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UniProtKB - Q8TDT2 (GP152_HUMAN)

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Protein

Probable G-protein coupled receptor 152

Gene

GPR152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 152
Alternative name(s):
G-protein coupled receptor PGR5
Gene namesi
Name:GPR152
Synonyms:PGR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23622. GPR152.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 65CytoplasmicSequence analysisAdd BLAST11
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 148CytoplasmicSequence analysisAdd BLAST22
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 257CytoplasmicSequence analysisAdd BLAST42
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 281ExtracellularSequence analysis3
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 470CytoplasmicSequence analysisAdd BLAST168

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175514.
PharmGKBiPA134897297.

Polymorphism and mutation databases

BioMutaiGPR152.
DMDMi48428096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696351 – 470Probable G-protein coupled receptor 152Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TDT2.
PRIDEiQ8TDT2.

PTM databases

iPTMnetiQ8TDT2.
PhosphoSitePlusiQ8TDT2.

Expressioni

Gene expression databases

BgeeiENSG00000175514.
CleanExiHS_GPR152.
ExpressionAtlasiQ8TDT2. baseline and differential.

Organism-specific databases

HPAiHPA035078.

Interactioni

Protein-protein interaction databases

IntActiQ8TDT2. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8TDT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEY. Eukaryota.
ENOG410XYP4. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112775.
HOVERGENiHBG051788.
InParanoidiQ8TDT2.
KOiK08436.
OMAiYYFLWGV.
OrthoDBiEOG091G0A6G.
PhylomeDBiQ8TDT2.
TreeFamiTF338313.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027313. GPR152_orphan_prd.
IPR026234. MRGPCRFAMILY.
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF51. PTHR11334:SF51. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TDT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM 
        60         70         80         90        100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG 
       110        120        130        140        150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW 
       160        170        180        190        200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG 
       210        220        230        240        250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR 
       260        270        280        290        300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA 
       310        320        330        340        350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS 
       360        370        380        390        400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS 
       410        420        430        440        450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA 
       460        470
SEGESPSSTP PEAAPGAGPT
Length:470
Mass (Da):50,962
Last modified:June 1, 2002 - v1
Checksum:i8B566AE95D9D79B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059323317L → V. Corresponds to variant dbSNP:rs1638559Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569571 mRNA. Translation: AAS76893.1.
AB083620 Genomic DNA. Translation: BAB89333.1.
AB065853 Genomic DNA. Translation: BAC06071.1.
BC119779 mRNA. Translation: AAI19780.1.
BC122869 mRNA. Translation: AAI22870.1.
AY255600 mRNA. Translation: AAO85112.1.
CCDSiCCDS8165.1.
RefSeqiNP_996880.1. NM_206997.1.
UniGeneiHs.567997.

Genome annotation databases

EnsembliENST00000312457; ENSP00000310255; ENSG00000175514.
GeneIDi390212.
KEGGihsa:390212.
UCSCiuc001olm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGP152_HUMAN
AccessioniPrimary (citable) accession number: Q8TDT2
Secondary accession number(s): Q0VD88, Q86SM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families