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Protein

Actin-related protein T2

Gene

ACTRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TDY3.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein T2
Short name:
ARP-T2
Alternative name(s):
Actin-related protein M2
Gene namesi
Name:ACTRT2
Synonyms:ARPM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24026. ACTRT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672647.

Polymorphism and mutation databases

BioMutaiACTRT2.
DMDMi47115879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Actin-related protein T2PRO_0000089144Add
BLAST

Proteomic databases

PaxDbiQ8TDY3.
PeptideAtlasiQ8TDY3.
PRIDEiQ8TDY3.

PTM databases

iPTMnetiQ8TDY3.
PhosphoSiteiQ8TDY3.

Expressioni

Gene expression databases

BgeeiQ8TDY3.
CleanExiHS_ACTRT2.
GenevisibleiQ8TDY3. HS.

Organism-specific databases

HPAiHPA006480.
HPA025079.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367658.

Structurei

3D structure databases

ProteinModelPortaliQ8TDY3.
SMRiQ8TDY3. Positions 11-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ8TDY3.
OMAiWFSTWIG.
OrthoDBiEOG7QRQV3.
PhylomeDBiQ8TDY3.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027666. ACTRT2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF38. PTHR11937:SF38. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE
60 70 80 90 100
ANQKKYFVGE EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV
110 120 130 140 150
KPSDQPLLAT EPSLNPRENR EKMAEVMFEN FGVPAFYLSD QAVLALYASA
160 170 180 190 200
CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT KLHVAGRDIT ELLMQLLLAS
210 220 230 240 250
GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR EYKLPDGNII
260 270 280 290 300
SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV
310 320 330 340 350
LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS
360 370
LSSFKQMWVT AADFKEFGTS VVQRRCF
Length:377
Mass (Da):41,702
Last modified:May 10, 2004 - v2
Checksum:i73272DE854B48FEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551Missing in AAH29499 (PubMed:15489334).Curated
Sequence conflicti224 – 2241A → P in BAB85862 (PubMed:11750065).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471G → R.
Corresponds to variant rs3795263 [ dbSNP | Ensembl ].
VAR_020416

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057364 mRNA. Translation: BAB85862.1.
AF440740 mRNA. Translation: AAM00433.1.
AL356984 Genomic DNA. Translation: CAH72587.1.
CH471248 Genomic DNA. Translation: EAW61142.1.
BC029499 mRNA. Translation: AAH29499.1.
CCDSiCCDS45.1.
RefSeqiNP_536356.3. NM_080431.4.
UniGeneiHs.236635.

Genome annotation databases

EnsembliENST00000378404; ENSP00000367658; ENSG00000169717.
GeneIDi140625.
KEGGihsa:140625.
UCSCiuc001ajz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057364 mRNA. Translation: BAB85862.1.
AF440740 mRNA. Translation: AAM00433.1.
AL356984 Genomic DNA. Translation: CAH72587.1.
CH471248 Genomic DNA. Translation: EAW61142.1.
BC029499 mRNA. Translation: AAH29499.1.
CCDSiCCDS45.1.
RefSeqiNP_536356.3. NM_080431.4.
UniGeneiHs.236635.

3D structure databases

ProteinModelPortaliQ8TDY3.
SMRiQ8TDY3. Positions 11-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367658.

PTM databases

iPTMnetiQ8TDY3.
PhosphoSiteiQ8TDY3.

Polymorphism and mutation databases

BioMutaiACTRT2.
DMDMi47115879.

Proteomic databases

PaxDbiQ8TDY3.
PeptideAtlasiQ8TDY3.
PRIDEiQ8TDY3.

Protocols and materials databases

DNASUi140625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378404; ENSP00000367658; ENSG00000169717.
GeneIDi140625.
KEGGihsa:140625.
UCSCiuc001ajz.4. human.

Organism-specific databases

CTDi140625.
GeneCardsiACTRT2.
HGNCiHGNC:24026. ACTRT2.
HPAiHPA006480.
HPA025079.
MIMi608535. gene.
neXtProtiNX_Q8TDY3.
PharmGKBiPA142672647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ8TDY3.
OMAiWFSTWIG.
OrthoDBiEOG7QRQV3.
PhylomeDBiQ8TDY3.
TreeFamiTF354237.

Enzyme and pathway databases

SignaLinkiQ8TDY3.

Miscellaneous databases

GenomeRNAii140625.
PROiQ8TDY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDY3.
CleanExiHS_ACTRT2.
GenevisibleiQ8TDY3. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027666. ACTRT2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF38. PTHR11937:SF38. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin."
    Harata M., Nishimori K., Hatta S.
    Biochim. Biophys. Acta 1522:130-133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head."
    Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.
    Exp. Cell Res. 279:177-187(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACTT2_HUMAN
AccessioniPrimary (citable) accession number: Q8TDY3
Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.