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Q8TDN4

- CABL1_HUMAN

UniProt

Q8TDN4 - CABL1_HUMAN

Protein

CDK5 and ABL1 enzyme substrate 1

Gene

CABLES1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. nervous system development Source: Ensembl
    5. regulation of cell cycle Source: InterPro
    6. regulation of cell division Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ8TDN4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 and ABL1 enzyme substrate 1
    Alternative name(s):
    Interactor with CDK3 1
    Short name:
    Ik3-1
    Gene namesi
    Name:CABLES1
    Synonyms:CABLES
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:25097. CABLES1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880184.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 633633CDK5 and ABL1 enzyme substrate 1PRO_0000080510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei168 – 1681Phosphoserine2 Publications
    Modified residuei287 – 2871Phosphoserine2 Publications
    Modified residuei313 – 3131Phosphoserine; by CDK2 and CDK3By similarity
    Modified residuei415 – 4151Phosphothreonine3 Publications

    Post-translational modificationi

    Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TDN4.
    PaxDbiQ8TDN4.
    PRIDEiQ8TDN4.

    PTM databases

    PhosphoSiteiQ8TDN4.

    Expressioni

    Tissue specificityi

    Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.2 Publications

    Developmental stagei

    Expression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase.1 Publication

    Inductioni

    Up-regulated by progesterone and down-regulated by estrogen in benign endometrium.1 Publication

    Gene expression databases

    ArrayExpressiQ8TDN4.
    BgeeiQ8TDN4.
    CleanExiHS_CABLES1.
    GenevestigatoriQ8TDN4.

    Interactioni

    Subunit structurei

    Found in a complex with p53/TP53. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK5Q005354EBI-604615,EBI-1041567
    TP63Q9H3D4-17EBI-604615,EBI-2400586

    Protein-protein interaction databases

    BioGridi124877. 3 interactions.
    IntActiQ8TDN4. 4 interactions.
    MINTiMINT-6615967.
    STRINGi9606.ENSP00000256925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDN4.
    SMRiQ8TDN4. Positions 501-629.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 109109Interacts with TDRD7By similarityAdd
    BLAST
    Regioni179 – 492314Interacts with CDK3By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 134133Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiNOG256533.
    HOGENOMiHOG000231236.
    HOVERGENiHBG050759.
    InParanoidiQ8TDN4.
    OMAiQNYCSLE.
    OrthoDBiEOG7P5T0S.
    PhylomeDBiQ8TDN4.
    TreeFamiTF323936.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF025798. Cables. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDN4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAAATT AACSSGSAGT DAAGASGLQQ PPPQPQPQPA AAAPAQPPPE    50
    PPRKPRMDPR RRQAALSFLT NISLDGRLPP QDAEWGGGEE GGAAKPGAGG 100
    ACGARTRFSL LAAAERGGCI ALAAPGTPAA GLAAGSGPCL PQPSSLPPLI 150
    PGGHATVSGP GVARGFASPL GAGRASGEQW QPPRPAPLAA CAQLQLLDGS 200
    GAAGQEELEE DDAFISVQVP AAAFLGSGTP GSGSGSRGRL NSFTQGILPI 250
    AFSRPTSQNY CSLEQPGQGG STSAFEQLQR SRRRLISQRS SLETLEDIEE 300
    NAPLRRCRTL SGSPRPKNFK KIHFIKNMRQ HDTRNGRIVL ISGRRSFCSI 350
    FSVLPYRDST QVGDLKLDGG RQSTGAVSLK EIIGLEGVEL GADGKTVSYT 400
    QFLLPTNAFG ARRNTIDSTS SFSQFRNLSH RSLSIGRASG TQGSLDTGSD 450
    LGDFMDYDPN LLDDPQWPCG KHKRVLIFPS YMTTVIDYVK PSDLKKDMNE 500
    TFKEKFPHIK LTLSKIRSLK REMRKLAQED CGLEEPTVAM AFVYFEKLAL 550
    KGKLNKQNRK LCAGACVLLA AKIGSDLKKH EVKHLIDKLE EKFRLNRREL 600
    IAFEFPVLVA LEFALHLPEH EVMPHYRRLV QSS 633

    Note: No experimental confirmation available.

    Length:633
    Mass (Da):67,599
    Last modified:February 1, 2005 - v2
    Checksum:iD3569C6BFF635A82
    GO
    Isoform 2 (identifier: Q8TDN4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-265: Missing.
         266-282: PGQGGSTSAFEQLQRSR → MLSKRGCHARIYADFPI

    Show »
    Length:368
    Mass (Da):41,871
    Checksum:i4F6D839AD0468961
    GO
    Isoform 3 (identifier: Q8TDN4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-497: Missing.

