Q8TDW7 (FAT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin Fat 3
Short name=hFat3

Alternative name(s):
Cadherin family member 15
FAT tumor suppressor homolog 3

Gene names

Name:	FAT3
Synonyms:	CDHF15, KIAA1989

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4589 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the interactions between neurites derived from specific subsets of neurons during development By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate. Ref.4
Sequence similarities	Contains 33 cadherin domains. Contains 4 EGF-like domains. Contains 1 laminin G-like domain.
Sequence caution	The sequence AAH16722.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDW7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1204-1260: LITTTSRKLD...KPQFPEKVYQ → SCSVAQAGMQ...PPCPATFLNS
     1261-4589: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TDW7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4351-4382: Missing.

Note: Gene prediction based on similarity to rat ortholog and partial EST and cDNA data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 4589	4557	Protocadherin Fat 3		PRO_0000324634
Regions
	Topological domain	33 – 4154	4122	Extracellular Potential
	Transmembrane	4155 – 4175	21	Helical; Potential
	Topological domain	4176 – 4589	414	Cytoplasmic Potential
	Domain	44 – 158	115	Cadherin 1
	Domain	159 – 266	108	Cadherin 2
	Domain	264 – 375	112	Cadherin 3
	Domain	377 – 472	96	Cadherin 4
	Domain	473 – 578	106	Cadherin 5
	Domain	579 – 681	103	Cadherin 6
	Domain	727 – 831	105	Cadherin 7
	Domain	832 – 936	105	Cadherin 8
	Domain	937 – 1043	107	Cadherin 9
	Domain	1044 – 1148	105	Cadherin 10
	Domain	1149 – 1254	106	Cadherin 11
	Domain	1255 – 1359	105	Cadherin 12
	Domain	1363 – 1460	98	Cadherin 13
	Domain	1461 – 1566	106	Cadherin 14
	Domain	1567 – 1769	203	Cadherin 15
	Domain	1770 – 1883	114	Cadherin 16
	Domain	1884 – 1986	103	Cadherin 17
	Domain	1983 – 2084	102	Cadherin 18
	Domain	2085 – 2186	102	Cadherin 19
	Domain	2187 – 2287	101	Cadherin 20
	Domain	2288 – 2394	107	Cadherin 21
	Domain	2395 – 2496	102	Cadherin 22
	Domain	2497 – 2600	104	Cadherin 23
	Domain	2601 – 2708	108	Cadherin 24
	Domain	2709 – 2814	106	Cadherin 25
	Domain	2815 – 2924	110	Cadherin 26
	Domain	2925 – 3029	105	Cadherin 27
	Domain	3030 – 3131	102	Cadherin 28
	Domain	3132 – 3236	105	Cadherin 29
	Domain	3237 – 3341	105	Cadherin 30
	Domain	3342 – 3446	105	Cadherin 31
	Domain	3447 – 3551	105	Cadherin 32
	Domain	3552 – 3653	102	Cadherin 33
	Domain	3795 – 3833	39	EGF-like 1
	Domain	3835 – 4018	184	Laminin G-like
	Domain	4021 – 4058	38	EGF-like 2
	Domain	4060 – 4096	37	EGF-like 3
	Domain	4098 – 4134	37	EGF-like 4; calcium-binding Potential
	Compositional bias	4438 – 4509	72	Pro-rich
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential
	Glycosylation	482	1	N-linked (GlcNAc...) Potential
	Glycosylation	563	1	N-linked (GlcNAc...) Potential
	Glycosylation	668	1	N-linked (GlcNAc...) Potential
	Glycosylation	800	1	N-linked (GlcNAc...) Potential
	Glycosylation	880	1	N-linked (GlcNAc...) Potential
	Glycosylation	899	1	N-linked (GlcNAc...) Potential
	Glycosylation	1007	1	N-linked (GlcNAc...) Potential
	Glycosylation	1368	1	N-linked (GlcNAc...) Potential
