Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TDQ0

- HAVR2_HUMAN

UniProt

Q8TDQ0 - HAVR2_HUMAN

Protein

Hepatitis A virus cellular receptor 2

Gene

HAVCR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.2 Publications

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatitis A virus cellular receptor 2
    Short name:
    HAVcr-2
    Alternative name(s):
    T-cell immunoglobulin and mucin domain-containing protein 3
    Short name:
    TIMD-3
    T-cell immunoglobulin mucin receptor 3
    Short name:
    TIM-3
    T-cell membrane protein 3
    Gene namesi
    Name:HAVCR2
    Synonyms:TIM3, TIMD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:18437. HAVCR2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134883425.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 301280Hepatitis A virus cellular receptor 2PRO_0000042101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 110PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 63PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 109PROSITE-ProRule annotation
    Glycosylationi145 – 1451O-linked (GalNAc...)1 Publication
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TDQ0.
    PRIDEiQ8TDQ0.

    PTM databases

    PhosphoSiteiQ8TDQ0.

    Expressioni

    Tissue specificityi

    T-helper type 1 lymphocyte (Th1)-specific.

    Gene expression databases

    ArrayExpressiQ8TDQ0.
    BgeeiQ8TDQ0.
    CleanExiHS_HAVCR2.
    GenevestigatoriQ8TDQ0.

    Organism-specific databases

    HPAiCAB026003.
    HPA010505.

    Interactioni

    Protein-protein interaction databases

    BioGridi124313. 3 interactions.
    STRINGi9606.ENSP00000312002.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDQ0.
    SMRiQ8TDQ0. Positions 26-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 202181ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 30178CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 124103Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. TIM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41841.
    HOVERGENiHBG098563.
    InParanoidiQ8TDQ0.
    OMAiPRMLTTR.
    OrthoDBiEOG74XS6M.
    PhylomeDBiQ8TDQ0.
    TreeFamiTF336163.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDQ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSHLPFDCV LLLLLLLLTR SSEVEYRAEV GQNAYLPCFY TPAAPGNLVP    50
    VCWGKGACPV FECGNVVLRT DERDVNYWTS RYWLNGDFRK GDVSLTIENV 100
    TLADSGIYCC RIQIPGIMND EKFNLKLVIK PAKVTPAPTR QRDFTAAFPR 150
    MLTTRGHGPA ETQTLGSLPD INLTQISTLA NELRDSRLAN DLRDSGATIR 200
    IGIYIGAGIC AGLALALIFG ALIFKWYSHS KEKIQNLSLI SLANLPPSGL 250
    ANAVAEGIRS EENIYTIEEN VYEVEEPNEY YCYVSSRQQP SQPLGCRFAM 300
    P 301
    Length:301
    Mass (Da):33,394
    Last modified:November 2, 2010 - v3
    Checksum:i519A5B0D512B6173
    GO
    Isoform 2 (identifier: Q8TDQ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-142: AKVTPAPTRQR → GEWTFACHLYE
         143-301: Missing.

    Show »
    Length:142
    Mass (Da):16,149
    Checksum:iE2C82D8B5AABC23E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1011T → I in AAM19100. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401R → L.6 Publications
    Corresponds to variant rs1036199 [ dbSNP | Ensembl ].
    VAR_025342

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei132 – 14211AKVTPAPTRQR → GEWTFACHLYE in isoform 2. 1 PublicationVSP_017287Add
    BLAST
    Alternative sequencei143 – 301159Missing in isoform 2. 1 PublicationVSP_017288Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251707 mRNA. Translation: AAM19100.1.
    AY069944 mRNA. Translation: AAL55401.1.
    AK027334 mRNA. Translation: BAB55044.1.
    AK314406 mRNA. Translation: BAG37029.1.
    AC011377 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61614.1.
    BC020843 mRNA. Translation: AAH20843.1.
    BC063431 mRNA. Translation: AAH63431.1.
    CCDSiCCDS4333.1. [Q8TDQ0-1]
    RefSeqiNP_116171.3. NM_032782.4. [Q8TDQ0-1]
    UniGeneiHs.710500.

