Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TDW7

- FAT3_HUMAN

UniProt

Q8TDW7 - FAT3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protocadherin Fat 3

Gene

FAT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 3
Short name:
hFat3
Alternative name(s):
Cadherin family member 15
FAT tumor suppressor homolog 3
Gene namesi
Name:FAT3
Synonyms:CDHF15, KIAA1989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23112. FAT3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 41544122ExtracellularSequence AnalysisAdd
BLAST
Transmembranei4155 – 417521HelicalSequence AnalysisAdd
BLAST
Topological domaini4176 – 4589414CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 45894557Protocadherin Fat 3PRO_0000324634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1007 – 10071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1368 – 13681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1430 – 14301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1752 – 17521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1945 – 19451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1994 – 19941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1997 – 19971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2209 – 22091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2293 – 22931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2332 – 23321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2468 – 24681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3001 – 30011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3202 – 32021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3330 – 33301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3450 – 34501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3619 – 36191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3742 – 37421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3799 ↔ 3810By similarity
Disulfide bondi3804 ↔ 3822By similarity
Disulfide bondi3824 ↔ 3832By similarity
Glycosylationi3927 – 39271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3985 ↔ 4018By similarity
Disulfide bondi4025 ↔ 4036By similarity
Disulfide bondi4030 ↔ 4046By similarity
Disulfide bondi4048 ↔ 4057By similarity
Disulfide bondi4064 ↔ 4075By similarity
Disulfide bondi4069 ↔ 4084By similarity
Disulfide bondi4086 ↔ 4095By similarity
Disulfide bondi4102 ↔ 4113By similarity
Disulfide bondi4107 ↔ 4122By similarity
Disulfide bondi4124 ↔ 4133By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8TDW7.
PaxDbiQ8TDW7.
PRIDEiQ8TDW7.

PTM databases

PhosphoSiteiQ8TDW7.

Expressioni

Tissue specificityi

Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.1 Publication

Gene expression databases

BgeeiQ8TDW7.
CleanExiHS_FAT3.
ExpressionAtlasiQ8TDW7. baseline and differential.
GenevestigatoriQ8TDW7.

Organism-specific databases

HPAiHPA026878.

Interactioni

Protein-protein interaction databases

BioGridi125669. 7 interactions.
STRINGi9606.ENSP00000387040.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW7.
SMRiQ8TDW7. Positions 117-336, 385-3619, 3798-4133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 158115Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 266108Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini264 – 375112Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini377 – 47296Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini473 – 578106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini579 – 681103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini727 – 831105Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 936105Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini937 – 1043107Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1044 – 1148105Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1149 – 1254106Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1255 – 1359105Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1363 – 146098Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1461 – 1566106Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1567 – 1769203Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1770 – 1883114Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini1884 – 1986103Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini1983 – 2084102Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini2085 – 2186102Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2187 – 2287101Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2288 – 2394107Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2395 – 2496102Cadherin 22PROSITE-ProRule annotationAdd
BLAST
Domaini2497 – 2600104Cadherin 23PROSITE-ProRule annotationAdd
BLAST
Domaini2601 – 2708108Cadherin 24PROSITE-ProRule annotationAdd
BLAST
Domaini2709 – 2814106Cadherin 25PROSITE-ProRule annotationAdd
BLAST
Domaini2815 – 2924110Cadherin 26PROSITE-ProRule annotationAdd
BLAST
Domaini2925 – 3029105Cadherin 27PROSITE-ProRule annotationAdd
BLAST
Domaini3030 – 3131102Cadherin 28PROSITE-ProRule annotationAdd
BLAST
Domaini3132 – 3236105Cadherin 29PROSITE-ProRule annotationAdd
BLAST
Domaini3237 – 3341105Cadherin 30PROSITE-ProRule annotationAdd
BLAST
Domaini3342 – 3446105Cadherin 31PROSITE-ProRule annotationAdd
BLAST
Domaini3447 – 3551105Cadherin 32PROSITE-ProRule annotationAdd
BLAST
Domaini3552 – 3653102Cadherin 33PROSITE-ProRule annotationAdd
BLAST
Domaini3795 – 383339EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini3835 – 4018184Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini4021 – 405838EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini4060 – 409637EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini4098 – 413437EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4438 – 450972Pro-richAdd
BLAST

