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Q8TDW7

- FAT3_HUMAN

UniProt

Q8TDW7 - FAT3_HUMAN

Protein

Protocadherin Fat 3

Gene

FAT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    May play a role in the interactions between neurites derived from specific subsets of neurons during development.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin Fat 3
    Short name:
    hFat3
    Alternative name(s):
    Cadherin family member 15
    FAT tumor suppressor homolog 3
    Gene namesi
    Name:FAT3
    Synonyms:CDHF15, KIAA1989
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23112. FAT3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134962612.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 45894557Protocadherin Fat 3PRO_0000324634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1007 – 10071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1368 – 13681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1430 – 14301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1752 – 17521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1945 – 19451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1994 – 19941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1997 – 19971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2209 – 22091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2293 – 22931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2332 – 23321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2468 – 24681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3001 – 30011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3202 – 32021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3330 – 33301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3450 – 34501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3619 – 36191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3742 – 37421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3799 ↔ 3810By similarity
    Disulfide bondi3804 ↔ 3822By similarity
    Disulfide bondi3824 ↔ 3832By similarity
    Glycosylationi3927 – 39271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3985 ↔ 4018By similarity
    Disulfide bondi4025 ↔ 4036By similarity
    Disulfide bondi4030 ↔ 4046By similarity
    Disulfide bondi4048 ↔ 4057By similarity
    Disulfide bondi4064 ↔ 4075By similarity
    Disulfide bondi4069 ↔ 4084By similarity
    Disulfide bondi4086 ↔ 4095By similarity
    Disulfide bondi4102 ↔ 4113By similarity
    Disulfide bondi4107 ↔ 4122By similarity
    Disulfide bondi4124 ↔ 4133By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8TDW7.
    PaxDbiQ8TDW7.
    PRIDEiQ8TDW7.

    PTM databases

    PhosphoSiteiQ8TDW7.

    Expressioni

    Tissue specificityi

    Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.1 Publication

    Gene expression databases

    ArrayExpressiQ8TDW7.
    BgeeiQ8TDW7.
    CleanExiHS_FAT3.
    GenevestigatoriQ8TDW7.

    Organism-specific databases

    HPAiHPA026878.