	Glycosylation	1430	1	N-linked (GlcNAc...) Potential
	Glycosylation	1752	1	N-linked (GlcNAc...) Potential
	Glycosylation	1945	1	N-linked (GlcNAc...) Potential
	Glycosylation	1994	1	N-linked (GlcNAc...) Potential
	Glycosylation	1997	1	N-linked (GlcNAc...) Potential
	Glycosylation	2209	1	N-linked (GlcNAc...) Potential
	Glycosylation	2293	1	N-linked (GlcNAc...) Potential
	Glycosylation	2332	1	N-linked (GlcNAc...) Potential
	Glycosylation	2468	1	N-linked (GlcNAc...) Potential
	Glycosylation	3001	1	N-linked (GlcNAc...) Potential
	Glycosylation	3202	1	N-linked (GlcNAc...) Potential
	Glycosylation	3330	1	N-linked (GlcNAc...) Potential
	Glycosylation	3450	1	N-linked (GlcNAc...) Potential
	Glycosylation	3619	1	N-linked (GlcNAc...) Potential
	Glycosylation	3742	1	N-linked (GlcNAc...) Potential
	Glycosylation	3927	1	N-linked (GlcNAc...) Potential
	Disulfide bond	3799 ↔ 3810		By similarity
	Disulfide bond	3804 ↔ 3822		By similarity
	Disulfide bond	3824 ↔ 3832		By similarity
	Disulfide bond	3985 ↔ 4018		By similarity
	Disulfide bond	4025 ↔ 4036		By similarity
	Disulfide bond	4030 ↔ 4046		By similarity
	Disulfide bond	4048 ↔ 4057		By similarity
	Disulfide bond	4064 ↔ 4075		By similarity
	Disulfide bond	4069 ↔ 4084		By similarity
	Disulfide bond	4086 ↔ 4095		By similarity
	Disulfide bond	4102 ↔ 4113		By similarity
	Disulfide bond	4107 ↔ 4122		By similarity
	Disulfide bond	4124 ↔ 4133		By similarity
Natural variations
	Alternative sequence	1204 – 1260	57	LITTT…EKVYQ → SCSVAQAGMQWHDRSSLQSR TPGFKGYPCLSLLSSWDYRH APPCPATFLNS in isoform 2.		VSP_032327
	Alternative sequence	1261 – 4589	3329	Missing in isoform 2.		VSP_032328
	Alternative sequence	4351 – 4382	32	Missing in isoform 3.		VSP_040467
	Natural variant	412	1	S → F. Corresponds to variant rs10830902 [ dbSNP | Ensembl ].		VAR_039851
	Natural variant	462	1	I → V. Corresponds to variant rs16917409 [ dbSNP | Ensembl ].		VAR_039852
	Natural variant	1167	1	V → G. Corresponds to variant rs11821058 [ dbSNP | Ensembl ].		VAR_039853
	Natural variant	1726	1	Q → R. Corresponds to variant rs7949157 [ dbSNP | Ensembl ].		VAR_039854
	Natural variant	2293	1	N → S. Corresponds to variant rs16918105 [ dbSNP | Ensembl ].		VAR_039855
	Natural variant	2622	1	V → F. Corresponds to variant rs17615477 [ dbSNP | Ensembl ].		VAR_039856
	Natural variant	2755	1	I → V. Corresponds to variant rs3847531 [ dbSNP | Ensembl ].		VAR_039857
	Natural variant	3518	1	V → L. Corresponds to variant rs10765565 [ dbSNP | Ensembl ].		VAR_039858
	Natural variant	3812	1	S → G. Ref.3 Corresponds to variant rs4753069 [ dbSNP | Ensembl ].		VAR_039859

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: C993CE7F08EC6BF9	FASTA	4,589	505,523
	10 20 30 40 50 60 MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA TVYENSAART 70 80 90 100 110 120 YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE 130 140 150 160 170 180 IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSVAQV 190 200 210 220 230 240 TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL 250 260 270 280 290 300 YGNNGVSSTA KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 310 320 330 340 350 360 VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK GSPQKCSALK 370 380 390 400 410 420 AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL SPEPIDVEYK LSPGEDAVYF 430 440 450 460 470 480 KINPRSGLIV TARPLNTVKK EVYKLEVTNK EGDLKAQVTI SIEDANDHTP EFQQPLYDAY 490 500 510 520 530 540 VNESVPVGTS VLTVSASDKD KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP 550 560 570 580 590 600 EIYRFIVRAS DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 610 620 630 640 650 660 SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA LRITATDGEN 670 680 690 700 710 720 LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA KANGKLNLED GFLDFYSINR 730 740 750 760 770 780 QGPYFDKSFP SDVAVKEDLP VGANILKIKA YDADSGFNGK VLFTISDGNT DSCFNIDMET 790 800 810 820 830 840 GQLKVLMPMD REHTDLYLLN ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI 850 860 870 880 890 900 LESSGIGTEI IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 910 920 930 940 950 960 SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP VGTVIAWLET 970 980 990 1000 1010 1020 HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY EKQQFYNLTV RAKDKGRPVS 1030 1040 1050 1060 1070 1080 LSSVSFVEVE VVDVNENLHT PYFPDFAVVG SVKENSRIGT SVLQVTARDE DSGRDGEIQY 1090 1100 1110 1120 1130 1140 SIRDGSGLGR FSIDDESGVI TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED 1150 1160 1170 1180 1190 1200 VNDNAPLTSE PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 1210 1220 1230 1240 1250 1260 KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN KPQFPEKVYQ 1270 1280 1290 1300 1310 1320 IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND DGKFFIDPKT GMVSSRKQFT 1330 1340 1350 1360 1370 1380 AGSYDILTIK AVDNGRPQKS STARLHIEWI KKPPPSPIPL TFDEPFYNFT VMESDRVTEI 1390 1400 1410 1420 1430 1440 VGVVSVQPAN TPLWFDIVGG NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN 1450 1460 1470 1480 1490 1500 VAVTQVFIKV LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS 1510 1520 1530 1540 1550 1560 IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA RVIVNVEDAN 1570 1580 1590 1600 1610 1620 DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE LIYTIEAGNT GNMFKIEPVL 1630 1640 1650 1660 1670 1680 GIITICKEPD MTTMGQFVLS IKVTDQGSPP MSATAIVRIS VTMSDNSHPK FIHKDYQAEV 1690 1700 1710 1720 1730 1740 NENVDIGTSV ILISAISQST LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI 1750 1760 1770 1780 1790 1800 IQATNMAGMA SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA 1810 1820 1830 1840 1850 1860 TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH VHVRDSGSPQ 1870 1880 1890 1900 1910 1920 LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV EVLKVSATDP DSEVPPELTY 1930 1940 1950 1960 1970 1980 SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL 1990 2000 2010 2020 2030 2040 HFTQSFYSTS ISENNTNITK VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV 2050 2060 2070 2080 2090 2100 PFDREEQELY ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG 2110 2120 2130 2140 2150 2160 TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS NIEYGVTILA 2170 2180 2190 2200 2210 2220 KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR MNTPILSINA TSPEGQGIIY 2230 2240 2250 2260 2270 2280 IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV TSAYKLTIRA SDALTGARAE VTVDLLVNDV 2290 