Sequence similaritiesi

Contains 33 cadherin domains.PROSITE-ProRule annotation
Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ8TDW7.
KOiK16506.
OMAiKFFIDPK.
PhylomeDBiQ8TDW7.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 32 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TDW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA
60 70 80 90 100
TVYENSAART YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA
110 120 130 140 150
DFCFLRIRTK GGNSAILNRE IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD
160 170 180 190 200
MNDLRPLFSP TTYSVTIAES TPLRTSVAQV TATDADIGSN GEFYYYFKNK
210 220 230 240 250
VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL YGNNGVSSTA
260 270 280 290 300
KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES
310 320 330 340 350
VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK
360 370 380 390 400
GSPQKCSALK AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL
410 420 430 440 450
SPEPIDVEYK LSPGEDAVYF KINPRSGLIV TARPLNTVKK EVYKLEVTNK
460 470 480 490 500
EGDLKAQVTI SIEDANDHTP EFQQPLYDAY VNESVPVGTS VLTVSASDKD
510 520 530 540 550
KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP EIYRFIVRAS
560 570 580 590 600
DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV
610 620 630 640 650
SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA
660 670 680 690 700
LRITATDGEN LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA
710 720 730 740 750
KANGKLNLED GFLDFYSINR QGPYFDKSFP SDVAVKEDLP VGANILKIKA
760 770 780 790 800
YDADSGFNGK VLFTISDGNT DSCFNIDMET GQLKVLMPMD REHTDLYLLN
810 820 830 840 850
ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI LESSGIGTEI
860 870 880 890 900
IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY
910 920 930 940 950
SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP
960 970 980 990 1000
VGTVIAWLET HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY
1010 1020 1030 1040 1050
EKQQFYNLTV RAKDKGRPVS LSSVSFVEVE VVDVNENLHT PYFPDFAVVG
1060 1070 1080 1090 1100
SVKENSRIGT SVLQVTARDE DSGRDGEIQY SIRDGSGLGR FSIDDESGVI
1110 1120 1130 1140 1150
TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED VNDNAPLTSE
1160 1170 1180 1190 1200
PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI
1210 1220 1230 1240 1250
KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN
1260 1270 1280 1290 1300
KPQFPEKVYQ IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND
1310 1320 1330 1340 1350
DGKFFIDPKT GMVSSRKQFT AGSYDILTIK AVDNGRPQKS STARLHIEWI
1360 1370 1380 1390 1400
KKPPPSPIPL TFDEPFYNFT VMESDRVTEI VGVVSVQPAN TPLWFDIVGG
1410 1420 1430 1440 1450
NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN VAVTQVFIKV
1460 1470 1480 1490 1500
LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS
1510 1520 1530 1540 1550
IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA
1560 1570 1580 1590 1600
RVIVNVEDAN DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE
1610 1620 1630 1640 1650
LIYTIEAGNT GNMFKIEPVL GIITICKEPD MTTMGQFVLS IKVTDQGSPP
1660 1670 1680 1690 1700
MSATAIVRIS VTMSDNSHPK FIHKDYQAEV NENVDIGTSV ILISAISQST
1710 1720 1730 1740 1750
LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI IQATNMAGMA
1760 1770 1780 1790 1800
SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA
1810 1820 1830 1840 1850
TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH
1860 1870 1880 1890 1900
VHVRDSGSPQ LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV
1910 1920 1930 1940 1950
EVLKVSATDP DSEVPPELTY SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH
1960 1970 1980 1990 2000
YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL HFTQSFYSTS ISENNTNITK
2010 2020 2030 2040 2050
VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV PFDREEQELY
2060 2070 2080 2090 2100
ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG
2110 2120 2130 2140 2150
TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS
2160 2170 2180 2190 2200
NIEYGVTILA KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR
2210 2220 2230 2240 2250
MNTPILSINA TSPEGQGIIY IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV
2260 2270 2280 2290 2300
TSAYKLTIRA SDALTGARAE VTVDLLVNDV NDNPPIFDQP TYNTTLSEAS
