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Protein

G-protein coupled bile acid receptor 1

Gene

GPBAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.2 Publications

GO - Molecular functioni

  • bile acid receptor activity Source: UniProtKB
  • G-protein coupled bile acid receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418555. G alpha (s) signalling events.

Chemistry

SwissLipidsiSLP:000001566.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Alternative name(s):
G-protein coupled receptor GPCR19
Short name:
hGPCR19
Membrane-type receptor for bile acids
Short name:
M-BAR
hBG37
Short name:
BG37
Gene namesi
Name:GPBAR1
Synonyms:TGR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19680. GPBAR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence analysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini41 – 5010CytoplasmicSequence analysis
Transmembranei51 – 7121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini72 – 8514ExtracellularSequence analysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini107 – 12519CytoplasmicSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 16519ExtracellularSequence analysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini187 – 22842CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini250 – 26112ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini283 – 33048CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903170.

Chemistry

ChEMBLiCHEMBL5409.
GuidetoPHARMACOLOGYi37.

Polymorphism and mutation databases

BioMutaiGPBAR1.
DMDMi74762624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330G-protein coupled bile acid receptor 1PRO_0000069500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 155PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDU6.
PRIDEiQ8TDU6.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.3 Publications

Gene expression databases

BgeeiQ8TDU6.
CleanExiHS_GPBAR1.
GenevisibleiQ8TDU6. HS.

Organism-specific databases

HPAiHPA062890.

Interactioni

Protein-protein interaction databases

IntActiQ8TDU6. 8 interactions.
STRINGi9606.ENSP00000428824.

Chemistry

BindingDBiQ8TDU6.

Structurei

3D structure databases

ProteinModelPortaliQ8TDU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
GeneTreeiENSGT00390000010256.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ8TDU6.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG7MWGXP.
PhylomeDBiQ8TDU6.
TreeFamiTF333321.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA
60 70 80 90 100
GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL
110 120 130 140 150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT
160 170 180 190 200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC
210 220 230 240 250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA
260 270 280 290 300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ
310 320 330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN
Length:330
Mass (Da):35,248
Last modified:June 1, 2002 - v1
Checksum:iB3A1AEDADEAFE021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086170 mRNA. Translation: BAC65343.1.
AB089307 mRNA. Translation: BAC55235.1.
AB083601 Genomic DNA. Translation: BAB89314.1.
AK122658 mRNA. Translation: BAG53647.1.
AK122660 mRNA. Translation: BAG53648.1.
CH471063 Genomic DNA. Translation: EAW70598.1.
BC033625 mRNA. Translation: AAH33625.1.
CCDSiCCDS46515.1.
RefSeqiNP_001070659.1. NM_001077191.1.
NP_001070662.1. NM_001077194.1.
NP_001308879.1. NM_001321950.1.
NP_733800.1. NM_170699.2.
XP_011509045.1. XM_011510743.1.
UniGeneiHs.160954.

Genome annotation databases

EnsembliENST00000479077; ENSP00000430698; ENSG00000179921.
ENST00000519574; ENSP00000430202; ENSG00000179921.
ENST00000521462; ENSP00000428824; ENSG00000179921.
ENST00000522678; ENSP00000430886; ENSG00000179921.
GeneIDi151306.
KEGGihsa:151306.
UCSCiuc010zjw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086170 mRNA. Translation: BAC65343.1.
AB089307 mRNA. Translation: BAC55235.1.
AB083601 Genomic DNA. Translation: BAB89314.1.
AK122658 mRNA. Translation: BAG53647.1.
AK122660 mRNA. Translation: BAG53648.1.
CH471063 Genomic DNA. Translation: EAW70598.1.
BC033625 mRNA. Translation: AAH33625.1.
CCDSiCCDS46515.1.
RefSeqiNP_001070659.1. NM_001077191.1.
NP_001070662.1. NM_001077194.1.
NP_001308879.1. NM_001321950.1.
NP_733800.1. NM_170699.2.
XP_011509045.1. XM_011510743.1.
UniGeneiHs.160954.

3D structure databases

ProteinModelPortaliQ8TDU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TDU6. 8 interactions.
STRINGi9606.ENSP00000428824.

Chemistry

BindingDBiQ8TDU6.
ChEMBLiCHEMBL5409.
GuidetoPHARMACOLOGYi37.
SwissLipidsiSLP:000001566.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPBAR1.
DMDMi74762624.

Proteomic databases

PaxDbiQ8TDU6.
PRIDEiQ8TDU6.

Protocols and materials databases

DNASUi151306.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000479077; ENSP00000430698; ENSG00000179921.
ENST00000519574; ENSP00000430202; ENSG00000179921.
ENST00000521462; ENSP00000428824; ENSG00000179921.
ENST00000522678; ENSP00000430886; ENSG00000179921.
GeneIDi151306.
KEGGihsa:151306.
UCSCiuc010zjw.1. human.

Organism-specific databases

CTDi151306.
GeneCardsiGPBAR1.
HGNCiHGNC:19680. GPBAR1.
HPAiHPA062890.
MIMi610147. gene.
neXtProtiNX_Q8TDU6.
PharmGKBiPA134903170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
GeneTreeiENSGT00390000010256.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ8TDU6.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG7MWGXP.
PhylomeDBiQ8TDU6.
TreeFamiTF333321.

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiG_protein-coupled_bile_acid_receptor.
GenomeRNAii151306.
PROiQ8TDU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDU6.
CleanExiHS_GPBAR1.
GenevisibleiQ8TDU6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiGPBAR_HUMAN
AccessioniPrimary (citable) accession number: Q8TDU6
Secondary accession number(s): B3KV35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.