Q8TDW5 (SYTL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-like protein 5

Gene names

Name:	SYTL5
Synonyms:	SLP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	730 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Subunit structure	Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Highly expressed in placenta and liver.
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 RabBD (Rab-binding) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: Compara intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Rab27a	Q9ERI2	2	EBI-2939487,EBI-398172	From a different organism.
Rab3a	P63011	2	EBI-2939487,EBI-398393	From a different organism.
Rab6a	P35279	2	EBI-2939487,EBI-444674	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 730	730	Synaptotagmin-like protein 5		PRO_0000190219
Regions
	Domain	7 – 123	117	RabBD
	Domain	408 – 511	104	C2 1
	Domain	574 – 678	105	C2 2
	Zinc finger	64 – 106	43	FYVE-type
Natural variations
	Alternative sequence	384	1	S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2.		VSP_042659
	Natural variant	275	1	I → V. Corresponds to variant rs4827331 [ dbSNP | Ensembl ].		VAR_024601
	Natural variant	302	1	R → C. Corresponds to variant rs57226394 [ dbSNP | Ensembl ].		VAR_061753

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D9E0DA98880A95ED	FASTA	730	81,523
	10 20 30 40 50 60 MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA 70 80 90 100 110 120 SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF 130 140 150 160 170 180 FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG 190 200 210 220 230 240 PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND 250 260 270 280 290 300 QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 310 320 330 340 350 360 HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET 370 380 390 400 410 420 EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD YGNVKVSGEI LLHISYCYKT 430 440 450 460 470 480 GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY LLPDKSRNNK RKTKIRTGTN PEFNETLKYT 490 500 510 520 530 540 ISHTQLETRT LQLSVWHYDR FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG 550 560 570 580 590 600 LQYKGELTVV LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT 610 620 630 640 650 660 AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP QDIKNVCLEL 670 680 690 700 710 720 TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE QRLWQKMANN PGTPFEGVLM 730 LRSSMGKCRL
	Isoform 2 [UniParc]. Checksum: BDCE53EAABC65723	FASTA	752	83,918
	10 20 30 40 50 60 MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA 70 80 90 100 110 120 SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF 130 140 150 160 170 180 FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG 190 200 210 220 230 240 PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND 250 260 270 280 290 300 QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 310 320 330 340 350 360 HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET 370 380 390 400 410 420 EESIDALVSS QLSTNTHRLA SGLSTSSQAG SDRKWTYLNV PDADSDTTSL NSMMSVYSET 430 440 450 460 470 480 GDYGNVKVSG EILLHISYCY KTGGLYIFVK NCRNLAIGDE KKQRTDAYVK SYLLPDKSRN 490 500 510 520 530 540 NKRKTKIRTG TNPEFNETLK YTISHTQLET RTLQLSVWHY DRFGRNSFLG EVEIPFDSWN 550 560 570 580 590 600 FENPTDEWFV LQPKVEFAPD IGLQYKGELT VVLRYIPPEE NLMLPPEQLQ GNKTFKKGKK 610 620 630 640 650 660 KESPVISGGI LEVFIKEAKN LTAVKSGGTS DSFVKGYLLP DDSKATKHKT LVIKKSVNPQ 670 680 690 700 710 720 WNHTFMFSGI HPQDIKNVCL ELTIWDKEAF SSNIFLGGVR LNSGSGVSHG KNVDWMDSQG 730 740 750 EEQRLWQKMA NNPGTPFEGV LMLRSSMGKC RL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains." Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K. Biochem. Biophys. Res. Commun. 293:899-906(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, INTERACTION WITH PHOSPHOLIPIDS. Tissue: Placenta.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB080222 mRNA. Translation: BAB88906.1. AL121578 Genomic DNA. No translation available. BC131585 mRNA. Translation: AAI31586.1.
IPI	IPI00152647. IPI00829637.
RefSeq	NP_001156806.1. NM_001163334.1. NP_001156807.1. NM_001163335.1. NP_620135.1. NM_138780.2.
UniGene	Hs.662334.
3D structure databases
ProteinModelPortal	Q8TDW5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TDW5. 3 interactions.
STRING	9606.ENSP00000297875.
PTM databases
PhosphoSite	Q8TDW5.
Polymorphism databases
DMDM	33301662.
Proteomic databases
PaxDb	Q8TDW5.
PRIDE	Q8TDW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297875; ENSP00000297875; ENSG00000147041. ENST00000357972; ENSP00000350657; ENSG00000147041. ENST00000456733; ENSP00000395220; ENSG00000147041.
GeneID	94122.
KEGG	hsa:94122.
UCSC	uc004ddu.3. human.
Organism-specific databases
CTD	94122.
GeneCards	GC0XP037865.
HGNC	HGNC:15589. SYTL5.
HPA	HPA026074.
neXtProt	NX_Q8TDW5.
PharmGKB	PA37988.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293068.
HOGENOM	HOG000231332.
HOVERGEN	HBG054255.
InParanoid	Q8TDW5.
OMA	FDRGDPC.
OrthoDB	EOG4XSKP8.
PhylomeDB	Q8TDW5.
Gene expression databases
Bgee	Q8TDW5.
CleanEx	HS_SYTL5.
Genevestigator	Q8TDW5.
GermOnline	ENSG00000147041. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR010911. Rab-bd_domain. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00168. C2. 2 hits. [Graphical view]
SMART	SM00239. C2. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits. SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50004. C2. 2 hits. PS50916. RABBD. 1 hit. PS50178. ZF_FYVE. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	94122.
NextBio	78406.

Entry information

Entry name

SYTL5_HUMAN

Accession

Primary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.