    Interactioni

    Protein-protein interaction databases

    BioGridi125669. 2 interactions.
    STRINGi9606.ENSP00000387040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDW7.
    SMRiQ8TDW7. Positions 117-336, 385-3619, 3798-4133.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 41544122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini4176 – 4589414CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4155 – 417521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 158115Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 266108Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini264 – 375112Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini377 – 47296Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini473 – 578106Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini579 – 681103Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini727 – 831105Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini832 – 936105Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini937 – 1043107Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1044 – 1148105Cadherin 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1149 – 1254106Cadherin 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1255 – 1359105Cadherin 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1363 – 146098Cadherin 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1461 – 1566106Cadherin 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1567 – 1769203Cadherin 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1770 – 1883114Cadherin 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1884 – 1986103Cadherin 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1983 – 2084102Cadherin 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini2085 – 2186102Cadherin 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini2187 – 2287101Cadherin 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini2288 – 2394107Cadherin 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini2395 – 2496102Cadherin 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini2497 – 2600104Cadherin 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini2601 – 2708108Cadherin 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini2709 – 2814106Cadherin 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini2815 – 2924110Cadherin 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini2925 – 3029105Cadherin 27PROSITE-ProRule annotationAdd
    BLAST
    Domaini3030 – 3131102Cadherin 28PROSITE-ProRule annotationAdd
    BLAST
    Domaini3132 – 3236105Cadherin 29PROSITE-ProRule annotationAdd
    BLAST
    Domaini3237 – 3341105Cadherin 30PROSITE-ProRule annotationAdd
    BLAST
    Domaini3342 – 3446105Cadherin 31PROSITE-ProRule annotationAdd
    BLAST
    Domaini3447 – 3551105Cadherin 32PROSITE-ProRule annotationAdd
    BLAST
    Domaini3552 – 3653102Cadherin 33PROSITE-ProRule annotationAdd
    BLAST
    Domaini3795 – 383339EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini3835 – 4018184Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini4021 – 405838EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini4060 – 409637EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini4098 – 413437EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4438 – 450972Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 33 cadherin domains.PROSITE-ProRule annotation
    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000046499.
    HOVERGENiHBG005641.
    InParanoidiQ8TDW7.
    KOiK16506.
    OMAiKFFIDPK.
    PhylomeDBiQ8TDW7.
    TreeFamiTF316403.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    2.60.40.60. 34 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00028. Cadherin. 26 hits.
    PF07645. EGF_CA. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 32 hits.
    SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 34 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00232. CADHERIN_1. 19 hits.
    PS50268. CADHERIN_2. 32 hits.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 1 hit.
    PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA     50
    TVYENSAART YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA 100
    DFCFLRIRTK GGNSAILNRE IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD 150
    MNDLRPLFSP TTYSVTIAES TPLRTSVAQV TATDADIGSN GEFYYYFKNK 200
    VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL YGNNGVSSTA 250
    KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 300
    VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK 350
    GSPQKCSALK AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL 400
    SPEPIDVEYK LSPGEDAVYF KINPRSGLIV TARPLNTVKK EVYKLEVTNK 450
    EGDLKAQVTI SIEDANDHTP EFQQPLYDAY VNESVPVGTS VLTVSASDKD 500
    KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP EIYRFIVRAS 550
    DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 600
    SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA 650
    LRITATDGEN LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA 700
    KANGKLNLED GFLDFYSINR QGPYFDKSFP SDVAVKEDLP VGANILKIKA 750
    YDADSGFNGK VLFTISDGNT DSCFNIDMET GQLKVLMPMD REHTDLYLLN 800
    ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI LESSGIGTEI 850
    IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 900
    SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP 950
    VGTVIAWLET HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY 1000
    EKQQFYNLTV RAKDKGRPVS LSSVSFVEVE VVDVNENLHT PYFPDFAVVG 1050
    SVKENSRIGT SVLQVTARDE DSGRDGEIQY SIRDGSGLGR FSIDDESGVI 1100
    TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED VNDNAPLTSE 1150
    PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 1200
    KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN 1250
    KPQFPEKVYQ IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND 1300
    DGKFFIDPKT GMVSSRKQFT AGSYDILTIK AVDNGRPQKS STARLHIEWI 1350
    KKPPPSPIPL TFDEPFYNFT VMESDRVTEI VGVVSVQPAN TPLWFDIVGG 1400
    NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN VAVTQVFIKV 1450
    LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS 1500
    IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA 1550
    RVIVNVEDAN DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE 1600
    LIYTIEAGNT GNMFKIEPVL GIITICKEPD MTTMGQFVLS IKVTDQGSPP 1650
    MSATAIVRIS VTMSDNSHPK FIHKDYQAEV NENVDIGTSV ILISAISQST 1700
    LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI IQATNMAGMA 1750
    SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA 1800
    TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH 1850
    VHVRDSGSPQ LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV 1900
    EVLKVSATDP DSEVPPELTY SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH 1950
    YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL HFTQSFYSTS ISENNTNITK 2000
    VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV PFDREEQELY 2050
    ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG 2100
    TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS 2150
    NIEYGVTILA KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR 2200
    MNTPILSINA TSPEGQGIIY IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV 2250
    TSAYKLTIRA SDALTGARAE VTVDLLVNDV NDNPPIFDQP TYNTTLSEAS 2300
    LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID SSSGLILTAR 2350
    MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE 2400
    SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV 2450
    ITLSNHRKQR MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST 2500
    YVAEVRENVA AGTKVIHVRA TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG 2550
    QVITTERLDR ENPLEGDVSI FVRALDGGGR TTFCTVRVIV VDENDNAPQF 2600
    MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY SEASVSVADL 2650
    LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP 2700
    PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN 2750
    NKGGIFVIEQ ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV 2800
    DIKVLDLNDN KPVFETSSYD TIIMEGMPVG TKLTQVRAID MDWGANGQVT 2850
    YSLHSDSQPE KVMEAFNIDS NTGWISTLKD LDHETDPTFT FSVVASDLGE 2900
    AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG EVVAVLSTWD 2950
    RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL 3000
    NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK 3050
    VSAKDADIGS NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS 3100
    LMAKATDGGG RFCQSNIHLI LEDVNDNPPV FSSDHYNTCV YENTATKALL 3150
    TRVQAVDPDI GINRKVVYSL ADSAGGVFSI DSSSGIIILE QPLDREQQSS 3200
    YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD YLVTVPEDTS 3250
    PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD 3300
    YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI 3350
    SEDALVGDSV ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV 3400
    KKKLDRERVS GYSLLVQAVD SGIPAMSSTA TVNIDISDVN DNSPVFTPAN 3450
    YTAVIQENKP VGTSILQLVV TDRDSFHNGP PFSFSILSGN EEEEFVLDPH 3500
    GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR VIEESTHKPT 3550
    AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS 3600
    HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT 3650
    IRFENVSPED FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD 3700
    MLFAVEMHSS EFYKPAYLIQ KLSNARRHLE NIMRISAILE KNCSGLDCQE 3750
    QHCEQGLSLD SHALMTYSTA RISFVCPRFY RNVRCTCNGG LCPGSNDPCV 3800
    EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF AGNSYIKYRL 3850
    SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS 3900
    GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL 3950
    STESSIYFGA LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN 4000
    KRSSFAEVVG LTELKLGCVL YPDACKRSPC QHGGSCTGLP SGGYQCTCLS 4050
    QFTGRNCESE ITACFPNPCR NGGSCDPIGN TFICNCKAGL TGVTCEEDIN 4100
    ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV PNIQAGHSYV 4150
    GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL 4200
    LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD 4250
    KIVDGLGGEH QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD 4300
    SIRKNGWDAG TENKGVDDPG EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN 4350
    ASIVTVIQLV NNVVDTIENE VSVMDQGQNY NRAYHWDTSD WMPGARLSDI 4400
    EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP HEEEFLSQDQ 4450
    LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP 4500
    NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS 4550
    ANCGFDDSEV AMSDYESVGE LSLASLHIPF VETQHQTQV 4589
    Length:4,589
    Mass (Da):505,523
    Last modified:March 18, 2008 - v2
    Checksum:iC993CE7F08EC6BF9
    GO
    Isoform 2 (identifier: Q8TDW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
         1261-4589: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,254
    Mass (Da):138,836
    Checksum:i446C226D45882B6B
    GO
    Isoform 3 (identifier: Q8TDW7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4351-4382: Missing.

    Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.

    Show »
    Length:4,557
    Mass (Da):501,978
    Checksum:i66964BED3E55BC0A
    GO

    Sequence cautioni

    The sequence AAH16722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti412 – 4121S → F.
    Corresponds to variant rs10830902 [ dbSNP | Ensembl ].
    VAR_039851
    Natural varianti462 – 4621I → V.
    Corresponds to variant rs16917409 [ dbSNP | Ensembl ].
    VAR_039852
    Natural varianti1167 – 11671V → G.
    Corresponds to variant rs11821058 [ dbSNP | Ensembl ].
    VAR_039853
    Natural varianti1726 – 17261Q → R.
    Corresponds to variant rs7949157 [ dbSNP | Ensembl ].
    VAR_039854
    Natural varianti2293 – 22931N → S.
    Corresponds to variant rs16918105 [ dbSNP | Ensembl ].
    VAR_039855
    Natural varianti2622 – 26221V → F.
    Corresponds to variant rs17615477 [ dbSNP | Ensembl ].
    VAR_039856
    Natural varianti2755 – 27551I → V.
    Corresponds to variant rs3847531 [ dbSNP | Ensembl ].
    VAR_039857
    Natural varianti3518 – 35181V → L.
    Corresponds to variant rs10765565 [ dbSNP | Ensembl ].
    VAR_039858
    Natural varianti3812 – 38121S → G.1 Publication
    Corresponds to variant rs4753069 [ dbSNP | Ensembl ].
    VAR_039859

