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Q8TDV0 (GP151_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene names
Name:GPR151
Synonyms:PGR7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05899.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Probable G-protein coupled receptor 151
PRO_0000069632

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 719Cytoplasmic Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 11624Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15316Cytoplasmic Potential
Transmembrane154 – 17421Helical; Name=4; Potential
Topological domain175 – 20127Extracellular Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Topological domain223 – 25230Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28613Extracellular Potential
Transmembrane287 – 30721Helical; Name=7; Potential
Topological domain308 – 419112Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 187 By similarity

Natural variations

Natural variant401P → L.
Corresponds to variant rs17104742 [ dbSNP | Ensembl ].
VAR_049404
Natural variant1441A → V.
Corresponds to variant rs7713676 [ dbSNP | Ensembl ].
VAR_049405
Natural variant2611L → V.
Corresponds to variant rs7709485 [ dbSNP | Ensembl ].
VAR_049406

Sequences

Sequence LengthMass (Da)Tools
Q8TDV0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 769780E6B1FC6140

FASTA41946,637
        10         20         30         40         50         60 
MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG FVGNLCVIGI 

        70         80         90        100        110        120 
LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS KSVWDLGWFV CKSSDWFIHT 

       130        140        150        160        170        180 
CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH NYTIWSVLVA IWTVASLLPL PEWFFSTIRH 

       190        200        210        220        230        240 
HEGVEMCLVD VPAVAEEFMS MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR 

       250        260        270        280        290        300 
NQIRSKQVTV MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS 

       310        320        330        340        350        360 
ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV PSPESPASIP 

       370        380        390        400        410 
EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ DNDPIPWEHE DQETGEGVK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel G-protein-coupled receptor."
Ignatov A., Schaller H.C.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-274.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY351676 mRNA. Translation: AAQ62567.1.
AB083592 Genomic DNA. Translation: BAB89305.1.
AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation.
AY255557 mRNA. Translation: AAO85069.1.
RefSeqNP_919227.2. NM_194251.2.
UniGeneHs.483732.

3D structure databases

ProteinModelPortalQ8TDV0.
SMRQ8TDV0. Positions 36-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308733.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8TDV0.

Polymorphism databases

DMDM48428097.

Proteomic databases

PaxDbQ8TDV0.
PRIDEQ8TDV0.

Protocols and materials databases

DNASU134391.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311104; ENSP00000308733; ENSG00000173250.
GeneID134391.
KEGGhsa:134391.
UCSCuc003lod.1. human.

Organism-specific databases

CTD134391.
GeneCardsGC05M145874.
HGNCHGNC:23624. GPR151.
neXtProtNX_Q8TDV0.
PharmGKBPA134975199.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288736.
HOGENOMHOG000112774.
HOVERGENHBG051787.
InParanoidQ8TDV0.
KOK08435.
OMACKSSDWF.
OrthoDBEOG74FF0X.
PhylomeDBQ8TDV0.
TreeFamTF332591.

Gene expression databases

BgeeQ8TDV0.
CleanExHS_GPR151.
GenevestigatorQ8TDV0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR151.
GenomeRNAi134391.
NextBio83369.
PROQ8TDV0.

Entry information

Entry nameGP151_HUMAN
AccessionPrimary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries