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Q8TDN1 (KCNG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
Gene names
Name:KCNG4
Synonyms:KCNG3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subunit structure

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Tissue specificity

Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TDN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TDN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     253-256: GECS → VSGL
     257-519: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Potassium voltage-gated channel subfamily G member 4
PRO_0000054080

Regions

Topological domain1 – 221221Cytoplasmic Potential
Transmembrane222 – 24221Helical; Name=Segment S1; Potential
Transmembrane259 – 27921Helical; Name=Segment S2; Potential
Topological domain280 – 28910Cytoplasmic Potential
Transmembrane290 – 31021Helical; Name=Segment S3; Potential
Transmembrane335 – 35521Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain356 – 37015Cytoplasmic Potential
Transmembrane371 – 39121Helical; Name=Segment S5; Potential
Intramembrane406 – 42621Pore-forming; Name=Segment H5; Potential
Transmembrane434 – 45421Helical; Name=Segment S6; Potential
Topological domain455 – 51965Cytoplasmic Potential
Motif418 – 4236Selectivity filter By similarity

Natural variations

Alternative sequence253 – 2564GECS → VSGL in isoform 2.
VSP_001029
Alternative sequence257 – 519263Missing in isoform 2.
VSP_001030
Natural variant81G → W.
Corresponds to variant rs35379218 [ dbSNP | Ensembl ].
VAR_053861
Natural variant2061R → W.
Corresponds to variant rs11646443 [ dbSNP | Ensembl ].
VAR_053862
Natural variant2551C → Y.
Corresponds to variant rs17736370 [ dbSNP | Ensembl ].
VAR_053863
Natural variant3211E → K.
Corresponds to variant rs4782905 [ dbSNP | Ensembl ].
VAR_053864
Natural variant3251G → R.
Corresponds to variant rs7196482 [ dbSNP | Ensembl ].
VAR_053865
Natural variant4271R → H.
Corresponds to variant rs35649980 [ dbSNP | Ensembl ].
VAR_053866

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E5BBA354931AB0A4

FASTA51958,979
        10         20         30         40         50         60 
MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL DASPVDLKKE 

        70         80         90        100        110        120 
ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL CDDYDEDSQE FFFDRSPSAF 

       130        140        150        160        170        180 
GVIVSFLAAG KLVLLQEMCA LSFQEELAYW GIEEAHLERC CLRKLLRKLE ELEELAKLHR 

       190        200        210        220        230        240 
EDVLRQQRET RRPASHSSRW GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV 

       250        260        270        280        290        300 
STMPDLRAEE DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI 

       310        320        330        340        350        360 
LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL ARHSLGLQTL 

       370        380        390        400        410        420 
GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL EFTSIPASYW WAIISMTTVG 

       430        440        450        460        470        480 
YGDMVPRSVP GQMVALSSIL SGILIMAFPA TSIFHTFSHS YLELKKEQEQ LQARLRHLQN 

       490        500        510 
TGPASECELL DPHVASEHEL MNDVNDLILE GPALPIMHM 

« Hide

Isoform 2 [UniParc].

Checksum: 5A48EFC68637F8B8
Show »

FASTA25629,334

References

« Hide 'large scale' references
[1]"Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF348984 mRNA. Translation: AAL83911.1.
BC008969 mRNA. Translation: AAH08969.1.
CCDSCCDS10945.1. [Q8TDN1-1]
RefSeqNP_758857.1. NM_172347.2. [Q8TDN1-1]
UniGeneHs.335877.
Hs.560407.
Hs.737415.

3D structure databases

ProteinModelPortalQ8TDN1.
SMRQ8TDN1. Positions 58-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125002. 2 interactions.
STRING9606.ENSP00000312129.

Chemistry

ChEMBLCHEMBL2362996.

PTM databases

PhosphoSiteQ8TDN1.

Polymorphism databases

DMDM26006803.

Proteomic databases

PaxDbQ8TDN1.
PRIDEQ8TDN1.

Protocols and materials databases

DNASU93107.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308251; ENSP00000312129; ENSG00000168418. [Q8TDN1-1]
ENST00000568181; ENSP00000457897; ENSG00000168418. [Q8TDN1-2]
GeneID93107.
KEGGhsa:93107.
UCSCuc002fhu.1. human. [Q8TDN1-2]
uc010voc.2. human. [Q8TDN1-1]

Organism-specific databases

CTD93107.
GeneCardsGC16M084255.
HGNCHGNC:19697. KCNG4.
HPAHPA039161.
MIM607603. gene.
neXtProtNX_Q8TDN1.
PharmGKBPA134989953.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ8TDN1.
KOK04903.
OMAEMVENPQ.
OrthoDBEOG7K9K2K.
PhylomeDBQ8TDN1.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ8TDN1.
BgeeQ8TDN1.
CleanExHS_KCNG3.
HS_KCNG4.
GenevestigatorQ8TDN1.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNG4.
GenomeRNAi93107.
NextBio77984.
PROQ8TDN1.
SOURCESearch...

Entry information

Entry nameKCNG4_HUMAN
AccessionPrimary (citable) accession number: Q8TDN1
Secondary accession number(s): Q96H24
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM