Reviewed, UniProtKB/Swiss-Prot Q8TDY3 (ACTT2_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin-related protein T2
      Short name=ARP-T2
Alternative name(s):
    Actin-related protein M2

Gene names

Name:	ACTRT2
Synonyms:	ARPM2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Actin-related protein T2		PRO_0000089144
Natural variations
	Natural variant	247	1	G → R: dbSNP rs3795263.		VAR_020416
Experimental info
	Sequence conflict	55	1	Missing in AAH29499. Ref.5
	Sequence conflict	224	1	A → P in BAB85862. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TDY3-1 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 73272DE854B48FEB	FASTA	377	41,702
	10 20 30 40 50 60 MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE 70 80 90 100 110 120 EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR 130 140 150 160 170 180 EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT 190 200 210 220 230 240 KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR 250 260 270 280 290 300 EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV 310 320 330 340 350 360 LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT 370 AADFKEFGTS VVQRRCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin." Harata M., Nishimori K., Hatta S. Biochim. Biophys. Acta 1522:130-133(2001) [PubMed: 11750065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head." Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W. Exp. Cell Res. 279:177-187(2002) [PubMed: 12243744] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB057364 mRNA. Translation: BAB85862.1. AF440740 mRNA. Translation: AAM00433.1. AL356984 Genomic DNA. Translation: CAH72587.1. CH471248 Genomic DNA. Translation: EAW61142.1. BC029499 mRNA. Translation: AAH29499.1.
IPI	IPI00154776.
RefSeq	NP_536356.3.
UniGene	Hs.236635
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TDY3.
Proteomic databases
PRIDE	Q8TDY3.
Genome annotation databases
Ensembl	ENST00000378404; ENSP00000367658; ENSG00000169717; Homo sapiens. [Genome view]
GeneID	140625.
KEGG	hsa:140625.
UCSC	uc001ajz.1. human.
Organism-specific databases
CTD	140625.
GeneCards	GC01P002962.
H-InvDB	HIX0000062.
HGNC	HGNC:24026. ACTRT2.
HPA	HPA006480. HPA025079.
MIM	608535. gene.
PharmGKB	PA142672647.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TDY3.
OMA	FYLSDQA
OrthoDB	EOG90GG9Z
Gene expression databases
ArrayExpress	Q8TDY3.
Bgee	Q8TDY3.
CleanEx	HS_ACTRT2.
Genevestigator	Q8TDY3.
GermOnline	ENSG00000169717. Homo sapiens.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84197.
SOURCE	Search...

Entry information

Entry name

ACTT2_HUMAN

Accession

Primary (citable) accession number: Q8TDY3
Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	November 24, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.