Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mas-related G-protein coupled receptor member D

Gene

MRGPRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca2+ influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member D
Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7
Gene namesi
Name:MRGPRD
Synonyms:MRGD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29626. MRGPRD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 595CytoplasmicSequence analysis
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 11232ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 1429CytoplasmicSequence analysis
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 18421ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini206 – 21813CytoplasmicSequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini240 – 25718ExtracellularSequence analysisAdd
BLAST
Transmembranei258 – 28023Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini281 – 32141CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978563.

Chemistry

GuidetoPHARMACOLOGYi152.

Polymorphism and mutation databases

BioMutaiMRGPRD.
DMDMi50401085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Mas-related G-protein coupled receptor member DPRO_0000069756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TDS7.
PaxDbiQ8TDS7.
PRIDEiQ8TDS7.

Expressioni

Gene expression databases

BgeeiQ8TDS7.
CleanExiHS_MRGPRD.

Organism-specific databases

HPAiHPA031346.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310631.

Structurei

3D structure databases

ProteinModelPortaliQ8TDS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ8TDS7.
KOiK08392.
OMAiGVLTPVM.
OrthoDBiEOG78SQJK.
PhylomeDBiQ8TDS7.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW
60 70 80 90 100
LLGFRMHRNP FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL
110 120 130 140 150
MKRLMYFAYT VGLSLLTAIS TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW
160 170 180 190 200
TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM VQAALIMGVL TPVMTLSSLT
210 220 230 240 250
LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY WFVLYWLSLP
260 270 280 290 300
PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
310 320
REEPELEGGE TPTVGTNEMG A
Length:321
Mass (Da):36,118
Last modified:June 1, 2002 - v1
Checksum:iB45AB7FEB2154B40
GO

Sequence cautioni

The sequence BAC06005.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427820 mRNA. Translation: AAR05120.1.
AB154410 mRNA. Translation: BAD20638.1.
AB083627 Genomic DNA. Translation: BAB89340.1.
AB065786 Genomic DNA. Translation: BAC06005.1. Different initiation.
CCDSiCCDS31625.1.
RefSeqiNP_944605.2. NM_198923.2.
UniGeneiHs.527802.

Genome annotation databases

EnsembliENST00000309106; ENSP00000310631; ENSG00000172938.
GeneIDi116512.
KEGGihsa:116512.
UCSCiuc010rqf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427820 mRNA. Translation: AAR05120.1.
AB154410 mRNA. Translation: BAD20638.1.
AB083627 Genomic DNA. Translation: BAB89340.1.
AB065786 Genomic DNA. Translation: BAC06005.1. Different initiation.
CCDSiCCDS31625.1.
RefSeqiNP_944605.2. NM_198923.2.
UniGeneiHs.527802.

3D structure databases

ProteinModelPortaliQ8TDS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310631.

Chemistry

GuidetoPHARMACOLOGYi152.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMRGPRD.
DMDMi50401085.

Proteomic databases

EPDiQ8TDS7.
PaxDbiQ8TDS7.
PRIDEiQ8TDS7.

Protocols and materials databases

DNASUi116512.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309106; ENSP00000310631; ENSG00000172938.
GeneIDi116512.
KEGGihsa:116512.
UCSCiuc010rqf.2. human.

Organism-specific databases

CTDi116512.
GeneCardsiMRGPRD.
HGNCiHGNC:29626. MRGPRD.
HPAiHPA031346.
MIMi607231. gene.
neXtProtiNX_Q8TDS7.
PharmGKBiPA134978563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ8TDS7.
KOiK08392.
OMAiGVLTPVM.
OrthoDBiEOG78SQJK.
PhylomeDBiQ8TDS7.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMRGPRD.
GenomeRNAii116512.
NextBioi79958.
PROiQ8TDS7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDS7.
CleanExiHS_MRGPRD.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."
    Zylka M.J., Dong X., Southwell A.L., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, POSSIBLE FUNCTION.
    Tissue: Liver.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMRGRD_HUMAN
AccessioniPrimary (citable) accession number: Q8TDS7
Secondary accession number(s): Q8NGK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.