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Protein

Protocadherin Fat 3

Gene

FAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 3
Short name:
hFat3
Alternative name(s):
Cadherin family member 15
FAT tumor suppressor homolog 3
Gene namesi
Name:FAT3
Synonyms:CDHF15, KIAA1989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23112. FAT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 4154ExtracellularSequence analysisAdd BLAST4122
Transmembranei4155 – 4175HelicalSequence analysisAdd BLAST21
Topological domaini4176 – 4589CytoplasmicSequence analysisAdd BLAST414

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi120114.
OpenTargetsiENSG00000165323.
ENSG00000282908.
PharmGKBiPA134962612.

Polymorphism and mutation databases

BioMutaiFAT3.
DMDMi172045818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000032463433 – 4589Protocadherin Fat 3Add BLAST4557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Glycosylationi563N-linked (GlcNAc...)Sequence analysis1
Glycosylationi668N-linked (GlcNAc...)Sequence analysis1
Glycosylationi800N-linked (GlcNAc...)Sequence analysis1
Glycosylationi880N-linked (GlcNAc...)Sequence analysis1
Glycosylationi899N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1007N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1752N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1945N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1994N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1997N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2332N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3001N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3450N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3619N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3742N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3799 ↔ 3810By similarity
Disulfide bondi3804 ↔ 3822By similarity
Disulfide bondi3824 ↔ 3832By similarity
Glycosylationi3927N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3985 ↔ 4018By similarity
Disulfide bondi4025 ↔ 4036By similarity
Disulfide bondi4030 ↔ 4046By similarity
Disulfide bondi4048 ↔ 4057By similarity
Disulfide bondi4064 ↔ 4075By similarity
Disulfide bondi4069 ↔ 4084By similarity
Disulfide bondi4086 ↔ 4095By similarity
Disulfide bondi4102 ↔ 4113By similarity
Disulfide bondi4107 ↔ 4122By similarity
Disulfide bondi4124 ↔ 4133By similarity
Modified residuei4542Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

EPDiQ8TDW7.
MaxQBiQ8TDW7.
PaxDbiQ8TDW7.
PeptideAtlasiQ8TDW7.
PRIDEiQ8TDW7.

PTM databases

iPTMnetiQ8TDW7.
PhosphoSitePlusiQ8TDW7.

Expressioni

Tissue specificityi

Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.1 Publication

Gene expression databases

BgeeiENSG00000165323.
CleanExiHS_FAT3.
ExpressionAtlasiQ8TDW7. baseline and differential.
GenevisibleiQ8TDW7. HS.

Organism-specific databases

HPAiHPA026878.

Interactioni

Protein-protein interaction databases

BioGridi125669. 23 interactors.
STRINGi9606.ENSP00000298047.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW7.
SMRiQ8TDW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 158Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini159 – 266Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini264 – 375Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini377 – 472Cadherin 4PROSITE-ProRule annotationAdd BLAST96
Domaini473 – 578Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini579 – 681Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini727 – 831Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini832 – 936Cadherin 8PROSITE-ProRule annotationAdd BLAST105
Domaini937 – 1043Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1044 – 1148Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1149 – 1254Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1255 – 1359Cadherin 12PROSITE-ProRule annotationAdd BLAST105
Domaini1363 – 1460Cadherin 13PROSITE-ProRule annotationAdd BLAST98
Domaini1461 – 1566Cadherin 14PROSITE-ProRule annotationAdd BLAST106
Domaini1567 – 1769Cadherin 15PROSITE-ProRule annotationAdd BLAST203
Domaini1770 – 1883Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1884 – 1986Cadherin 17PROSITE-ProRule annotationAdd BLAST103
Domaini1983 – 2084Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2085 – 2186Cadherin 19PROSITE-ProRule annotationAdd BLAST102
Domaini2187 – 2287Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2288 – 2394Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2395 – 2496Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2497 – 2600Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2601 – 2708Cadherin 24PROSITE-ProRule annotationAdd BLAST108
Domaini2709 – 2814Cadherin 25PROSITE-ProRule annotationAdd BLAST106
Domaini2815 – 2924Cadherin 26PROSITE-ProRule annotationAdd BLAST110
Domaini2925 – 3029Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3030 – 3131Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3132 – 3236Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3237 – 3341Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3342 – 3446Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3447 – 3551Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3552 – 3653Cadherin 33PROSITE-ProRule annotationAdd BLAST102
Domaini3795 – 3833EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3835 – 4018Laminin G-likePROSITE-ProRule annotationAdd BLAST184
Domaini4021 – 4058EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini4060 – 4096EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini4098 – 4134EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4438 – 4509Pro-richAdd BLAST72

