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Protein

Glucose-dependent insulinotropic receptor

Gene

GPR119

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147262-MONOMER.
ReactomeiR-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
SIGNORiQ8TDV5.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:GPR119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:19060. GPR119.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 37CytoplasmicSequence analysis4
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 335CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi139760.
OpenTargetsiENSG00000147262.
PharmGKBiPA134928131.

Chemistry databases

ChEMBLiCHEMBL5652.
GuidetoPHARMACOLOGYi126.

Polymorphism and mutation databases

BioMutaiGPR119.
DMDMi62510696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696071 – 335Glucose-dependent insulinotropic receptorAdd BLAST335

Proteomic databases

PaxDbiQ8TDV5.
PRIDEiQ8TDV5.

PTM databases

iPTMnetiQ8TDV5.
PhosphoSitePlusiQ8TDV5.

Expressioni

Tissue specificityi

Predominantly expressed in the pancreas, especially in the islets.1 Publication

Gene expression databases

BgeeiENSG00000147262.
CleanExiHS_GPR119.

Interactioni

Protein-protein interaction databases

BioGridi126586. 1 interactor.
STRINGi9606.ENSP00000276218.

Chemistry databases

BindingDBiQ8TDV5.

Structurei

3D structure databases

ProteinModelPortaliQ8TDV5.
SMRiQ8TDV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ8TDV5.
KOiK08424.
OMAiQSWCFVL.
OrthoDBiEOG091G0I71.
PhylomeDBiQ8TDV5.
TreeFamiTF325411.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSFSFGVI LAVLASLIIA TNTLVAVAVL LLIHKNDGVS LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LLTDQLSSPS RPTQKTLCSL RMAFVTSSAA ASVLTVMLIT
110 120 130 140 150
FDRYLAIKQP FRYLKIMSGF VAGACIAGLW LVSYLIGFLP LGIPMFQQTA
160 170 180 190 200
YKGQCSFFAV FHPHFVLTLS CVGFFPAMLL FVFFYCDMLK IASMHSQQIR
210 220 230 240 250
KMEHAGAMAG GYRSPRTPSD FKALRTVSVL IGSFALSWTP FLITGIVQVA
260 270 280 290 300
CQECHLYLVL ERYLWLLGVG NSLLNPLIYA YWQKEVRLQL YHMALGVKKV
310 320 330
LTSFLLFLSA RNCGPERPRE SSCHIVTISS SEFDG
Length:335
Mass (Da):36,889
Last modified:June 1, 2002 - v1
Checksum:i16BAF93AEA145FB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325I → T in AAI01167 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037221309S → L.Corresponds to variant rs5975187dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083584 Genomic DNA. Translation: BAB89297.1.
AB065936 Genomic DNA. Translation: BAC06151.1.
AY288416 mRNA. Translation: AAP72125.1.
AL035423 Genomic DNA. Translation: CAI42442.1.
BC095502 mRNA. Translation: AAH95502.1.
BC101166 mRNA. Translation: AAI01167.1.
BC101167 mRNA. Translation: AAI01168.1.
BC101168 mRNA. Translation: AAI01169.1.
BC126179 mRNA. Translation: AAI26180.1.
BC126181 mRNA. Translation: AAI26182.1.
CCDSiCCDS14625.1.
RefSeqiNP_848566.1. NM_178471.2.
UniGeneiHs.496762.

Genome annotation databases

EnsembliENST00000276218; ENSP00000276218; ENSG00000147262.
GeneIDi139760.
KEGGihsa:139760.
UCSCiuc011muv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083584 Genomic DNA. Translation: BAB89297.1.
AB065936 Genomic DNA. Translation: BAC06151.1.
AY288416 mRNA. Translation: AAP72125.1.
AL035423 Genomic DNA. Translation: CAI42442.1.
BC095502 mRNA. Translation: AAH95502.1.
BC101166 mRNA. Translation: AAI01167.1.
BC101167 mRNA. Translation: AAI01168.1.
BC101168 mRNA. Translation: AAI01169.1.
BC126179 mRNA. Translation: AAI26180.1.
BC126181 mRNA. Translation: AAI26182.1.
CCDSiCCDS14625.1.
RefSeqiNP_848566.1. NM_178471.2.
UniGeneiHs.496762.

3D structure databases

ProteinModelPortaliQ8TDV5.
SMRiQ8TDV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126586. 1 interactor.
STRINGi9606.ENSP00000276218.

Chemistry databases

BindingDBiQ8TDV5.
ChEMBLiCHEMBL5652.
GuidetoPHARMACOLOGYi126.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDV5.
PhosphoSitePlusiQ8TDV5.

Polymorphism and mutation databases

BioMutaiGPR119.
DMDMi62510696.

Proteomic databases

PaxDbiQ8TDV5.
PRIDEiQ8TDV5.

Protocols and materials databases

DNASUi139760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276218; ENSP00000276218; ENSG00000147262.
GeneIDi139760.
KEGGihsa:139760.
UCSCiuc011muv.3. human.

Organism-specific databases

CTDi139760.
DisGeNETi139760.
GeneCardsiGPR119.
HGNCiHGNC:19060. GPR119.
MIMi300513. gene.
neXtProtiNX_Q8TDV5.
OpenTargetsiENSG00000147262.
PharmGKBiPA134928131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ8TDV5.
KOiK08424.
OMAiQSWCFVL.
OrthoDBiEOG091G0I71.
PhylomeDBiQ8TDV5.
TreeFamiTF325411.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147262-MONOMER.
ReactomeiR-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
SIGNORiQ8TDV5.

Miscellaneous databases

GeneWikiiGPR119.
GenomeRNAii139760.
PROiQ8TDV5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147262.
CleanExiHS_GPR119.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP119_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV5
Secondary accession number(s): Q495H7, Q4VBN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.