2300 2310 2320 2330 2340 NDNPPIFDQP TYNTTLSEAS LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID 2350 2360 2370 2380 2390 2400 SSSGLILTAR MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE 2410 2420 2430 2440 2450 2460 SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV ITLSNHRKQR 2470 2480 2490 2500 2510 2520 MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST YVAEVRENVA AGTKVIHVRA 2530 2540 2550 2560 2570 2580 TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG QVITTERLDR ENPLEGDVSI FVRALDGGGR 2590 2600 2610 2620 2630 2640 TTFCTVRVIV VDENDNAPQF MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY 2650 2660 2670 2680 2690 2700 SEASVSVADL LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP 2710 2720 2730 2740 2750 2760 PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN NKGGIFVIEQ 2770 2780 2790 2800 2810 2820 ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV DIKVLDLNDN KPVFETSSYD 2830 2840 2850 2860 2870 2880 TIIMEGMPVG TKLTQVRAID MDWGANGQVT YSLHSDSQPE KVMEAFNIDS NTGWISTLKD 2890 2900 2910 2920 2930 2940 LDHETDPTFT FSVVASDLGE AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG 2950 2960 2970 2980 2990 3000 EVVAVLSTWD RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL 3010 3020 3030 3040 3050 3060 NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK VSAKDADIGS 3070 3080 3090 3100 3110 3120 NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS LMAKATDGGG RFCQSNIHLI 3130 3140 3150 3160 3170 3180 LEDVNDNPPV FSSDHYNTCV YENTATKALL TRVQAVDPDI GINRKVVYSL ADSAGGVFSI 3190 3200 3210 3220 3230 3240 DSSSGIIILE QPLDREQQSS YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD 3250 3260 3270 3280 3290 3300 YLVTVPEDTS PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD 3310 3320 3330 3340 3350 3360 YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI SEDALVGDSV 3370 3380 3390 3400 3410 3420 ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV KKKLDRERVS GYSLLVQAVD 3430 3440 3450 3460 3470 3480 SGIPAMSSTA TVNIDISDVN DNSPVFTPAN YTAVIQENKP VGTSILQLVV TDRDSFHNGP 3490 3500 3510 3520 3530 3540 PFSFSILSGN EEEEFVLDPH GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR 3550 3560 3570 3580 3590 3600 VIEESTHKPT AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS 3610 3620 3630 3640 3650 3660 HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT IRFENVSPED 3670 3680 3690 3700 3710 3720 FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD MLFAVEMHSS EFYKPAYLIQ 3730 3740 3750 3760 3770 3780 KLSNARRHLE NIMRISAILE KNCSGLDCQE QHCEQGLSLD SHALMTYSTA RISFVCPRFY 3790 3800 3810 3820 3830 3840 RNVRCTCNGG LCPGSNDPCV EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF 3850 3860 3870 3880 3890 3900 AGNSYIKYRL SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS 3910 3920 3930 3940 3950 3960 GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL STESSIYFGA 3970 3980 3990 4000 4010 4020 LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN KRSSFAEVVG LTELKLGCVL 4030 4040 4050 4060 4070 4080 YPDACKRSPC QHGGSCTGLP SGGYQCTCLS QFTGRNCESE ITACFPNPCR NGGSCDPIGN 4090 4100 4110 4120 4130 4140 TFICNCKAGL TGVTCEEDIN ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV 4150 4160 4170 4180 4190 4200 