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Q8TDW5 (SYTL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-like protein 5
Gene names
Name:SYTL5
Synonyms:SLP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length730 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Subunit structure

Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Tissue specificity

Highly expressed in placenta and liver.

Sequence similarities

Contains 2 C2 domains.

Contains 1 FYVE-type zinc finger.

Contains 1 RabBD (Rab-binding) domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processexocytosis

Inferred from electronic annotation. Source: Ensembl

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Rab27aQ9ERI22EBI-2939487,EBI-398172From a different organism.
Rab3aP630112EBI-2939487,EBI-398393From a different organism.
Rab6aP352792EBI-2939487,EBI-444674From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TDW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TDW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 730730Synaptotagmin-like protein 5
PRO_0000190219

Regions

Domain7 – 123117RabBD
Domain408 – 511104C2 1
Domain574 – 678105C2 2
Zinc finger64 – 10643FYVE-type

Natural variations

Alternative sequence3841S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2.
VSP_042659
Natural variant2751I → V.
Corresponds to variant rs4827331 [ dbSNP | Ensembl ].
VAR_024601
Natural variant3021R → C.
Corresponds to variant rs57226394 [ dbSNP | Ensembl ].
VAR_061753

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D9E0DA98880A95ED

FASTA73081,523
        10         20         30         40         50         60 
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA 

        70         80         90        100        110        120 
SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF 

       130        140        150        160        170        180 
FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG 

       190        200        210        220        230        240 
PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND 

       250        260        270        280        290        300 
QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 

       310        320        330        340        350        360 
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET 

       370        380        390        400        410        420 
EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD YGNVKVSGEI LLHISYCYKT 

       430        440        450        460        470        480 
GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY LLPDKSRNNK RKTKIRTGTN PEFNETLKYT 

       490        500        510        520        530        540 
ISHTQLETRT LQLSVWHYDR FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG 

       550        560        570        580        590        600 
LQYKGELTVV LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT 

       610        620        630        640        650        660 
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP QDIKNVCLEL 

       670        680        690        700        710        720 
TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE QRLWQKMANN PGTPFEGVLM 

       730 
LRSSMGKCRL 

« Hide

Isoform 2 [UniParc].

Checksum: BDCE53EAABC65723
Show »

FASTA75283,918

References

« Hide 'large scale' references
[1]"Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains."
Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.
Biochem. Biophys. Res. Commun. 293:899-906(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, INTERACTION WITH PHOSPHOLIPIDS.
Tissue: Placenta.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB080222 mRNA. Translation: BAB88906.1.
AL121578 Genomic DNA. No translation available.
BC131585 mRNA. Translation: AAI31586.1.
RefSeqNP_001156806.1. NM_001163334.1.
NP_001156807.1. NM_001163335.1.
NP_620135.1. NM_138780.2.
UniGeneHs.662334.

3D structure databases

ProteinModelPortalQ8TDW5.
SMRQ8TDW5. Positions 8-130, 406-716.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125121. 3 interactions.
IntActQ8TDW5. 3 interactions.
STRING9606.ENSP00000297875.

PTM databases

PhosphoSiteQ8TDW5.

Polymorphism databases

DMDM33301662.

Proteomic databases

PaxDbQ8TDW5.
PRIDEQ8TDW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1]
ENST00000357972; ENSP00000350657; ENSG00000147041. [Q8TDW5-1]
ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2]
GeneID94122.
KEGGhsa:94122.
UCSCuc004ddu.3. human. [Q8TDW5-1]
uc004ddx.3. human. [Q8TDW5-2]

Organism-specific databases

CTD94122.
GeneCardsGC0XP037865.
HGNCHGNC:15589. SYTL5.
HPAHPA026074.
neXtProtNX_Q8TDW5.
PharmGKBPA37988.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293068.
HOGENOMHOG000231332.
HOVERGENHBG054255.
InParanoidQ8TDW5.
KOK17598.
OMAFDRGDPC.
OrthoDBEOG7JMGDC.
PhylomeDBQ8TDW5.
TreeFamTF341184.

Gene expression databases

BgeeQ8TDW5.
CleanExHS_SYTL5.
GenevestigatorQ8TDW5.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProIPR000008. C2_dom.
IPR028702. Slp5.
IPR010911. Znf_FYVE-typ.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi94122.
NextBio78406.
PROQ8TDW5.

Entry information

Entry nameSYTL5_HUMAN
AccessionPrimary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM