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Q8TDV0

- GP151_HUMAN

UniProt

Q8TDV0 - GP151_HUMAN

Protein

Probable G-protein coupled receptor 151

Gene

GPR151

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 151
    Alternative name(s):
    G-protein coupled receptor PGR7
    GPCR-2037
    Gene namesi
    Name:GPR151
    Synonyms:PGR7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:23624. GPR151.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134975199.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Probable G-protein coupled receptor 151PRO_0000069632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TDV0.
    PRIDEiQ8TDV0.

    PTM databases

    PhosphoSiteiQ8TDV0.

    Expressioni

    Gene expression databases

    BgeeiQ8TDV0.
    CleanExiHS_GPR151.
    GenevestigatoriQ8TDV0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDV0.
    SMRiQ8TDV0. Positions 32-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 719CytoplasmicSequence Analysis
    Topological domaini93 – 11624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 20127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 25230CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini308 – 419112CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288736.
    HOGENOMiHOG000112774.
    HOVERGENiHBG051787.
    InParanoidiQ8TDV0.
    KOiK08435.
    OMAiCKSSDWF.
    OrthoDBiEOG74FF0X.
    PhylomeDBiQ8TDV0.
    TreeFamiTF332591.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TDV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG    50
    FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS 100
    KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH 150
    NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS 200
    MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV 250
    MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS 300
    ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV 350
    PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ 400
    DNDPIPWEHE DQETGEGVK 419
    Length:419
    Mass (Da):46,637
    Last modified:June 1, 2002 - v1
    Checksum:i769780E6B1FC6140
    GO

    Sequence cautioni

    The sequence BAC05899.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401P → L.
    Corresponds to variant rs17104742 [ dbSNP | Ensembl ].
    VAR_049404
    Natural varianti144 – 1441A → V.
    Corresponds to variant rs7713676 [ dbSNP | Ensembl ].
    VAR_049405
    Natural varianti261 – 2611L → V.
    Corresponds to variant rs7709485 [ dbSNP | Ensembl ].
    VAR_049406

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY351676 mRNA. Translation: AAQ62567.1.
    AB083592 Genomic DNA. Translation: BAB89305.1.
    AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation.
    AY255557 mRNA. Translation: AAO85069.1.
    CCDSiCCDS34266.1.
    RefSeqiNP_919227.2. NM_194251.2.
    UniGeneiHs.483732.

    Genome annotation databases

    EnsembliENST00000311104; ENSP00000308733; ENSG00000173250.
    GeneIDi134391.
    KEGGihsa:134391.
    UCSCiuc003lod.1. human.

    Polymorphism databases

    DMDMi48428097.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY351676 mRNA. Translation: AAQ62567.1 .
    AB083592 Genomic DNA. Translation: BAB89305.1 .
    AB065674 Genomic DNA. Translation: BAC05899.1 . Different initiation.
    AY255557 mRNA. Translation: AAO85069.1 .
    CCDSi CCDS34266.1.
    RefSeqi NP_919227.2. NM_194251.2.
    UniGenei Hs.483732.

    3D structure databases

    ProteinModelPortali Q8TDV0.
    SMRi Q8TDV0. Positions 32-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308733.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8TDV0.

    Polymorphism databases

    DMDMi 48428097.

    Proteomic databases

    PaxDbi Q8TDV0.
    PRIDEi Q8TDV0.

    Protocols and materials databases

    DNASUi 134391.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311104 ; ENSP00000308733 ; ENSG00000173250 .
    GeneIDi 134391.
    KEGGi hsa:134391.
    UCSCi uc003lod.1. human.

    Organism-specific databases

    CTDi 134391.
    GeneCardsi GC05M145874.
    HGNCi HGNC:23624. GPR151.
    neXtProti NX_Q8TDV0.
    PharmGKBi PA134975199.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288736.
    HOGENOMi HOG000112774.
    HOVERGENi HBG051787.
    InParanoidi Q8TDV0.
    KOi K08435.
    OMAi CKSSDWF.
    OrthoDBi EOG74FF0X.
    PhylomeDBi Q8TDV0.
    TreeFami TF332591.

    Miscellaneous databases

    GeneWikii GPR151.
    GenomeRNAii 134391.
    NextBioi 83369.
    PROi Q8TDV0.

    Gene expression databases

    Bgeei Q8TDV0.
    CleanExi HS_GPR151.
    Genevestigatori Q8TDV0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel G-protein-coupled receptor."
      Ignatov A., Schaller H.C.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-274.

    Entry informationi

    Entry nameiGP151_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDV0
    Secondary accession number(s): Q86SN8, Q8NGV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3