PNIQAGHSYV GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL 4210 4220 4230 4240 4250 4260 LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD KIVDGLGGEH 4270 4280 4290 4300 4310 4320 QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD SIRKNGWDAG TENKGVDDPG 4330 4340 4350 4360 4370 4380 EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN ASIVTVIQLV NNVVDTIENE VSVMDQGQNY 4390 4400 4410 4420 4430 4440 NRAYHWDTSD WMPGARLSDI EEVPNYENQD GGSAHQGSTR ELESDYYLGG YDIDSEYPPP 4450 4460 4470 4480 4490 4500 HEEEFLSQDQ LPPPLPEDFP DQYEALPPSQ PVSLASTLSP DCRRRPQFHP SQYLPPHPFP 4510 4520 4530 4540 4550 4560 NETDLVGPPA SCEFSTFAVS MNQGTEPTGP ADSVSLSLHN SRGTSSSDVS ANCGFDDSEV 4570 4580 AMSDYESVGE LSLASLHIPF VETQHQTQV
	Isoform 2 [UniParc]. Checksum: 446C226D45882B6B	FASTA	1,254	138,836
	10 20 30 40 50 60 MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA TVYENSAART 70 80 90 100 110 120 YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE 130 140 150 160 170 180 IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSVAQV 190 200 210 220 230 240 TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL 250 260 270 280 290 300 YGNNGVSSTA KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 310 320 330 340 350 360 VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK GSPQKCSALK 370 380 390 400 410 420 AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL SPEPIDVEYK LSPGEDAVYF 430 440 450 460 470 480 KINPRSGLIV TARPLNTVKK EVYKLEVTNK EGDLKAQVTI SIEDANDHTP EFQQPLYDAY 490 500 510 520 530 540 VNESVPVGTS VLTVSASDKD KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP 550 560 570 580 590 600 EIYRFIVRAS DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 610 620 630 640 650 660 SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA LRITATDGEN 670 680 690 700 710 720 LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA KANGKLNLED GFLDFYSINR 730 740 750 760 770 780 QGPYFDKSFP SDVAVKEDLP VGANILKIKA YDADSGFNGK VLFTISDGNT DSCFNIDMET 790 800 810 820 830 840 GQLKVLMPMD REHTDLYLLN ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI 850 860 870 880 890 900 LESSGIGTEI IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 910 920 930 940 950 960 SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP VGTVIAWLET 970 980 990 1000 1010 1020 HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY EKQQFYNLTV RAKDKGRPVS 1030 1040 1050 1060 1070 1080 LSSVSFVEVE VVDVNENLHT PYFPDFAVVG SVKENSRIGT SVLQVTARDE DSGRDGEIQY 1090 1100 1110 1120 1130 1140 SIRDGSGLGR FSIDDESGVI TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED 1150 1160 1170 1180 1190 1200 VNDNAPLTSE PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 1210 1220 1230 1240 1250 KTGSCSVAQA GMQWHDRSSL QSRTPGFKGY PCLSLLSSWD YRHAPPCPAT FLNS
	Isoform 3 [UniParc]. Checksum: 66964BED3E55BC0A	FASTA	4,557	501,978
