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Q8TDW7 (FAT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin Fat 3

Short name=hFat3
Alternative name(s):
Cadherin family member 15
FAT tumor suppressor homolog 3
Gene names
Name:FAT3
Synonyms:CDHF15, KIAA1989
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4589 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the interactions between neurites derived from specific subsets of neurons during development By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate. Ref.4

Sequence similarities

Contains 33 cadherin domains.

Contains 4 EGF-like domains.

Contains 1 laminin G-like domain.

Sequence caution

The sequence AAH16722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TDW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TDW7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
     1261-4589: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8TDW7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4351-4382: Missing.
Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 45894557Protocadherin Fat 3
PRO_0000324634

Regions

Topological domain33 – 41544122Extracellular Potential
Transmembrane4155 – 417521Helical; Potential
Topological domain4176 – 4589414Cytoplasmic Potential
Domain44 – 158115Cadherin 1
Domain159 – 266108Cadherin 2
Domain264 – 375112Cadherin 3
Domain377 – 47296Cadherin 4
Domain473 – 578106Cadherin 5
Domain579 – 681103Cadherin 6
Domain727 – 831105Cadherin 7
Domain832 – 936105Cadherin 8
Domain937 – 1043107Cadherin 9
Domain1044 – 1148105Cadherin 10
Domain1149 – 1254106Cadherin 11
Domain1255 – 1359105Cadherin 12
Domain1363 – 146098Cadherin 13
Domain1461 – 1566106Cadherin 14
Domain1567 – 1769203Cadherin 15
Domain1770 – 1883114Cadherin 16
Domain1884 – 1986103Cadherin 17
Domain1983 – 2084102Cadherin 18
Domain2085 – 2186102Cadherin 19
Domain2187 – 2287101Cadherin 20
Domain2288 – 2394107Cadherin 21
Domain2395 – 2496102Cadherin 22
Domain2497 – 2600104Cadherin 23
Domain2601 – 2708108Cadherin 24
Domain2709 – 2814106Cadherin 25
Domain2815 – 2924110Cadherin 26
Domain2925 – 3029105Cadherin 27
Domain3030 – 3131102Cadherin 28
Domain3132 – 3236105Cadherin 29
Domain3237 – 3341105Cadherin 30
Domain3342 – 3446105Cadherin 31
Domain3447 – 3551105Cadherin 32
Domain3552 – 3653102Cadherin 33
Domain3795 – 383339EGF-like 1
Domain3835 – 4018184Laminin G-like
Domain4021 – 405838EGF-like 2
Domain4060 – 409637EGF-like 3
Domain4098 – 413437EGF-like 4; calcium-binding Potential
Compositional bias4438 – 450972Pro-rich

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation4821N-linked (GlcNAc...) Potential
Glycosylation5631N-linked (GlcNAc...) Potential
Glycosylation6681N-linked (GlcNAc...) Potential
Glycosylation8001N-linked (GlcNAc...) Potential
Glycosylation8801N-linked (GlcNAc...) Potential
Glycosylation8991N-linked (GlcNAc...) Potential
Glycosylation10071N-linked (GlcNAc...) Potential
Glycosylation13681N-linked (GlcNAc...) Potential
Glycosylation14301N-linked (GlcNAc...) Potential
Glycosylation17521N-linked (GlcNAc...) Potential
Glycosylation19451N-linked (GlcNAc...) Potential
Glycosylation19941N-linked (GlcNAc...) Potential
Glycosylation19971N-linked (GlcNAc...) Potential
Glycosylation22091N-linked (GlcNAc...) Potential
Glycosylation22931N-linked (GlcNAc...) Potential
Glycosylation23321N-linked (GlcNAc...) Potential
Glycosylation24681N-linked (GlcNAc...) Potential
Glycosylation30011N-linked (GlcNAc...) Potential
Glycosylation32021N-linked (GlcNAc...) Potential
Glycosylation33301N-linked (GlcNAc...) Potential
Glycosylation34501N-linked (GlcNAc...) Potential
Glycosylation36191N-linked (GlcNAc...) Potential
Glycosylation37421N-linked (GlcNAc...) Potential
Glycosylation39271N-linked (GlcNAc...) Potential
Disulfide bond3799 ↔ 3810 By similarity
Disulfide bond3804 ↔ 3822 By similarity
Disulfide bond3824 ↔ 3832 By similarity
Disulfide bond3985 ↔ 4018 By similarity
Disulfide bond4025 ↔ 4036 By similarity
Disulfide bond4030 ↔ 4046 By similarity
Disulfide bond4048 ↔ 4057 By similarity
Disulfide bond4064 ↔ 4075 By similarity
Disulfide bond4069 ↔ 4084 By similarity
Disulfide bond4086 ↔ 4095 By similarity
Disulfide bond4102 ↔ 4113 By similarity
Disulfide bond4107 ↔ 4122 By similarity
Disulfide bond4124 ↔ 4133 By similarity

