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Q8TDR4

- TCP1L_HUMAN

UniProt

Q8TDR4 - TCP1L_HUMAN

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Protein

T-complex protein 10A homolog 2

Gene

TCP10L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.2 Publications

GO - Molecular functioni

  1. protein self-association Source: UniProtKB
  2. repressing transcription factor binding Source: UniProtKB
  3. RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 10A homolog 2
Short name:
T-complex protein 10A-2
Short name:
TCP10A-2
Alternative name(s):
TCP10-like
Gene namesi
Name:TCP10L
ORF Names:PRED77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:11657. TCP10L.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi82 – 821L → F: Greatly decreases in vitro transcription inhibition activity. 1 Publication
Mutagenesisi89 – 891L → P: Disrupts self-association. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA36408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215T-complex protein 10A homolog 2PRO_0000072462Add
BLAST

Proteomic databases

PaxDbiQ8TDR4.
PRIDEiQ8TDR4.

Expressioni

Tissue specificityi

Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).2 Publications

Gene expression databases

BgeeiQ8TDR4.
CleanExiHS_TCP10L.
ExpressionAtlasiQ8TDR4. baseline.
GenevestigatoriQ8TDR4.

Organism-specific databases

HPAiHPA044709.

Interactioni

Subunit structurei

Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-3923210,EBI-3923210
DAPK3O432935EBI-3923210,EBI-77293
MXD4Q145826EBI-3923210,EBI-3943670

Protein-protein interaction databases

BioGridi126602. 8 interactions.
IntActiQ8TDR4. 5 interactions.
STRINGi9606.ENSP00000300258.

Structurei

3D structure databases

ProteinModelPortaliQ8TDR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 9622Leucine-zipperAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 11042Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TCP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85408.
GeneTreeiENSGT00530000064597.
HOGENOMiHOG000136328.
HOVERGENiHBG082781.
InParanoidiQ8TDR4.
OMAiQDRRATP.
OrthoDBiEOG7MH0ZX.
PhylomeDBiQ8TDR4.

Family and domain databases

InterProiIPR026581. TCP10_fam.
[Graphical view]
PANTHERiPTHR10331. PTHR10331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TDR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL
60 70 80 90 100
QQQIIRLHQE LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR
110 120 130 140 150
WKARKKSAAS PHAGQESHTL ALEPAFGKIS PLSADEETIP KYAGHKNQSA
160 170 180 190 200
TLLGQRSSSN NSAPPKPMSL KIERISSWKT PPQENRDKNL SRRRQDRRAT
210
PTGRPTPCAE RRGGV
Length:215
Mass (Da):23,863
Last modified:June 1, 2002 - v1
Checksum:iCF3F74AB520F55FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451H → R.2 Publications
Corresponds to variant rs9622 [ dbSNP | Ensembl ].
VAR_016099
Natural varianti194 – 1941R → H.
Corresponds to variant rs16989521 [ dbSNP | Ensembl ].
VAR_049089

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115967 mRNA. Translation: AAM18531.1.
AK058078 mRNA. Translation: BAB71653.1.
AK223529 mRNA. Translation: BAD97249.1.
AP001714 Genomic DNA. No translation available.
BC033855 mRNA. Translation: AAH33855.1.
CCDSiCCDS13616.1.
RefSeqiNP_653260.1. NM_144659.5.
UniGeneiHs.728804.

Genome annotation databases

EnsembliENST00000300258; ENSP00000300258; ENSG00000242220.
GeneIDi140290.
KEGGihsa:140290.
UCSCiuc002ypw.4. human.

Polymorphism databases

DMDMi23822246.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115967 mRNA. Translation: AAM18531.1 .
AK058078 mRNA. Translation: BAB71653.1 .
AK223529 mRNA. Translation: BAD97249.1 .
AP001714 Genomic DNA. No translation available.
BC033855 mRNA. Translation: AAH33855.1 .
CCDSi CCDS13616.1.
RefSeqi NP_653260.1. NM_144659.5.
UniGenei Hs.728804.

3D structure databases

ProteinModelPortali Q8TDR4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126602. 8 interactions.
IntActi Q8TDR4. 5 interactions.
STRINGi 9606.ENSP00000300258.

Polymorphism databases

DMDMi 23822246.

Proteomic databases

PaxDbi Q8TDR4.
PRIDEi Q8TDR4.

Protocols and materials databases

DNASUi 140290.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300258 ; ENSP00000300258 ; ENSG00000242220 .
GeneIDi 140290.
KEGGi hsa:140290.
UCSCi uc002ypw.4. human.

Organism-specific databases

CTDi 140290.
GeneCardsi GC21M033947.
HGNCi HGNC:11657. TCP10L.
HPAi HPA044709.
MIMi 608365. gene.
neXtProti NX_Q8TDR4.
PharmGKBi PA36408.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85408.
GeneTreei ENSGT00530000064597.
HOGENOMi HOG000136328.
HOVERGENi HBG082781.
InParanoidi Q8TDR4.
OMAi QDRRATP.
OrthoDBi EOG7MH0ZX.
PhylomeDBi Q8TDR4.

Miscellaneous databases

GeneWikii TCP10L.
GenomeRNAii 140290.
NextBioi 84079.
PROi Q8TDR4.
SOURCEi Search...

Gene expression databases

Bgeei Q8TDR4.
CleanExi HS_TCP10L.
ExpressionAtlasi Q8TDR4. baseline.
Genevestigatori Q8TDR4.

Family and domain databases

InterProi IPR026581. TCP10_fam.
[Graphical view ]
PANTHERi PTHR10331. PTHR10331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity."
    Chen Z., Yu L., Wu H., Yu J., Zhang L., Jiang D., Ma L., Li D., Zhao S.
    J. Hum. Genet. 48:556-563(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LEU-82.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-145.
    Tissue: Testis.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-145.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3."
    Yu H., Jiang D., Guo Z., Saiyin H., Guo J., Wang X., Yu L.
    Int. J. Androl. 28:163-170(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ZIPK/DAPK3.
  7. "Human liver specific transcriptional factor TCP10L binds to MAD4."
    Jiang D.J., Yu H.X., Hexige S.Y., Guo Z.K., Wang X., Ma L.J., Chen Z., Zhao S.Y., Yu L.
    J. Biochem. Mol. Biol. 37:402-407(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAD4.
  8. "Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif."
    Zhong Z., Qiu J., Chen X., Wan B., Ni J., Yang Y., Bai M., Zhang H., Yu L.
    Mol. Biol. Rep. 35:171-178(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, MUTAGENESIS OF LEU-89.
  9. "TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma."
    Zuo J., Cai H., Wu Y., Ma H., Jiang W., Liu C., Han D., Ji G., Yu L.
    Biochem. Biophys. Res. Commun. 446:61-67(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTCP1L_HUMAN
AccessioniPrimary (citable) accession number: Q8TDR4
Secondary accession number(s): Q53EW0, Q96LN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3