	10 20 30 40 50 60 MDIIMGHCVG TRPPACCLIL LLFKLLATVS QGLPGTGPLG FHFTHSIYNA TVYENSAART 70 80 90 100 110 120 YVNSQSRMGI TLIDLSWDIK YRIVSGDEEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE 130 140 150 160 170 180 IQDNYLLIVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSVAQV 190 200 210 220 230 240 TATDADIGSN GEFYYYFKNK VDLFSVHPTS GVISLSGRLN YDEKNRYDLE ILAVDRGMKL 250 260 270 280 290 300 YGNNGVSSTA KLYVHIERIN EHAPTIHVVT HVPFSLEKEP TYAVVTVDDL DDGANGEIES 310 320 330 340 350 360 VSIVAGDPLD QFFLAKEGKW LNEYKIKERK QIDWESFPYG YNLTLQAKDK GSPQKCSALK 370 380 390 400 410 420 AVYIGNPTRD TVPIRFEKEV YDVSISEFSP PGVVVAIVKL SPEPIDVEYK LSPGEDAVYF 430 440 450 460 470 480 KINPRSGLIV TARPLNTVKK EVYKLEVTNK EGDLKAQVTI SIEDANDHTP EFQQPLYDAY 490 500 510 520 530 540 VNESVPVGTS VLTVSASDKD KGENGYITYS IASLNLLPFV INQFTGVIST TEELDFESSP 550 560 570 580 590 600 EIYRFIVRAS DWGSPYRHES EVNVTIRIGN VNDNSPLFEK VACQGVISYD FPVGGHITAV 610 620 630 640 650 660 SAIDIDELEL VKYKIISGNE LGFFYLNPDS GVLQLKKSLT NSGIKNGNFA LRITATDGEN 670 680 690 700 710 720 LADPMSINIS VLHGKVSSKS FSCRETRVAQ KLAEKLLIKA KANGKLNLED GFLDFYSINR 730 740 750 760 770 780 QGPYFDKSFP SDVAVKEDLP VGANILKIKA YDADSGFNGK VLFTISDGNT DSCFNIDMET 790 800 810 820 830 840 GQLKVLMPMD REHTDLYLLN ITIYDLGNPQ KSSWRLLTIN VEDANDNSPV FIQDSYSVNI 850 860 870 880 890 900 LESSGIGTEI IQVEARDKDL GSNGEVTYSV LTDTQQFAIN SSTGIVYVAD QLDRESKANY 910 920 930 940 950 960 SLKIEARDKA ESGQQLFSVV TLKVFLDDVN DCSPAFIPSS YSVKVLEDLP VGTVIAWLET 970 980 990 1000 1010 1020 HDPDLGLGGQ VRYSLVNDYN GRFEIDKASG AIRLSKELDY EKQQFYNLTV RAKDKGRPVS 1030 1040 1050 1060 1070 1080 LSSVSFVEVE VVDVNENLHT PYFPDFAVVG SVKENSRIGT SVLQVTARDE DSGRDGEIQY 1090 1100 1110 1120 1130 1140 SIRDGSGLGR FSIDDESGVI TAADILDRET MGSYWLTVYA TDRGVVPLYS TIEVYIEVED 1150 1160 1170 1180 1190 1200 VNDNAPLTSE PIYYPVVMEN SPKDVSVIQI QAEDPDSSSN EKLTYRITSG NPQNFFAINI 1210 1220 1230 1240 1250 1260 KTGLITTTSR KLDREQQAEH FLEVTVTDGG PSPKQSTIWV VVQVLDENDN KPQFPEKVYQ 1270 1280 1290 1300 1310 1320 IKLPERDRKK RGEPIYRAFA FDRDEGPNAE ISYSIVDGND DGKFFIDPKT GMVSSRKQFT 1330 1340 1350 1360 1370 1380 AGSYDILTIK AVDNGRPQKS STARLHIEWI KKPPPSPIPL TFDEPFYNFT VMESDRVTEI 1390 1400 1410 1420 1430 1440 VGVVSVQPAN TPLWFDIVGG NFDSAFDAEK GVGTIVIAKP LDAEQRSIYN MSVEVTDGTN 1450 1460 1470 1480 1490 1500 VAVTQVFIKV LDNNDNGPEF SQPNYDVTIS EDVLPDTEIL QIEATDRDEK HKLSYTVHSS 1510 1520 1530 1540 1550 1560 IDSISMRKFR IDPSTGVLYT AERLDHEAQD KHILNIMVRD QEFPYRRNLA RVIVNVEDAN 1570 1580 1590 1600 1610 1620 DHSPYFTNPL YEASVFESAA LGSAVLQVTA LDKDKGENAE LIYTIEAGNT GNMFKIEPVL 1630 1640 1650 1660 1670 1680 GIITICKEPD MTTMGQFVLS IKVTDQGSPP MSATAIVRIS VTMSDNSHPK FIHKDYQAEV 1690 1700 1710 1720 1730 1740 NENVDIGTSV ILISAISQST LIYEVKDGDI NGIFTINPYS GVITTQKALD YERTSSYQLI 1750 1760 1770 1780 1790 1800 IQATNMAGMA SNATVNIQIV DENDNAPVFL FSQYSGSLSE AAPINSIVRS LDNSPLVIRA 1810 1820 1830 1840 1850 1860 TDADSNRNAL LVYQIVESTA KKFFTVDSST GAIRTIANLD HETIAHFHFH VHVRDSGSPQ 1870 1880 1890 1900 1910 1920 LTAESPVEVN IEVTDVNDNP PVFTQAVFET ILLLPTYVGV EVLKVSATDP DSEVPPELTY 1930 1940 1950 1960 1970 1980 SLMEGSLDHF LIDSNSGVLT IKNNNLSKDH YMLIVKVSDG KFYSTSMVTI MVKEAMDSGL 1990 2000 2010 2020 2030 2040 HFTQSFYSTS ISENNTNITK VAIVNAVGNR LNEPLKYSIL NPGNKFKIKS TSGVIQTTGV 2050 2060 2070 2080 2090 2100 PFDREEQELY ELVVEASREL DHLRVARVVV RVNIEDINDN SPVFVGLPYY AAVQVDAEPG 2110 2120 2130 2140 2150 2160 TLIYQVTAID KDKGPNGEVT YVLQDDYGHF EINPNSGNVI LKEAFNSDLS NIEYGVTILA 2170 2180 2190 2200 2210 2220 KDGGKPSLST SVELPITIVN KAMPVFDKPF YTASVNEDIR MNTPILSINA TSPEGQGIIY 2230 2240 2250 2260 2270 2280 IIIDGDPFKQ FNIDFDTGVL KVVSPLDYEV TSAYKLTIRA SDALTGARAE VTVDLLVNDV 2290 2300 2310 2320 