    Show »
    Length:136
    Mass (Da):15,856
    Checksum:iABF7C651A93CAED8
    GO
    Isoform 4 (identifier: Q8TDN4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-327: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:306
    Mass (Da):34,593
    Checksum:i9586F33703C72027
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4121R → W in AAL83906. (PubMed:11585773)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 497497Missing in isoform 3. 1 PublicationVSP_012695Add
    BLAST
    Alternative sequencei1 – 327327Missing in isoform 4. 1 PublicationVSP_045014Add
    BLAST
    Alternative sequencei1 – 265265Missing in isoform 2. 1 PublicationVSP_012696Add
    BLAST
    Alternative sequencei266 – 28217PGQGG…LQRSR → MLSKRGCHARIYADFPI in isoform 2. 1 PublicationVSP_012697Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093243 mRNA. Translation: BAC04107.1.
    AK296407 mRNA. Translation: BAG59072.1.
    AC105247 Genomic DNA. No translation available.
    AC011731 Genomic DNA. No translation available.
    BC004124 mRNA. Translation: AAH04124.2.
    BC037218 mRNA. Translation: AAH37218.1.
    AF348525 mRNA. Translation: AAL83906.1.
    CCDSiCCDS42417.1. [Q8TDN4-1]
    CCDS42418.1. [Q8TDN4-2]
    CCDS58615.1. [Q8TDN4-4]
    RefSeqiNP_001094089.1. NM_001100619.2. [Q8TDN4-1]
    NP_001243367.1. NM_001256438.1. [Q8TDN4-4]
    NP_612384.1. NM_138375.2. [Q8TDN4-2]
    UniGeneiHs.11108.

    Genome annotation databases

    EnsembliENST00000256925; ENSP00000256925; ENSG00000134508. [Q8TDN4-1]
    ENST00000400473; ENSP00000383321; ENSG00000134508. [Q8TDN4-4]
    ENST00000420687; ENSP00000413851; ENSG00000134508. [Q8TDN4-2]
    GeneIDi91768.
    KEGGihsa:91768.
    UCSCiuc002kub.2. human. [Q8TDN4-3]
    uc002kuc.2. human. [Q8TDN4-1]
    uc002kud.2. human. [Q8TDN4-2]
    uc031rhr.1. human.

    Polymorphism databases

    DMDMi73921298.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093243 mRNA. Translation: BAC04107.1 .
    AK296407 mRNA. Translation: BAG59072.1 .
    AC105247 Genomic DNA. No translation available.
    AC011731 Genomic DNA. No translation available.
    BC004124 mRNA. Translation: AAH04124.2 .
    BC037218 mRNA. Translation: AAH37218.1 .
    AF348525 mRNA. Translation: AAL83906.1 .
    CCDSi CCDS42417.1. [Q8TDN4-1 ]
    CCDS42418.1. [Q8TDN4-2 ]
    CCDS58615.1. [Q8TDN4-4 ]
    RefSeqi NP_001094089.1. NM_001100619.2. [Q8TDN4-1 ]
    NP_001243367.1. NM_001256438.1. [Q8TDN4-4 ]
    NP_612384.1. NM_138375.2. [Q8TDN4-2 ]
    UniGenei Hs.11108.

    3D structure databases

    ProteinModelPortali Q8TDN4.
    SMRi Q8TDN4. Positions 501-629.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124877. 3 interactions.
    IntActi Q8TDN4. 4 interactions.
    MINTi MINT-6615967.
    STRINGi 9606.ENSP00000256925.

    PTM databases

    PhosphoSitei Q8TDN4.

    Polymorphism databases

    DMDMi 73921298.

    Proteomic databases

    MaxQBi Q8TDN4.
    PaxDbi Q8TDN4.
    PRIDEi Q8TDN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256925 ; ENSP00000256925 ; ENSG00000134508 . [Q8TDN4-1 ]
    ENST00000400473 ; ENSP00000383321 ; ENSG00000134508 . [Q8TDN4-4 ]
    ENST00000420687 ; ENSP00000413851 ; ENSG00000134508 . [Q8TDN4-2 ]
    GeneIDi 91768.
    KEGGi hsa:91768.
    UCSCi uc002kub.2. human. [Q8TDN4-3 ]
    uc002kuc.2. human. [Q8TDN4-1 ]
    uc002kud.2. human. [Q8TDN4-2 ]
    uc031rhr.1. human.

    Organism-specific databases

    CTDi 91768.
    GeneCardsi GC18P020714.
    HGNCi HGNC:25097. CABLES1.
    MIMi 609194. gene.
    neXtProti NX_Q8TDN4.
    PharmGKBi PA134880184.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256533.
    HOGENOMi HOG000231236.
    HOVERGENi HBG050759.
    InParanoidi Q8TDN4.
    OMAi QNYCSLE.
    OrthoDBi EOG7P5T0S.
    PhylomeDBi Q8TDN4.
    TreeFami TF323936.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinki Q8TDN4.

    Miscellaneous databases

    ChiTaRSi CABLES1. human.
    GeneWikii CABLES1.
    GenomeRNAii 91768.
    NextBioi 77447.
    PROi Q8TDN4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDN4.
    Bgeei Q8TDN4.
    CleanExi HS_CABLES1.
    Genevestigatori Q8TDN4.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF025798. Cables. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Testis and Thalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Lung.
    4. "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
      Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
      Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-633 (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INVOLVEMENT IN CANCER.
      Tissue: Brain.
    5. "Differential effect of ik3-1/cables on p53- and p73-induced cell death."
      Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.
      J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH TP53.
    6. "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer."
      Zukerberg L.R., DeBernardo R.L., Kirley S.D., D'Apuzzo M., Lynch M.P., Littell R.D., Duska L.R., Boring L., Rueda B.R.
      Cancer Res. 64:202-208(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, INDUCTION.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-287 AND THR-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-287 AND THR-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCABL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDN4
    Secondary accession number(s): B4DK60
    , Q8N3Y8, Q8NA22, Q9BTG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3