SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TDV5

- GP119_HUMAN

UniProt

Q8TDV5 - GP119_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glucose-dependent insulinotropic receptor
Gene
GPR119
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. phosphatidylcholine binding Source: Ensembl

GO - Biological processi

  1. insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:GPR119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:19060. GPR119.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Extracellular Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini34 – 374Cytoplasmic Reviewed prediction
Transmembranei38 – 5821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini59 – 8123Extracellular Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini103 – 12523Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini147 – 16418Extracellular Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini186 – 22641Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini248 – 26215Extracellular Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini284 – 33552Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Glucose-dependent insulinotropic receptor
PRO_0000069607Add
BLAST

Proteomic databases

PaxDbiQ8TDV5.
PRIDEiQ8TDV5.

PTM databases

PhosphoSiteiQ8TDV5.

Expressioni

Tissue specificityi

Predominantly expressed in the pancreas, especially in the islets.1 Publication

Gene expression databases

BgeeiQ8TDV5.
CleanExiHS_GPR119.
GenevestigatoriQ8TDV5.

Organism-specific databases

HPAiHPA043747.

Interactioni

Protein-protein interaction databases

BioGridi126586. 2 interactions.
STRINGi9606.ENSP00000276218.

Structurei

3D structure databases

ProteinModelPortaliQ8TDV5.
SMRiQ8TDV5. Positions 1-287.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG246868.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ8TDV5.
KOiK08424.
OMAiSFFAVFH.
OrthoDBiEOG75B85V.
PhylomeDBiQ8TDV5.
TreeFamiTF325411.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDV5-1 [UniParc]FASTAAdd to Basket

« Hide

MESSFSFGVI LAVLASLIIA TNTLVAVAVL LLIHKNDGVS LCFTLNLAVA    50
DTLIGVAISG LLTDQLSSPS RPTQKTLCSL RMAFVTSSAA ASVLTVMLIT 100
FDRYLAIKQP FRYLKIMSGF VAGACIAGLW LVSYLIGFLP LGIPMFQQTA 150
YKGQCSFFAV FHPHFVLTLS CVGFFPAMLL FVFFYCDMLK IASMHSQQIR 200
KMEHAGAMAG GYRSPRTPSD FKALRTVSVL IGSFALSWTP FLITGIVQVA 250
CQECHLYLVL ERYLWLLGVG NSLLNPLIYA YWQKEVRLQL YHMALGVKKV 300
LTSFLLFLSA RNCGPERPRE SSCHIVTISS SEFDG 335
Length:335
Mass (Da):36,889
Last modified:June 1, 2002 - v1
Checksum:i16BAF93AEA145FB0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti309 – 3091S → L.
Corresponds to variant rs5975187 [ dbSNP | Ensembl ].
VAR_037221

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251I → T in AAI01167. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083584 Genomic DNA. Translation: BAB89297.1.
AB065936 Genomic DNA. Translation: BAC06151.1.
AY288416 mRNA. Translation: AAP72125.1.
AL035423 Genomic DNA. Translation: CAI42442.1.
BC095502 mRNA. Translation: AAH95502.1.
BC101166 mRNA. Translation: AAI01167.1.
BC101167 mRNA. Translation: AAI01168.1.
BC101168 mRNA. Translation: AAI01169.1.
BC126179 mRNA. Translation: AAI26180.1.
BC126181 mRNA. Translation: AAI26182.1.
CCDSiCCDS14625.1.
RefSeqiNP_848566.1. NM_178471.2.
UniGeneiHs.496762.

Genome annotation databases

EnsembliENST00000276218; ENSP00000276218; ENSG00000147262.
GeneIDi139760.
KEGGihsa:139760.
UCSCiuc011muv.2. human.

Polymorphism databases

DMDMi62510696.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083584 Genomic DNA. Translation: BAB89297.1 .
AB065936 Genomic DNA. Translation: BAC06151.1 .
AY288416 mRNA. Translation: AAP72125.1 .
AL035423 Genomic DNA. Translation: CAI42442.1 .
BC095502 mRNA. Translation: AAH95502.1 .
BC101166 mRNA. Translation: AAI01167.1 .
BC101167 mRNA. Translation: AAI01168.1 .
BC101168 mRNA. Translation: AAI01169.1 .
BC126179 mRNA. Translation: AAI26180.1 .
BC126181 mRNA. Translation: AAI26182.1 .
CCDSi CCDS14625.1.
RefSeqi NP_848566.1. NM_178471.2.
UniGenei Hs.496762.

3D structure databases

ProteinModelPortali Q8TDV5.
SMRi Q8TDV5. Positions 1-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126586. 2 interactions.
STRINGi 9606.ENSP00000276218.

Chemistry

BindingDBi Q8TDV5.
ChEMBLi CHEMBL5652.
GuidetoPHARMACOLOGYi 126.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8TDV5.

Polymorphism databases

DMDMi 62510696.

Proteomic databases

PaxDbi Q8TDV5.
PRIDEi Q8TDV5.

Protocols and materials databases

DNASUi 139760.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276218 ; ENSP00000276218 ; ENSG00000147262 .
GeneIDi 139760.
KEGGi hsa:139760.
UCSCi uc011muv.2. human.

Organism-specific databases

CTDi 139760.
GeneCardsi GC0XM129518.
HGNCi HGNC:19060. GPR119.
HPAi HPA043747.
MIMi 300513. gene.
neXtProti NX_Q8TDV5.
PharmGKBi PA134928131.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246868.
HOGENOMi HOG000112765.
HOVERGENi HBG051773.
InParanoidi Q8TDV5.
KOi K08424.
OMAi SFFAVFH.
OrthoDBi EOG75B85V.
PhylomeDBi Q8TDV5.
TreeFami TF325411.

Enzyme and pathway databases

Reactomei REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

GeneWikii GPR119.
GenomeRNAii 139760.
NextBioi 84036.
PROi Q8TDV5.
SOURCEi Search...

Gene expression databases

Bgeei Q8TDV5.
CleanExi HS_GPR119.
Genevestigatori Q8TDV5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view ]
PANTHERi PTHR22750:SF7. PTHR22750:SF7. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor."
    Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K.
    Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, CHARACTERIZATION.
  7. "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents."
    Overton H.A., Babbs A.J., Doel S.M., Fyfe M.C.T., Gardner L.S., Griffin G., Jackson H.C., Procter M.J., Rasamison C.M., Tang-Christensen M., Widdowson P.S., Williams G.M., Reynet C.
    Cell Metab. 3:167-175(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING, FUNCTION.

Entry informationi

Entry nameiGP119_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV5
Secondary accession number(s): Q495H7, Q4VBN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi