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Protein

Probable G-protein coupled receptor 152

Gene

GPR152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 152
Alternative name(s):
G-protein coupled receptor PGR5
Gene namesi
Name:GPR152
Synonyms:PGR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23622. GPR152.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6511CytoplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini87 – 10519ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14822CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini170 – 19425ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 25742CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 2813ExtracellularSequence analysis
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 470168CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897297.

Polymorphism and mutation databases

BioMutaiGPR152.
DMDMi48428096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Probable G-protein coupled receptor 152PRO_0000069635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TDT2.
PRIDEiQ8TDT2.

PTM databases

iPTMnetiQ8TDT2.

Expressioni

Gene expression databases

CleanExiHS_GPR152.
ExpressionAtlasiQ8TDT2. baseline and differential.

Organism-specific databases

HPAiHPA035078.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310255.

Structurei

3D structure databases

ProteinModelPortaliQ8TDT2.
SMRiQ8TDT2. Positions 16-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEY. Eukaryota.
ENOG410XYP4. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112775.
HOVERGENiHBG051788.
InParanoidiQ8TDT2.
KOiK08436.
OMAiYYFLWGV.
OrthoDBiEOG7KWSHQ.
PhylomeDBiQ8TDT2.
TreeFamiTF338313.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027313. GPR152_orphan_prd.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF1. PTHR11334:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM
60 70 80 90 100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG
110 120 130 140 150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW
160 170 180 190 200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG
210 220 230 240 250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR
260 270 280 290 300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA
310 320 330 340 350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS
360 370 380 390 400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS
410 420 430 440 450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA
460 470
SEGESPSSTP PEAAPGAGPT
Length:470
Mass (Da):50,962
Last modified:June 1, 2002 - v1
Checksum:i8B566AE95D9D79B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171L → V.
Corresponds to variant rs1638559 [ dbSNP | Ensembl ].
VAR_059323

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569571 mRNA. Translation: AAS76893.1.
AB083620 Genomic DNA. Translation: BAB89333.1.
AB065853 Genomic DNA. Translation: BAC06071.1.
BC119779 mRNA. Translation: AAI19780.1.
BC122869 mRNA. Translation: AAI22870.1.
AY255600 mRNA. Translation: AAO85112.1.
CCDSiCCDS8165.1.
RefSeqiNP_996880.1. NM_206997.1.
UniGeneiHs.567997.

Genome annotation databases

EnsembliENST00000312457; ENSP00000310255; ENSG00000175514.
GeneIDi390212.
KEGGihsa:390212.
UCSCiuc001olm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569571 mRNA. Translation: AAS76893.1.
AB083620 Genomic DNA. Translation: BAB89333.1.
AB065853 Genomic DNA. Translation: BAC06071.1.
BC119779 mRNA. Translation: AAI19780.1.
BC122869 mRNA. Translation: AAI22870.1.
AY255600 mRNA. Translation: AAO85112.1.
CCDSiCCDS8165.1.
RefSeqiNP_996880.1. NM_206997.1.
UniGeneiHs.567997.

3D structure databases

ProteinModelPortaliQ8TDT2.
SMRiQ8TDT2. Positions 16-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310255.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDT2.

Polymorphism and mutation databases

BioMutaiGPR152.
DMDMi48428096.

Proteomic databases

PaxDbiQ8TDT2.
PRIDEiQ8TDT2.

Protocols and materials databases

DNASUi390212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312457; ENSP00000310255; ENSG00000175514.
GeneIDi390212.
KEGGihsa:390212.
UCSCiuc001olm.3. human.

Organism-specific databases

CTDi390212.
GeneCardsiGPR152.
HGNCiHGNC:23622. GPR152.
HPAiHPA035078.
neXtProtiNX_Q8TDT2.
PharmGKBiPA134897297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVEY. Eukaryota.
ENOG410XYP4. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112775.
HOVERGENiHBG051788.
InParanoidiQ8TDT2.
KOiK08436.
OMAiYYFLWGV.
OrthoDBiEOG7KWSHQ.
PhylomeDBiQ8TDT2.
TreeFamiTF338313.

Miscellaneous databases

GeneWikiiGPR152.
GenomeRNAii390212.
PROiQ8TDT2.

Gene expression databases

CleanExiHS_GPR152.
ExpressionAtlasiQ8TDT2. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027313. GPR152_orphan_prd.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF1. PTHR11334:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR152."
    Bonner T.I., Nagle J.W., Kauffman D.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-197.

Entry informationi

Entry nameiGP152_HUMAN
AccessioniPrimary (citable) accession number: Q8TDT2
Secondary accession number(s): Q0VD88, Q86SM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.