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Protein

Ribosome biogenesis protein BRX1 homolog

Gene

BRIX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BRX1 homolog
Alternative name(s):
Brix domain-containing protein 2
Gene namesi
Name:BRIX1
Synonyms:BRIX, BXDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113460.12.
HGNCiHGNC:24170. BRIX1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113460.
PharmGKBiPA165660166.

Polymorphism and mutation databases

BioMutaiBRIX1.
DMDMi30580352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202301 – 353Ribosome biogenesis protein BRX1 homologAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei261PhosphoserineCombined sources1
Modified residuei276N6-acetyllysineCombined sources1
Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TDN6.
MaxQBiQ8TDN6.
PaxDbiQ8TDN6.
PeptideAtlasiQ8TDN6.
PRIDEiQ8TDN6.

PTM databases

iPTMnetiQ8TDN6.
PhosphoSitePlusiQ8TDN6.
SwissPalmiQ8TDN6.

Expressioni

Gene expression databases

BgeeiENSG00000113460.
CleanExiHS_BXDC2.
GenevisibleiQ8TDN6. HS.

Organism-specific databases

HPAiHPA039614.

Interactioni

Protein-protein interaction databases

BioGridi120586. 122 interactors.
CORUMiQ8TDN6.
IntActiQ8TDN6. 23 interactors.
MINTiMINT-1373627.
STRINGi9606.ENSP00000338862.

Structurei

3D structure databases

ProteinModelPortaliQ8TDN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 249BrixPROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Belongs to the BRX1 family.Curated

Phylogenomic databases

eggNOGiKOG2971. Eukaryota.
COG5154. LUCA.
GeneTreeiENSGT00390000014467.
HOGENOMiHOG000212937.
HOVERGENiHBG039185.
InParanoidiQ8TDN6.
KOiK14820.
OMAiKPKRNEK.
OrthoDBiEOG091G0C4X.
PhylomeDBiQ8TDN6.
TreeFamiTF105766.

Family and domain databases

InterProiView protein in InterPro
IPR036621. Anticodon-bd_dom_sf.
IPR007109. Brix.
IPR026532. BRX1.
PANTHERiPTHR13634. PTHR13634. 2 hits.
PfamiView protein in Pfam
PF04427. Brix. 1 hit.
SMARTiView protein in SMART
SM00879. Brix. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiView protein in PROSITE
PS50833. BRIX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TDN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATKRKRRG GFAVQAKKPK RNEIDAEPPA KRHATAEEVE EEERDRIPGP
60 70 80 90 100
VCKGKWKNKE RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL
110 120 130 140 150
FVINEVCEMK NCNKCIYFEA KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA
160 170 180 190 200
ELKMTGNCLK GSRPLLSFDP AFDELPHYAL LKELLIQIFS TPRYHPKSQP
210 220 230 240 250
FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL IKIFQGSFGG
260 270 280 290 300
PTLYENPHYQ SPNMHRRVIR SITAAKYREK QQVKDVQKLR KKEPKTLLPH
310 320 330 340 350
DPTADVFVTP AEEKPIEIQW VKPEPKVDLK ARKKRIYKRQ RKMKQRMDSG

KTK
Length:353
Mass (Da):41,401
Last modified:May 9, 2003 - v2
Checksum:iF05597673A13B7CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 27GFAVQ…EIDAE → RLCSSGEEAKKKRNRCG in AAL83818 (PubMed:11843177).CuratedAdd BLAST17
Sequence conflicti34A → V in AAL83818 (PubMed:11843177).Curated1
Sequence conflicti286V → VP in AAL83818 (PubMed:11843177).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347667 mRNA. Translation: AAL83818.1.
AY364244 mRNA. Translation: AAQ76803.1.
AK289610 mRNA. Translation: BAF82299.1.
CH471119 Genomic DNA. Translation: EAW55909.1.
BC001546 mRNA. Translation: AAH01546.2.
BC036741 mRNA. Translation: AAH36741.1.
CCDSiCCDS34143.1.
RefSeqiNP_060791.3. NM_018321.3.
UniGeneiHs.718510.

Genome annotation databases

EnsembliENST00000336767; ENSP00000338862; ENSG00000113460.
GeneIDi55299.
KEGGihsa:55299.
UCSCiuc003jja.4. human.

Similar proteinsi

Entry informationi

Entry nameiBRX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDN6
Secondary accession number(s): A8K0P5
, Q3ZTT4, Q8N453, Q96DH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: October 25, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families