Reviewed, UniProtKB/Swiss-Prot Q8TDS7 (MRGRD_HUMAN)

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member D

Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7

Gene names

Name:	MRGPRD
Synonyms:	MRGD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca2+ influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Mas-related G-protein coupled receptor member D		PRO_0000069756
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 54	21	1 Potential
	Topological domain	55 – 59	5	Cytoplasmic Potential
	Transmembrane	60 – 80	21	2 Potential
	Topological domain	81 – 112	32	Extracellular Potential
	Transmembrane	113 – 133	21	3 Potential
	Topological domain	134 – 142	9	Cytoplasmic Potential
	Transmembrane	143 – 163	21	4 Potential
	Topological domain	164 – 184	21	Extracellular Potential
	Transmembrane	185 – 205	21	5 Potential
	Topological domain	206 – 218	13	Cytoplasmic Potential
	Transmembrane	219 – 239	21	6 Potential
	Topological domain	240 – 257	18	Extracellular Potential
	Transmembrane	258 – 280	23	7 Potential
	Topological domain	281 – 321	41	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	92	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TDS7-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B45AB7FEB2154B40	FASTA	321	36,118
	10 20 30 40 50 60 MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP 70 80 90 100 110 120 FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS 130 140 150 160 170 180 TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM 190 200 210 220 230 240 VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY 250 260 270 280 290 300 WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL 310 320 REEPELEGGE TPTVGTNEMG A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family." Zylka M.J., Dong X., Southwell A.L., Anderson D.J. Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed: 12909716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of a G protein-coupled receptor specifically responsive to beta-alanine." Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H., Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T., Itoh Y., Hinuma S. J. Biol. Chem. 279:23559-23564(2004) [PubMed: 15037633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, POSSIBLE FUNCTION. Tissue: Liver.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed: 12044878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY427820 mRNA. Translation: AAR05120.1. AB154410 mRNA. Translation: BAD20638.1. AB083627 Genomic DNA. Translation: BAB89340.1. AB065786 Genomic DNA. Translation: BAC06005.1. Different initiation.
IPI	IPI00447219.
RefSeq	NP_944605.2.
UniGene	Hs.527802
3D structure databases
SMR	Q8TDS7. Positions 36-278.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TDS7.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8TDS7.
Genome annotation databases
Ensembl	ENST00000309106; ENSP00000310631; ENSG00000172938; Homo sapiens. [Genome view]
GeneID	116512.
KEGG	hsa:116512.
UCSC	uc001oon.1. human.
Organism-specific databases
CTD	116512.
GeneCards	GC11M068504.
H-InvDB	HIX0035840.
HGNC	HGNC:29626. MRGPRD.
MIM	607231. gene.
PharmGKB	PA134978563.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16936.
HOGENOM	HBG403162.
HOVERGEN	HBG003592.
InParanoid	Q8TDS7.
OMA	DKVHELM.
OrthoDB	EOG92C0TX.
Gene expression databases
ArrayExpress	Q8TDS7.
Bgee	Q8TDS7.
CleanEx	HS_MRGPRD.
Genevestigator	Q8TDS7.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	79958.
SOURCE	Search...

Entry information

Entry name

MRGRD_HUMAN

Accession

Primary (citable) accession number: Q8TDS7
Secondary accession number(s): Q8NGK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2002
Last modified:	March 2, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.