Q8TDQ1 (CLM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CMRF35-like molecule 1
Short name=CLM-1

Alternative name(s):
CD300 antigen-like family member F
Immune receptor expressed on myeloid cells 1
Short name=IREM-1
Immunoglobulin superfamily member 13
Short name=IgSF13
NK inhibitory receptor
CD_antigen=CD300f

Gene names

Name:	CD300LF
Synonyms:	CD300F, CLM1, IGSF13, IREM1, NKIR
ORF Names:	UNQ3105/PRO10111

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Ref.2
Subunit structure	Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner. Ref.1 Ref.2
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells. Ref.1 Ref.2
Post-translational modification	Phosphorylated on tyrosine. Ref.1
Sequence similarities	Belongs to the CD300 family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MPLLTLYLLLFWLS → MWLPQLDLMRVISAKSQ
     128-128: A → ASTPAPTTPTSTTFTA
     187-221: AAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKAT → GTAAPGGRPLLCRPDPAAGRNLPAKGYHEAFLCPG
     222-290: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TDQ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MPLLTLYLLLFWLS → MWLPQLDLMRVISAKSQ
     150-162: HKLLKLSVLLPLI → YCSPWRATSAMQT
     163-290: Missing.

Isoform 4 (identifier: Q8TDQ1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MPLLTLYLLLFWLS → MWLPQLDLMRVISAKSQ
     149-191: RHKLLKLSVL...KYQQKAAGMS → SSRDVPRAGT...GYHEAFLCPG
     192-290: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8TDQ1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     150-244: HKLLKLSVLL...EYVTMASLPK → SEGSQAANYR...GYHEAFLCPG
     245-290: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q8TDQ1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MPLLTLYLLLFWLS → MWLPQLDLMRVISAKSQ

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Ref.8

Chain

20 – 290

271

CMRF35-like molecule 1

PRO_0000247825

Regions

Topological domain

20 – 156

137

Extracellular Potential

Transmembrane

157 – 177

21

Helical; Potential

Topological domain

178 – 290

113

Cytoplasmic Potential

Domain

20 – 126

107

Ig-like V-type

Sites

Site

205

1

Phosphatase-binding

Amino acid modifications

Glycosylation

88

1

N-linked (GlcNAc...) Potential

Disulfide bond

40 ↔ 108

Ref.9

Disulfide bond

54 ↔ 62

Ref.9

Natural variations

Alternative sequence

1 – 14

14

MPLLT…LFWLS → MWLPQLDLMRVISAKSQ in isoform 2, isoform 3, isoform 4 and isoform 6.

VSP_020056

Alternative sequence

128

1

A → ASTPAPTTPTSTTFTA in isoform 2.

VSP_020057

Alternative sequence

149 – 191

43

RHKLL…AAGMS → SSRDVPRAGTAAPGGRPLLC RPDPAAGRNLPAKGYHEAFL CPG in isoform 4.

VSP_020058

Alternative sequence

150 – 244

95

HKLLK…ASLPK → SEGSQAANYRPAAHQAQAPE AQCPPAPHLHHIAAAFGGRL TLGLEDDEVPAESSRDVPRA GTAAPGGRPLLCRPDPAAGR NLPAKGYHEAFLCPG in isoform 5.

VSP_020059

Alternative sequence

150 – 162

13

HKLLK…LLPLI → YCSPWRATSAMQT in isoform 3.

VSP_020060

Alternative sequence

163 – 290

128

Missing in isoform 3.

VSP_020061

Alternative sequence

187 – 221

35

AAGMS…PQKAT → GTAAPGGRPLLCRPDPAAGR NLPAKGYHEAFLCPG in isoform 2.

VSP_020062

Alternative sequence

192 – 290

99

Missing in isoform 4.

VSP_020063

Alternative sequence

222 – 290

69

Missing in isoform 2.

VSP_020064

Alternative sequence

245 – 290

46

Missing in isoform 5.

VSP_020065

Natural variant

19

1

V → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7
Corresponds to variant rs35489971 [ dbSNP | Ensembl ].

VAR_039128

Natural variant

218

1

Q → R. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs2034310 [ dbSNP | Ensembl ].

VAR_027152

Experimental info

Mutagenesis

205

1

Y → F: No interaction with PTPN6. Ref.2

Mutagenesis

249

1

Y → F: Interaction with PTPN6. Ref.2

Mutagenesis

284

1

Y → F: Interaction with PTPN6. Ref.2

Sequence conflict

37

1

T → A in AAZ81566. Ref.5

Sequence conflict

64

1

I → V in AAZ81566. Ref.5

Sequence conflict

78

1

D → N in AAP42153. Ref.2

Sequence conflict

135

1

T → I in AAP42152. Ref.2

Sequence conflict

138

1

S → F in AAM19099. Ref.1

Sequence conflict

212

1

L → Q in AAP42152. Ref.2

Sequence conflict

268

1

H → R in AAP57942. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

290

Helix Strand Turn

Details...

