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Protein

Oxoeicosanoid receptor 1

Gene

OXER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.2 Publications

GO - Molecular functioni

  • 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Source: UniProtKB
  • 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Source: UniProtKB
  • 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • regulation of cAMP biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162881-MONOMER.
ReactomeiR-HSA-391903. Eicosanoid ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Chemistry databases

SwissLipidsiSLP:000001564.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxoeicosanoid receptor 1
Alternative name(s):
5-oxo-ETE G-protein coupled receptor
G-protein coupled receptor 170
G-protein coupled receptor R527
G-protein coupled receptor TG1019
Gene namesi
Name:OXER1
Synonyms:GPR170, TG1019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24884. OXER1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97ExtracellularSequence analysisAdd BLAST97
Transmembranei98 – 118Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicSequence analysis8
Transmembranei127 – 147Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini148 – 168ExtracellularSequence analysisAdd BLAST21
Transmembranei169 – 191Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini192 – 211CytoplasmicSequence analysisAdd BLAST20
Transmembranei212 – 232Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini233 – 254ExtracellularSequence analysisAdd BLAST22
Transmembranei255 – 275Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini276 – 295CytoplasmicSequence analysisAdd BLAST20
Transmembranei296 – 316Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini317 – 336ExtracellularSequence analysisAdd BLAST20
Transmembranei337 – 357Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini358 – 423CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi165140.
OpenTargetsiENSG00000162881.
PharmGKBiPA134983779.

Chemistry databases

ChEMBLiCHEMBL1628461.
GuidetoPHARMACOLOGYi271.

Polymorphism and mutation databases

BioMutaiOXER1.
DMDMi74762623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699931 – 423Oxoeicosanoid receptor 1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi165 ↔ 237PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDS5.
PRIDEiQ8TDS5.

PTM databases

iPTMnetiQ8TDS5.
PhosphoSitePlusiQ8TDS5.

Expressioni

Tissue specificityi

Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.2 Publications

Gene expression databases

BgeeiENSG00000162881.
CleanExiHS_OXER1.
GenevisibleiQ8TDS5. HS.

Organism-specific databases

HPAiHPA051433.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367930.

Chemistry databases

BindingDBiQ8TDS5.

Structurei

3D structure databases

ProteinModelPortaliQ8TDS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 92Ser-richAdd BLAST47

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER0. Eukaryota.
ENOG4111C61. LUCA.
GeneTreeiENSGT00510000046798.
HOGENOMiHOG000115310.
InParanoidiQ8TDS5.
KOiK10043.
OMAiPWTSNTV.
OrthoDBiEOG091G0AN6.
PhylomeDBiQ8TDS5.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCHRGGQLI VPIIPLCPEH SCRGRRLQNL LSGPWPKQPM ELHNLSSPSP
60 70 80 90 100
SLSSSVLPPS FSPSPSSAPS AFTTVGGSSG GPCHPTSSSL VSAFLAPILA
110 120 130 140 150
LEFVLGLVGN SLALFIFCIH TRPWTSNTVF LVSLVAADFL LISNLPLRVD
160 170 180 190 200
YYLLHETWRF GAAACKVNLF MLSTNRTASV VFLTAIALNR YLKVVQPHHV
210 220 230 240 250
LSRASVGAAA RVAGGLWVGI LLLNGHLLLS TFSGPSCLSY RVGTKPSASL
260 270 280 290 300
RWHQALYLLE FFLPLALILF AIVSIGLTIR NRGLGGQAGP QRAMRVLAMV
310 320 330 340 350
VAVYTICFLP SIIFGMASMV AFWLSACRSL DLCTQLFHGS LAFTYLNSVL
360 370 380 390 400
DPVLYCFSSP NFLHQSRALL GLTRGRQGPV SDESSYQPSR QWRYREASRK
410 420
AEAIGKLKVQ GEVSLEKEGS SQG
Length:423
Mass (Da):45,811
Last modified:June 1, 2002 - v1
Checksum:i72ADA9F43A9EC051
GO

Sequence cautioni

The sequence AAO17739 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05878 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049428316M → L.Corresponds to variant rs17029947dbSNPEnsembl.1
Natural variantiVAR_023940407L → V.1 PublicationCorresponds to variant rs2278586dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083055 mRNA. Translation: BAC11806.2.
AY158687 mRNA. Translation: AAO17739.1. Different initiation.
AB065652 Genomic DNA. Translation: BAC05878.1. Different initiation.
AB083630 Genomic DNA. Translation: BAB89343.1.
AC098824 Genomic DNA. Translation: AAY14700.1.
BC063549 mRNA. Translation: AAH63549.1.
CCDSiCCDS1810.1.
RefSeqiNP_683765.1. NM_148962.4.
UniGeneiHs.168439.

Genome annotation databases

EnsembliENST00000378661; ENSP00000367930; ENSG00000162881.
GeneIDi165140.
KEGGihsa:165140.
UCSCiuc002rss.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083055 mRNA. Translation: BAC11806.2.
AY158687 mRNA. Translation: AAO17739.1. Different initiation.
AB065652 Genomic DNA. Translation: BAC05878.1. Different initiation.
AB083630 Genomic DNA. Translation: BAB89343.1.
AC098824 Genomic DNA. Translation: AAY14700.1.
BC063549 mRNA. Translation: AAH63549.1.
CCDSiCCDS1810.1.
RefSeqiNP_683765.1. NM_148962.4.
UniGeneiHs.168439.

3D structure databases

ProteinModelPortaliQ8TDS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367930.

Chemistry databases

BindingDBiQ8TDS5.
ChEMBLiCHEMBL1628461.
GuidetoPHARMACOLOGYi271.
SwissLipidsiSLP:000001564.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDS5.
PhosphoSitePlusiQ8TDS5.

Polymorphism and mutation databases

BioMutaiOXER1.
DMDMi74762623.

Proteomic databases

PaxDbiQ8TDS5.
PRIDEiQ8TDS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378661; ENSP00000367930; ENSG00000162881.
GeneIDi165140.
KEGGihsa:165140.
UCSCiuc002rss.4. human.

Organism-specific databases

CTDi165140.
DisGeNETi165140.
GeneCardsiOXER1.
H-InvDBHIX0161867.
HGNCiHGNC:24884. OXER1.
HPAiHPA051433.
neXtProtiNX_Q8TDS5.
OpenTargetsiENSG00000162881.
PharmGKBiPA134983779.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IER0. Eukaryota.
ENOG4111C61. LUCA.
GeneTreeiENSGT00510000046798.
HOGENOMiHOG000115310.
InParanoidiQ8TDS5.
KOiK10043.
OMAiPWTSNTV.
OrthoDBiEOG091G0AN6.
PhylomeDBiQ8TDS5.
TreeFamiTF330775.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162881-MONOMER.
ReactomeiR-HSA-391903. Eicosanoid ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiOxoeicosanoid_receptor_1.
GenomeRNAii165140.
PROiQ8TDS5.

Gene expression databases

BgeeiENSG00000162881.
CleanExiHS_OXER1.
GenevisibleiQ8TDS5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXER1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDS5
Secondary accession number(s): Q86WP7, Q8NGW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.