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Q8TDW5

- SYTL5_HUMAN

UniProt

Q8TDW5 - SYTL5_HUMAN

Protein

Synaptotagmin-like protein 5

Gene

SYTL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri64 – 10643FYVE-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. exocytosis Source: Ensembl
    2. intracellular protein transport Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-like protein 5
    Gene namesi
    Name:SYTL5
    Synonyms:SLP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:15589. SYTL5.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37988.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 730730Synaptotagmin-like protein 5PRO_0000190219Add
    BLAST

    Proteomic databases

    MaxQBiQ8TDW5.
    PaxDbiQ8TDW5.
    PRIDEiQ8TDW5.

    PTM databases

    PhosphoSiteiQ8TDW5.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta and liver.

    Gene expression databases

    BgeeiQ8TDW5.
    CleanExiHS_SYTL5.
    GenevestigatoriQ8TDW5.

    Organism-specific databases

    HPAiHPA026074.

    Interactioni

    Subunit structurei

    Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Rab27aQ9ERI22EBI-2939487,EBI-398172From a different organism.
    Rab3aP630112EBI-2939487,EBI-398393From a different organism.
    Rab6aP352792EBI-2939487,EBI-444674From a different organism.

    Protein-protein interaction databases

    BioGridi125121. 3 interactions.
    IntActiQ8TDW5. 3 interactions.
    STRINGi9606.ENSP00000297875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDW5.
    SMRiQ8TDW5. Positions 8-130, 406-716.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 123117RabBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini408 – 511104C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini574 – 678105C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 FYVE-type zinc finger.Curated
    Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri64 – 10643FYVE-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG293068.
    HOGENOMiHOG000231332.
    HOVERGENiHBG054255.
    InParanoidiQ8TDW5.
    KOiK17598.
    OMAiFDRGDPC.
    OrthoDBiEOG7JMGDC.
    PhylomeDBiQ8TDW5.
    TreeFamiTF341184.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR028702. Slp5.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
    PfamiPF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 3 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS50004. C2. 2 hits.
    PS50916. RABBD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK    50
    RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS 100
    WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA 150
    EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII 200
    TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS 250
    SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 300
    HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG 350
    ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD 400
    YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY 450
    LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR 500
    FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV 550
    LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT 600
    AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP 650
    QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE 700
    QRLWQKMANN PGTPFEGVLM LRSSMGKCRL 730
    Length:730
    Mass (Da):81,523
    Last modified:June 1, 2002 - v1
    Checksum:iD9E0DA98880A95ED
    GO
    Isoform 2 (identifier: Q8TDW5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         384-384: S → STSSQAGSDRKWTYLNVPDADSD

    Note: No experimental confirmation available.

    Show »
    Length:752
    Mass (Da):83,918
    Checksum:iBDCE53EAABC65723
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti275 – 2751I → V.
    Corresponds to variant rs4827331 [ dbSNP | Ensembl ].
    VAR_024601
    Natural varianti302 – 3021R → C.
    Corresponds to variant rs57226394 [ dbSNP | Ensembl ].
    VAR_061753

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei384 – 3841S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2. 1 PublicationVSP_042659

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080222 mRNA. Translation: BAB88906.1.
    AL121578 Genomic DNA. No translation available.
    BC131585 mRNA. Translation: AAI31586.1.
    CCDSiCCDS14244.1. [Q8TDW5-1]
    CCDS55399.1. [Q8TDW5-2]
    RefSeqiNP_001156806.1. NM_001163334.1. [Q8TDW5-2]
    NP_001156807.1. NM_001163335.1. [Q8TDW5-1]
    NP_620135.1. NM_138780.2. [Q8TDW5-1]
    UniGeneiHs.662334.

    Genome annotation databases

    EnsembliENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1]
    ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2]
    GeneIDi94122.
    KEGGihsa:94122.
    UCSCiuc004ddu.3. human. [Q8TDW5-1]
    uc004ddx.3. human. [Q8TDW5-2]

    Polymorphism databases

    DMDMi33301662.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080222 mRNA. Translation: BAB88906.1 .
    AL121578 Genomic DNA. No translation available.
    BC131585 mRNA. Translation: AAI31586.1 .
    CCDSi CCDS14244.1. [Q8TDW5-1 ]
    CCDS55399.1. [Q8TDW5-2 ]
    RefSeqi NP_001156806.1. NM_001163334.1. [Q8TDW5-2 ]
    NP_001156807.1. NM_001163335.1. [Q8TDW5-1 ]
    NP_620135.1. NM_138780.2. [Q8TDW5-1 ]
    UniGenei Hs.662334.

    3D structure databases

    ProteinModelPortali Q8TDW5.
    SMRi Q8TDW5. Positions 8-130, 406-716.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125121. 3 interactions.
    IntActi Q8TDW5. 3 interactions.
    STRINGi 9606.ENSP00000297875.

    PTM databases

    PhosphoSitei Q8TDW5.

    Polymorphism databases

    DMDMi 33301662.

    Proteomic databases

    MaxQBi Q8TDW5.
    PaxDbi Q8TDW5.
    PRIDEi Q8TDW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297875 ; ENSP00000297875 ; ENSG00000147041 . [Q8TDW5-1 ]
    ENST00000456733 ; ENSP00000395220 ; ENSG00000147041 . [Q8TDW5-2 ]
    GeneIDi 94122.
    KEGGi hsa:94122.
    UCSCi uc004ddu.3. human. [Q8TDW5-1 ]
    uc004ddx.3. human. [Q8TDW5-2 ]

    Organism-specific databases

    CTDi 94122.
    GeneCardsi GC0XP037865.
    HGNCi HGNC:15589. SYTL5.
    HPAi HPA026074.
    neXtProti NX_Q8TDW5.
    PharmGKBi PA37988.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293068.
    HOGENOMi HOG000231332.
    HOVERGENi HBG054255.
    InParanoidi Q8TDW5.
    KOi K17598.
    OMAi FDRGDPC.
    OrthoDBi EOG7JMGDC.
    PhylomeDBi Q8TDW5.
    TreeFami TF341184.

    Miscellaneous databases

    GenomeRNAii 94122.
    NextBioi 78406.
    PROi Q8TDW5.

    Gene expression databases

    Bgeei Q8TDW5.
    CleanExi HS_SYTL5.
    Genevestigatori Q8TDW5.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR028702. Slp5.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10024:SF13. PTHR10024:SF13. 1 hit.
    Pfami PF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 3 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS50004. C2. 2 hits.
    PS50916. RABBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains."
      Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.
      Biochem. Biophys. Res. Commun. 293:899-906(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, INTERACTION WITH PHOSPHOLIPIDS.
      Tissue: Placenta.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiSYTL5_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDW5
    Secondary accession number(s): A2RRF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3