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Q8TDU9

- RL3R2_HUMAN

UniProt

Q8TDU9 - RL3R2_HUMAN

Protein

Relaxin-3 receptor 2

Gene

RXFP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.2 Publications

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: InterPro
    2. protein binding Source: IntAct

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.
    REACT_21314. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Relaxin-3 receptor 2
    Short name:
    RLN3 receptor 2
    Alternative name(s):
    G-protein coupled receptor 100
    G-protein coupled receptor GPCR142
    Insulin-like peptide INSL5 receptor
    Relaxin family peptide receptor 4
    Gene namesi
    Name:RXFP4
    Synonyms:GPR100, RLN3R2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14666. RXFP4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28848.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Relaxin-3 receptor 2PRO_0000070106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TDU9.
    PRIDEiQ8TDU9.

    PTM databases

    PhosphoSiteiQ8TDU9.

    Expressioni

    Tissue specificityi

    Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.1 Publication

    Gene expression databases

    BgeeiQ8TDU9.
    CleanExiHS_RXFP4.
    GenevestigatoriQ8TDU9.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RLN3Q8WXF39EBI-9519524,EBI-9519546

    Protein-protein interaction databases

    BioGridi130880. 1 interaction.
    IntActiQ8TDU9. 1 interaction.
    STRINGi9606.ENSP00000357301.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDU9.
    SMRiQ8TDU9. Positions 36-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini271 – 28111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 37472CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292372.
    HOGENOMiHOG000230485.
    HOVERGENiHBG101327.
    InParanoidiQ8TDU9.
    KOiK08398.
    OMAiCLLRFPS.
    OrthoDBiEOG7ZD1VG.
    PhylomeDBiQ8TDU9.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TDU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTLNTSASP PTFFWANASG GSVLSADDAP MPVKFLALRL MVALAYGLVG    50
    AIGLLGNLAV LWVLSNCARR APGPPSDTFV FNLALADLGL ALTLPFWAAE 100
    SALDFHWPFG GALCKMVLTA TVLNVYASIF LITALSVARY WVVAMAAGPG 150
    THLSLFWARI ATLAVWAAAA LVTVPTAVFG VEGEVCGVRL CLLRFPSRYW 200
    LGAYQLQRVV LAFMVPLGVI TTSYLLLLAF LQRRQRRRQD SRVVARSVRI 250
    LVASFFLCWF PNHVVTLWGV LVKFDLVPWN STFYTIQTYV FPVTTCLAHS 300
    NSCLNPVLYC LLRREPRQAL AGTFRDLRLR LWPQGGGWVQ QVALKQVGRR 350
    WVASNPRESR PSTLLTNLDR GTPG 374
    Length:374
    Mass (Da):41,141
    Last modified:June 1, 2002 - v1
    Checksum:i1929EA812C0804DA
    GO

    Sequence cautioni

    The sequence BAC05844.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti329 – 3291L → S.3 Publications
    Corresponds to variant rs2152051 [ dbSNP | Ensembl ].
    VAR_021516

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY394502 mRNA. Translation: AAQ92316.1.
    AY288415 mRNA. Translation: AAP72124.1.
    AY170824 mRNA. Translation: AAO17676.1.
    AB065617 Genomic DNA. Translation: BAC05844.1. Sequence problems.
    AB083593 Genomic DNA. Translation: BAB89306.1.
    AL355388 Genomic DNA. Translation: CAH72626.1.
    EU432129 mRNA. Translation: ABY87928.1.
    BC101507 mRNA. Translation: AAI01508.1.
    BC101509 mRNA. Translation: AAI01510.1.
    CCDSiCCDS1124.1.
    RefSeqiNP_871001.1. NM_181885.2.
    UniGeneiHs.449914.

    Genome annotation databases

    EnsembliENST00000368318; ENSP00000357301; ENSG00000173080.
    GeneIDi339403.
    KEGGihsa:339403.
    UCSCiuc010pgs.2. human.

    Polymorphism databases

    DMDMi38258194.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY394502 mRNA. Translation: AAQ92316.1 .
    AY288415 mRNA. Translation: AAP72124.1 .
    AY170824 mRNA. Translation: AAO17676.1 .
    AB065617 Genomic DNA. Translation: BAC05844.1 . Sequence problems.
    AB083593 Genomic DNA. Translation: BAB89306.1 .
    AL355388 Genomic DNA. Translation: CAH72626.1 .
    EU432129 mRNA. Translation: ABY87928.1 .
    BC101507 mRNA. Translation: AAI01508.1 .
    BC101509 mRNA. Translation: AAI01510.1 .
    CCDSi CCDS1124.1.
    RefSeqi NP_871001.1. NM_181885.2.
    UniGenei Hs.449914.

    3D structure databases

    ProteinModelPortali Q8TDU9.
    SMRi Q8TDU9. Positions 36-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130880. 1 interaction.
    IntActi Q8TDU9. 1 interaction.
    STRINGi 9606.ENSP00000357301.

    Chemistry

    ChEMBLi CHEMBL1628473.
    GuidetoPHARMACOLOGYi 354.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8TDU9.

    Polymorphism databases

    DMDMi 38258194.

    Proteomic databases

    PaxDbi Q8TDU9.
    PRIDEi Q8TDU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368318 ; ENSP00000357301 ; ENSG00000173080 .
    GeneIDi 339403.
    KEGGi hsa:339403.
    UCSCi uc010pgs.2. human.

    Organism-specific databases

    CTDi 339403.
    GeneCardsi GC01P155911.
    HGNCi HGNC:14666. RXFP4.
    MIMi 609043. gene.
    neXtProti NX_Q8TDU9.
    PharmGKBi PA28848.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292372.
    HOGENOMi HOG000230485.
    HOVERGENi HBG101327.
    InParanoidi Q8TDU9.
    KOi K08398.
    OMAi CLLRFPS.
    OrthoDBi EOG7ZD1VG.
    PhylomeDBi Q8TDU9.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.
    REACT_21314. Relaxin receptors.

    Miscellaneous databases

    GeneWikii Relaxin/insulin-like_family_peptide_receptor_4.
    GenomeRNAii 339403.
    NextBioi 97386.
    PROi Q8TDU9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDU9.
    CleanExi HS_RXFP4.
    Genevestigatori Q8TDU9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-329, FUNCTION AS A RECEPTOR FOR RLN3.
    2. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor."
      Boels K., Schaller H.C.
      Br. J. Pharmacol. 140:932-938(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH BRADYKININ AND KALLIDIN.
      Tissue: Pancreatic carcinoma.
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-329.
      Tissue: Testis.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-329.
      Tissue: Brain.
    9. Cited for: FUNCTION AS A RECEPTOR FOR INSL5.

    Entry informationi

    Entry nameiRL3R2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDU9
    Secondary accession number(s): B0M0L4, Q3MJB1, Q8NGZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3