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Protein

Serine/threonine-protein kinase Nek7

Gene

NEK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631ATP
Sitei97 – 971Autoinhibitory
Active sitei161 – 1611Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 489ATP

GO - Molecular functioni

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • positive regulation of telomerase activity Source: BHF-UCL
  • positive regulation of telomere capping Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • protein phosphorylation Source: UniProtKB
  • regulation of mitotic cell cycle Source: UniProtKB
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
SignaLinkiQ8TDX7.
SIGNORiQ8TDX7.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek7 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 7
Short name:
NimA-related protein kinase 7
Gene namesi
Name:NEK7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13386. NEK7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 281Y → A: Significant decrease in catalytic activity; when associated with A-31. 1 Publication
Mutagenesisi31 – 311L → A: Significant decrease in catalytic activity; when associated with A-28. 1 Publication
Mutagenesisi33 – 331N → D: Significant decrease in catalytic activity. 1 Publication
Mutagenesisi97 – 971Y → A: 5-fold increase in catalytic activity. 1 Publication
Mutagenesisi97 – 971Y → F or L: Moderate increase in catalytic activity. 1 Publication

Organism-specific databases

PharmGKBiPA31551.

Chemistry

ChEMBLiCHEMBL4849.
GuidetoPHARMACOLOGYi2122.

Polymorphism and mutation databases

BioMutaiNEK7.
DMDMi37537965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Serine/threonine-protein kinase Nek7PRO_0000086430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei191 – 1911PhosphothreonineBy similarity
Modified residuei195 – 1951Phosphoserine; by NEK91 Publication
Modified residuei199 – 1991PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation at Ser-195 required for its activation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TDX7.
MaxQBiQ8TDX7.
PaxDbiQ8TDX7.
PRIDEiQ8TDX7.

PTM databases

iPTMnetiQ8TDX7.
PhosphoSiteiQ8TDX7.

Expressioni

Tissue specificityi

Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.1 Publication

Gene expression databases

BgeeiQ8TDX7.
CleanExiHS_NEK7.
ExpressionAtlasiQ8TDX7. baseline and differential.
GenevisibleiQ8TDX7. HS.

Organism-specific databases

HPAiHPA015520.
HPA018193.

Interactioni

Subunit structurei

Monomer. Interacts with NEK9.2 Publications

Protein-protein interaction databases

BioGridi126636. 17 interactions.
IntActiQ8TDX7. 3 interactions.
STRINGi9606.ENSP00000356355.

Chemistry

BindingDBiQ8TDX7.

Structurei

Secondary structure

1
302
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 263Combined sources
Helixi31 – 333Combined sources
Beta strandi34 – 418Combined sources
Beta strandi47 – 537Combined sources
Turni54 – 563Combined sources
Beta strandi59 – 657Combined sources
Turni67 – 704Combined sources
Helixi73 – 8715Combined sources
Beta strandi97 – 1037Combined sources
Beta strandi106 – 1127Combined sources
Helixi119 – 12810Combined sources
Helixi135 – 15420Combined sources
Helixi164 – 1663Combined sources
Beta strandi167 – 1693Combined sources
Beta strandi175 – 1773Combined sources
Helixi205 – 2084Combined sources
Helixi215 – 23117Combined sources
Helixi243 – 2519Combined sources
Turni260 – 2623Combined sources
Helixi265 – 27410Combined sources
Helixi279 – 2813Combined sources
Helixi285 – 29915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQMX-ray2.10A1-302[»]
2WQNX-ray2.30A1-302[»]
5DE2X-ray2.78A/B1-302[»]
ProteinModelPortaliQ8TDX7.
SMRiQ8TDX7. Positions 21-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDX7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 299266Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 3314NTE motifAdd
BLAST

Domaini

Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.1 Publication
The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity.1 Publication

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0591. Eukaryota.
ENOG410XNQP. LUCA.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000233029.
HOVERGENiHBG105886.
InParanoidiQ8TDX7.
KOiK08857.
OMAiHACMASS.
OrthoDBiEOG74J983.
PhylomeDBiQ8TDX7.
TreeFamiTF105135.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEQSQGMQG PPVPQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR
60 70 80 90 100
AACLLDGVPV ALKKVQIFDL MDAKARADCI KEIDLLKQLN HPNVIKYYAS
110 120 130 140 150
FIEDNELNIV LELADAGDLS RMIKHFKKQK RLIPERTVWK YFVQLCSALE
160 170 180 190 200
HMHSRRVMHR DIKPANVFIT ATGVVKLGDL GLGRFFSSKT TAAHSLVGTP
210 220 230 240 250
YYMSPERIHE NGYNFKSDIW SLGCLLYEMA ALQSPFYGDK MNLYSLCKKI
260 270 280 290 300
EQCDYPPLPS DHYSEELRQL VNMCINPDPE KRPDVTYVYD VAKRMHACTA

SS
Length:302
Mass (Da):34,551
Last modified:June 1, 2002 - v1
Checksum:iC1FC990B34D94D4C
GO
Isoform 2 (identifier: Q8TDX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-119: IFDLMDAKAR...VLELADAGDL → VCLLPVWERR...VSHHGSFAKK
     120-302: Missing.