Sequence similaritiesi

Contains 33 cadherin domains.PROSITE-ProRule annotation
Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ8TDW7.
KOiK16506.
OMAiDQEFPYR.
OrthoDBiEOG091G00A0.
PhylomeDBiQ8TDW7.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 32 hits.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA
60 70 80 90 100
TVYENSAART YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA
110 120 130 140 150
DFCFLRIRTK GGNSAILNRE IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD
160 170 180 190 200
MNDLRPLFSP TTYSVTIAES TPLRTSVAQV TATDADIGSN GEFYYYFKNK
210 220 230 240 250
VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL YGNNGVSSTA
260 270 280 290 300
KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES
310 320 330 340 350
VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK
360 370 380 390 400
GSPQKCSALK AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL
410 420 430 440 450
SPEPIDVEYK LSPGEDAVYF KINPRSGLIV TARPLNTVKK EVYKLEVTNK
460 470 480 490 500
EGDLKAQVTI SIEDANDHTP EFQQPLYDAY VNESVPVGTS VLTVSASDKD
510 520 530 540 550
KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP EIYRFIVRAS
560 570 580 590 600
DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV
610 620 630 640 650
SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA
660 670 680 690 700
LRITATDGEN LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA
710 720 730 740 750
KANGKLNLED GFLDFYSINR QGPYFDKSFP SDVAVKEDLP VGANILKIKA
760 770 780 790 800
YDADSGFNGK VLFTISDGNT DSCFNIDMET GQLKVLMPMD REHTDLYLLN
810 820 830 840 850
ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI LESSGIGTEI
860 870 880 890 900
IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY
910 920 930 940 950
SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP
960 970 980 990 1000
VGTVIAWLET HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY
1010 1020 1030 1040 1050
EKQQFYNLTV RAKDKGRPVS LSSVSFVEVE VVDVNENLHT PYFPDFAVVG
1060 1070 1080 1090 1100
SVKENSRIGT SVLQVTARDE DSGRDGEIQY SIRDGSGLGR FSIDDESGVI
1110 1120 1130 1140 1150
TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED VNDNAPLTSE
1160 1170 1180 1190 1200
PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI
1210 1220 1230 1240 1250
KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN
1260 1270 1280 1290 1300
KPQFPEKVYQ IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND
1310 1320 1330 1340 1350
DGKFFIDPKT GMVSSRKQFT AGSYDILTIK AVDNGRPQKS STARLHIEWI
1360 1370 1380 1390 1400
KKPPPSPIPL TFDEPFYNFT VMESDRVTEI VGVVSVQPAN TPLWFDIVGG
1410 1420 1430 1440 1450
NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN VAVTQVFIKV
1460 1470 1480 1490 1500
LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS
1510 1520 1530 1540 1550
IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA
1560 1570 1580 1590 1600
RVIVNVEDAN DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE
1610 1620 1630 1640 1650
LIYTIEAGNT GNMFKIEPVL GIITICKEPD MTTMGQFVLS IKVTDQGSPP
1660 1670 1680 1690 1700
MSATAIVRIS VTMSDNSHPK FIHKDYQAEV NENVDIGTSV ILISAISQST
1710 1720 1730 1740 1750
LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI IQATNMAGMA
1760 1770 1780 1790 1800
SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA
1810 1820 1830 1840 1850
TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH
1860 1870 1880 1890 1900
VHVRDSGSPQ LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV
1910 1920 1930 1940 1950
EVLKVSATDP DSEVPPELTY SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH
1960 1970 1980 1990 2000
YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL HFTQSFYSTS ISENNTNITK
2010 2020 2030 2040 2050
VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV PFDREEQELY
2060 2070 2080 2090 2100
ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG
2110 2120 2130 2140 2150
TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS
2160 2170 2180 2190 2200
NIEYGVTILA KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR
2210 2220 2230 2240 2250
MNTPILSINA TSPEGQGIIY IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV
2260 2270 2280 2290 2300
TSAYKLTIRA SDALTGARAE VTVDLLVNDV NDNPPIFDQP TYNTTLSEAS
