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Q8TDV5

- GP119_HUMAN

UniProt

Q8TDV5 - GP119_HUMAN

Protein

Glucose-dependent insulinotropic receptor

Gene

GPR119

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. phosphatidylcholine binding Source: Ensembl

    GO - Biological processi

    1. insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-dependent insulinotropic receptor
    Alternative name(s):
    G-protein coupled receptor 119
    Gene namesi
    Name:GPR119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:19060. GPR119.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134928131.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Glucose-dependent insulinotropic receptorPRO_0000069607Add
    BLAST

    Proteomic databases

    PaxDbiQ8TDV5.
    PRIDEiQ8TDV5.

    PTM databases

    PhosphoSiteiQ8TDV5.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the pancreas, especially in the islets.1 Publication

    Gene expression databases

    BgeeiQ8TDV5.
    CleanExiHS_GPR119.
    GenevestigatoriQ8TDV5.

    Organism-specific databases

    HPAiHPA043747.

    Interactioni

    Protein-protein interaction databases

    BioGridi126586. 2 interactions.
    STRINGi9606.ENSP00000276218.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDV5.
    SMRiQ8TDV5. Positions 1-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini34 – 374CytoplasmicSequence Analysis
    Topological domaini59 – 8123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22641CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 33552CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG246868.
    HOGENOMiHOG000112765.
    HOVERGENiHBG051773.
    InParanoidiQ8TDV5.
    KOiK08424.
    OMAiSFFAVFH.
    OrthoDBiEOG75B85V.
    PhylomeDBiQ8TDV5.
    TreeFamiTF325411.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028336. GPR119.
    [Graphical view]
    PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TDV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESSFSFGVI LAVLASLIIA TNTLVAVAVL LLIHKNDGVS LCFTLNLAVA    50
    DTLIGVAISG LLTDQLSSPS RPTQKTLCSL RMAFVTSSAA ASVLTVMLIT 100
    FDRYLAIKQP FRYLKIMSGF VAGACIAGLW LVSYLIGFLP LGIPMFQQTA 150
    YKGQCSFFAV FHPHFVLTLS CVGFFPAMLL FVFFYCDMLK IASMHSQQIR 200
    KMEHAGAMAG GYRSPRTPSD FKALRTVSVL IGSFALSWTP FLITGIVQVA 250
    CQECHLYLVL ERYLWLLGVG NSLLNPLIYA YWQKEVRLQL YHMALGVKKV 300
    LTSFLLFLSA RNCGPERPRE SSCHIVTISS SEFDG 335
    Length:335
    Mass (Da):36,889
    Last modified:June 1, 2002 - v1
    Checksum:i16BAF93AEA145FB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti325 – 3251I → T in AAI01167. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti309 – 3091S → L.
    Corresponds to variant rs5975187 [ dbSNP | Ensembl ].
    VAR_037221

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083584 Genomic DNA. Translation: BAB89297.1.
    AB065936 Genomic DNA. Translation: BAC06151.1.
    AY288416 mRNA. Translation: AAP72125.1.
    AL035423 Genomic DNA. Translation: CAI42442.1.
    BC095502 mRNA. Translation: AAH95502.1.
    BC101166 mRNA. Translation: AAI01167.1.
    BC101167 mRNA. Translation: AAI01168.1.
    BC101168 mRNA. Translation: AAI01169.1.
    BC126179 mRNA. Translation: AAI26180.1.
    BC126181 mRNA. Translation: AAI26182.1.
    CCDSiCCDS14625.1.
    RefSeqiNP_848566.1. NM_178471.2.
    UniGeneiHs.496762.

    Genome annotation databases

    EnsembliENST00000276218; ENSP00000276218; ENSG00000147262.
    GeneIDi139760.
    KEGGihsa:139760.
    UCSCiuc011muv.2. human.

    Polymorphism databases

    DMDMi62510696.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083584 Genomic DNA. Translation: BAB89297.1 .
    AB065936 Genomic DNA. Translation: BAC06151.1 .
    AY288416 mRNA. Translation: AAP72125.1 .
    AL035423 Genomic DNA. Translation: CAI42442.1 .
    BC095502 mRNA. Translation: AAH95502.1 .
    BC101166 mRNA. Translation: AAI01167.1 .
    BC101167 mRNA. Translation: AAI01168.1 .
    BC101168 mRNA. Translation: AAI01169.1 .
    BC126179 mRNA. Translation: AAI26180.1 .
    BC126181 mRNA. Translation: AAI26182.1 .
    CCDSi CCDS14625.1.
    RefSeqi NP_848566.1. NM_178471.2.
    UniGenei Hs.496762.

    3D structure databases

    ProteinModelPortali Q8TDV5.
    SMRi Q8TDV5. Positions 1-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126586. 2 interactions.
    STRINGi 9606.ENSP00000276218.

    Chemistry

    BindingDBi Q8TDV5.
    ChEMBLi CHEMBL5652.
    GuidetoPHARMACOLOGYi 126.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8TDV5.

    Polymorphism databases

    DMDMi 62510696.

    Proteomic databases

    PaxDbi Q8TDV5.
    PRIDEi Q8TDV5.

    Protocols and materials databases

    DNASUi 139760.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276218 ; ENSP00000276218 ; ENSG00000147262 .
    GeneIDi 139760.
    KEGGi hsa:139760.
    UCSCi uc011muv.2. human.

    Organism-specific databases

    CTDi 139760.
    GeneCardsi GC0XM129518.
    HGNCi HGNC:19060. GPR119.
    HPAi HPA043747.
    MIMi 300513. gene.
    neXtProti NX_Q8TDV5.
    PharmGKBi PA134928131.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246868.
    HOGENOMi HOG000112765.
    HOVERGENi HBG051773.
    InParanoidi Q8TDV5.
    KOi K08424.
    OMAi SFFAVFH.
    OrthoDBi EOG75B85V.
    PhylomeDBi Q8TDV5.
    TreeFami TF325411.

    Enzyme and pathway databases

    Reactomei REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Miscellaneous databases

    GeneWikii GPR119.
    GenomeRNAii 139760.
    NextBioi 84036.
    PROi Q8TDV5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDV5.
    CleanExi HS_GPR119.
    Genevestigatori Q8TDV5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028336. GPR119.
    [Graphical view ]
    PANTHERi PTHR22750:SF7. PTHR22750:SF7. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor."
      Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K.
      Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, CHARACTERIZATION.
    7. "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents."
      Overton H.A., Babbs A.J., Doel S.M., Fyfe M.C.T., Gardner L.S., Griffin G., Jackson H.C., Procter M.J., Rasamison C.M., Tang-Christensen M., Widdowson P.S., Williams G.M., Reynet C.
      Cell Metab. 3:167-175(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING, FUNCTION.

    Entry informationi

    Entry nameiGP119_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDV5
    Secondary accession number(s): Q495H7, Q4VBN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3