Note: No experimental confirmation available.
Show »
Length:119
Mass (Da):13,402
Checksum:iC5CF3EAC5976AE9F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351R → G.1 Publication
Corresponds to variant rs55833332 [ dbSNP | Ensembl ].
VAR_040924
Natural varianti275 – 2751I → M in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_040925

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 11953IFDLM…DAGDL → VCLLPVWERRVCALNACYFL EIIKGSESLQYMATLTNLFE NLPVSHHGSFAKK in isoform 2. 1 PublicationVSP_041243Add
BLAST
Alternative sequencei120 – 302183Missing in isoform 2. 1 PublicationVSP_041244Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062450 mRNA. Translation: BAB85632.1.
CK819069 mRNA. No translation available.
AC093419 Genomic DNA. No translation available.
AC093561 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91294.1.
CCDSiCCDS1394.1. [Q8TDX7-1]
RefSeqiNP_598001.1. NM_133494.2. [Q8TDX7-1]
UniGeneiHs.24119.
Hs.745083.

Genome annotation databases

EnsembliENST00000367383; ENSP00000356353; ENSG00000151414. [Q8TDX7-2]
ENST00000367385; ENSP00000356355; ENSG00000151414. [Q8TDX7-1]
ENST00000538004; ENSP00000444621; ENSG00000151414. [Q8TDX7-1]
GeneIDi140609.
KEGGihsa:140609.
UCSCiuc001gun.5. human. [Q8TDX7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062450 mRNA. Translation: BAB85632.1.
CK819069 mRNA. No translation available.
AC093419 Genomic DNA. No translation available.
AC093561 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91294.1.
CCDSiCCDS1394.1. [Q8TDX7-1]
RefSeqiNP_598001.1. NM_133494.2. [Q8TDX7-1]
UniGeneiHs.24119.
Hs.745083.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQMX-ray2.10A1-302[»]
2WQNX-ray2.30A1-302[»]
5DE2X-ray2.78A/B1-302[»]
ProteinModelPortaliQ8TDX7.
SMRiQ8TDX7. Positions 21-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126636. 17 interactions.
IntActiQ8TDX7. 3 interactions.
STRINGi9606.ENSP00000356355.

Chemistry

BindingDBiQ8TDX7.
ChEMBLiCHEMBL4849.
GuidetoPHARMACOLOGYi2122.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ8TDX7.
PhosphoSiteiQ8TDX7.

Polymorphism and mutation databases

BioMutaiNEK7.
DMDMi37537965.

Proteomic databases

EPDiQ8TDX7.
MaxQBiQ8TDX7.
PaxDbiQ8TDX7.
PRIDEiQ8TDX7.

Protocols and materials databases

DNASUi140609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367383; ENSP00000356353; ENSG00000151414. [Q8TDX7-2]
ENST00000367385; ENSP00000356355; ENSG00000151414. [Q8TDX7-1]
ENST00000538004; ENSP00000444621; ENSG00000151414. [Q8TDX7-1]
GeneIDi140609.
KEGGihsa:140609.
UCSCiuc001gun.5. human. [Q8TDX7-1]

Organism-specific databases

CTDi140609.
GeneCardsiNEK7.
HGNCiHGNC:13386. NEK7.
HPAiHPA015520.
HPA018193.
MIMi606848. gene.
neXtProtiNX_Q8TDX7.
PharmGKBiPA31551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0591. Eukaryota.
ENOG410XNQP. LUCA.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000233029.
HOVERGENiHBG105886.
InParanoidiQ8TDX7.
KOiK08857.
OMAiHACMASS.
OrthoDBiEOG74J983.
PhylomeDBiQ8TDX7.
TreeFamiTF105135.

Enzyme and pathway databases

ReactomeiR-HSA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
SignaLinkiQ8TDX7.
SIGNORiQ8TDX7.

Miscellaneous databases

ChiTaRSiNEK7. human.
EvolutionaryTraceiQ8TDX7.
GenomeRNAii140609.
NextBioi84187.
PROiQ8TDX7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDX7.
CleanExiHS_NEK7.
ExpressionAtlasiQ8TDX7. baseline and differential.
GenevisibleiQ8TDX7. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3."
    Kimura M., Okano Y.
    Cytogenet. Cell Genet. 94:33-38(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Pancreatic islet.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases."
    Belham C., Roig J., Caldwell J.A., Aoyama Y., Kemp B.E., Comb M., Avruch J.
    J. Biol. Chem. 278:34897-34909(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-195.
  6. "Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression."
    Yissachar N., Salem H., Tennenbaum T., Motro B.
    FEBS Lett. 580:6489-6495(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "NEK7 is a centrosomal kinase critical for microtubule nucleation."
    Kim S., Lee K., Rhee K.
    Biochem. Biophys. Res. Commun. 360:56-62(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis."
    O'Regan L., Fry A.M.
    Mol. Cell. Biol. 29:3975-3990(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NEK9.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain."
    Meirelles G.V., Silva J.C., Mendonca Yde A., Ramos C.H., Torriani I.L., Kobarg J.
    BMC Struct. Biol. 11:12-12(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  12. "Mitotic regulation by NIMA-related kinases."
    O'regan L., Blot J., Fry A.M.
    Cell Div. 2:25-25(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9."
    Richards M.W., O'Regan L., Mas-Droux C., Blot J.M., Cheung J., Hoelder S., Fry A.M., Bayliss R.
    Mol. Cell 36:560-570(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), DOMAIN, ENZYME REGULATION, MUTAGENESIS OF TYR-28; LEU-31; ASN-33 AND TYR-97.
  15. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-35 AND MET-275.

Entry informationi

Entry nameiNEK7_HUMAN
AccessioniPrimary (citable) accession number: Q8TDX7
Secondary accession number(s): A6NGT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.