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Q8TDW5

- SYTL5_HUMAN

UniProt

Q8TDW5 - SYTL5_HUMAN

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Protein
Synaptotagmin-like protein 5
Gene
SYTL5, SLP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri64 – 10643FYVE-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. exocytosis Source: Ensembl
  2. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 5
Gene namesi
Name:SYTL5
Synonyms:SLP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:15589. SYTL5.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Synaptotagmin-like protein 5
PRO_0000190219Add
BLAST

Proteomic databases

MaxQBiQ8TDW5.
PaxDbiQ8TDW5.
PRIDEiQ8TDW5.

PTM databases

PhosphoSiteiQ8TDW5.

Expressioni

Tissue specificityi

Highly expressed in placenta and liver.

Gene expression databases

BgeeiQ8TDW5.
CleanExiHS_SYTL5.
GenevestigatoriQ8TDW5.

Organism-specific databases

HPAiHPA026074.

Interactioni

Subunit structurei

Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab27aQ9ERI22EBI-2939487,EBI-398172From a different organism.
Rab3aP630112EBI-2939487,EBI-398393From a different organism.
Rab6aP352792EBI-2939487,EBI-444674From a different organism.

Protein-protein interaction databases

BioGridi125121. 3 interactions.
IntActiQ8TDW5. 3 interactions.
STRINGi9606.ENSP00000297875.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW5.
SMRiQ8TDW5. Positions 8-130, 406-716.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 123117RabBD
Add
BLAST
Domaini408 – 511104C2 1
Add
BLAST
Domaini574 – 678105C2 2
Add
BLAST

Sequence similaritiesi

Contains 2 C2 domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293068.
HOGENOMiHOG000231332.
HOVERGENiHBG054255.
InParanoidiQ8TDW5.
KOiK17598.
OMAiFDRGDPC.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ8TDW5.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR028702. Slp5.
IPR010911. Znf_FYVE-typ.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK    50
RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS 100
WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA 150
EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII 200
TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS 250
SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 300
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG 350
ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD 400
YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY 450
LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR 500
FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV 550
LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT 600
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP 650
QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE 700
QRLWQKMANN PGTPFEGVLM LRSSMGKCRL 730
Length:730
Mass (Da):81,523
Last modified:June 1, 2002 - v1
Checksum:iD9E0DA98880A95ED
GO
Isoform 2 (identifier: Q8TDW5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD

Note: No experimental confirmation available.

Show »
Length:752
Mass (Da):83,918
Checksum:iBDCE53EAABC65723
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751I → V.
Corresponds to variant rs4827331 [ dbSNP | Ensembl ].
VAR_024601
Natural varianti302 – 3021R → C.
Corresponds to variant rs57226394 [ dbSNP | Ensembl ].
VAR_061753

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei384 – 3841S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2.
VSP_042659

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080222 mRNA. Translation: BAB88906.1.
AL121578 Genomic DNA. No translation available.
BC131585 mRNA. Translation: AAI31586.1.
CCDSiCCDS14244.1. [Q8TDW5-1]
CCDS55399.1. [Q8TDW5-2]
RefSeqiNP_001156806.1. NM_001163334.1. [Q8TDW5-2]
NP_001156807.1. NM_001163335.1. [Q8TDW5-1]
NP_620135.1. NM_138780.2. [Q8TDW5-1]
UniGeneiHs.662334.

Genome annotation databases

EnsembliENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1]
ENST00000357972; ENSP00000350657; ENSG00000147041. [Q8TDW5-1]
ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2]
GeneIDi94122.
KEGGihsa:94122.
UCSCiuc004ddu.3. human. [Q8TDW5-1]
uc004ddx.3. human. [Q8TDW5-2]

Polymorphism databases

DMDMi33301662.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080222 mRNA. Translation: BAB88906.1 .
AL121578 Genomic DNA. No translation available.
BC131585 mRNA. Translation: AAI31586.1 .
CCDSi CCDS14244.1. [Q8TDW5-1 ]
CCDS55399.1. [Q8TDW5-2 ]
RefSeqi NP_001156806.1. NM_001163334.1. [Q8TDW5-2 ]
NP_001156807.1. NM_001163335.1. [Q8TDW5-1 ]
NP_620135.1. NM_138780.2. [Q8TDW5-1 ]
UniGenei Hs.662334.

3D structure databases

ProteinModelPortali Q8TDW5.
SMRi Q8TDW5. Positions 8-130, 406-716.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125121. 3 interactions.
IntActi Q8TDW5. 3 interactions.
STRINGi 9606.ENSP00000297875.

PTM databases

PhosphoSitei Q8TDW5.

Polymorphism databases

DMDMi 33301662.

Proteomic databases

MaxQBi Q8TDW5.
PaxDbi Q8TDW5.
PRIDEi Q8TDW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297875 ; ENSP00000297875 ; ENSG00000147041 . [Q8TDW5-1 ]
ENST00000357972 ; ENSP00000350657 ; ENSG00000147041 . [Q8TDW5-1 ]
ENST00000456733 ; ENSP00000395220 ; ENSG00000147041 . [Q8TDW5-2 ]
GeneIDi 94122.
KEGGi hsa:94122.
UCSCi uc004ddu.3. human. [Q8TDW5-1 ]
uc004ddx.3. human. [Q8TDW5-2 ]

Organism-specific databases

CTDi 94122.
GeneCardsi GC0XP037865.
HGNCi HGNC:15589. SYTL5.
HPAi HPA026074.
neXtProti NX_Q8TDW5.
PharmGKBi PA37988.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293068.
HOGENOMi HOG000231332.
HOVERGENi HBG054255.
InParanoidi Q8TDW5.
KOi K17598.
OMAi FDRGDPC.
OrthoDBi EOG7JMGDC.
PhylomeDBi Q8TDW5.
TreeFami TF341184.

Miscellaneous databases

GenomeRNAii 94122.
NextBioi 78406.
PROi Q8TDW5.

Gene expression databases

Bgeei Q8TDW5.
CleanExi HS_SYTL5.
Genevestigatori Q8TDW5.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR028702. Slp5.
IPR010911. Znf_FYVE-typ.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10024:SF13. PTHR10024:SF13. 1 hit.
Pfami PF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains."
    Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.
    Biochem. Biophys. Res. Commun. 293:899-906(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, INTERACTION WITH PHOSPHOLIPIDS.
    Tissue: Placenta.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSYTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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