Q8TDS3 (Q8TDS3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Delta 4 progesterone receptor EMBL BAB91074.1

Submitted name:
Progesterone receptor Ensembl ENSP00000263463
Submitted name:
Progesterone receptor, isoform CRA_c EMBL EAW66999.1

Gene names

Name:	PR EMBL BAB91074.1
Synonyms:	PGR Ensembl ENSP00000263463 EMBL EAW66999.1
ORF Names:	hCG_39657 EMBL EAW66999.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAB91074.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	831 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL BAB91074.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8TDS3 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: EC4882171DD1C48B	FASTA	831	87,747
	10 20 30 40 50 60 MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF 70 80 90 100 110 120 PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL LDSVLDTLLA 130 140 150 160 170 180 PSGPGQSQPS PPACEVTSSW CLFGPELPED PPAAPATQRV LSPLMSRSGC KVGDSSGTAA 190 200 210 220 230 240 AHKVLPRGLS PARQLLLPAS ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK 250 260 270 280 290 300 PRALGGAAAG GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 310 320 330 340 350 360 MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS TPVAVGDFPD 370 380 390 400 410 420 CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS PRSYLVAGAN PAAFPDFPLG 430 440 450 460 470 480 PPPPLPPRAT PSRPGEAAVT AAPASASVSS ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC 490 500 510 520 530 540 KAPGASGCLL PRDGLPSTSA SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP 550 560 570 580 590 600 YLNYLRPDSE ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 610 620 630 640 650 660 YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGFRNL HIDDQITLIQ YSWMSLMVFG 670 680 690 700 710 720 LGWRSYKHVS GQMLYFAPDL ILNEQRMKES SFYSLCLTMW QIPQEFVKLQ VSQEEFLCMK 730 740 750 760 770 780 VLLLLNTIPL EGLRSQTQFE EMRSSYIREL IKAIGLRQKG VVSSSQRFYQ LTKLLDNLHD 790 800 810 820 830 LVKQLHLYCL NTFIQSRALS VEFPEMMSEV IAAQLPKILA GMVKPLLFHK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Progesterone receptor variants found in breast cells repress transcription by wild-type receptors." Richer J.K., Lange C.A., Wierman A.M., Brooks K.M., Tung L., Takimoto G.S., Horwitz K.B. Breast Cancer Res. Treat. 48:231-241(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Breast cancer EMBL BAB91074.1.
[2]	"Progesterone Receptor, alternative splicing variant, mRNA." Hisatomi H., Wakita K., Kohno N., Nagao K., Hirata H., Hikiji K. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Breast cancer EMBL BAB91074.1.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001533 Genomic DNA. No translation available. AB084248 mRNA. Translation: BAB91074.1. CH471065 Genomic DNA. Translation: EAW66999.1.
IPI	IPI00168906.
RefSeq	NP_001258090.1. NM_001271161.1.
UniGene	Hs.32405. Hs.742403.
3D structure databases
HSSP	HSSP built from PDB template 1RGD based on UniProtKB P06536.
SMR	Q8TDS3. Positions 563-830.
ModBase	Search...
Proteomic databases
PRIDE	Q8TDS3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263463; ENSP00000263463; ENSG00000082175.
GeneID	5241.
KEGG	hsa:5241.
UCSC	uc001pgi.2. human.
Organism-specific databases
CTD	5241.
HGNC	HGNC:8910. PGR.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000290653.
HOVERGEN	HBG007583.
KO	K08556.
Gene expression databases
ArrayExpress	Q8TDS3.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR000128. Progest_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF02161. Prog_receptor. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00544. PROGESTRONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5241.

Entry information

Entry name

Q8TDS3_HUMAN

Accession

Primary (citable) accession number: Q8TDS3

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.