2310 2320 2330 2340 2350
LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID SSSGLILTAR
2360 2370 2380 2390 2400
MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE
2410 2420 2430 2440 2450
SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV
2460 2470 2480 2490 2500
ITLSNHRKQR MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST
2510 2520 2530 2540 2550
YVAEVRENVA AGTKVIHVRA TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG
2560 2570 2580 2590 2600
QVITTERLDR ENPLEGDVSI FVRALDGGGR TTFCTVRVIV VDENDNAPQF
2610 2620 2630 2640 2650
MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY SEASVSVADL
2660 2670 2680 2690 2700
LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP
2710 2720 2730 2740 2750
PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN
2760 2770 2780 2790 2800
NKGGIFVIEQ ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV
2810 2820 2830 2840 2850
DIKVLDLNDN KPVFETSSYD TIIMEGMPVG TKLTQVRAID MDWGANGQVT
2860 2870 2880 2890 2900
YSLHSDSQPE KVMEAFNIDS NTGWISTLKD LDHETDPTFT FSVVASDLGE
2910 2920 2930 2940 2950
AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG EVVAVLSTWD
2960 2970 2980 2990 3000
RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL
3010 3020 3030 3040 3050
NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK
3060 3070 3080 3090 3100
VSAKDADIGS NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS
3110 3120 3130 3140 3150
LMAKATDGGG RFCQSNIHLI LEDVNDNPPV FSSDHYNTCV YENTATKALL
3160 3170 3180 3190 3200
TRVQAVDPDI GINRKVVYSL ADSAGGVFSI DSSSGIIILE QPLDREQQSS
3210 3220 3230 3240 3250
YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD YLVTVPEDTS
3260 3270 3280 3290 3300
PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD
3310 3320 3330 3340 3350
YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI
3360 3370 3380 3390 3400
SEDALVGDSV ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV
3410 3420 3430 3440 3450
KKKLDRERVS GYSLLVQAVD SGIPAMSSTA TVNIDISDVN DNSPVFTPAN
3460 3470 3480 3490 3500
YTAVIQENKP VGTSILQLVV TDRDSFHNGP PFSFSILSGN EEEEFVLDPH
3510 3520 3530 3540 3550
GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR VIEESTHKPT
3560 3570 3580 3590 3600
AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS
3610 3620 3630 3640 3650
HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT
3660 3670 3680 3690 3700
IRFENVSPED FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD
3710 3720 3730 3740 3750
MLFAVEMHSS EFYKPAYLIQ KLSNARRHLE NIMRISAILE KNCSGLDCQE
3760 3770 3780 3790 3800
QHCEQGLSLD SHALMTYSTA RISFVCPRFY RNVRCTCNGG LCPGSNDPCV
3810 3820 3830 3840 3850
EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF AGNSYIKYRL
3860 3870 3880 3890 3900
SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS
3910 3920 3930 3940 3950
GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL
3960 3970 3980 3990 4000
STESSIYFGA LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN
4010 4020 4030 4040 4050
KRSSFAEVVG LTELKLGCVL YPDACKRSPC QHGGSCTGLP SGGYQCTCLS
4060 4070 4080 4090 4100
QFTGRNCESE ITACFPNPCR NGGSCDPIGN TFICNCKAGL TGVTCEEDIN
4110 4120 4130 4140 4150
ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV PNIQAGHSYV
4160 4170 4180 4190 4200
GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL
4210 4220 4230 4240 4250
LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD
4260 4270 4280 4290 4300
KIVDGLGGEH QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD
4310 4320 4330 4340 4350
SIRKNGWDAG TENKGVDDPG EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN
4360 4370 4380 4390 4400
ASIVTVIQLV NNVVDTIENE VSVMDQGQNY NRAYHWDTSD WMPGARLSDI
4410 4420 4430 4440 4450
EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP HEEEFLSQDQ
4460 4470 4480 4490 4500
LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP
4510 4520 4530 4540 4550
NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS
4560 4570 4580
ANCGFDDSEV AMSDYESVGE LSLASLHIPF VETQHQTQV
Length:4,589
Mass (Da):505,523
Last modified:March 18, 2008 - v2
Checksum:iC993CE7F08EC6BF9
GO
Isoform 2 (identifier: Q8TDW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
     1261-4589: Missing.

Note: No experimental confirmation available.
Show »
Length:1,254
Mass (Da):138,836
Checksum:i446C226D45882B6B
GO
Isoform 3 (identifier: Q8TDW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4351-4382: Missing.

Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.
Show »
Length:4,557
Mass (Da):501,978
Checksum:i66964BED3E55BC0A
GO

Sequence cautioni

The sequence AAH16722 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039851412S → F.Corresponds to variant rs10830902dbSNPEnsembl.1
Natural variantiVAR_039852462I → V.Corresponds to variant rs16917409dbSNPEnsembl.1
Natural variantiVAR_0398531167V → G.Corresponds to variant rs11821058dbSNPEnsembl.1
Natural variantiVAR_0398541726Q → R.Corresponds to variant rs7949157dbSNPEnsembl.1
Natural variantiVAR_0398552293N → S.Corresponds to variant rs16918105dbSNPEnsembl.1
Natural variantiVAR_0398562622V → F.Corresponds to variant rs17615477dbSNPEnsembl.1
Natural variantiVAR_0398572755I → V.Corresponds to variant rs3847531dbSNPEnsembl.1
Natural variantiVAR_0398583518V → L.Corresponds to variant rs10765565dbSNPEnsembl.1
Natural variantiVAR_0398593812S → G.1 PublicationCorresponds to variant rs4753069dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0323271204 – 1260LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0323281261 – 4589Missing in isoform 2. 1 PublicationAdd BLAST3329
Alternative sequenceiVSP_0404674351 – 4382Missing in isoform 3. CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1. Different initiation.
AB076400 mRNA. Translation: BAB86868.1.
RefSeqiNP_001008781.2. NM_001008781.2. [Q8TDW7-3]
XP_016872670.1. XM_017017181.1. [Q8TDW7-1]
XP_016872672.1. XM_017017183.1. [Q8TDW7-3]
UniGeneiHs.98523.

Genome annotation databases

EnsembliENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
ENST00000634703; ENSP00000489369; ENSG00000282908. [Q8TDW7-3]
GeneIDi120114.
KEGGihsa:120114.
UCSCiuc001pdj.5. human. [Q8TDW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1. Different initiation.
AB076400 mRNA. Translation: BAB86868.1.
RefSeqiNP_001008781.2. NM_001008781.2. [Q8TDW7-3]
XP_016872670.1. XM_017017181.1. [Q8TDW7-1]
XP_016872672.1. XM_017017183.1. [Q8TDW7-3]
UniGeneiHs.98523.

3D structure databases

ProteinModelPortaliQ8TDW7.
SMRiQ8TDW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125669. 23 interactors.
STRINGi9606.ENSP00000298047.

PTM databases

iPTMnetiQ8TDW7.
PhosphoSitePlusiQ8TDW7.

Polymorphism and mutation databases

BioMutaiFAT3.
DMDMi172045818.

Proteomic databases

EPDiQ8TDW7.
MaxQBiQ8TDW7.
PaxDbiQ8TDW7.
PeptideAtlasiQ8TDW7.
PRIDEiQ8TDW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
ENST00000634703; ENSP00000489369; ENSG00000282908. [Q8TDW7-3]
GeneIDi120114.
KEGGihsa:120114.
UCSCiuc001pdj.5. human. [Q8TDW7-1]

Organism-specific databases

CTDi120114.
DisGeNETi120114.
GeneCardsiFAT3.
HGNCiHGNC:23112. FAT3.
HPAiHPA026878.
MIMi612483. gene.
neXtProtiNX_Q8TDW7.
OpenTargetsiENSG00000165323.
ENSG00000282908.
PharmGKBiPA134962612.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ8TDW7.
KOiK16506.
OMAiDQEFPYR.
OrthoDBiEOG091G00A0.
PhylomeDBiQ8TDW7.
TreeFamiTF316403.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165323-MONOMER.

Miscellaneous databases

ChiTaRSiFAT3. human.
GenomeRNAii120114.
PROiQ8TDW7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165323.
CleanExiHS_FAT3.
ExpressionAtlasiQ8TDW7. baseline and differential.
GenevisibleiQ8TDW7. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 32 hits.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW7
Secondary accession number(s): B5MDB0, Q96AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.