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Q8TDW7

- FAT3_HUMAN

UniProt

Q8TDW7 - FAT3_HUMAN

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Protein
Protocadherin Fat 3
Gene
FAT3, CDHF15, KIAA1989
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 3
Short name:
hFat3
Alternative name(s):
Cadherin family member 15
FAT tumor suppressor homolog 3
Gene namesi
Name:FAT3
Synonyms:CDHF15, KIAA1989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23112. FAT3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 41544122Extracellular Reviewed prediction
Add
BLAST
Transmembranei4155 – 417521Helical; Reviewed prediction
Add
BLAST
Topological domaini4176 – 4589414Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 45894557Protocadherin Fat 3
PRO_0000324634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi342 – 3421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi482 – 4821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi563 – 5631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi668 – 6681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi899 – 8991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1007 – 10071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1368 – 13681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1430 – 14301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1752 – 17521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1945 – 19451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1994 – 19941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1997 – 19971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2209 – 22091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2293 – 22931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2332 – 23321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2468 – 24681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3001 – 30011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3202 – 32021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3330 – 33301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3450 – 34501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3619 – 36191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3742 – 37421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3799 ↔ 3810 By similarity
Disulfide bondi3804 ↔ 3822 By similarity
Disulfide bondi3824 ↔ 3832 By similarity
Glycosylationi3927 – 39271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3985 ↔ 4018 By similarity
Disulfide bondi4025 ↔ 4036 By similarity
Disulfide bondi4030 ↔ 4046 By similarity
Disulfide bondi4048 ↔ 4057 By similarity
Disulfide bondi4064 ↔ 4075 By similarity
Disulfide bondi4069 ↔ 4084 By similarity
Disulfide bondi4086 ↔ 4095 By similarity
Disulfide bondi4102 ↔ 4113 By similarity
Disulfide bondi4107 ↔ 4122 By similarity
Disulfide bondi4124 ↔ 4133 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8TDW7.
PaxDbiQ8TDW7.
PRIDEiQ8TDW7.

PTM databases

PhosphoSiteiQ8TDW7.

Expressioni

Tissue specificityi

Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.1 Publication

Gene expression databases

ArrayExpressiQ8TDW7.
BgeeiQ8TDW7.
CleanExiHS_FAT3.
GenevestigatoriQ8TDW7.

Organism-specific databases

HPAiHPA026878.

