Reviewed,
UniProtKB/Swiss-Prot Q8TDY3 (ACTT2_HUMAN)
Last modified
November 24, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Actin-related protein T2 Short name=ARP-T2 Alternative name(s): Actin-related protein M2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 377 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Sequence similarities | Belongs to the actin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA cytoskeletonInferred from direct assay. Source: HPA |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 377 | 377 | Actin-related protein T2 | PRO_0000089144 | |||||
Natural variations | |||||||||
| Natural variant | 247 | 1 | G → R: dbSNP rs3795263. | VAR_020416 | |||||
Experimental info | |||||||||
| Sequence conflict | 55 | 1 | Missing in AAH29499. Ref.5 | ||||||
| Sequence conflict | 224 | 1 | A → P in BAB85862. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin." Harata M., Nishimori K., Hatta S. Biochim. Biophys. Acta 1522:130-133(2001) [PubMed: 11750065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head." Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W. Exp. Cell Res. 279:177-187(2002) [PubMed: 12243744] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| AB057364 mRNA. Translation: BAB85862.1. AF440740 mRNA. Translation: AAM00433.1. AL356984 Genomic DNA. Translation: CAH72587.1. CH471248 Genomic DNA. Translation: EAW61142.1. BC029499 mRNA. Translation: AAH29499.1. | |
| IPI | IPI00154776. |
| RefSeq | NP_536356.3. |
| UniGene | Hs.236635 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8TDY3. |
Proteomic databases | |
| PRIDE | Q8TDY3. |
Genome annotation databases | |
| Ensembl | ENST00000378404; ENSP00000367658; ENSG00000169717; Homo sapiens. [Genome view] |
| GeneID | 140625. |
| KEGG | hsa:140625. |
| UCSC | uc001ajz.1. human. |
Organism-specific databases | |
| CTD | 140625. |
| GeneCards | GC01P002962. |
| H-InvDB | HIX0000062. |
| HGNC | HGNC:24026. ACTRT2. |
| HPA | HPA006480. HPA025079. |
| MIM | 608535. gene. |
| PharmGKB | PA142672647. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q8TDY3. |
| OMA | FYLSDQA |
| OrthoDB | EOG90GG9Z |
Gene expression databases | |
| ArrayExpress | Q8TDY3. |
| Bgee | Q8TDY3. |
| CleanEx | HS_ACTRT2. |
| Genevestigator | Q8TDY3. |
| GermOnline | ENSG00000169717. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| PRINTS | PR00190. ACTIN. |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| PROSITE | PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 84197. |
| SOURCE | Search... |
Entry information
| Entry name | ACTT2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TDY3 Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