2330 2340 NDNPPIFDQP TYNTTLSEAS LIGTPVLQVV SIDADSENNK MVHYQIVQDT YNSTDYFHID 2350 2360 2370 2380 2390 2400 SSSGLILTAR MLDHELVQHC TLKVRSIDSG FPSLSSEVLV HIYISDVNDN PPVFNQLIYE 2410 2420 2430 2440 2450 2460 SYVSELAPRG HFVTCVQASD ADSSDFDRLE YSILSGNDRT SFLMDSKSGV ITLSNHRKQR 2470 2480 2490 2500 2510 2520 MEPLYSLNVS VSDGLFTSTA QVHIRVLGAN LYSPAFSQST YVAEVRENVA AGTKVIHVRA 2530 2540 2550 2560 2570 2580 TDGDPGTYGQ ISYAIINDFA KDRFLIDSNG QVITTERLDR ENPLEGDVSI FVRALDGGGR 2590 2600 2610 2620 2630 2640 TTFCTVRVIV VDENDNAPQF MTVEYRASVR ADVGRGHLVT QVQAIDPDDG ANSRITYSLY 2650 2660 2670 2680 2690 2700 SEASVSVADL LEIDPDNGWM VTKGNFNQLK NTVLSFFVKA VDGGIPVKHS LIPVYIHVLP 2710 2720 2730 2740 2750 2760 PETFLPSFTQ SQYSFTIAED TAIGSTVDTL RILPSQNVWF STVNGERPEN NKGGIFVIEQ 2770 2780 2790 2800 2810 2820 ETGTIKLDKR LDRETSPAFH FKVAATIPLD KVDIVFTVDV DIKVLDLNDN KPVFETSSYD 2830 2840 2850 2860 2870 2880 TIIMEGMPVG TKLTQVRAID MDWGANGQVT YSLHSDSQPE KVMEAFNIDS NTGWISTLKD 2890 2900 2910 2920 2930 2940 LDHETDPTFT FSVVASDLGE AFSLSSTALV SVRVTDINDN APVFAQEVYR GNVKESDPPG 2950 2960 2970 2980 2990 3000 EVVAVLSTWD RDTSDVNRQV SYHITGGNPR GRFALGLVQS EWKVYVKRPL DREEQDIYFL 3010 3020 3030 3040 3050 3060 NITATDGLFV TQAMVEVSVS DVNDNSPVCD QVAYTALLPE DIPSNKIILK VSAKDADIGS 3070 3080 3090 3100 3110 3120 NGYIRYSLYG SGNSEFFLDP ESGELKTLAL LDRERIPVYS LMAKATDGGG RFCQSNIHLI 3130 3140 3150 3160 3170 3180 LEDVNDNPPV FSSDHYNTCV YENTATKALL TRVQAVDPDI GINRKVVYSL ADSAGGVFSI 3190 3200 3210 3220 3230 3240 DSSSGIIILE QPLDREQQSS YNISVRATDQ SPGQSLSSLT TVTITVLDIN DNPPVFERRD 3250 3260 3270 3280 3290 3300 YLVTVPEDTS PGTQVLAVFA TSKDIGTNAE ITYLIRSGNE QGKFKINPKT GGISVSEVLD 3310 3320 3330 3340 3350 3360 YELCKRFYLV VEAKDGGTPA LSAVATVNIN LTDVNDNPPK FSQDVYSAVI SEDALVGDSV 3370 3380 3390 3400 3410 3420 ILLIAEDVDS QPNGQIHFSI VNGDRDNEFT VDPVLGLVKV KKKLDRERVS GYSLLVQAVD 3430 3440 3450 3460 3470 3480 SGIPAMSSTA TVNIDISDVN DNSPVFTPAN YTAVIQENKP VGTSILQLVV TDRDSFHNGP 3490 3500 3510 3520 3530 3540 PFSFSILSGN EEEEFVLDPH GILRSAVVFQ HTESLEYVLC VQAKDSGKPQ QVSHTYIRVR 3550 3560 3570 3580 3590 3600 VIEESTHKPT AIPLEIFIVT MEDDFPGGVI GKIHATDQDM YDVLTFALKS EQKSLFKVNS 3610 3620 3630 3640 3650 3660 HDGKIIALGG LDSGKYVLNV SVSDGRFQVP IDVVVHVEQL VHEMLQNTVT IRFENVSPED 3670 3680 3690 3700 3710 3720 FVGLHMHGFR RTLRNAVLTQ KQDSLRIISI QPVAGTNQLD MLFAVEMHSS EFYKPAYLIQ 3730 3740 3750 3760 3770 3780 KLSNARRHLE NIMRISAILE KNCSGLDCQE QHCEQGLSLD SHALMTYSTA RISFVCPRFY 3790 3800 3810 3820 3830 3840 RNVRCTCNGG LCPGSNDPCV EKPCPGDMQC VSYEASRRPF LCQCPPGKLG ECSGHTSLSF 3850 3860 3870 3880 3890 3900 AGNSYIKYRL SENSKEEDFK LALRLRTLQS NGIIMYTRAN PCIILKIVDG KLWFQLDCGS 3910 3920 3930 3940 3950 3960 GPGILGISGR AVNDGSWHSV FLELNRNFTS LSLDDSYVER RRAPLYFQTL STESSIYFGA 3970 3980 3990 4000 4010 4020 LVQADNIRSL TDTRVTQVLS GFQGCLDSVI LNNNELPLQN KRSSFAEVVG LTELKLGCVL 4030 4040 4050 4060 4070 4080 YPDACKRSPC QHGGSCTGLP SGGYQCTCLS QFTGRNCESE ITACFPNPCR NGGSCDPIGN 4090 4100 4110 4120 4130 4140 TFICNCKAGL TGVTCEEDIN ECEREECENG GSCVNVFGSF LCNCTPGYVG QYCGLRPVVV 4150 4160 4170 4180 4190 4200 PNIQAGHSYV GKEELIGIAV VLFVIFILVV LFIVFRKKVF RKNYSRNNIT LVQDPATAAL 4210 4220 4230 4240 4250 4260 LNKSNGIPFR NLRGSGDGRN VYQEVGPPQV PVRPMAYTPC FQSDSRSNLD KIVDGLGGEH 4270 4280 4290 4300 4310 4320 QEMTTFHPES PRILTARRGV