Interactioni

Protein-protein interaction databases

BioGridi125669. 2 interactions.
STRINGi9606.ENSP00000387040.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW7.
SMRiQ8TDW7. Positions 117-336, 385-3619, 3798-4133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 158115Cadherin 1
Add
BLAST
Domaini159 – 266108Cadherin 2
Add
BLAST
Domaini264 – 375112Cadherin 3
Add
BLAST
Domaini377 – 47296Cadherin 4
Add
BLAST
Domaini473 – 578106Cadherin 5
Add
BLAST
Domaini579 – 681103Cadherin 6
Add
BLAST
Domaini727 – 831105Cadherin 7
Add
BLAST
Domaini832 – 936105Cadherin 8
Add
BLAST
Domaini937 – 1043107Cadherin 9
Add
BLAST
Domaini1044 – 1148105Cadherin 10
Add
BLAST
Domaini1149 – 1254106Cadherin 11
Add
BLAST
Domaini1255 – 1359105Cadherin 12
Add
BLAST
Domaini1363 – 146098Cadherin 13
Add
BLAST
Domaini1461 – 1566106Cadherin 14
Add
BLAST
Domaini1567 – 1769203Cadherin 15
Add
BLAST
Domaini1770 – 1883114Cadherin 16
Add
BLAST
Domaini1884 – 1986103Cadherin 17
Add
BLAST
Domaini1983 – 2084102Cadherin 18
Add
BLAST
Domaini2085 – 2186102Cadherin 19
Add
BLAST
Domaini2187 – 2287101Cadherin 20
Add
BLAST
Domaini2288 – 2394107Cadherin 21
Add
BLAST
Domaini2395 – 2496102Cadherin 22
Add
BLAST
Domaini2497 – 2600104Cadherin 23
Add
BLAST
Domaini2601 – 2708108Cadherin 24
Add
BLAST
Domaini2709 – 2814106Cadherin 25
Add
BLAST
Domaini2815 – 2924110Cadherin 26
Add
BLAST
Domaini2925 – 3029105Cadherin 27
Add
BLAST
Domaini3030 – 3131102Cadherin 28
Add
BLAST
Domaini3132 – 3236105Cadherin 29
Add
BLAST
Domaini3237 – 3341105Cadherin 30
Add
BLAST
Domaini3342 – 3446105Cadherin 31
Add
BLAST
Domaini3447 – 3551105Cadherin 32
Add
BLAST
Domaini3552 – 3653102Cadherin 33
Add
BLAST
Domaini3795 – 383339EGF-like 1
Add
BLAST
Domaini3835 – 4018184Laminin G-like
Add
BLAST
Domaini4021 – 405838EGF-like 2
Add
BLAST
Domaini4060 – 409637EGF-like 3
Add
BLAST
Domaini4098 – 413437EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4438 – 450972Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 33 cadherin domains.
Contains 4 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ8TDW7.
KOiK16506.
OMAiKFFIDPK.
PhylomeDBiQ8TDW7.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 32 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TDW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA     50
TVYENSAART YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA 100
DFCFLRIRTK GGNSAILNRE IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD 150
MNDLRPLFSP TTYSVTIAES TPLRTSVAQV TATDADIGSN GEFYYYFKNK 200
VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL YGNNGVSSTA 250
KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 300
VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK 350
GSPQKCSALK AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL 400
SPEPIDVEYK LSPGEDAVYF KINPRSGLIV TARPLNTVKK EVYKLEVTNK 450
EGDLKAQVTI SIEDANDHTP EFQQPLYDAY VNESVPVGTS VLTVSASDKD 500
KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP EIYRFIVRAS 550
DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 600
SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA 650
LRITATDGEN LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA 700
KANGKLNLED GFLDFYSINR QGPYFDKSFP SDVAVKEDLP VGANILKIKA 750
YDADSGFNGK VLFTISDGNT DSCFNIDMET GQLKVLMPMD REHTDLYLLN 800
ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI LESSGIGTEI 850
IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 900
SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP 950
VGTVIAWLET HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY 1000
EKQQFYNLTV RAKDKGRPVS LSSVSFVEVE VVDVNENLHT PYFPDFAVVG 1050
SVKENSRIGT SVLQVTARDE DSGRDGEIQY SIRDGSGLGR FSIDDESGVI 1100
TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED VNDNAPLTSE 1150
PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 1200
KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN 1250
KPQFPEKVYQ IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND 1300
DGKFFIDPKT GMVSSRKQFT AGSYDILTIK AVDNGRPQKS STARLHIEWI 1350
KKPPPSPIPL TFDEPFYNFT VMESDRVTEI VGVVSVQPAN TPLWFDIVGG 1400
NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN VAVTQVFIKV 1450
LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS 1500
IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA 1550
RVIVNVEDAN DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE 1600
LIYTIEAGNT GNMFKIEPVL GIITICKEPD MTTMGQFVLS IKVTDQGSPP 1650
MSATAIVRIS VTMSDNSHPK FIHKDYQAEV NENVDIGTSV ILISAISQST 1700
LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI IQATNMAGMA 1750
SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA 1800
TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH 1850
VHVRDSGSPQ LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV 1900
EVLKVSATDP DSEVPPELTY SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH 1950
YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL HFTQSFYSTS ISENNTNITK 2000
VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV PFDREEQELY 2050
ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG 2100
TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS 2150
NIEYGVTILA KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR 2200
MNTPILSINA TSPEGQGIIY IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV 2250
TSAYKLTIRA SDALTGARAE VTVDLLVNDV NDNPPIFDQP TYNTTLSEAS 2300
LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID SSSGLILTAR 2350
MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE 2400
SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV 2450
ITLSNHRKQR MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST 2500
YVAEVRENVA AGTKVIHVRA TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG 2550
QVITTERLDR ENPLEGDVSI FVRALDGGGR TTFCTVRVIV VDENDNAPQF 2600
MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY SEASVSVADL 2650
LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP 2700
PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN 2750
NKGGIFVIEQ ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV 2800
DIKVLDLNDN KPVFETSSYD TIIMEGMPVG TKLTQVRAID MDWGANGQVT 2850
YSLHSDSQPE KVMEAFNIDS NTGWISTLKD LDHETDPTFT FSVVASDLGE 2900
AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG EVVAVLSTWD 2950
RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL 3000
NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK 3050
VSAKDADIGS NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS 3100
LMAKATDGGG RFCQSNIHLI LEDVNDNPPV FSSDHYNTCV YENTATKALL 3150
TRVQAVDPDI GINRKVVYSL ADSAGGVFSI DSSSGIIILE QPLDREQQSS 3200
YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD YLVTVPEDTS 3250
PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD 3300
YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI 3350
SEDALVGDSV ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV 3400
KKKLDRERVS GYSLLVQAVD SGIPAMSSTA TVNIDISDVN DNSPVFTPAN 3450
YTAVIQENKP VGTSILQLVV TDRDSFHNGP PFSFSILSGN EEEEFVLDPH 3500
GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR VIEESTHKPT 3550
AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS 3600
HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT 3650
IRFENVSPED FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD 3700
MLFAVEMHSS EFYKPAYLIQ KLSNARRHLE NIMRISAILE KNCSGLDCQE 3750
QHCEQGLSLD SHALMTYSTA RISFVCPRFY RNVRCTCNGG LCPGSNDPCV 3800
EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF AGNSYIKYRL 3850
SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS 3900
GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL 3950
STESSIYFGA LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN 4000
KRSSFAEVVG LTELKLGCVL YPDACKRSPC QHGGSCTGLP SGGYQCTCLS 4050
QFTGRNCESE ITACFPNPCR NGGSCDPIGN TFICNCKAGL TGVTCEEDIN 4100
ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV PNIQAGHSYV 4150
GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL 4200
LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD 4250
KIVDGLGGEH QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD 4300
SIRKNGWDAG TENKGVDDPG EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN 4350
ASIVTVIQLV NNVVDTIENE VSVMDQGQNY NRAYHWDTSD WMPGARLSDI 4400
EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP HEEEFLSQDQ 4450
LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP 4500
NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS 4550
ANCGFDDSEV AMSDYESVGE LSLASLHIPF VETQHQTQV 4589
Length:4,589
Mass (Da):505,523
Last modified:March 18, 2008 - v2
Checksum:iC993CE7F08EC6BF9
GO
Isoform 2 (identifier: Q8TDW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
     1261-4589: Missing.

