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Protein

CDK5 and ABL1 enzyme substrate 1

Gene

CABLES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiQ8TDN4.
SIGNORiQ8TDN4.

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 1
Alternative name(s):
Interactor with CDK3 1
Short name:
Ik3-1
Gene namesi
Name:CABLES1
Synonyms:CABLES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000134508.12.
HGNCiHGNC:25097. CABLES1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91768.
OpenTargetsiENSG00000134508.
PharmGKBiPA134880184.

Polymorphism and mutation databases

BioMutaiCABLES1.
DMDMi73921298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805101 – 633CDK5 and ABL1 enzyme substrate 1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei313Phosphoserine; by CDK2 and CDK3By similarity1
Modified residuei415PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDN4.
MaxQBiQ8TDN4.
PaxDbiQ8TDN4.
PeptideAtlasiQ8TDN4.
PRIDEiQ8TDN4.

PTM databases

iPTMnetiQ8TDN4.
PhosphoSitePlusiQ8TDN4.

Expressioni

Tissue specificityi

Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.2 Publications

Developmental stagei

Expression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase.1 Publication

Inductioni

Up-regulated by progesterone and down-regulated by estrogen in benign endometrium.1 Publication

Gene expression databases

BgeeiENSG00000134508.
CleanExiHS_CABLES1.
ExpressionAtlasiQ8TDN4. baseline and differential.
GenevisibleiQ8TDN4. HS.

Organism-specific databases

HPAiHPA064114.

Interactioni

Subunit structurei

Found in a complex with p53/TP53. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124877. 6 interactors.
IntActiQ8TDN4. 4 interactors.
MINTiMINT-6615967.
STRINGi9606.ENSP00000256925.

Structurei

3D structure databases

ProteinModelPortaliQ8TDN4.
SMRiQ8TDN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 109Interaction with TDRD7By similarityAdd BLAST109
Regioni179 – 492Interaction with CDK3By similarityAdd BLAST314

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 134Ala-richAdd BLAST133

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG4164. Eukaryota.
ENOG4110WYV. LUCA.
GeneTreeiENSGT00400000022086.
HOGENOMiHOG000231236.
HOVERGENiHBG050759.
InParanoidiQ8TDN4.
OMAiRASGEQW.
OrthoDBiEOG091G0CHB.
PhylomeDBiQ8TDN4.
TreeFamiTF323936.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 1 hit.
InterProiView protein in InterPro
IPR012388. CABLES1/2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
PANTHERiPTHR22896. PTHR22896. 1 hit.
PfamiView protein in Pfam
PF00134. Cyclin_N. 1 hit.
PIRSFiPIRSF025798. Cables. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAATT AACSSGSAGT DAAGASGLQQ PPPQPQPQPA AAAPAQPPPE
60 70 80 90 100
PPRKPRMDPR RRQAALSFLT NISLDGRLPP QDAEWGGGEE GGAAKPGAGG
110 120 130 140 150
ACGARTRFSL LAAAERGGCI ALAAPGTPAA GLAAGSGPCL PQPSSLPPLI
160 170 180 190 200
PGGHATVSGP GVARGFASPL GAGRASGEQW QPPRPAPLAA CAQLQLLDGS
210 220 230 240 250
GAAGQEELEE DDAFISVQVP AAAFLGSGTP GSGSGSRGRL NSFTQGILPI
260 270 280 290 300
AFSRPTSQNY CSLEQPGQGG STSAFEQLQR SRRRLISQRS SLETLEDIEE
310 320 330 340 350
NAPLRRCRTL SGSPRPKNFK KIHFIKNMRQ HDTRNGRIVL ISGRRSFCSI
360 370 380 390 400
FSVLPYRDST QVGDLKLDGG RQSTGAVSLK EIIGLEGVEL GADGKTVSYT
410 420 430 440 450
QFLLPTNAFG ARRNTIDSTS SFSQFRNLSH RSLSIGRASG TQGSLDTGSD
460 470 480 490 500
LGDFMDYDPN LLDDPQWPCG KHKRVLIFPS YMTTVIDYVK PSDLKKDMNE
510 520 530 540 550
TFKEKFPHIK LTLSKIRSLK REMRKLAQED CGLEEPTVAM AFVYFEKLAL
560 570 580 590 600
KGKLNKQNRK LCAGACVLLA AKIGSDLKKH EVKHLIDKLE EKFRLNRREL
610 620 630
IAFEFPVLVA LEFALHLPEH EVMPHYRRLV QSS
Note: No experimental confirmation available.
Length:633
Mass (Da):67,599
Last modified:February 1, 2005 - v2
Checksum:iD3569C6BFF635A82
GO
Isoform 2 (identifier: Q8TDN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.
     266-282: PGQGGSTSAFEQLQRSR → MLSKRGCHARIYADFPI

Show »
Length:368
Mass (Da):41,871
Checksum:i4F6D839AD0468961
GO
Isoform 3 (identifier: Q8TDN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-497: Missing.

Show »
Length:136
Mass (Da):15,856
Checksum:iABF7C651A93CAED8
GO
Isoform 4 (identifier: Q8TDN4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-327: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):34,593
Checksum:i9586F33703C72027
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412R → W in AAL83906 (PubMed:11585773).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126951 – 497Missing in isoform 3. 1 PublicationAdd BLAST497
Alternative sequenceiVSP_0450141 – 327Missing in isoform 4. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_0126961 – 265Missing in isoform 2. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_012697266 – 282PGQGG…LQRSR → MLSKRGCHARIYADFPI in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093243 mRNA. Translation: BAC04107.1.
AK296407 mRNA. Translation: BAG59072.1.
AC105247 Genomic DNA. No translation available.
AC011731 Genomic DNA. No translation available.
BC004124 mRNA. Translation: AAH04124.2.
BC037218 mRNA. Translation: AAH37218.1.
AF348525 mRNA. Translation: AAL83906.1.
CCDSiCCDS42417.1. [Q8TDN4-1]
CCDS42418.1. [Q8TDN4-2]
CCDS58615.1. [Q8TDN4-4]
RefSeqiNP_001094089.1. NM_001100619.2. [Q8TDN4-1]
NP_001243367.1. NM_001256438.1. [Q8TDN4-4]
NP_612384.1. NM_138375.2. [Q8TDN4-2]
UniGeneiHs.11108.

Genome annotation databases

EnsembliENST00000256925; ENSP00000256925; ENSG00000134508. [Q8TDN4-1]
ENST00000400473; ENSP00000383321; ENSG00000134508. [Q8TDN4-4]
ENST00000420687; ENSP00000413851; ENSG00000134508. [Q8TDN4-2]
GeneIDi91768.
KEGGihsa:91768.
UCSCiuc002kuc.3. human. [Q8TDN4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCABL1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDN4
Secondary accession number(s): B4DK60
, Q8N3Y8, Q8NA22, Q9BTG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: September 27, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families