2310 2320 2330 2340 2350
LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID SSSGLILTAR
2360 2370 2380 2390 2400
MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE
2410 2420 2430 2440 2450
SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV
2460 2470 2480 2490 2500
ITLSNHRKQR MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST
2510 2520 2530 2540 2550
YVAEVRENVA AGTKVIHVRA TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG
2560 2570 2580 2590 2600
QVITTERLDR ENPLEGDVSI FVRALDGGGR TTFCTVRVIV VDENDNAPQF
2610 2620 2630 2640 2650
MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY SEASVSVADL
2660 2670 2680 2690 2700
LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP
2710 2720 2730 2740 2750
PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN
2760 2770 2780 2790 2800
NKGGIFVIEQ ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV
2810 2820 2830 2840 2850
DIKVLDLNDN KPVFETSSYD TIIMEGMPVG TKLTQVRAID MDWGANGQVT
2860 2870 2880 2890 2900
YSLHSDSQPE KVMEAFNIDS NTGWISTLKD LDHETDPTFT FSVVASDLGE
2910 2920 2930 2940 2950
AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG EVVAVLSTWD
2960 2970 2980 2990 3000
RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL
3010 3020 3030 3040 3050
NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK
3060 3070 3080 3090 3100
VSAKDADIGS NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS
3110 3120 3130 3140 3150
LMAKATDGGG RFCQSNIHLI LEDVNDNPPV FSSDHYNTCV YENTATKALL
3160 3170 3180 3190 3200
TRVQAVDPDI GINRKVVYSL ADSAGGVFSI DSSSGIIILE QPLDREQQSS
3210 3220 3230 3240 3250
YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD YLVTVPEDTS
3260 3270 3280 3290 3300
PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD
3310 3320 3330 3340 3350
YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI
3360 3370 3380 3390 3400
SEDALVGDSV ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV
3410 3420 3430 3440 3450
KKKLDRERVS GYSLLVQAVD SGIPAMSSTA TVNIDISDVN DNSPVFTPAN
3460 3470 3480 3490 3500
YTAVIQENKP VGTSILQLVV TDRDSFHNGP PFSFSILSGN EEEEFVLDPH
3510 3520 3530 3540 3550
GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR VIEESTHKPT
3560 3570 3580 3590 3600
AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS
3610 3620 3630 3640 3650
HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT
3660 3670 3680 3690 3700
IRFENVSPED FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD
3710 3720 3730 3740 3750
MLFAVEMHSS EFYKPAYLIQ KLSNARRHLE NIMRISAILE KNCSGLDCQE
3760 3770 3780 3790 3800
QHCEQGLSLD SHALMTYSTA RISFVCPRFY RNVRCTCNGG LCPGSNDPCV
3810 3820 3830 3840 3850
EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF AGNSYIKYRL
3860 3870 3880 3890 3900
SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS
3910 3920 3930 3940 3950
GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL
3960 3970 3980 3990 4000
STESSIYFGA LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN
4010 4020 4030 4040 4050
KRSSFAEVVG LTELKLGCVL YPDACKRSPC QHGGSCTGLP SGGYQCTCLS
4060 4070 4080 4090 4100
QFTGRNCESE ITACFPNPCR NGGSCDPIGN TFICNCKAGL TGVTCEEDIN
4110 4120 4130 4140 4150
ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV PNIQAGHSYV
4160 4170 4180 4190 4200
GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL
4210 4220 4230 4240 4250
LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD
4260 4270 4280 4290 4300
KIVDGLGGEH QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD
4310 4320 4330 4340 4350
SIRKNGWDAG TENKGVDDPG EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN
4360 4370 4380 4390 4400
ASIVTVIQLV NNVVDTIENE VSVMDQGQNY NRAYHWDTSD WMPGARLSDI
4410 4420 4430 4440 4450
EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP HEEEFLSQDQ
4460 4470 4480 4490 4500
LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP
4510 4520 4530 4540 4550
NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS
4560 4570 4580
ANCGFDDSEV AMSDYESVGE LSLASLHIPF VETQHQTQV
Length:4,589
Mass (Da):505,523
Last modified:March 18, 2008 - v2
Checksum:iC993CE7F08EC6BF9
GO
Isoform 2 (identifier: Q8TDW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
     1261-4589: Missing.

