Q8TDV5 (GP119_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-dependent insulinotropic receptor

Alternative name(s):
G-protein coupled receptor 119

Gene names

Name:

GPR119

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Predominantly expressed in the pancreas, especially in the islets. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Lipid-binding
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	insulin secretion Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylcholine binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Glucose-dependent insulinotropic receptor		PRO_0000069607
Regions
	Topological domain	1 – 12	12	Extracellular Potential
	Transmembrane	13 – 33	21	Helical; Name=1; Potential
	Topological domain	34 – 37	4	Cytoplasmic Potential
	Transmembrane	38 – 58	21	Helical; Name=2; Potential
	Topological domain	59 – 81	23	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Name=3; Potential
	Topological domain	103 – 125	23	Cytoplasmic Potential
	Transmembrane	126 – 146	21	Helical; Name=4; Potential
	Topological domain	147 – 164	18	Extracellular Potential
	Transmembrane	165 – 185	21	Helical; Name=5; Potential
	Topological domain	186 – 226	41	Cytoplasmic Potential
	Transmembrane	227 – 247	21	Helical; Name=6; Potential
	Topological domain	248 – 262	15	Extracellular Potential
	Transmembrane	263 – 283	21	Helical; Name=7; Potential
	Topological domain	284 – 335	52	Cytoplasmic Potential
Natural variations
	Natural variant	309	1	S → L. Corresponds to variant rs5975187 [ dbSNP | Ensembl ].		VAR_037221
Experimental info
	Sequence conflict	325	1	I → T in AAI01167. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q8TDV5 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 16BAF93AEA145FB0	FASTA	335	36,889
	10 20 30 40 50 60 MESSFSFGVI LAVLASLIIA TNTLVAVAVL LLIHKNDGVS LCFTLNLAVA DTLIGVAISG 70 80 90 100 110 120 LLTDQLSSPS RPTQKTLCSL RMAFVTSSAA ASVLTVMLIT FDRYLAIKQP FRYLKIMSGF 130 140 150 160 170 180 VAGACIAGLW LVSYLIGFLP LGIPMFQQTA YKGQCSFFAV FHPHFVLTLS CVGFFPAMLL 190 200 210 220 230 240 FVFFYCDMLK IASMHSQQIR KMEHAGAMAG GYRSPRTPSD FKALRTVSVL IGSFALSWTP 250 260 270 280 290 300 FLITGIVQVA CQECHLYLVL ERYLWLLGVG NSLLNPLIYA YWQKEVRLQL YHMALGVKKV 310 320 330 LTSFLLFLSA RNCGPERPRE SSCHIVTISS SEFDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B. FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor." Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K. Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, CHARACTERIZATION.
[7]	"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents." Overton H.A., Babbs A.J., Doel S.M., Fyfe M.C.T., Gardner L.S., Griffin G., Jackson H.C., Procter M.J., Rasamison C.M., Tang-Christensen M., Widdowson P.S., Williams G.M., Reynet C. Cell Metab. 3:167-175(2006) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB083584 Genomic DNA. Translation: BAB89297.1. AB065936 Genomic DNA. Translation: BAC06151.1. AY288416 mRNA. Translation: AAP72125.1. AL035423 Genomic DNA. Translation: CAI42442.1. BC095502 mRNA. Translation: AAH95502.1. BC101166 mRNA. Translation: AAI01167.1. BC101167 mRNA. Translation: AAI01168.1. BC101168 mRNA. Translation: AAI01169.1. BC126179 mRNA. Translation: AAI26180.1. BC126181 mRNA. Translation: AAI26182.1.
IPI	IPI00152634.
RefSeq	NP_848566.1. NM_178471.2.
UniGene	Hs.496762.
3D structure databases
ProteinModelPortal	Q8TDV5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000276218.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8TDV5.
Polymorphism databases
DMDM	62510696.
Proteomic databases
PaxDb	Q8TDV5.
PRIDE	Q8TDV5.
Protocols and materials databases
DNASU	139760.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276218; ENSP00000276218; ENSG00000147262.
GeneID	139760.
KEGG	hsa:139760.
UCSC	uc011muv.2. human.
Organism-specific databases
CTD	139760.
GeneCards	GC0XM129518.
HGNC	HGNC:19060. GPR119.
HPA	HPA043747.
MIM	300513. gene.
neXtProt	NX_Q8TDV5.
PharmGKB	PA134928131.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246868.
HOGENOM	HOG000112765.
HOVERGEN	HBG051773.
InParanoid	Q8TDV5.
KO	K08424.
OMA	SFFAVFH.
OrthoDB	EOG4JHCGQ.
PhylomeDB	Q8TDV5.
Gene expression databases
Bgee	Q8TDV5.
CleanEx	HS_GPR119.
Genevestigator	Q8TDV5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8TDV5.
ChEMBL	CHEMBL5652.
GenomeRNAi	139760.
NextBio	84036.
SOURCE	Search...

Entry information

Entry name

GP119_HUMAN

Accession

Primary (citable) accession number: Q8TDV5
Secondary accession number(s): Q495H7, Q4VBN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.