Note: No experimental confirmation available.

Show »
Length:1,254
Mass (Da):138,836
Checksum:i446C226D45882B6B
GO
Isoform 3 (identifier: Q8TDW7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4351-4382: Missing.

Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.

Show »
Length:4,557
Mass (Da):501,978
Checksum:i66964BED3E55BC0A
GO

Sequence cautioni

The sequence AAH16722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti412 – 4121S → F.
Corresponds to variant rs10830902 [ dbSNP | Ensembl ].
VAR_039851
Natural varianti462 – 4621I → V.
Corresponds to variant rs16917409 [ dbSNP | Ensembl ].
VAR_039852
Natural varianti1167 – 11671V → G.
Corresponds to variant rs11821058 [ dbSNP | Ensembl ].
VAR_039853
Natural varianti1726 – 17261Q → R.
Corresponds to variant rs7949157 [ dbSNP | Ensembl ].
VAR_039854
Natural varianti2293 – 22931N → S.
Corresponds to variant rs16918105 [ dbSNP | Ensembl ].
VAR_039855
Natural varianti2622 – 26221V → F.
Corresponds to variant rs17615477 [ dbSNP | Ensembl ].
VAR_039856
Natural varianti2755 – 27551I → V.
Corresponds to variant rs3847531 [ dbSNP | Ensembl ].
VAR_039857
Natural varianti3518 – 35181V → L.
Corresponds to variant rs10765565 [ dbSNP | Ensembl ].
VAR_039858
Natural varianti3812 – 38121S → G.1 Publication
Corresponds to variant rs4753069 [ dbSNP | Ensembl ].
VAR_039859