Note: No experimental confirmation available.

Show »
Length:1,254
Mass (Da):138,836
Checksum:i446C226D45882B6B
GO
Isoform 3 (identifier: Q8TDW7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4351-4382: Missing.

Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.

Show »
Length:4,557
Mass (Da):501,978
Checksum:i66964BED3E55BC0A
GO

Sequence cautioni

The sequence AAH16722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti412 – 4121S → F.
Corresponds to variant rs10830902 [ dbSNP | Ensembl ].
VAR_039851
Natural varianti462 – 4621I → V.
Corresponds to variant rs16917409 [ dbSNP | Ensembl ].
VAR_039852
Natural varianti1167 – 11671V → G.
Corresponds to variant rs11821058 [ dbSNP | Ensembl ].
VAR_039853
Natural varianti1726 – 17261Q → R.
Corresponds to variant rs7949157 [ dbSNP | Ensembl ].
VAR_039854
Natural varianti2293 – 22931N → S.
Corresponds to variant rs16918105 [ dbSNP | Ensembl ].
VAR_039855
Natural varianti2622 – 26221V → F.
Corresponds to variant rs17615477 [ dbSNP | Ensembl ].
VAR_039856
Natural varianti2755 – 27551I → V.
Corresponds to variant rs3847531 [ dbSNP | Ensembl ].
VAR_039857
Natural varianti3518 – 35181V → L.
Corresponds to variant rs10765565 [ dbSNP | Ensembl ].
VAR_039858
Natural varianti3812 – 38121S → G.1 Publication
Corresponds to variant rs4753069 [ dbSNP | Ensembl ].
VAR_039859

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1204 – 126057LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2. 1 PublicationVSP_032327Add
BLAST
Alternative sequencei1261 – 45893329Missing in isoform 2. 1 PublicationVSP_032328Add
BLAST
Alternative sequencei4351 – 438232Missing in isoform 3. CuratedVSP_040467Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1. Different initiation.
AB076400 mRNA. Translation: BAB86868.1.
RefSeqiNP_001008781.2. NM_001008781.2. [Q8TDW7-3]
UniGeneiHs.98523.

Genome annotation databases

EnsembliENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
GeneIDi120114.
KEGGihsa:120114.
UCSCiuc001pdj.4. human. [Q8TDW7-3]

Polymorphism databases

DMDMi172045818.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1 . Different initiation.
AB076400 mRNA. Translation: BAB86868.1 .
RefSeqi NP_001008781.2. NM_001008781.2. [Q8TDW7-3 ]
UniGenei Hs.98523.

3D structure databases

ProteinModelPortali Q8TDW7.
SMRi Q8TDW7. Positions 117-336, 385-3619, 3798-4133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125669. 7 interactions.
STRINGi 9606.ENSP00000387040.

PTM databases

PhosphoSitei Q8TDW7.

Polymorphism databases

DMDMi 172045818.

Proteomic databases

MaxQBi Q8TDW7.
PaxDbi Q8TDW7.
PRIDEi Q8TDW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409404 ; ENSP00000387040 ; ENSG00000165323 . [Q8TDW7-3 ]
GeneIDi 120114.
KEGGi hsa:120114.
UCSCi uc001pdj.4. human. [Q8TDW7-3 ]

Organism-specific databases

CTDi 120114.
GeneCardsi GC11P092164.
HGNCi HGNC:23112. FAT3.
HPAi HPA026878.
MIMi 612483. gene.
neXtProti NX_Q8TDW7.
PharmGKBi PA134962612.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118805.
HOGENOMi HOG000046499.
HOVERGENi HBG005641.
InParanoidi Q8TDW7.
KOi K16506.
OMAi KFFIDPK.
PhylomeDBi Q8TDW7.
TreeFami TF316403.

Miscellaneous databases

ChiTaRSi FAT3. human.
GenomeRNAii 120114.
NextBioi 80524.
PROi Q8TDW7.
SOURCEi Search...

Gene expression databases

Bgeei Q8TDW7.
CleanExi HS_FAT3.
ExpressionAtlasi Q8TDW7. baseline and differential.
Genevestigatori Q8TDW7.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00028. Cadherin. 26 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 32 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1026-4589 (ISOFORM 2).
    Tissue: Brain.
  3. "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs."
    Mitsui K., Nakajima D., Ohara O., Nakayama M.
    Biochem. Biophys. Res. Commun. 290:1260-1266(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3493-4589 (ISOFORM 1), VARIANT GLY-3812.
    Tissue: Brain.
  4. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."
    Katoh Y., Katoh M.
    Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFAT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW7
Secondary accession number(s): B5MDB0, Q96AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3