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Q8TDR4 (TCP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-complex protein 10A homolog 2

Short name=T-complex protein 10A-2
Short name=TCP10A-2
Alternative name(s):
TCP10-like
Gene names
Name:TCP10L
ORF Names:PRED77
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Ref.6

Subcellular location

Nucleus Ref.6.

Tissue specificity

Expressed in the seminiferous tubules (at protein level). Liver and testis.

Sequence similarities

Belongs to the TCP10 family.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215T-complex protein 10A homolog 2
PRO_0000072462

Regions

Region75 – 9622Leucine-zipper
Coiled coil69 – 11042 Potential

Natural variations

Natural variant1451H → R. Ref.3 Ref.4
Corresponds to variant rs9622 [ dbSNP | Ensembl ].
VAR_016099
Natural variant1941R → H.
Corresponds to variant rs16989521 [ dbSNP | Ensembl ].
VAR_049089

Sequences

Sequence LengthMass (Da)Tools
Q8TDR4 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: CF3F74AB520F55FE

FASTA21523,863
        10         20         30         40         50         60 
MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL QQQIIRLHQE 

        70         80         90        100        110        120 
LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR WKARKKSAAS PHAGQESHTL 

       130        140        150        160        170        180 
ALEPAFGKIS PLSADEETIP KYAGHKNQSA TLLGQRSSSN NSAPPKPMSL KIERISSWKT 

       190        200        210 
PPQENRDKNL SRRRQDRRAT PTGRPTPCAE RRGGV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new human cDNA homologous to human T-complex protein 10A mRNA."
Ge H.P., Yu L., Jin L., Fan Y.X., Yang Y.M., Zhao S.Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-145.
Tissue: Testis.
[4]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-145.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3."
Yu H., Jiang D., Guo Z., Saiyin H., Guo J., Wang X., Yu L.
Int. J. Androl. 28:163-170(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ZIPK/DAPK3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF115967 mRNA. Translation: AAM18531.1.
AK058078 mRNA. Translation: BAB71653.1.
AK223529 mRNA. Translation: BAD97249.1.
AP001714 Genomic DNA. No translation available.
BC033855 mRNA. Translation: AAH33855.1.
CCDSCCDS13616.1.
RefSeqNP_653260.1. NM_144659.5.
UniGeneHs.728804.

3D structure databases

ProteinModelPortalQ8TDR4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126602. 8 interactions.
IntActQ8TDR4. 5 interactions.
STRING9606.ENSP00000300258.

Polymorphism databases

DMDM23822246.

Proteomic databases

PaxDbQ8TDR4.
PRIDEQ8TDR4.

Protocols and materials databases

DNASU140290.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300258; ENSP00000300258; ENSG00000242220.
GeneID140290.
KEGGhsa:140290.
UCSCuc002ypw.4. human.

Organism-specific databases

CTD140290.
GeneCardsGC21M033947.
HGNCHGNC:11657. TCP10L.
HPAHPA044709.
MIM608365. gene.
neXtProtNX_Q8TDR4.
PharmGKBPA36408.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85408.
HOGENOMHOG000136328.
HOVERGENHBG082781.
InParanoidQ8TDR4.
OMAQDRRATP.
OrthoDBEOG7MH0ZX.
PhylomeDBQ8TDR4.

Gene expression databases

BgeeQ8TDR4.
CleanExHS_TCP10L.
GenevestigatorQ8TDR4.

Family and domain databases

InterProIPR026581. TCP10_fam.
[Graphical view]
PANTHERPTHR10331. PTHR10331. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTCP10L. human.
GeneWikiTCP10L.
GenomeRNAi140290.
NextBio84079.
PROQ8TDR4.
SOURCESearch...

Entry information

Entry nameTCP1L_HUMAN
AccessionPrimary (citable) accession number: Q8TDR4
Secondary accession number(s): Q53EW0, Q96LN5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM