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Protein

Mas-related G-protein coupled receptor member D

Gene

MRGPRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca2+ influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member D
Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7
Gene namesi
Name:MRGPRD
Synonyms:MRGD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29626. MRGPRD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 59CytoplasmicSequence analysis5
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 112ExtracellularSequence analysisAdd BLAST32
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 142CytoplasmicSequence analysis9
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 184ExtracellularSequence analysisAdd BLAST21
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 218CytoplasmicSequence analysisAdd BLAST13
Transmembranei219 – 239Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini240 – 257ExtracellularSequence analysisAdd BLAST18
Transmembranei258 – 280Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini281 – 321CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116512.
OpenTargetsiENSG00000172938.
PharmGKBiPA134978563.

Chemistry databases

GuidetoPHARMACOLOGYi152.

Polymorphism and mutation databases

BioMutaiMRGPRD.
DMDMi50401085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697561 – 321Mas-related G-protein coupled receptor member DAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TDS7.
PRIDEiQ8TDS7.

PTM databases

iPTMnetiQ8TDS7.
PhosphoSitePlusiQ8TDS7.

Expressioni

Gene expression databases

BgeeiENSG00000172938.
CleanExiHS_MRGPRD.

Organism-specific databases

HPAiHPA031346.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310631.

Structurei

3D structure databases

ProteinModelPortaliQ8TDS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ8TDS7.
KOiK08392.
OMAiGVLTPVM.
OrthoDBiEOG091G0EM7.
PhylomeDBiQ8TDS7.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW
60 70 80 90 100
LLGFRMHRNP FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL
110 120 130 140 150
MKRLMYFAYT VGLSLLTAIS TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW
160 170 180 190 200
TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM VQAALIMGVL TPVMTLSSLT
210 220 230 240 250
LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY WFVLYWLSLP
260 270 280 290 300
PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
310 320
REEPELEGGE TPTVGTNEMG A
Length:321
Mass (Da):36,118
Last modified:June 1, 2002 - v1
Checksum:iB45AB7FEB2154B40
GO

Sequence cautioni

The sequence BAC06005 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427820 mRNA. Translation: AAR05120.1.
AB154410 mRNA. Translation: BAD20638.1.
AB083627 Genomic DNA. Translation: BAB89340.1.
AB065786 Genomic DNA. Translation: BAC06005.1. Different initiation.
CCDSiCCDS31625.1.
RefSeqiNP_944605.2. NM_198923.2.
UniGeneiHs.527802.

Genome annotation databases

EnsembliENST00000309106; ENSP00000310631; ENSG00000172938.
GeneIDi116512.
KEGGihsa:116512.
UCSCiuc010rqf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427820 mRNA. Translation: AAR05120.1.
AB154410 mRNA. Translation: BAD20638.1.
AB083627 Genomic DNA. Translation: BAB89340.1.
AB065786 Genomic DNA. Translation: BAC06005.1. Different initiation.
CCDSiCCDS31625.1.
RefSeqiNP_944605.2. NM_198923.2.
UniGeneiHs.527802.

3D structure databases

ProteinModelPortaliQ8TDS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310631.

Chemistry databases

GuidetoPHARMACOLOGYi152.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDS7.
PhosphoSitePlusiQ8TDS7.

Polymorphism and mutation databases

BioMutaiMRGPRD.
DMDMi50401085.

Proteomic databases

PaxDbiQ8TDS7.
PRIDEiQ8TDS7.

Protocols and materials databases

DNASUi116512.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309106; ENSP00000310631; ENSG00000172938.
GeneIDi116512.
KEGGihsa:116512.
UCSCiuc010rqf.2. human.

Organism-specific databases

CTDi116512.
DisGeNETi116512.
GeneCardsiMRGPRD.
HGNCiHGNC:29626. MRGPRD.
HPAiHPA031346.
MIMi607231. gene.
neXtProtiNX_Q8TDS7.
OpenTargetsiENSG00000172938.
PharmGKBiPA134978563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ8TDS7.
KOiK08392.
OMAiGVLTPVM.
OrthoDBiEOG091G0EM7.
PhylomeDBiQ8TDS7.
TreeFamiTF336336.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172938-MONOMER.

Miscellaneous databases

GeneWikiiMRGPRD.
GenomeRNAii116512.
PROiQ8TDS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172938.
CleanExiHS_MRGPRD.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRD_HUMAN
AccessioniPrimary (citable) accession number: Q8TDS7
Secondary accession number(s): Q8NGK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.