Beta strand

21 – 23

3

Beta strand

26 – 31

6

Beta strand

36 – 42

7

Beta strand

49 – 59

11

Beta strand

63 – 67

5

Beta strand

70 – 72

3

Beta strand

75 – 77

3

Beta strand

80 – 85

6

Turn

86 – 89

4

Beta strand

90 – 95

6

Helix

100 – 102

3

Beta strand

104 – 112

9

Beta strand

115 – 126

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 27AA95664B82B945	FASTA	290	32,335
	10 20 30 40 50 60 MPLLTLYLLL FWLSGYSIVT QITGPTTVNG LERGSLTVQC VYRSGWETYL KWWCRGAIWR 70 80 90 100 110 120 DCKILVKTSG SEQEVKRDRV SIKDNQKNRT FTVTMEDLMK TDADTYWCGI EKTGNDLGVT 130 140 150 160 170 180 VQVTIDPAPV TQEETSSSPT LTGHHLDNRH KLLKLSVLLP LIFTILLLLL VAASLLAWRM 190 200 210 220 230 240 MKYQQKAAGM SPEQVLQPLE GDLCYADLTL QLAGTSPQKA TTKLSSAQVD QVEVEYVTMA 250 260 270 280 290 SLPKEDISYA SLTLGAEDQE PTYCNMGHLS SHLPGRGPEE PTEYSTISRP
	Isoform 2 [UniParc]. Checksum: C67579996CFFA382	FASTA	239	26,480
	10 20 30 40 50 60 MWLPQLDLMR VISAKSQGYS IVTQITGPTT VNGLERGSLT VQCVYRSGWE TYLKWWCRGA 70 80 90 100 110 120 IWRDCKILVK TSGSEQEVKR DRVSIKDNQK NRTFTVTMED LMKTDADTYW CGIEKTGNDL 130 140 150 160 170 180 GVTVQVTIDP ASTPAPTTPT STTFTAPVTQ EETSSSPTLT GHHLDNRHKL LKLSVLLPLI 190 200 210 220 230 FTILLLLLVA ASLLAWRMMK YQQKGTAAPG GRPLLCRPDP AAGRNLPAKG YHEAFLCPG
	Isoform 3 [UniParc]. Checksum: 8D46CA836B7E8AAE	FASTA	165	18,684
	10 20 30 40 50 60 MWLPQLDLMR VISAKSQGYS IVTQITGPTT VNGLERGSLT VQCVYRSGWE TYLKWWCRGA 70 80 90 100 110 120 IWRDCKILVK TSGSEQEVKR DRVSIKDNQK NRTFTVTMED LMKTDADTYW CGIEKTGNDL 130 140 150 160 GVTVQVTIDP APVTQEETSS SPTLTGHHLD NRYCSPWRAT SAMQT
	Isoform 4 [UniParc]. Checksum: 9274E383F4A98236	FASTA	194	21,427
	10 20 30 40 50 60 MWLPQLDLMR VISAKSQGYS IVTQITGPTT VNGLERGSLT VQCVYRSGWE TYLKWWCRGA 70 80 90 100 110 120 IWRDCKILVK TSGSEQEVKR DRVSIKDNQK NRTFTVTMED LMKTDADTYW CGIEKTGNDL 130 140 150 160 170 180 GVTVQVTIDP APVTQEETSS SPTLTGHHLD NSSRDVPRAG TAAPGGRPLL CRPDPAAGRN 190 LPAKGYHEAF LCPG
	Isoform 5 [UniParc]. Checksum: 8CB8B81FCB47821A	FASTA	244	26,671
	10 20 30 40 50 60 MPLLTLYLLL FWLSGYSIVT QITGPTTVNG LERGSLTVQC VYRSGWETYL KWWCRGAIWR 70 80 90 100 110 120 DCKILVKTSG SEQEVKRDRV SIKDNQKNRT FTVTMEDLMK TDADTYWCGI EKTGNDLGVT 130 140 150 160 170 180 VQVTIDPAPV TQEETSSSPT LTGHHLDNRS EGSQAANYRP AAHQAQAPEA QCPPAPHLHH 190 200 210 220 230 240 IAAAFGGRLT LGLEDDEVPA ESSRDVPRAG TAAPGGRPLL CRPDPAAGRN LPAKGYHEAF LCPG
	Isoform 6 [UniParc]. Checksum: C8AC14CA781BCFC4	FASTA	293	32,628
	10 20 30 40 50 60 MWLPQLDLMR VISAKSQGYS IVTQITGPTT VNGLERGSLT VQCVYRSGWE TYLKWWCRGA 70 80 90 100 110 120 IWRDCKILVK TSGSEQEVKR DRVSIKDNQK NRTFTVTMED LMKTDADTYW CGIEKTGNDL 130 140 150 160 170 180 GVTVQVTIDP APVTQEETSS SPTLTGHHLD NRHKLLKLSV LLPLIFTILL LLLVAASLLA 190 200 210 220 230 240 WRMMKYQQKA AGMSPEQVLQ PLEGDLCYAD LTLQLAGTSP QKATTKLSSA QVDQVEVEYV 250 260 270 280 290 TMASLPKEDI SYASLTLGAE DQEPTYCNMG HLSSHLPGRG PEEPTEYSTI SRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes." Sui L., Li N., Liu Q., Zhang W., Wan T., Wang B., Luo K., Sun H., Cao X. Biochem. Biophys. Res. Commun. 319:920-928(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH PTPN6, PHOSPHORYLATION, VARIANTS ALA-19 AND ARG-218.
[2]	"IREM-1 is a novel inhibitory receptor expressed by myeloid cells." Alvarez-Errico D., Aguilar H., Kitzig F., Brckalo T., Sayos J., Lopez-Botet M. Eur. J. Immunol. 34:3690-3701(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 6), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH PTPN6, SITE, MUTAGENESIS OF TYR-205; TYR-249 AND TYR-284, VARIANTS ALA-19 AND ARG-218.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-19 AND ARG-218.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS ALA-19 AND ARG-218. Tissue: Small intestine and Umbilical cord blood.
[5]	Lin L., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Tang Z., Wen S., Li H., Yang S. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-19.
[6]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ALA-19. Tissue: Lung.
[8]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
[9]	"The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1." Marquez J.A., Galfre E., Dupeux F., Flot D., Moran O., Dimasi N. J. Mol. Biol. 367:310-318(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 21-140, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF251706 mRNA. Translation: AAM19099.1.
AF375480 mRNA. Translation: AAP42152.1.
AF375481 mRNA. Translation: AAP42153.1.
AY303545 mRNA. Translation: AAP57942.1.
AY358545 mRNA. Translation: AAQ88909.1.
AK092757 mRNA. Translation: BAC03966.1.
AK315165 mRNA. Translation: BAG37609.1.
DQ153249 mRNA. Translation: AAZ81566.1.
AC016888 Genomic DNA. No translation available.
AC064805 Genomic DNA. No translation available.
BC028199 mRNA. Translation: AAH28199.1.

