Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 148

Gene

GPR148

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 148
Alternative name(s):
Brain and testis restricted GPCR
G-protein coupled receptor PGR6
Gene namesi
Name:GPR148
Synonyms:BTR, PGR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23623. GPR148.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51ExtracellularSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 85CytoplasmicSequence analysisAdd BLAST13
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 130ExtracellularSequence analysisAdd BLAST24
Transmembranei131 – 151Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini152 – 165CytoplasmicSequence analysisAdd BLAST14
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 214ExtracellularSequence analysisAdd BLAST28
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 261CytoplasmicSequence analysisAdd BLAST26
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 299ExtracellularSequence analysisAdd BLAST17
Transmembranei300 – 322Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini323 – 347CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173302.
PharmGKBiPA134942667.

Polymorphism and mutation databases

BioMutaiGPR148.
DMDMi311033389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696251 – 347Probable G-protein coupled receptor 148Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TDV2.
PeptideAtlasiQ8TDV2.
PRIDEiQ8TDV2.

PTM databases

iPTMnetiQ8TDV2.
PhosphoSitePlusiQ8TDV2.

Expressioni

Tissue specificityi

Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.1 Publication

Gene expression databases

BgeeiENSG00000173302.
CleanExiHS_GPR148.

Organism-specific databases

HPAiHPA060527.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308908.

Structurei

3D structure databases

ProteinModelPortaliQ8TDV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi107 – 110Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00510000049775.
HOGENOMiHOG000168260.
InParanoidiQ8TDV2.
KOiK08432.
OMAiTYLAVIH.
OrthoDBiEOG091G0DIK.
PhylomeDBiQ8TDV2.
TreeFamiTF333617.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDELAPCPV GTTAWPALIQ LISKTPCMPQ AASNTSLGLG DLRVPSSMLY
60 70 80 90 100
WLFLPSSLLA AATLAVSPLL LVTILRNQRL RQEPHYLLPA NILLSDLAYI
110 120 130 140 150
LLHMLISSSS LGGWELGRMA CGILTDAVFA ACTSTILSFT AIVLHTYLAV
160 170 180 190 200
IHPLRYLSFM SHGAAWKAVA LIWLVACCFP TFLIWLSKWQ DAQLEEQGAS
210 220 230 240 250
YILPPSMGTQ PGCGLLVIVT YTSILCVLFL CTALIANCFW RIYAEAKTSG
260 270 280 290 300
IWGQGYSRAR GTLLIHSVLI TLYVSTGVVF SLDMVLTRYH HIDSGTHTWL
310 320 330 340
LAANSEVLMM LPRAMLTYLY LLRYRQLLGM VRGHLPSRRH QAIFTIS
Length:347
Mass (Da):38,288
Last modified:November 2, 2010 - v2
Checksum:iEA2ECACE2BD542A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 62CMPQA…LLAAA → SS in AAP34196 (PubMed:15688318).CuratedAdd BLAST36
Sequence conflicti130A → D in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti138S → F in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti141A → G in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti155R → G in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti168A → P in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti171L → F in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti199A → V in AAP34196 (PubMed:15688318).Curated1
Sequence conflicti215L → F in AAP34196 (PubMed:15688318).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049403317T → P.4 PublicationsCorresponds to variant rs272128dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083589 Genomic DNA. Translation: BAB89302.1.
AY280965 mRNA. Translation: AAP34196.1.
AY569570 mRNA. Translation: AAS76892.1.
AC140481 Genomic DNA. No translation available.
BC105013 mRNA. Translation: AAI05014.1.
BC105041 mRNA. Translation: AAI05042.1.
AY255532 mRNA. Translation: AAO85044.1.
CCDSiCCDS2163.1.
RefSeqiNP_997247.2. NM_207364.2.
UniGeneiHs.452574.

Genome annotation databases

EnsembliENST00000309926; ENSP00000308908; ENSG00000173302.
GeneIDi344561.
KEGGihsa:344561.
UCSCiuc002trv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083589 Genomic DNA. Translation: BAB89302.1.
AY280965 mRNA. Translation: AAP34196.1.
AY569570 mRNA. Translation: AAS76892.1.
AC140481 Genomic DNA. No translation available.
BC105013 mRNA. Translation: AAI05014.1.
BC105041 mRNA. Translation: AAI05042.1.
AY255532 mRNA. Translation: AAO85044.1.
CCDSiCCDS2163.1.
RefSeqiNP_997247.2. NM_207364.2.
UniGeneiHs.452574.

3D structure databases

ProteinModelPortaliQ8TDV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308908.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDV2.
PhosphoSitePlusiQ8TDV2.

Polymorphism and mutation databases

BioMutaiGPR148.
DMDMi311033389.

Proteomic databases

PaxDbiQ8TDV2.
PeptideAtlasiQ8TDV2.
PRIDEiQ8TDV2.

Protocols and materials databases

DNASUi344561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309926; ENSP00000308908; ENSG00000173302.
GeneIDi344561.
KEGGihsa:344561.
UCSCiuc002trv.2. human.

Organism-specific databases

CTDi344561.
GeneCardsiGPR148.
HGNCiHGNC:23623. GPR148.
HPAiHPA060527.
neXtProtiNX_Q8TDV2.
OpenTargetsiENSG00000173302.
PharmGKBiPA134942667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00510000049775.
HOGENOMiHOG000168260.
InParanoidiQ8TDV2.
KOiK08432.
OMAiTYLAVIH.
OrthoDBiEOG091G0DIK.
PhylomeDBiQ8TDV2.
TreeFamiTF333617.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173302-MONOMER.

Miscellaneous databases

GeneWikiiGPR148.
GenomeRNAii344561.
PROiQ8TDV2.

Gene expression databases

BgeeiENSG00000173302.
CleanExiHS_GPR148.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP148_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV2
Secondary accession number(s): Q2M369, Q86SP7, Q86U87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.