ID   ACER1_HUMAN             Reviewed;         264 AA.
AC   Q8TDN7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   09-FEB-2010, entry version 48.
DE   RecName: Full=Alkaline ceramidase 1;
DE            Short=Alkaline CDase 1;
DE            Short=AlkCDase 1;
DE            EC=3.5.1.23;
DE   AltName: Full=N-acylsphingosine amidohydrolase 3;
DE   AltName: Full=Acylsphingosine deacylase 3;
GN   Name=ACER1; Synonyms=ASAH3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22791695; PubMed=12783875; DOI=10.1074/jbc.M303875200;
RA   Mao C., Xu R., Szulc Z.M., Bielawski J., Becker K.P., Bielawska A.,
RA   Galadari S.H., Hu W., Obeid L.M.;
RT   "Cloning and characterization of a mouse endoplasmic reticulum
RT   alkaline ceramidase: an enzyme that preferentially regulates
RT   metabolism of very long chain ceramides.";
RL   J. Biol. Chem. 278:31184-31191(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16477081; DOI=10.1194/jlr.M600001-JLR200;
RA   Houben E., Holleran W.M., Yaginuma T., Mao C., Obeid L.M., Rogiers V.,
RA   Takagi Y., Elias P.M., Uchida Y.;
RT   "Differentiation-associated expression of ceramidase isoforms in
RT   cultured keratinocytes and epidermis.";
RL   J. Lipid Res. 47:1063-1070(2006).
CC   -!- FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine
CC       and free fatty acid at an optimal pH of 8.0. Has a highly
CC       restricted substrate specificity for the natural stereoisomer of
CC       ceramide with D-erythro-sphingosine but not D-ribo-
CC       phytosphingosine or D-erythro-dihydrosphingosine as a backbone.
CC       May have a role in regulating the levels of bioactive lipids
CC       ceramide and sphingosine 1-phosphate, as well as complex
CC       sphingolipids (By similarity).
CC   -!- CATALYTIC ACTIVITY: N-acylsphingosine + H(2)O = a carboxylate +
CC       sphingosine.
CC   -!- ENZYME REGULATION: Inhibited by sphingosine (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Mainly expressed in epidermis.
CC   -!- SIMILARITY: Belongs to the alkaline ceramidase family.
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DR   EMBL; AF347024; AAL83822.1; -; mRNA.
DR   EMBL; BC112122; AAI12123.1; -; mRNA.
DR   EMBL; BC112124; AAI12125.1; -; mRNA.
DR   IPI; IPI00152570; -.
DR   RefSeq; NP_597999.1; -.
DR   UniGene; Hs.352609; -.
DR   STRING; Q8TDN7; -.
DR   Ensembl; ENST00000301452; ENSP00000301452; ENSG00000167769; Homo sapiens.
DR   GeneID; 125981; -.
DR   KEGG; hsa:125981; -.
DR   UCSC; uc002mel.1; human.
DR   CTD; 125981; -.
DR   GeneCards; GC19M006259; -.
DR   HGNC; HGNC:18356; ACER1.
DR   PharmGKB; PA134897634; -.
DR   eggNOG; prNOG04896; -.
DR   HOGENOM; HBG446871; -.
DR   HOVERGEN; Q8TDN7; -.
DR   InParanoid; Q8TDN7; -.
DR   OMA; FQYSELV; -.
DR   OrthoDB; EOG9M682S; -.
DR   PhylomeDB; Q8TDN7; -.
DR   BRENDA; 3.5.1.23; 247.
DR   Reactome; REACT_602; Metabolism of lipids and lipoproteins.
DR   NextBio; 81606; -.
DR   ArrayExpress; Q8TDN7; -.
DR   Bgee; Q8TDN7; -.
DR   CleanEx; HS_ACER1; -.
DR   Genevestigator; Q8TDN7; -.
DR   GermOnline; ENSG00000167769; Homo sapiens.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; EXP:Reactome.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017040; F:ceramidase activity; EXP:Reactome.
PE   2: Evidence at transcript level;
KW   Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase;
KW   Lipid metabolism; Membrane; Transmembrane.
FT   CHAIN         1    264       Alkaline ceramidase 1.
FT                                /FTId=PRO_0000247745.
FT   TRANSMEM     28     48       Potential.
FT   TRANSMEM     58     78       Potential.
FT   TRANSMEM     82    102       Potential.
FT   TRANSMEM    120    137       Potential.
FT   TRANSMEM    139    159       Potential.
FT   TRANSMEM    177    197       Potential.
FT   TRANSMEM    207    227       Potential.
FT   CARBOHYD    116    116       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   264 AA;  31095 MW;  E16E5DB81D064F60 CRC64;
     MPSIFAYQSS EVDWCESNFQ YSELVAEFYN TFSNIPFFIF GPLMMLLMHP YAQKRSRYIY
     VVWVLFMIIG LFSMYFHMTL SFLGQLLDEI AILWLLGSGY SIWMPRCYFP SFLGGNRSQF
     IRLVFITTVV STLLSFLRPT VNAYALNSIA LHILYIVCQE YRKTSNKELR HLIEVSVVLW
     AVALTSWISD RLLCSFWQRI HFFYLHSIWH VLISITFPYG MVTMALVDAN YEMPGETLKV
     RYWPRDSWPV GLPYVEIRGD DKDC
//