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1204 – 126057LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2.
VSP_032327Add
BLAST
Alternative sequencei1261 – 45893329Missing in isoform 2.
VSP_032328Add
BLAST
Alternative sequencei4351 – 438232Missing in isoform 3.
VSP_040467Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1. Different initiation.
AB076400 mRNA. Translation: BAB86868.1.
RefSeqiNP_001008781.2. NM_001008781.2. [Q8TDW7-3]
UniGeneiHs.98523.

Genome annotation databases

EnsembliENST00000298047; ENSP00000298047; ENSG00000165323. [Q8TDW7-1]
ENST00000409404; ENSP00000387040; ENSG00000165323. [Q8TDW7-3]
GeneIDi120114.
KEGGihsa:120114.
UCSCiuc001pdj.4. human. [Q8TDW7-3]

Polymorphism databases

DMDMi172045818.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000722 Genomic DNA. No translation available.
AP000805 Genomic DNA. No translation available.
AP002514 Genomic DNA. No translation available.
AP003171 Genomic DNA. No translation available.
AP003718 Genomic DNA. No translation available.
BC016722 mRNA. Translation: AAH16722.1 . Different initiation.
AB076400 mRNA. Translation: BAB86868.1 .
RefSeqi NP_001008781.2. NM_001008781.2. [Q8TDW7-3 ]
UniGenei Hs.98523.

3D structure databases

ProteinModelPortali Q8TDW7.
SMRi Q8TDW7. Positions 117-336, 385-3619, 3798-4133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125669. 2 interactions.
STRINGi 9606.ENSP00000387040.

PTM databases

PhosphoSitei Q8TDW7.

Polymorphism databases

DMDMi 172045818.

Proteomic databases

MaxQBi Q8TDW7.
PaxDbi Q8TDW7.
PRIDEi Q8TDW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298047 ; ENSP00000298047 ; ENSG00000165323 . [Q8TDW7-1 ]
ENST00000409404 ; ENSP00000387040 ; ENSG00000165323 . [Q8TDW7-3 ]
GeneIDi 120114.
KEGGi hsa:120114.
UCSCi uc001pdj.4. human. [Q8TDW7-3 ]

Organism-specific databases

CTDi 120114.
GeneCardsi GC11P092164.
HGNCi HGNC:23112. FAT3.
HPAi HPA026878.
MIMi 612483. gene.
neXtProti NX_Q8TDW7.
PharmGKBi PA134962612.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000046499.
HOVERGENi HBG005641.
InParanoidi Q8TDW7.
KOi K16506.
OMAi KFFIDPK.
PhylomeDBi Q8TDW7.
TreeFami TF316403.

Miscellaneous databases

ChiTaRSi FAT3. human.
GenomeRNAii 120114.
NextBioi 80524.
PROi Q8TDW7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TDW7.
Bgeei Q8TDW7.
CleanExi HS_FAT3.
Genevestigatori Q8TDW7.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
2.60.40.60. 34 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00028. Cadherin. 26 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 32 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 19 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1026-4589 (ISOFORM 2).
    Tissue: Brain.
  3. "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs."
    Mitsui K., Nakajima D., Ohara O., Nakayama M.
    Biochem. Biophys. Res. Commun. 290:1260-1266(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3493-4589 (ISOFORM 1), VARIANT GLY-3812.
    Tissue: Brain.
  4. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."
    Katoh Y., Katoh M.
    Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFAT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW7
Secondary accession number(s): B5MDB0, Q96AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 11, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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