GPR152

Functionⁱ

Orphan receptor.

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable G-protein coupled receptor 152 Alternative name(s): G-protein coupled receptor PGR5
Gene namesⁱ	Name:GPR152 Synonyms:PGR5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23622. GPR152.

HGNCⁱ

HGNC:23622. GPR152.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	55 – 65	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	66 – 86	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	87 – 105	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	106 – 126	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	127 – 148	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	149 – 169	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	170 – 194	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	195 – 215	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	216 – 257	CytoplasmicSequence analysisAdd BLAST	42
Transmembraneⁱ	258 – 278	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	279 – 281	ExtracellularSequence analysis	3
Transmembraneⁱ	282 – 302	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	303 – 470	CytoplasmicSequence analysisAdd BLAST	168

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000175514.
PharmGKBⁱ	PA134897297.

Polymorphism and mutation databases

BioMutaⁱ	GPR152.
DMDMⁱ	48428096.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069635	1 – 470	Probable G-protein coupled receptor 152Add BLAST		470

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	104 ↔ 182	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q8TDT2.
PRIDEⁱ	Q8TDT2.

PTM databases

iPTMnetⁱ	Q8TDT2.
PhosphoSitePlusⁱ	Q8TDT2.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000175514.
CleanExⁱ	HS_GPR152.
ExpressionAtlasⁱ	Q8TDT2. baseline and differential.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035078.

HPAⁱ

HPA035078.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8TDT2. 2 interactors.
STRINGⁱ	9606.ENSP00000310255.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TDT2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVEY. Eukaryota. ENOG410XYP4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118990.
HOGENOMⁱ	HOG000112775.
HOVERGENⁱ	HBG051788.
InParanoidⁱ	Q8TDT2.
KEGG Orthology (KO) More...KOⁱ	K08436.
OMAⁱ	YYFLWGV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A6G.
PhylomeDBⁱ	Q8TDT2.
TreeFamⁱ	TF338313.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR027313. GPR152_orphan_prd. IPR026234. MRGPCRFAMILY.
PANTHERⁱ	PTHR11334. PTHR11334. 1 hit. PTHR11334:SF51. PTHR11334:SF51. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TDT2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM 
        60         70         80         90        100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG 
       110        120        130        140        150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW 
       160        170        180        190        200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG 
       210        220        230        240        250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR 
       260        270        280        290        300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA 
       310        320        330        340        350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS 
       360        370        380        390        400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS 
       410        420        430        440        450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA 
       460        470
SEGESPSSTP PEAAPGAGPT

Length:470

Mass (Da):50,962

Last modified:June 1, 2002 - v1

Checksum:ⁱ8B566AE95D9D79B4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059323	317	L → V. Corresponds to variant dbSNP:rs1638559Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY569571 mRNA. Translation: AAS76893.1. AB083620 Genomic DNA. Translation: BAB89333.1. AB065853 Genomic DNA. Translation: BAC06071.1. BC119779 mRNA. Translation: AAI19780.1. BC122869 mRNA. Translation: AAI22870.1. AY255600 mRNA. Translation: AAO85112.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8165.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996880.1. NM_206997.1.
UniGeneⁱ	Hs.567997.

Genome annotation databases

Ensemblⁱ	ENST00000312457; ENSP00000310255; ENSG00000175514.
GeneIDⁱ	390212.
KEGGⁱ	hsa:390212.
UCSC genome browser More...UCSCⁱ	uc001olm.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY569571 mRNA. Translation: AAS76893.1. AB083620 Genomic DNA. Translation: BAB89333.1. AB065853 Genomic DNA. Translation: BAC06071.1. BC119779 mRNA. Translation: AAI19780.1. BC122869 mRNA. Translation: AAI22870.1. AY255600 mRNA. Translation: AAO85112.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8165.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996880.1. NM_206997.1.
UniGeneⁱ	Hs.567997.

3D structure databases

ProteinModelPortalⁱ	Q8TDT2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8TDT2. 2 interactors.
STRINGⁱ	9606.ENSP00000310255.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8TDT2.
PhosphoSitePlusⁱ	Q8TDT2.

Polymorphism and mutation databases

BioMutaⁱ	GPR152.
DMDMⁱ	48428096.

Proteomic databases

PaxDbⁱ	Q8TDT2.
PRIDEⁱ	Q8TDT2.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	390212.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312457; ENSP00000310255; ENSG00000175514.
GeneIDⁱ	390212.
KEGGⁱ	hsa:390212.
UCSC genome browser More...UCSCⁱ	uc001olm.3. human.

Organism-specific databases

CTDⁱ	390212.
GeneCardsⁱ	GPR152.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23622. GPR152.
Human Protein Atlas More...HPAⁱ	HPA035078.
neXtProtⁱ	NX_Q8TDT2.
Open Targets More...OpenTargetsⁱ	ENSG00000175514.
PharmGKBⁱ	PA134897297.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVEY. Eukaryota. ENOG410XYP4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118990.
HOGENOMⁱ	HOG000112775.
HOVERGENⁱ	HBG051788.
InParanoidⁱ	Q8TDT2.
KEGG Orthology (KO) More...KOⁱ	K08436.
OMAⁱ	YYFLWGV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A6G.
PhylomeDBⁱ	Q8TDT2.
TreeFamⁱ	TF338313.

Miscellaneous databases

GeneWikiⁱ	GPR152.
GenomeRNAiⁱ	390212.
Protein Ontology More...PROⁱ	PR:Q8TDT2.

Gene expression databases

Bgeeⁱ	ENSG00000175514.
CleanExⁱ	HS_GPR152.
ExpressionAtlasⁱ	Q8TDT2. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR027313. GPR152_orphan_prd. IPR026234. MRGPCRFAMILY.
PANTHERⁱ	PTHR11334. PTHR11334. 1 hit. PTHR11334:SF51. PTHR11334:SF51. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP152_HUMAN
Accessionⁱ	Q8TDT2Primary (citable) accession number: Q8TDT2 Secondary accession number(s): Q0VD88, Q86SM0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	June 1, 2002
	Last modified:	April 12, 2017
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TDT2 (GP152_HUMAN)

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Probable G-protein coupled receptor 152

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