Q8TDU6 (GPBAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled bile acid receptor 1

Alternative name(s):
G-protein coupled receptor GPCR19
Short name=hGPCR19
Membrane-type receptor for bile acids
Short name=M-BAR
hBG37
Short name=BG37

Gene names

Name:	GPBAR1
Synonyms:	TGR5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Ref.1 Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.2.
Tissue specificity	Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. Ref.1 Ref.2 Ref.3
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	G-protein coupled bile acid receptor 1		PRO_0000069500
Regions
	Topological domain	1 – 19	19	Extracellular Potential
	Transmembrane	20 – 40	21	Helical; Name=1; Potential
	Topological domain	41 – 50	10	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Name=2; Potential
	Topological domain	72 – 85	14	Extracellular Potential
	Transmembrane	86 – 106	21	Helical; Name=3; Potential
	Topological domain	107 – 125	19	Cytoplasmic Potential
	Transmembrane	126 – 146	21	Helical; Name=4; Potential
	Topological domain	147 – 165	19	Extracellular Potential
	Transmembrane	166 – 186	21	Helical; Name=5; Potential
	Topological domain	187 – 228	42	Cytoplasmic Potential
	Transmembrane	229 – 249	21	Helical; Name=6; Potential
	Topological domain	250 – 261	12	Extracellular Potential
	Transmembrane	262 – 282	21	Helical; Name=7; Potential
	Topological domain	283 – 330	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
	Disulfide bond	85 ↔ 155		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TDU6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B3A1AEDADEAFE021	FASTA	330	35,248
	10 20 30 40 50 60 MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA 70 80 90 100 110 120 GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER YMAVLRPLQP 130 140 150 160 170 180 PGSIRLALLL TWAGPLLFAS LPALGWNHWT PGANCSSQAI FPAPYLYLEV YGLLLPAVGA 190 200 210 220 230 240 AAFLSVRVLA TAHRQLQDIC RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY 250 260 270 280 290 300 VATLLLSVLA YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ 310 320 330 GLWGRASRDS PGPSIAYHPS SQSSVDLDLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of membrane-type receptor for bile acids (M-BAR)." Maruyama T., Miyamoto Y., Nakamura T., Tamai Y., Okada H., Sugiyama E., Nakamura T., Itadani H., Tanaka K. Biochem. Biophys. Res. Commun. 298:714-719(2002) [PubMed: 12419312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"A G protein-coupled receptor responsive to bile acids." Kawamata Y., Fujii R., Hosoya M., Harada M., Yoshida H., Miwa M., Fukusumi S., Habata Y., Itoh T., Shintani Y., Hinuma S., Fujisawa Y., Fujino M. J. Biol. Chem. 278:9435-9440(2003) [PubMed: 12524422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed: 12044878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], TISSUE SPECIFICITY.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB086170 mRNA. Translation: BAC65343.1. AB089307 mRNA. Translation: BAC55235.1. AB083601 Genomic DNA. Translation: BAB89314.1. BC033625 mRNA. Translation: AAH33625.1.
IPI	IPI00152620.
RefSeq	NP_001070659.1. NM_001077191.1. NP_001070662.1. NM_001077194.1. NP_733800.1. NM_170699.2.
UniGene	Hs.160954.
3D structure databases
ProteinModelPortal	Q8TDU6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TDU6. 8 interactions.
STRING	Q8TDU6.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	74762624.
Proteomic databases
PRIDE	Q8TDU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000423576; ENSP00000397905; ENSG00000251341.
GeneID	151306.
KEGG	hsa:151306.
Organism-specific databases
CTD	151306.
GeneCards	GC02P219124.
H-InvDB	HIX0200322.
HGNC	HGNC:19680. GPBAR1.
MIM	610147. gene.
neXtProt	NX_Q8TDU6.
PharmGKB	PA134903170.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08711.
GeneTree	ENSGT00390000010256.
HOGENOM	HBG715392.
HOVERGEN	HBG081571.
OMA	WGPYVAT.
OrthoDB	EOG45DWQ3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8TDU6.
Bgee	Q8TDU6.
CleanEx	HS_GPBAR1.
Genevestigator	Q8TDU6.
GermOnline	ENSG00000179921. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K08400.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	86666.
SOURCE	Search...

Entry information

Entry name

GPBAR_HUMAN

Accession

Primary (citable) accession number: Q8TDU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.