Q8TDV0 (GP151_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 151

Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037

Gene names

Name:	GPR151
Synonyms:	PGR7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05899.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Probable G-protein coupled receptor 151		PRO_0000069632
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 62	21	Helical; Name=1; Potential
	Topological domain	63 – 71	9	Cytoplasmic Potential
	Transmembrane	72 – 92	21	Helical; Name=2; Potential
	Topological domain	93 – 116	24	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 153	16	Cytoplasmic Potential
	Transmembrane	154 – 174	21	Helical; Name=4; Potential
	Topological domain	175 – 201	27	Extracellular Potential
	Transmembrane	202 – 222	21	Helical; Name=5; Potential
	Topological domain	223 – 252	30	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Name=6; Potential
	Topological domain	274 – 286	13	Extracellular Potential
	Transmembrane	287 – 307	21	Helical; Name=7; Potential
	Topological domain	308 – 419	112	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 187		By similarity
Natural variations
	Natural variant	40	1	P → L. Corresponds to variant rs17104742 [ dbSNP | Ensembl ].		VAR_049404
	Natural variant	144	1	A → V. Corresponds to variant rs7713676 [ dbSNP | Ensembl ].		VAR_049405
	Natural variant	261	1	L → V. Corresponds to variant rs7709485 [ dbSNP | Ensembl ].		VAR_049406

Sequences

	Sequence		Length	Mass (Da)
	Q8TDV0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 769780E6B1FC6140	FASTA	419	46,637
	10 20 30 40 50 60 MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG FVGNLCVIGI 70 80 90 100 110 120 LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS KSVWDLGWFV CKSSDWFIHT 130 140 150 160 170 180 CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH NYTIWSVLVA IWTVASLLPL PEWFFSTIRH 190 200 210 220 230 240 HEGVEMCLVD VPAVAEEFMS MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR 250 260 270 280 290 300 NQIRSKQVTV MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS 310 320 330 340 350 360 ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV PSPESPASIP 370 380 390 400 410 EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ DNDPIPWEHE DQETGEGVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel G-protein-coupled receptor." Ignatov A., Schaller H.C. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-274.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY351676 mRNA. Translation: AAQ62567.1. AB083592 Genomic DNA. Translation: BAB89305.1. AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation. AY255557 mRNA. Translation: AAO85069.1.
IPI	IPI00375312.
RefSeq	NP_919227.2. NM_194251.2.
UniGene	Hs.483732.
3D structure databases
ProteinModelPortal	Q8TDV0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308733.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8TDV0.
Polymorphism databases
DMDM	48428097.
Proteomic databases
PaxDb	Q8TDV0.
PRIDE	Q8TDV0.
Protocols and materials databases
DNASU	134391.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311104; ENSP00000308733; ENSG00000173250.
GeneID	134391.
KEGG	hsa:134391.
UCSC	uc003lod.1. human.
Organism-specific databases
CTD	134391.
GeneCards	GC05M145874.
HGNC	HGNC:23624. GPR151.
neXtProt	NX_Q8TDV0.
PharmGKB	PA134975199.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288736.
HOGENOM	HOG000112774.
HOVERGEN	HBG051787.
InParanoid	Q8TDV0.
KO	K08435.
OMA	FGKLYPL.
OrthoDB	EOG4N5VX8.
PhylomeDB	Q8TDV0.
Gene expression databases
Bgee	Q8TDV0.
CleanEx	HS_GPR151.
Genevestigator	Q8TDV0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	134391.
NextBio	83369.

Entry information

Entry name

GP151_HUMAN

Accession

Primary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.