IPI

IPI00167988.
IPI00182205.
IPI00385550.
IPI00419649.
IPI00651716.
IPI00783431.

RefSeq

NP_620587.2. NM_139018.3.

UniGene

Hs.567706.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2NMS	X-ray	2.60	A	21-140	[»]

ProteinModelPortal

Q8TDQ1.

SMR

Q8TDQ1. Positions 19-129.

ModBase

Search...

PTM databases

PhosphoSite

Q8TDQ1.

Polymorphism databases

DMDM

296439398.

Proteomic databases

PaxDb

Q8TDQ1.

PRIDE

Q8TDQ1.

Protocols and materials databases

DNASU

146722.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000301573; ENSP00000301573; ENSG00000186074.
ENST00000326165; ENSP00000327075; ENSG00000186074.
ENST00000343125; ENSP00000343751; ENSG00000186074.
ENST00000361254; ENSP00000355294; ENSG00000186074.
ENST00000462044; ENSP00000464223; ENSG00000186074.
ENST00000464910; ENSP00000464257; ENSG00000186074.
ENST00000469092; ENSP00000463743; ENSG00000186074.
ENST00000581500; ENSP00000464610; ENSG00000186074.

GeneID

146722.

KEGG

hsa:146722.

UCSC

uc002jlf.3. human.
uc002jlg.3. human.
uc002jlh.3. human.
uc002jli.3. human.
uc002jlj.1. human.

Organism-specific databases

CTD

146722.

GeneCards

GC17M072690.

H-InvDB

HIX0021633.

HGNC

HGNC:29883. CD300LF.

HPA

HPA013712.

MIM

609807. gene.

neXtProt

NX_Q8TDQ1.

PharmGKB

PA142672153.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG75577.

HOVERGEN

HBG050999.

InParanoid

Q8TDQ1.

OMA

PQLDLMR.

OrthoDB

EOG479F8P.

Gene expression databases

Bgee

Q8TDQ1.

Genevestigator

Q8TDQ1.

GermOnline

ENSG00000186074. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00409. IG. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8TDQ1.

GenomeRNAi

146722.

NextBio

85431.

SOURCE

Search...

Entry information

Entry name

CLM1_HUMAN

Accession

Primary (citable) accession number: Q8TDQ1
Secondary accession number(s): B2RCL2 , C9JDN3, Q3Y6P0, Q6UX24, Q7Z6A6, Q7Z7I4, Q7Z7I5, Q8N6D0, Q8NAF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.