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Protein

Synaptotagmin-like protein 5

Gene

SYTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri64 – 10643FYVE-typeAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: GO_Central
  2. calcium ion binding Source: GO_Central
  3. clathrin binding Source: GO_Central
  4. syntaxin binding Source: GO_Central

GO - Biological processi

  1. calcium ion-dependent exocytosis of neurotransmitter Source: GO_Central
  2. intracellular protein transport Source: InterPro
  3. regulation of calcium ion-dependent exocytosis Source: GO_Central
  4. synaptic vesicle exocytosis Source: GO_Central
  5. vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 5
Gene namesi
Name:SYTL5
Synonyms:SLP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:15589. SYTL5.

Subcellular locationi

  1. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. exocytic vesicle Source: GO_Central
  2. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37988.

Polymorphism and mutation databases

BioMutaiSYTL5.
DMDMi33301662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Synaptotagmin-like protein 5PRO_0000190219Add
BLAST

Proteomic databases

MaxQBiQ8TDW5.
PaxDbiQ8TDW5.
PRIDEiQ8TDW5.

PTM databases

PhosphoSiteiQ8TDW5.

Expressioni

Tissue specificityi

Highly expressed in placenta and liver.

Gene expression databases

BgeeiQ8TDW5.
CleanExiHS_SYTL5.
GenevestigatoriQ8TDW5.

Organism-specific databases

HPAiHPA026074.

Interactioni

Subunit structurei

Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-2939487,EBI-739624
Rab27aQ9ERI22EBI-2939487,EBI-398172From a different organism.
RAB27BO001943EBI-2939487,EBI-10179046
Rab3aP630112EBI-2939487,EBI-398393From a different organism.
Rab6aP352792EBI-2939487,EBI-444674From a different organism.
WACQ9BTA93EBI-2939487,EBI-749118

Protein-protein interaction databases

BioGridi125121. 6 interactions.
IntActiQ8TDW5. 6 interactions.
STRINGi9606.ENSP00000297875.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW5.
SMRiQ8TDW5. Positions 8-130, 406-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 123117RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini408 – 511104C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini574 – 678105C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.Curated
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri64 – 10643FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293068.
GeneTreeiENSGT00780000121872.
HOGENOMiHOG000231332.
HOVERGENiHBG054255.
InParanoidiQ8TDW5.
KOiK17598.
OMAiIFDRGDP.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ8TDW5.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028702. Slp5.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS
110 120 130 140 150
WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA
160 170 180 190 200
EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII
210 220 230 240 250
TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS
260 270 280 290 300
SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG
360 370 380 390 400
ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD
410 420 430 440 450
YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY
460 470 480 490 500
LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR
510 520 530 540 550
FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV
560 570 580 590 600
LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT
610 620 630 640 650
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP
660 670 680 690 700
QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE
710 720 730
QRLWQKMANN PGTPFEGVLM LRSSMGKCRL
Length:730
Mass (Da):81,523
Last modified:June 1, 2002 - v1
Checksum:iD9E0DA98880A95ED
GO
Isoform 2 (identifier: Q8TDW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD

Note: No experimental confirmation available.

Show »
Length:752
Mass (Da):83,918
Checksum:iBDCE53EAABC65723
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751I → V.
Corresponds to variant rs4827331 [ dbSNP | Ensembl ].
VAR_024601
Natural varianti302 – 3021R → C.
Corresponds to variant rs57226394 [ dbSNP | Ensembl ].
VAR_061753

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei384 – 3841S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2. 1 PublicationVSP_042659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080222 mRNA. Translation: BAB88906.1.
AL121578 Genomic DNA. No translation available.
BC131585 mRNA. Translation: AAI31586.1.
CCDSiCCDS14244.1. [Q8TDW5-1]
CCDS55399.1. [Q8TDW5-2]
RefSeqiNP_001156806.1. NM_001163334.1. [Q8TDW5-2]
NP_001156807.1. NM_001163335.1. [Q8TDW5-1]
NP_620135.1. NM_138780.2. [Q8TDW5-1]
UniGeneiHs.662334.

Genome annotation databases

EnsembliENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1]
ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2]
GeneIDi94122.
KEGGihsa:94122.
UCSCiuc004ddu.3. human. [Q8TDW5-1]
uc004ddx.3. human. [Q8TDW5-2]

Polymorphism and mutation databases

BioMutaiSYTL5.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080222 mRNA. Translation: BAB88906.1.
AL121578 Genomic DNA. No translation available.
BC131585 mRNA. Translation: AAI31586.1.
CCDSiCCDS14244.1. [Q8TDW5-1]
CCDS55399.1. [Q8TDW5-2]
RefSeqiNP_001156806.1. NM_001163334.1. [Q8TDW5-2]
NP_001156807.1. NM_001163335.1. [Q8TDW5-1]
NP_620135.1. NM_138780.2. [Q8TDW5-1]
UniGeneiHs.662334.

3D structure databases

ProteinModelPortaliQ8TDW5.
SMRiQ8TDW5. Positions 8-130, 406-716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125121. 6 interactions.
IntActiQ8TDW5. 6 interactions.
STRINGi9606.ENSP00000297875.

PTM databases

PhosphoSiteiQ8TDW5.

Polymorphism and mutation databases

BioMutaiSYTL5.
DMDMi33301662.

Proteomic databases

MaxQBiQ8TDW5.
PaxDbiQ8TDW5.
PRIDEiQ8TDW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1]
ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2]
GeneIDi94122.
KEGGihsa:94122.
UCSCiuc004ddu.3. human. [Q8TDW5-1]
uc004ddx.3. human. [Q8TDW5-2]

Organism-specific databases

CTDi94122.
GeneCardsiGC0XP037865.
HGNCiHGNC:15589. SYTL5.
HPAiHPA026074.
neXtProtiNX_Q8TDW5.
PharmGKBiPA37988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293068.
GeneTreeiENSGT00780000121872.
HOGENOMiHOG000231332.
HOVERGENiHBG054255.
InParanoidiQ8TDW5.
KOiK17598.
OMAiIFDRGDP.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ8TDW5.
TreeFamiTF341184.

Miscellaneous databases

GenomeRNAii94122.
NextBioi78406.
PROiQ8TDW5.

Gene expression databases

BgeeiQ8TDW5.
CleanExiHS_SYTL5.
GenevestigatoriQ8TDW5.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028702. Slp5.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains."
    Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.
    Biochem. Biophys. Res. Commun. 293:899-906(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, INTERACTION WITH PHOSPHOLIPIDS.
    Tissue: Placenta.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSYTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.