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Protein

Suppressor of tumorigenicity 7 protein-like

Gene

ST7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of tumorigenicity 7 protein-like
Alternative name(s):
ST7-related protein
Gene namesi
Name:ST7L
Synonyms:ST7R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18441. ST7L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54879.
OpenTargetsiENSG00000007341.
PharmGKBiPA38331.

Polymorphism and mutation databases

BioMutaiST7L.
DMDMi74751431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003392271 – 575Suppressor of tumorigenicity 7 protein-likeAdd BLAST575

Proteomic databases

MaxQBiQ8TDW4.
PaxDbiQ8TDW4.
PeptideAtlasiQ8TDW4.
PRIDEiQ8TDW4.

PTM databases

iPTMnetiQ8TDW4.
PhosphoSitePlusiQ8TDW4.

Expressioni

Gene expression databases

BgeeiENSG00000007341.
CleanExiHS_ST7L.
ExpressionAtlasiQ8TDW4. baseline and differential.
GenevisibleiQ8TDW4. HS.

Organism-specific databases

HPAiHPA042324.

Interactioni

Protein-protein interaction databases

BioGridi120227. 19 interactors.
STRINGi9606.ENSP00000350734.

Structurei

3D structure databases

ProteinModelPortaliQ8TDW4.
SMRiQ8TDW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ST7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOVERGENiHBG054916.
InParanoidiQ8TDW4.
OMAiPEIMGIF.
OrthoDBiEOG091G05WJ.
PhylomeDBiQ8TDW4.
TreeFamiTF314162.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR007311. ST7.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 1 hit.
PfamiPF04184. ST7. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRGGVGEA AAVGASPASV PGLNPTLGWR ERLRAGLAGT GASLWFVAGL
60 70 80 90 100
GLLYALRIPL RLCENLAAVT VFLNSLTPKF YVALTGTSSL ISGLIFIFEW
110 120 130 140 150
WYFHKHGTSF IEQVSVSHLQ PLMGGTESSI SEPGSPSRNR ENETSRQNLS
160 170 180 190 200
ECKVWRNPLN LFRGAEYRRY TWVTGKEPLT YYDMNLSAQD HQTFFTCDTD
210 220 230 240 250
FLRPSDTVMQ KAWRERNPPA RIKAAYQALE LNNDCATAYV LLAEEEATTI
260 270 280 290 300
VDAERLFKQA LKAGETIYRQ SQQCQHQSPQ HEAQLRRDTN VLVYIKRRLA
310 320 330 340 350
MCARKLGRIR EAVKIMRDLM KEFPPLTMLN IHENLLESLL ELQAYPDVQA
360 370 380 390 400
VLAKYDDISL PKSAAICYTA ALLKTRTVSE KFSPETASRR GLSTAEINAV
410 420 430 440 450
EAIHRAVEFN PHVPKYLLEM KSLILPPEHI LKRGDSEAIA YAFFHLQHWK
460 470 480 490 500
RIEGALNLLQ CTWEGTFRMI PYPLEKGHLF YPYPSCTETA DRELLPTFHH
510 520 530 540 550
VSVYPKKELP LFIHFTAGFC SSTAMIAILT HQFPEIMGIF AKAVLGLWCP
560 570
QPWASSGFEE NTQDLKSEDL GLSSG
Length:575
Mass (Da):64,779
Last modified:June 1, 2002 - v1
Checksum:i26F30D175DD6E8A0
GO
Isoform 2 (identifier: Q8TDW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-496: Missing.

Show »
Length:544
Mass (Da):61,111
Checksum:i88CDD2D91F8046A5
GO
Isoform 3 (identifier: Q8TDW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: Missing.

Show »
Length:558
Mass (Da):62,884
Checksum:iE191DC80594FF5A7
GO
Isoform 4 (identifier: Q8TDW4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):44,655
Checksum:i6784552BCBC7B263
GO
Isoform 5 (identifier: Q8TDW4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-566: LGLWCPQPWASSGFEENTQDLK → SMISRTCVDYL
     567-575: Missing.

Show »
Length:555
Mass (Da):62,714
Checksum:i5182E3020871ECD5
GO
Isoform 6 (identifier: Q8TDW4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: Missing.
     545-566: LGLWCPQPWASSGFEENTQDLK → SMISRTCVDYL
     567-575: Missing.

Show »
Length:538
Mass (Da):60,819
Checksum:i31C82C38F028CD73
GO
Isoform 7 (identifier: Q8TDW4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-568: LGLWCPQPWASSGFEENTQDLKSE → VGVKTQKENAD
     569-575: Missing.

Show »
Length:555
Mass (Da):62,615
Checksum:i9CBFCBAAD5F69963
GO
Isoform 8 (identifier: Q8TDW4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     416-503: YLLEMKSLIL...LLPTFHHVSV → VEIYPFSPQLNIKAVDNSAISKYPANIY
     504-575: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):36,665
Checksum:i9BF14DF740862D0F
GO

Sequence cautioni

The sequence BAA91060 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45803 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204P → H in AAH37830 (PubMed:15489334).Curated1
Sequence conflicti236A → T in CAD98103 (PubMed:17974005).Curated1
Sequence conflicti274C → Y in CAD97948 (PubMed:17974005).Curated1
Sequence conflicti282E → V in CAD98103 (PubMed:17974005).Curated1
Sequence conflicti287R → I in CAD97948 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043934451R → Q.1 PublicationCorresponds to variant rs6658555dbSNPEnsembl.1
Natural variantiVAR_043935455A → T.Corresponds to variant rs3736764dbSNPEnsembl.1
Natural variantiVAR_043936571G → D.Corresponds to variant rs12069022dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0341271 – 183Missing in isoform 4. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_0341281 – 122Missing in isoform 8. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_03412969 – 85Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_034130416 – 503YLLEM…HHVSV → VEIYPFSPQLNIKAVDNSAI SKYPANIY in isoform 8. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_034131466 – 496Missing in isoform 2. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_034132504 – 575Missing in isoform 8. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_034133545 – 568LGLWC…DLKSE → VGVKTQKENAD in isoform 7. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_034134545 – 566LGLWC…TQDLK → SMISRTCVDYL in isoform 5 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_034135567 – 575Missing in isoform 5 and isoform 6. 2 Publications9
Alternative sequenceiVSP_034136569 – 575Missing in isoform 7. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081317 mRNA. Translation: BAB88871.1.
AB081318 mRNA. Translation: BAB88872.1.
AB081319 mRNA. Translation: BAB88873.1.
AB081320 mRNA. Translation: BAB88874.1.
AK000291 mRNA. Translation: BAA91060.1. Different initiation.
AK097837 mRNA. Translation: BAC05180.1.
AK291042 mRNA. Translation: BAF83731.1.
BX537988 mRNA. Translation: CAD97948.1.
BX538338 mRNA. Translation: CAD98103.1.
BX640667 mRNA. Translation: CAE45803.1. Different initiation.
AL929470, AL109932 Genomic DNA. Translation: CAI16522.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16523.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16524.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16526.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16527.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22700.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22701.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22702.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22704.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22705.1.
AL109932 Genomic DNA. Translation: CAI22707.1.
CH471122 Genomic DNA. Translation: EAW56520.1.
CH471122 Genomic DNA. Translation: EAW56522.1.
CH471122 Genomic DNA. Translation: EAW56523.1.
CH471122 Genomic DNA. Translation: EAW56524.1.
BC037830 mRNA. Translation: AAH37830.1.
BC047392 mRNA. Translation: AAH47392.1.
BC065501 mRNA. Translation: AAH65501.1.
CCDSiCCDS76189.1. [Q8TDW4-4]
CCDS848.1. [Q8TDW4-1]
CCDS849.1. [Q8TDW4-3]
CCDS850.1. [Q8TDW4-2]
CCDS852.1. [Q8TDW4-5]
RefSeqiNP_001295193.1. NM_001308264.1. [Q8TDW4-4]
NP_060214.2. NM_017744.4. [Q8TDW4-1]
NP_620055.1. NM_138727.3. [Q8TDW4-3]
NP_620056.1. NM_138728.2. [Q8TDW4-2]
NP_620057.1. NM_138729.3. [Q8TDW4-5]
UniGeneiHs.201921.

Genome annotation databases

EnsembliENST00000343210; ENSP00000345312; ENSG00000007341. [Q8TDW4-5]
ENST00000358039; ENSP00000350734; ENSG00000007341. [Q8TDW4-1]
ENST00000360743; ENSP00000353972; ENSG00000007341. [Q8TDW4-2]
ENST00000361846; ENSP00000436499; ENSG00000007341. [Q8TDW4-7]
ENST00000369666; ENSP00000358680; ENSG00000007341. [Q8TDW4-6]
ENST00000369669; ENSP00000358683; ENSG00000007341. [Q8TDW4-4]
ENST00000490067; ENSP00000417140; ENSG00000007341. [Q8TDW4-3]
ENST00000490715; ENSP00000436544; ENSG00000007341. [Q8TDW4-7]
GeneIDi54879.
KEGGihsa:54879.
UCSCiuc001ecc.4. human. [Q8TDW4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081317 mRNA. Translation: BAB88871.1.
AB081318 mRNA. Translation: BAB88872.1.
AB081319 mRNA. Translation: BAB88873.1.
AB081320 mRNA. Translation: BAB88874.1.
AK000291 mRNA. Translation: BAA91060.1. Different initiation.
AK097837 mRNA. Translation: BAC05180.1.
AK291042 mRNA. Translation: BAF83731.1.
BX537988 mRNA. Translation: CAD97948.1.
BX538338 mRNA. Translation: CAD98103.1.
BX640667 mRNA. Translation: CAE45803.1. Different initiation.
AL929470, AL109932 Genomic DNA. Translation: CAI16522.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16523.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16524.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16526.1.
AL929470, AL109932 Genomic DNA. Translation: CAI16527.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22700.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22701.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22702.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22704.1.
AL109932, AL929470 Genomic DNA. Translation: CAI22705.1.
AL109932 Genomic DNA. Translation: CAI22707.1.
CH471122 Genomic DNA. Translation: EAW56520.1.
CH471122 Genomic DNA. Translation: EAW56522.1.
CH471122 Genomic DNA. Translation: EAW56523.1.
CH471122 Genomic DNA. Translation: EAW56524.1.
BC037830 mRNA. Translation: AAH37830.1.
BC047392 mRNA. Translation: AAH47392.1.
BC065501 mRNA. Translation: AAH65501.1.
CCDSiCCDS76189.1. [Q8TDW4-4]
CCDS848.1. [Q8TDW4-1]
CCDS849.1. [Q8TDW4-3]
CCDS850.1. [Q8TDW4-2]
CCDS852.1. [Q8TDW4-5]
RefSeqiNP_001295193.1. NM_001308264.1. [Q8TDW4-4]
NP_060214.2. NM_017744.4. [Q8TDW4-1]
NP_620055.1. NM_138727.3. [Q8TDW4-3]
NP_620056.1. NM_138728.2. [Q8TDW4-2]
NP_620057.1. NM_138729.3. [Q8TDW4-5]
UniGeneiHs.201921.

3D structure databases

ProteinModelPortaliQ8TDW4.
SMRiQ8TDW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120227. 19 interactors.
STRINGi9606.ENSP00000350734.

PTM databases

iPTMnetiQ8TDW4.
PhosphoSitePlusiQ8TDW4.

Polymorphism and mutation databases

BioMutaiST7L.
DMDMi74751431.

Proteomic databases

MaxQBiQ8TDW4.
PaxDbiQ8TDW4.
PeptideAtlasiQ8TDW4.
PRIDEiQ8TDW4.

Protocols and materials databases

DNASUi54879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343210; ENSP00000345312; ENSG00000007341. [Q8TDW4-5]
ENST00000358039; ENSP00000350734; ENSG00000007341. [Q8TDW4-1]
ENST00000360743; ENSP00000353972; ENSG00000007341. [Q8TDW4-2]
ENST00000361846; ENSP00000436499; ENSG00000007341. [Q8TDW4-7]
ENST00000369666; ENSP00000358680; ENSG00000007341. [Q8TDW4-6]
ENST00000369669; ENSP00000358683; ENSG00000007341. [Q8TDW4-4]
ENST00000490067; ENSP00000417140; ENSG00000007341. [Q8TDW4-3]
ENST00000490715; ENSP00000436544; ENSG00000007341. [Q8TDW4-7]
GeneIDi54879.
KEGGihsa:54879.
UCSCiuc001ecc.4. human. [Q8TDW4-1]

Organism-specific databases

CTDi54879.
DisGeNETi54879.
GeneCardsiST7L.
HGNCiHGNC:18441. ST7L.
HPAiHPA042324.
neXtProtiNX_Q8TDW4.
OpenTargetsiENSG00000007341.
PharmGKBiPA38331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOVERGENiHBG054916.
InParanoidiQ8TDW4.
OMAiPEIMGIF.
OrthoDBiEOG091G05WJ.
PhylomeDBiQ8TDW4.
TreeFamiTF314162.

Miscellaneous databases

ChiTaRSiST7L. human.
GenomeRNAii54879.
PROiQ8TDW4.

Gene expression databases

BgeeiENSG00000007341.
CleanExiHS_ST7L.
ExpressionAtlasiQ8TDW4. baseline and differential.
GenevisibleiQ8TDW4. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR007311. ST7.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 1 hit.
PfamiPF04184. ST7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST7L_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW4
Secondary accession number(s): A8K4S7
, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q9NXF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.