Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 151

Gene

GPR151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene namesi
Name:GPR151
Synonyms:PGR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23624. GPR151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 719CytoplasmicSequence Analysis
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 20127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 25230CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 419112CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134975199.

Polymorphism and mutation databases

BioMutaiGPR151.
DMDMi48428097.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Probable G-protein coupled receptor 151PRO_0000069632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDV0.
PRIDEiQ8TDV0.

PTM databases

PhosphoSiteiQ8TDV0.

Expressioni

Gene expression databases

BgeeiQ8TDV0.
CleanExiHS_GPR151.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308733.

Structurei

3D structure databases

ProteinModelPortaliQ8TDV0.
SMRiQ8TDV0. Positions 32-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288736.
GeneTreeiENSGT00640000091572.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ8TDV0.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ8TDV0.
TreeFamiTF332591.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG
60 70 80 90 100
FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS
110 120 130 140 150
KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH
160 170 180 190 200
NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS
210 220 230 240 250
MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV
260 270 280 290 300
MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS
310 320 330 340 350
ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV
360 370 380 390 400
PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ
410
DNDPIPWEHE DQETGEGVK
Length:419
Mass (Da):46,637
Last modified:June 1, 2002 - v1
Checksum:i769780E6B1FC6140
GO

Sequence cautioni

The sequence BAC05899.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401P → L.
Corresponds to variant rs17104742 [ dbSNP | Ensembl ].
VAR_049404
Natural varianti144 – 1441A → V.
Corresponds to variant rs7713676 [ dbSNP | Ensembl ].
VAR_049405
Natural varianti261 – 2611L → V.
Corresponds to variant rs7709485 [ dbSNP | Ensembl ].
VAR_049406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351676 mRNA. Translation: AAQ62567.1.
AB083592 Genomic DNA. Translation: BAB89305.1.
AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation.
AY255557 mRNA. Translation: AAO85069.1.
CCDSiCCDS34266.1.
RefSeqiNP_919227.2. NM_194251.2.
UniGeneiHs.483732.

Genome annotation databases

EnsembliENST00000311104; ENSP00000308733; ENSG00000173250.
GeneIDi134391.
KEGGihsa:134391.
UCSCiuc003lod.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351676 mRNA. Translation: AAQ62567.1.
AB083592 Genomic DNA. Translation: BAB89305.1.
AB065674 Genomic DNA. Translation: BAC05899.1. Different initiation.
AY255557 mRNA. Translation: AAO85069.1.
CCDSiCCDS34266.1.
RefSeqiNP_919227.2. NM_194251.2.
UniGeneiHs.483732.

3D structure databases

ProteinModelPortaliQ8TDV0.
SMRiQ8TDV0. Positions 32-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308733.

Chemistry

ChEMBLiCHEMBL3085617.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8TDV0.

Polymorphism and mutation databases

BioMutaiGPR151.
DMDMi48428097.

Proteomic databases

PaxDbiQ8TDV0.
PRIDEiQ8TDV0.

Protocols and materials databases

DNASUi134391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311104; ENSP00000308733; ENSG00000173250.
GeneIDi134391.
KEGGihsa:134391.
UCSCiuc003lod.1. human.

Organism-specific databases

CTDi134391.
GeneCardsiGC05M145874.
HGNCiHGNC:23624. GPR151.
neXtProtiNX_Q8TDV0.
PharmGKBiPA134975199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288736.
GeneTreeiENSGT00640000091572.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ8TDV0.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ8TDV0.
TreeFamiTF332591.

Miscellaneous databases

GeneWikiiGPR151.
GenomeRNAii134391.
NextBioi83369.
PROiQ8TDV0.

Gene expression databases

BgeeiQ8TDV0.
CleanExiHS_GPR151.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel G-protein-coupled receptor."
    Ignatov A., Schaller H.C.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-274.

Entry informationi

Entry nameiGP151_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.