Natural variations

Alternative sequence1204 – 126057LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2.
VSP_032327
Alternative sequence1261 – 45893329Missing in isoform 2.
VSP_032328
Alternative sequence4351 – 438232Missing in isoform 3.
VSP_040467
Natural variant4121S → F.
Corresponds to variant rs10830902 [ dbSNP | Ensembl ].
VAR_039851
Natural variant4621I → V.
Corresponds to variant rs16917409 [ dbSNP | Ensembl ].
VAR_039852
Natural variant11671V → G.
Corresponds to variant rs11821058 [ dbSNP | Ensembl ].
VAR_039853
Natural variant17261Q → R.
Corresponds to variant rs7949157 [ dbSNP | Ensembl ].
VAR_039854
Natural variant22931N → S.
Corresponds to variant rs16918105 [ dbSNP | Ensembl ].
VAR_039855
Natural variant26221V → F.
Corresponds to variant rs17615477 [ dbSNP | Ensembl ].
VAR_039856
Natural variant27551I → V.
Corresponds to variant rs3847531 [ dbSNP | Ensembl ].
VAR_039857
Natural variant35181V → L.
Corresponds to variant rs10765565 [ dbSNP | Ensembl ].
VAR_039858
Natural variant38121S → G. Ref.3
Corresponds to variant rs4753069 [ dbSNP | Ensembl ].
VAR_039859

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: C993CE7F08EC6BF9

FASTA4,589505,523
        10         20         30         40         50         60 
MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA TVYENSAART 

        70         80         90        100        110        120 
YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE 

       130        140        150        160        170        180 
IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSVAQV 

       190        200        210        220        230        240 
TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL 

       250        260        270        280        290        300 
YGNNGVSSTA KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 

       310        320        330        340        350        360 
VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK GSPQKCSALK 

       370        380        390        400        410        420 
AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL SPEPIDVEYK LSPGEDAVYF 

       430        440        450        460        470        480 
KINPRSGLIV TARPLNTVKK EVYKLEVTNK EGDLKAQVTI SIEDANDHTP EFQQPLYDAY 

       490        500        510        520        530        540 
VNESVPVGTS VLTVSASDKD KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP 

       550        560        570        580        590        600 
EIYRFIVRAS DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 

       610        620        630        640        650        660 
SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA LRITATDGEN 

       670        680        690        700        710        720 
LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA KANGKLNLED GFLDFYSINR 

       730        740        750        760        770        780 
QGPYFDKSFP SDVAVKEDLP VGANILKIKA YDADSGFNGK VLFTISDGNT DSCFNIDMET 

       790        800        810        820        830        840 
GQLKVLMPMD REHTDLYLLN ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI 

       850        860        870        880        890        900 
LESSGIGTEI IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 

       910        920        930        940        950        960 
SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP VGTVIAWLET 

       970        980        990       1000       1010       1020 
HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY EKQQFYNLTV RAKDKGRPVS 

      1030       1040       1050       1060       1070       1080 
LSSVSFVEVE VVDVNENLHT PYFPDFAVVG SVKENSRIGT SVLQVTARDE DSGRDGEIQY 

      1090       1100       1110       1120       1130       1140 
SIRDGSGLGR FSIDDESGVI TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED 

      1150       1160       1170       1180       1190       1200 
VNDNAPLTSE PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 

      1210       1220       1230       1240       1250       1260 
KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN KPQFPEKVYQ 

      1270       1280       1290       1300       1310       1320 
IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND DGKFFIDPKT GMVSSRKQFT 

      1330       1340       1350       1360       1370       1380 
AGSYDILTIK AVDNGRPQKS STARLHIEWI KKPPPSPIPL TFDEPFYNFT VMESDRVTEI 

      1390       1400       1410       1420       1430       1440 
VGVVSVQPAN TPLWFDIVGG NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN 

      1450       1460       1470       1480       1490       1500 
VAVTQVFIKV LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS 

      1510       1520       1530       1540       1550       1560 
IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA RVIVNVEDAN 

      1570       1580       1590       1600       1610       1620 
DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE LIYTIEAGNT GNMFKIEPVL 

      1630       1640       1650       1660       1670       1680 
GIITICKEPD MTTMGQFVLS IKVTDQGSPP MSATAIVRIS VTMSDNSHPK FIHKDYQAEV 

      1690       1700       1710       1720       1730       1740 
NENVDIGTSV ILISAISQST LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI 

      1750       1760       1770       1780       1790       1800 
IQATNMAGMA SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA 

      1810       1820       1830       1840       1850       1860 
TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH VHVRDSGSPQ 

      1870       1880       1890       1900       1910       1920 
LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV EVLKVSATDP DSEVPPELTY 

      1930       1940       1950       1960       1970       1980 
SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL 

      1990       2000       2010       2020       2030       2040 
HFTQSFYSTS ISENNTNITK VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV 

      2050       2060       2070       2080       2090       2100 
PFDREEQELY ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG 

      2110       2120       2130       2140       2150       2160 
TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS NIEYGVTILA 

      2170       2180       2190       2200       2210       2220 
KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR MNTPILSINA TSPEGQGIIY 

      2230       2240       2250       2260       2270       2280 
IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV TSAYKLTIRA SDALTGARAE VTVDLLVNDV 

      2290       2300       2310       2320       2330       2340 
NDNPPIFDQP TYNTTLSEAS LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID 

      2350       2360       2370       2380       2390       2400 
SSSGLILTAR MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE 

      2410       2420       2430       2440       2450       2460 
SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV ITLSNHRKQR 

      2470       2480       2490       2500       2510       2520 
MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST YVAEVRENVA AGTKVIHVRA 

      2530       2540       2550       2560       2570       2580 
TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG QVITTERLDR ENPLEGDVSI FVRALDGGGR 

      2590       2600       2610       2620       2630       2640 
TTFCTVRVIV VDENDNAPQF MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY 

      2650       2660       2670       2680       2690       2700 
SEASVSVADL LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP 

      2710       2720       2730       2740       2750       2760 
PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN NKGGIFVIEQ 

      2770       2780       2790       2800       2810       2820 
ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV DIKVLDLNDN KPVFETSSYD 

      2830       2840       2850       2860       2870       2880 
TIIMEGMPVG TKLTQVRAID MDWGANGQVT YSLHSDSQPE KVMEAFNIDS NTGWISTLKD 

      2890       2900       2910       2920       2930       2940 
LDHETDPTFT FSVVASDLGE AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG 

      2950       2960       2970       2980       2990       3000 
EVVAVLSTWD RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL 

      3010       3020       3030       3040       3050       3060 
NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK VSAKDADIGS 

      3070       3080       3090       3100       3110       3120 
NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS LMAKATDGGG RFCQSNIHLI 

      3130       3140       3150       3160       3170       3180 
LEDVNDNPPV FSSDHYNTCV YENTATKALL TRVQAVDPDI GINRKVVYSL ADSAGGVFSI 

      3190       3200       3210       3220       3230       3240 
DSSSGIIILE QPLDREQQSS YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD 

      3250       3260       3270       3280       3290       3300 
YLVTVPEDTS PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD 

      3310       3320       3330       3340       3350       3360 
YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI SEDALVGDSV 

      3370       3380       3390       3400       3410       3420 
ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV KKKLDRERVS GYSLLVQAVD 

      3430       3440       3450       3460       3470       3480 
SGIPAMSSTA TVNIDISDVN DNSPVFTPAN YTAVIQENKP VGTSILQLVV TDRDSFHNGP 

      3490       3500       3510       3520       3530       3540 
PFSFSILSGN EEEEFVLDPH GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR 

      3550       3560       3570       3580       3590       3600 
VIEESTHKPT AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS 

      3610       3620       3630       3640       3650       3660 
HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT IRFENVSPED 