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1204 – 126057LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2. 1 PublicationVSP_032327Add
    BLAST
    Alternative sequencei1261 – 45893329Missing in isoform 2. 1 PublicationVSP_032328Add
    BLAST
    Alternative sequencei4351 – 438232Missing in isoform 3. CuratedVSP_040467Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000722 Genomic DNA. No translation available.
    AP000805 Genomic DNA. No translation available.
    AP002514 Genomic DNA. No translation available.
    AP003171 Genomic DNA. No translation available.
    AP003718 Genomic DNA. No translation available.
    BC016722 mRNA. Translation: AAH16722.1. Different initiation.
    AB076400 mRNA. Translation: BAB86868.1.
    RefSeqiNP_001008781.2. NM_001008781.2. [Q8TDW7-3]
    UniGeneiHs.98523.

    Genome annotation databases

    EnsembliENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
    GeneIDi120114.
    KEGGihsa:120114.
    UCSCiuc001pdj.4. human. [Q8TDW7-3]

    Polymorphism databases

    DMDMi172045818.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000722 Genomic DNA. No translation available.
    AP000805 Genomic DNA. No translation available.
    AP002514 Genomic DNA. No translation available.
    AP003171 Genomic DNA. No translation available.
    AP003718 Genomic DNA. No translation available.
    BC016722 mRNA. Translation: AAH16722.1 . Different initiation.
    AB076400 mRNA. Translation: BAB86868.1 .
    RefSeqi NP_001008781.2. NM_001008781.2. [Q8TDW7-3 ]
    UniGenei Hs.98523.

    3D structure databases

    ProteinModelPortali Q8TDW7.
    SMRi Q8TDW7. Positions 117-336, 385-3619, 3798-4133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125669. 2 interactions.
    STRINGi 9606.ENSP00000387040.

    PTM databases

    PhosphoSitei Q8TDW7.

    Polymorphism databases

    DMDMi 172045818.

    Proteomic databases

    MaxQBi Q8TDW7.
    PaxDbi Q8TDW7.
    PRIDEi Q8TDW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409404 ; ENSP00000387040 ; ENSG00000165323 . [Q8TDW7-3 ]
    GeneIDi 120114.
    KEGGi hsa:120114.
    UCSCi uc001pdj.4. human. [Q8TDW7-3 ]

    Organism-specific databases

    CTDi 120114.
    GeneCardsi GC11P092164.
    HGNCi HGNC:23112. FAT3.
    HPAi HPA026878.
    MIMi 612483. gene.
    neXtProti NX_Q8TDW7.
    PharmGKBi PA134962612.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000046499.
    HOVERGENi HBG005641.
    InParanoidi Q8TDW7.
    KOi K16506.
    OMAi KFFIDPK.
    PhylomeDBi Q8TDW7.
    TreeFami TF316403.

    Miscellaneous databases

    ChiTaRSi FAT3. human.
    GenomeRNAii 120114.
    NextBioi 80524.
    PROi Q8TDW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDW7.
    Bgeei Q8TDW7.
    CleanExi HS_FAT3.
    Genevestigatori Q8TDW7.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    2.60.40.60. 34 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00028. Cadherin. 26 hits.
    PF07645. EGF_CA. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 32 hits.
    SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 34 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00232. CADHERIN_1. 19 hits.
    PS50268. CADHERIN_2. 32 hits.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 1 hit.
    PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1026-4589 (ISOFORM 2).
      Tissue: Brain.
    3. "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs."
      Mitsui K., Nakajima D., Ohara O., Nakayama M.
      Biochem. Biophys. Res. Commun. 290:1260-1266(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3493-4589 (ISOFORM 1), VARIANT GLY-3812.
      Tissue: Brain.
    4. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."
      Katoh Y., Katoh M.
      Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFAT3_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDW7
    Secondary accession number(s): B5MDB0, Q96AU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3