    Genome annotation databases

    EnsembliENST00000307851; ENSP00000312002; ENSG00000135077. [Q8TDQ0-1]
    GeneIDi84868.
    KEGGihsa:84868.
    UCSCiuc003lwk.2. human. [Q8TDQ0-1]
    uc003lwl.3. human. [Q8TDQ0-2]

    Polymorphism databases

    DMDMi311033536.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251707 mRNA. Translation: AAM19100.1 .
    AY069944 mRNA. Translation: AAL55401.1 .
    AK027334 mRNA. Translation: BAB55044.1 .
    AK314406 mRNA. Translation: BAG37029.1 .
    AC011377 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61614.1 .
    BC020843 mRNA. Translation: AAH20843.1 .
    BC063431 mRNA. Translation: AAH63431.1 .
    CCDSi CCDS4333.1. [Q8TDQ0-1 ]
    RefSeqi NP_116171.3. NM_032782.4. [Q8TDQ0-1 ]
    UniGenei Hs.710500.

    3D structure databases

    ProteinModelPortali Q8TDQ0.
    SMRi Q8TDQ0. Positions 26-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124313. 3 interactions.
    STRINGi 9606.ENSP00000312002.

    PTM databases

    PhosphoSitei Q8TDQ0.

    Polymorphism databases

    DMDMi 311033536.

    Proteomic databases

    PaxDbi Q8TDQ0.
    PRIDEi Q8TDQ0.

    Protocols and materials databases

    DNASUi 84868.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307851 ; ENSP00000312002 ; ENSG00000135077 . [Q8TDQ0-1 ]
    GeneIDi 84868.
    KEGGi hsa:84868.
    UCSCi uc003lwk.2. human. [Q8TDQ0-1 ]
    uc003lwl.3. human. [Q8TDQ0-2 ]

    Organism-specific databases

    CTDi 84868.
    GeneCardsi GC05M156512.
    H-InvDB HIX0005353.
    HGNCi HGNC:18437. HAVCR2.
    HPAi CAB026003.
    HPA010505.
    MIMi 606652. gene.
    neXtProti NX_Q8TDQ0.
    PharmGKBi PA134883425.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41841.
    HOVERGENi HBG098563.
    InParanoidi Q8TDQ0.
    OMAi PRMLTTR.
    OrthoDBi EOG74XS6M.
    PhylomeDBi Q8TDQ0.
    TreeFami TF336163.

    Miscellaneous databases

    GeneWikii HAVCR2.
    GenomeRNAii 84868.
    NextBioi 75147.
    PROi Q8TDQ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDQ0.
    Bgeei Q8TDQ0.
    CleanExi HS_HAVCR2.
    Genevestigatori Q8TDQ0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
      Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.
      Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-140.
    2. "Novel human hepatitis A virus cellular receptor."
      Zhang W., Wan T., Li N., Cao X.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-140.
    3. "A homolog to human kidney injury molecule-1 is expressed in hepatoma cells."
      Kuehn E.W., Ichimura T., Bonventre J.V.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-140.
      Tissue: Hepatoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-140.
      Tissue: Embryo and Umbilical cord blood.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-140.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-140.
      Tissue: Lung and Pancreas.
    8. "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance."
      Sanchez-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., Manlongat N., Bender O., Kamradt T., Kuchroo V.K., Gutierrez-Ramos J.-C., Coyle A.J., Strom T.B.
      Nat. Immunol. 4:1093-1101(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."
      Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K.
      Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A RECEPTOR FOR LGALS9.
    10. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-145, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiHAVR2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDQ0
    Secondary accession number(s): B2RAY2, Q8WW60, Q96K94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3