      3670       3680       3690       3700       3710       3720 
FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD MLFAVEMHSS EFYKPAYLIQ 

      3730       3740       3750       3760       3770       3780 
KLSNARRHLE NIMRISAILE KNCSGLDCQE QHCEQGLSLD SHALMTYSTA RISFVCPRFY 

      3790       3800       3810       3820       3830       3840 
RNVRCTCNGG LCPGSNDPCV EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF 

      3850       3860       3870       3880       3890       3900 
AGNSYIKYRL SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS 

      3910       3920       3930       3940       3950       3960 
GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL STESSIYFGA 

      3970       3980       3990       4000       4010       4020 
LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN KRSSFAEVVG LTELKLGCVL 

      4030       4040       4050       4060       4070       4080 
YPDACKRSPC QHGGSCTGLP SGGYQCTCLS QFTGRNCESE ITACFPNPCR NGGSCDPIGN 

      4090       4100       4110       4120       4130       4140 
TFICNCKAGL TGVTCEEDIN ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV 

      4150       4160       4170       4180       4190       4200 
PNIQAGHSYV GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL 

      4210       4220       4230       4240       4250       4260 
LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD KIVDGLGGEH 

      4270       4280       4290       4300       4310       4320 
QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD SIRKNGWDAG TENKGVDDPG 

      4330       4340       4350       4360       4370       4380 
EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN ASIVTVIQLV NNVVDTIENE VSVMDQGQNY 

      4390       4400       4410       4420       4430       4440 
NRAYHWDTSD WMPGARLSDI EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP 

      4450       4460       4470       4480       4490       4500 
HEEEFLSQDQ LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP 

      4510       4520       4530       4540       4550       4560 
NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS ANCGFDDSEV 

      4570       4580 
AMSDYESVGE LSLASLHIPF VETQHQTQV 

« Hide

Isoform 2 [UniParc].

Checksum: 446C226D45882B6B
Show »

FASTA1,254138,836
Isoform 3 [UniParc].

Checksum: 66964BED3E55BC0A
Show »

FASTA4,557501,978

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1026-4589 (ISOFORM 2).
Tissue: Brain.
[3]"Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs."
Mitsui K., Nakajima D., Ohara O., Nakayama M.
Biochem. Biophys. Res. Commun. 290:1260-1266(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3493-4589 (ISOFORM 1), VARIANT GLY-3812.
Tissue: Brain.
[4]"Comparative integromics on FAT1, FAT2, FAT3 and FAT4."
Katoh Y., Katoh M.
Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1. Different initiation.
AB076400 mRNA. Translation: BAB86868.1.
RefSeqNP_001008781.2. NM_001008781.2.
UniGeneHs.98523.

3D structure databases

ProteinModelPortalQ8TDW7.
SMRQ8TDW7. Positions 47-3625, 3798-4133.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125669. 2 interactions.
STRING9606.ENSP00000387040.

PTM databases

PhosphoSiteQ8TDW7.

Polymorphism databases

DMDM172045818.

Proteomic databases

PaxDbQ8TDW7.
PRIDEQ8TDW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298047; ENSP00000298047; ENSG00000165323. [Q8TDW7-1]
ENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
GeneID120114.
KEGGhsa:120114.
UCSCuc001pdj.4. human. [Q8TDW7-3]

Organism-specific databases

CTD120114.
GeneCardsGC11P092164.
HGNCHGNC:23112. FAT3.
HPAHPA026878.
MIM612483. gene.
neXtProtNX_Q8TDW7.
PharmGKBPA134962612.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000046499.
HOVERGENHBG005641.
InParanoidQ8TDW7.
KOK16506.
OMAKFFIDPK.
PhylomeDBQ8TDW7.
TreeFamTF316403.

Gene expression databases

ArrayExpressQ8TDW7.
BgeeQ8TDW7.
CleanExHS_FAT3.
GenevestigatorQ8TDW7.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamPF00028. Cadherin. 26 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 32 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAT3. human.
GenomeRNAi120114.
NextBio80524.
PROQ8TDW7.
SOURCESearch...

Entry information

Entry nameFAT3_HUMAN
AccessionPrimary (citable) accession number: Q8TDW7
Secondary accession number(s): B5MDB0, Q96AU6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM