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Protein

T-complex protein 10A homolog 2

Gene

TCP10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB
  • repressing transcription factor binding Source: UniProtKB
  • RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 10A homolog 2
Short name:
T-complex protein 10A-2
Short name:
TCP10A-2
Alternative name(s):
TCP10-like
Gene namesi
Name:TCP10L
ORF Names:PRED77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000242220.6.
HGNCiHGNC:11657. TCP10L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82L → F: Greatly decreases in vitro transcription inhibition activity. 1 Publication1
Mutagenesisi89L → P: Disrupts self-association. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

OpenTargetsiENSG00000242220.
PharmGKBiPA36408.

Polymorphism and mutation databases

BioMutaiTCP10L.
DMDMi23822246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724621 – 215T-complex protein 10A homolog 2Add BLAST215

Proteomic databases

PaxDbiQ8TDR4.
PeptideAtlasiQ8TDR4.
PRIDEiQ8TDR4.

PTM databases

iPTMnetiQ8TDR4.
PhosphoSitePlusiQ8TDR4.

Expressioni

Tissue specificityi

Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000242220.
CleanExiHS_TCP10L.
ExpressionAtlasiQ8TDR4. baseline and differential.
GenevisibleiQ8TDR4. HS.

Organism-specific databases

HPAiHPA044709.

Interactioni

Subunit structurei

Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB
  • repressing transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126602. 45 interactors.
IntActiQ8TDR4. 5 interactors.
STRINGi9606.ENSP00000300258.

Structurei

3D structure databases

ProteinModelPortaliQ8TDR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 96Leucine-zipperAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 110Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the TCP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KII0. Eukaryota.
ENOG4110Q7Q. LUCA.
GeneTreeiENSGT00530000064597.
HOGENOMiHOG000136328.
HOVERGENiHBG082781.
InParanoidiQ8TDR4.
OMAiTPCAERR.
OrthoDBiEOG091G00Z1.
PhylomeDBiQ8TDR4.

Family and domain databases

InterProiView protein in InterPro
IPR026581. TCP10_fam.
PANTHERiPTHR10331. PTHR10331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TDR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL
60 70 80 90 100
QQQIIRLHQE LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR
110 120 130 140 150
WKARKKSAAS PHAGQESHTL ALEPAFGKIS PLSADEETIP KYAGHKNQSA
160 170 180 190 200
TLLGQRSSSN NSAPPKPMSL KIERISSWKT PPQENRDKNL SRRRQDRRAT
210
PTGRPTPCAE RRGGV
Length:215
Mass (Da):23,863
Last modified:June 1, 2002 - v1
Checksum:iCF3F74AB520F55FE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016099145H → R2 PublicationsCorresponds to variant dbSNP:rs9622Ensembl.1
Natural variantiVAR_049089194R → H. Corresponds to variant dbSNP:rs16989521Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115967 mRNA. Translation: AAM18531.1.
AK058078 mRNA. Translation: BAB71653.1.
AK223529 mRNA. Translation: BAD97249.1.
AP001714 Genomic DNA. No translation available.
BC033855 mRNA. Translation: AAH33855.1.
CCDSiCCDS13616.1.
RefSeqiNP_653260.1. NM_144659.5.
UniGeneiHs.728804.

Genome annotation databases

EnsembliENST00000300258; ENSP00000300258; ENSG00000242220.
GeneIDi140290.
KEGGihsa:140290.
UCSCiuc002ypw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCP1L_HUMAN
AccessioniPrimary (citable) accession number: Q8TDR4
Secondary accession number(s): Q53EW0, Q96LN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families