VVCSVAPNLP AVSPCRSDCD SIRKNGWDAG TENKGVDDPG 4330 4340 4350 4360 4370 4380 EVTCFAGSNK GSNSEVQSLS SFQSDSGDDN AYHWDTSDWM PGARLSDIEE VPNYENQDGG 4390 4400 4410 4420 4430 4440 SAHQGSTREL ESDYYLGGYD IDSEYPPPHE EEFLSQDQLP PPLPEDFPDQ YEALPPSQPV 4450 4460 4470 4480 4490 4500 SLASTLSPDC RRRPQFHPSQ YLPPHPFPNE TDLVGPPASC EFSTFAVSMN QGTEPTGPAD 4510 4520 4530 4540 4550 SVSLSLHNSR GTSSSDVSAN CGFDDSEVAM SDYESVGELS LASLHIPFVE TQHQTQV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1026-4589 (ISOFORM 2). Tissue: Brain.
[3]	"Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs." Mitsui K., Nakajima D., Ohara O., Nakayama M. Biochem. Biophys. Res. Commun. 290:1260-1266(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3493-4589 (ISOFORM 1), VARIANT GLY-3812. Tissue: Brain.
[4]	"Comparative integromics on FAT1, FAT2, FAT3 and FAT4." Katoh Y., Katoh M. Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000722 Genomic DNA. No translation available. AP000805 Genomic DNA. No translation available. AP002514 Genomic DNA. No translation available. AP003171 Genomic DNA. No translation available. AP003718 Genomic DNA. No translation available. BC016722 mRNA. Translation: AAH16722.1. Different initiation. AB076400 mRNA. Translation: BAB86868.1.
IPI	IPI00847978. IPI00888216. IPI00973508.
RefSeq	NP_001008781.2. NM_001008781.2.
UniGene	Hs.98523.
3D structure databases
HSSP	HSSP built from PDB template 1TOZ based on UniProtKB P46531.
ProteinModelPortal	Q8TDW7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000387040.
PTM databases
PhosphoSite	Q8TDW7.
Polymorphism databases
DMDM	172045818.
Proteomic databases
PaxDb	Q8TDW7.
PRIDE	Q8TDW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298047; ENSP00000298047; ENSG00000165323. ENST00000409404; ENSP00000387040; ENSG00000165323.
GeneID	120114.
KEGG	hsa:120114.
UCSC	uc001pdj.4. human.
Organism-specific databases
CTD	120114.
GeneCards	GC11P092164.
HGNC	HGNC:23112. FAT3.
HPA	HPA026878.
MIM	612483. gene.
neXtProt	NX_Q8TDW7.
PharmGKB	PA134962612.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000046499.
HOVERGEN	HBG005641.
InParanoid	Q8TDW7.
KO	K16506.
OMA	DNGWMVT.
OrthoDB	EOG4CNQQ3.
Gene expression databases
ArrayExpress	Q8TDW7.
Bgee	Q8TDW7.
CleanEx	HS_FAT3.
Genevestigator	Q8TDW7.
Family and domain databases
Gene3D	2.60.120.200. 1 hit. 2.60.40.60. 34 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR001791. Laminin_G. [Graphical view]
Pfam	PF00028. Cadherin. 26 hits. PF07645. EGF_CA. 1 hit. PF02210. Laminin_G_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 32 hits. SM00181. EGF. 2 hits. SM00179. EGF_CA. 1 hit. SM00282. LamG. 1 hit. [Graphical view]
SUPFAM	SSF49313. Cadherin. 34 hits. SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00232. CADHERIN_1. 19 hits. PS50268. CADHERIN_2. 32 hits. PS00022. EGF_1. 3 hits. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 1 hit. PS50025. LAM_G_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAT3. human.
GenomeRNAi	120114.
NextBio	80524.
SOURCE	Search...

Entry information

Entry name

FAT3_HUMAN

Accession

Primary (citable) accession number: Q8TDW7
Secondary accession number(s): B5MDB0, Q96AU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.