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Q8TDR4

- TCP1L_HUMAN

UniProt

Q8TDR4 - TCP1L_HUMAN

Protein

T-complex protein 10A homolog 2

Gene

TCP10L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-complex protein 10A homolog 2
    Short name:
    T-complex protein 10A-2
    Short name:
    TCP10A-2
    Alternative name(s):
    TCP10-like
    Gene namesi
    Name:TCP10L
    ORF Names:PRED77
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:11657. TCP10L.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36408.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215T-complex protein 10A homolog 2PRO_0000072462Add
    BLAST

    Proteomic databases

    PaxDbiQ8TDR4.
    PRIDEiQ8TDR4.

    Expressioni

    Tissue specificityi

    Expressed in the seminiferous tubules (at protein level). Liver and testis.

    Gene expression databases

    BgeeiQ8TDR4.
    CleanExiHS_TCP10L.
    GenevestigatoriQ8TDR4.

    Organism-specific databases

    HPAiHPA044709.

    Interactioni

    Subunit structurei

    Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper).1 Publication

    Protein-protein interaction databases

    BioGridi126602. 8 interactions.
    IntActiQ8TDR4. 5 interactions.
    STRINGi9606.ENSP00000300258.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDR4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 9622Leucine-zipperAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili69 – 11042Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TCP10 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG85408.
    HOGENOMiHOG000136328.
    HOVERGENiHBG082781.
    InParanoidiQ8TDR4.
    OMAiQDRRATP.
    OrthoDBiEOG7MH0ZX.
    PhylomeDBiQ8TDR4.

    Family and domain databases

    InterProiIPR026581. TCP10_fam.
    [Graphical view]
    PANTHERiPTHR10331. PTHR10331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TDR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL    50
    QQQIIRLHQE LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR 100
    WKARKKSAAS PHAGQESHTL ALEPAFGKIS PLSADEETIP KYAGHKNQSA 150
    TLLGQRSSSN NSAPPKPMSL KIERISSWKT PPQENRDKNL SRRRQDRRAT 200
    PTGRPTPCAE RRGGV 215
    Length:215
    Mass (Da):23,863
    Last modified:June 1, 2002 - v1
    Checksum:iCF3F74AB520F55FE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451H → R.2 Publications
    Corresponds to variant rs9622 [ dbSNP | Ensembl ].
    VAR_016099
    Natural varianti194 – 1941R → H.
    Corresponds to variant rs16989521 [ dbSNP | Ensembl ].
    VAR_049089

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115967 mRNA. Translation: AAM18531.1.
    AK058078 mRNA. Translation: BAB71653.1.
    AK223529 mRNA. Translation: BAD97249.1.
    AP001714 Genomic DNA. No translation available.
    BC033855 mRNA. Translation: AAH33855.1.
    CCDSiCCDS13616.1.
    RefSeqiNP_653260.1. NM_144659.5.
    UniGeneiHs.728804.

    Genome annotation databases

    EnsembliENST00000300258; ENSP00000300258; ENSG00000242220.
    GeneIDi140290.
    KEGGihsa:140290.
    UCSCiuc002ypw.4. human.

    Polymorphism databases

    DMDMi23822246.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115967 mRNA. Translation: AAM18531.1 .
    AK058078 mRNA. Translation: BAB71653.1 .
    AK223529 mRNA. Translation: BAD97249.1 .
    AP001714 Genomic DNA. No translation available.
    BC033855 mRNA. Translation: AAH33855.1 .
    CCDSi CCDS13616.1.
    RefSeqi NP_653260.1. NM_144659.5.
    UniGenei Hs.728804.

    3D structure databases

    ProteinModelPortali Q8TDR4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126602. 8 interactions.
    IntActi Q8TDR4. 5 interactions.
    STRINGi 9606.ENSP00000300258.

    Polymorphism databases

    DMDMi 23822246.

    Proteomic databases

    PaxDbi Q8TDR4.
    PRIDEi Q8TDR4.

    Protocols and materials databases

    DNASUi 140290.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300258 ; ENSP00000300258 ; ENSG00000242220 .
    GeneIDi 140290.
    KEGGi hsa:140290.
    UCSCi uc002ypw.4. human.

    Organism-specific databases

    CTDi 140290.
    GeneCardsi GC21M033947.
    HGNCi HGNC:11657. TCP10L.
    HPAi HPA044709.
    MIMi 608365. gene.
    neXtProti NX_Q8TDR4.
    PharmGKBi PA36408.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85408.
    HOGENOMi HOG000136328.
    HOVERGENi HBG082781.
    InParanoidi Q8TDR4.
    OMAi QDRRATP.
    OrthoDBi EOG7MH0ZX.
    PhylomeDBi Q8TDR4.

    Miscellaneous databases

    ChiTaRSi TCP10L. human.
    GeneWikii TCP10L.
    GenomeRNAii 140290.
    NextBioi 84079.
    PROi Q8TDR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDR4.
    CleanExi HS_TCP10L.
    Genevestigatori Q8TDR4.

    Family and domain databases

    InterProi IPR026581. TCP10_fam.
    [Graphical view ]
    PANTHERi PTHR10331. PTHR10331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new human cDNA homologous to human T-complex protein 10A mRNA."
      Ge H.P., Yu L., Jin L., Fan Y.X., Yang Y.M., Zhao S.Y.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-145.
      Tissue: Testis.
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-145.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3."
      Yu H., Jiang D., Guo Z., Saiyin H., Guo J., Wang X., Yu L.
      Int. J. Androl. 28:163-170(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ZIPK/DAPK3.

    Entry informationi

    Entry nameiTCP1L_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDR4
    Secondary accession number(s): Q53EW0, Q96LN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3