. |
| InParanoid | Q8TDY3. |
| OMA | FYLSDQA. |
| OrthoDB | EOG4NVZKF. |
| PhylomeDB | Q8TDY3. |
Gene expression databases | |
| ArrayExpress | Q8TDY3. |
| Bgee | Q8TDY3. |
| CleanEx | HS_ACTRT2. |
| Genevestigator | Q8TDY3. |
| GermOnline | ENSG00000169717. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. IPR020902. Actin/actin-like_CS. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| PRINTS | PR00190. ACTIN. |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| PROSITE | PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 84197. |
| SOURCE | Search... |
Entry information
| Entry name | ACTT2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TDY3 Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with