UniProtKB - Q8TDT2 (GP152_HUMAN)
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Protein
Probable G-protein coupled receptor 152
Gene
GPR152
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G-protein coupled receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 152Alternative name(s): G-protein coupled receptor PGR5 |
Gene namesi | Name:GPR152 Synonyms:PGR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175514.2. |
HGNCi | HGNC:23622. GPR152. |
neXtProti | NX_Q8TDT2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 65 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 66 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 105 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 106 – 126 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 148 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 149 – 169 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 194 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 195 – 215 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 257 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 258 – 278 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 281 | ExtracellularSequence analysis | 3 | |
Transmembranei | 282 – 302 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 303 – 470 | CytoplasmicSequence analysisAdd BLAST | 168 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000175514. |
PharmGKBi | PA134897297. |
Polymorphism and mutation databases
BioMutai | GPR152. |
DMDMi | 48428096. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069635 | 1 – 470 | Probable G-protein coupled receptor 152Add BLAST | 470 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 104 ↔ 182 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q8TDT2. |
PRIDEi | Q8TDT2. |
PTM databases
iPTMneti | Q8TDT2. |
PhosphoSitePlusi | Q8TDT2. |
Expressioni
Gene expression databases
Bgeei | ENSG00000175514. |
CleanExi | HS_GPR152. |
ExpressionAtlasi | Q8TDT2. baseline and differential. |
Organism-specific databases
HPAi | HPA035078. |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVEY. Eukaryota. ENOG410XYP4. LUCA. |
GeneTreei | ENSGT00760000118990. |
HOGENOMi | HOG000112775. |
HOVERGENi | HBG051788. |
InParanoidi | Q8TDT2. |
KOi | K08436. |
OMAi | YYFLWGV. |
OrthoDBi | EOG091G0A6G. |
PhylomeDBi | Q8TDT2. |
TreeFami | TF338313. |
Family and domain databases
InterProi | View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR027313. GPR152_orphan_prd. IPR026234. MRGPCRFAMILY. |
PANTHERi | PTHR11334. PTHR11334. 1 hit. PTHR11334:SF1. PTHR11334:SF1. 1 hit. |
Pfami | View protein in Pfam PF00001. 7tm_1. 1 hit. |
PRINTSi | PR00237. GPCRRHODOPSN. |
PROSITEi | View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8TDT2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM
60 70 80 90 100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG
110 120 130 140 150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW
160 170 180 190 200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG
210 220 230 240 250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR
260 270 280 290 300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA
310 320 330 340 350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS
360 370 380 390 400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS
410 420 430 440 450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA
460 470
SEGESPSSTP PEAAPGAGPT
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059323 | 317 | L → V. Corresponds to variant dbSNP:rs1638559Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY569571 mRNA. Translation: AAS76893.1. AB083620 Genomic DNA. Translation: BAB89333.1. AB065853 Genomic DNA. Translation: BAC06071.1. BC119779 mRNA. Translation: AAI19780.1. BC122869 mRNA. Translation: AAI22870.1. AY255600 mRNA. Translation: AAO85112.1. |
CCDSi | CCDS8165.1. |
RefSeqi | NP_996880.1. NM_206997.1. |
UniGenei | Hs.567997. |
Genome annotation databases
Ensembli | ENST00000312457; ENSP00000310255; ENSG00000175514. |
GeneIDi | 390212. |
KEGGi | hsa:390212. |
UCSCi | uc001olm.3. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | GP152_HUMAN | |
Accessioni | Q8TDT2Primary (citable) accession number: Q8TDT2 Secondary accession number(s): Q0VD88, Q86SM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | October 25, 2017 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |