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Q8TDV0

- GP151_HUMAN

UniProt

Q8TDV0 - GP151_HUMAN

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Protein

Probable G-protein coupled receptor 151

Gene
GPR151, PGR7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene namesi
Name:GPR151
Synonyms:PGR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:23624. GPR151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Extracellular Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini63 – 719Cytoplasmic Reviewed prediction
Transmembranei72 – 9221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini93 – 11624Extracellular Reviewed predictionAdd
BLAST
Transmembranei117 – 13721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini138 – 15316Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei154 – 17421Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini175 – 20127Extracellular Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini223 – 25230Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei253 – 27321Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini274 – 28613Extracellular Reviewed predictionAdd
BLAST
Transmembranei287 – 30721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini308 – 419112Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134975199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Probable G-protein coupled receptor 151PRO_0000069632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDV0.
PRIDEiQ8TDV0.

PTM databases

PhosphoSiteiQ8TDV0.

Expressioni

Gene expression databases

BgeeiQ8TDV0.
CleanExiHS_GPR151.
GenevestigatoriQ8TDV0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308733.

Structurei

3D structure databases

ProteinModelPortaliQ8TDV0.
SMRiQ8TDV0. Positions 32-322.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288736.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ8TDV0.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ8TDV0.
TreeFamiTF332591.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDV0-1 [UniParc]FASTAAdd to Basket

« Hide

MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG    50
FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS 100
KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH 150
NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS 200
MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV 250
MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS 300
ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV 350
PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ 400
DNDPIPWEHE DQETGEGVK 419
Length:419
Mass (Da):46,637
Last modified:June 1, 2002 - v1
Checksum:i769780E6B1FC6140
GO

Sequence cautioni

The sequence BAC05899.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401P → L.
Corresponds to variant rs17104742 [ dbSNP | Ensembl ].
VAR_049404
Natural varianti144 – 1441A → V.
Corresponds to variant rs7713676 [ dbSNP | Ensembl ].
VAR_049405
Natural varianti261 – 2611L → V.
Corresponds to variant rs7709485 [ dbSNP | Ensembl ].
VAR_049406

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY351676 mRNA. Translation: AAQ62567.1.
AB083592 Genomic DNA. Translation: BAB89305.1.
AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation.
AY255557 mRNA. Translation: AAO85069.1.
CCDSiCCDS34266.1.
RefSeqiNP_919227.2. NM_194251.2.
UniGeneiHs.483732.

Genome annotation databases

EnsembliENST00000311104; ENSP00000308733; ENSG00000173250.
GeneIDi134391.
KEGGihsa:134391.
UCSCiuc003lod.1. human.

Polymorphism databases

DMDMi48428097.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY351676 mRNA. Translation: AAQ62567.1 .
AB083592 Genomic DNA. Translation: BAB89305.1 .
AB065674 Genomic DNA. Translation: BAC05899.1 . Different initiation.
AY255557 mRNA. Translation: AAO85069.1 .
CCDSi CCDS34266.1.
RefSeqi NP_919227.2. NM_194251.2.
UniGenei Hs.483732.

3D structure databases

ProteinModelPortali Q8TDV0.
SMRi Q8TDV0. Positions 32-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308733.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8TDV0.

Polymorphism databases

DMDMi 48428097.

Proteomic databases

PaxDbi Q8TDV0.
PRIDEi Q8TDV0.

Protocols and materials databases

DNASUi 134391.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311104 ; ENSP00000308733 ; ENSG00000173250 .
GeneIDi 134391.
KEGGi hsa:134391.
UCSCi uc003lod.1. human.

Organism-specific databases

CTDi 134391.
GeneCardsi GC05M145874.
HGNCi HGNC:23624. GPR151.
neXtProti NX_Q8TDV0.
PharmGKBi PA134975199.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288736.
HOGENOMi HOG000112774.
HOVERGENi HBG051787.
InParanoidi Q8TDV0.
KOi K08435.
OMAi CKSSDWF.
OrthoDBi EOG74FF0X.
PhylomeDBi Q8TDV0.
TreeFami TF332591.

Miscellaneous databases

GeneWikii GPR151.
GenomeRNAii 134391.
NextBioi 83369.
PROi Q8TDV0.

Gene expression databases

Bgeei Q8TDV0.
CleanExi HS_GPR151.
Genevestigatori Q8TDV0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel G-protein-coupled receptor."
    Ignatov A., Schaller H.C.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-274.

Entry informationi

Entry nameiGP151_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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