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Protein

Potassium voltage-gated channel subfamily G member 4

Gene

KCNG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).1 Publication

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB
  • ion channel binding Source: UniProtKB

GO - Biological processi

  • potassium ion transmembrane transport Source: UniProtKB
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168418-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
Gene namesi
Name:KCNG4
Synonyms:KCNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19697. KCNG4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 218CytoplasmicBy similarityAdd BLAST218
Transmembranei219 – 240Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini241 – 261ExtracellularBy similarityAdd BLAST21
Transmembranei262 – 283Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini284 – 294CytoplasmicBy similarityAdd BLAST11
Transmembranei295 – 314Helical; Name=Segment S3By similarityAdd BLAST20
Topological domaini315 – 328ExtracellularBy similarityAdd BLAST14
Transmembranei329 – 353Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST25
Topological domaini354 – 368CytoplasmicBy similarityAdd BLAST15
Transmembranei369 – 390Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini391 – 405ExtracellularBy similarityAdd BLAST15
Intramembranei406 – 417Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei418 – 425By similarity8
Topological domaini426 – 432ExtracellularBy similarity7
Transmembranei433 – 461Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini462 – 519CytoplasmicBy similarityAdd BLAST58

GO - Cellular componenti

  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi93107.
OpenTargetsiENSG00000168418.
PharmGKBiPA134989953.

Chemistry databases

ChEMBLiCHEMBL2362996.

Polymorphism and mutation databases

BioMutaiKCNG4.
DMDMi26006803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540801 – 519Potassium voltage-gated channel subfamily G member 4Add BLAST519

Proteomic databases

PaxDbiQ8TDN1.
PeptideAtlasiQ8TDN1.
PRIDEiQ8TDN1.

PTM databases

PhosphoSitePlusiQ8TDN1.
SwissPalmiQ8TDN1.

Expressioni

Tissue specificityi

Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Gene expression databases

BgeeiENSG00000168418.
CleanExiHS_KCNG3.
HS_KCNG4.
ExpressionAtlasiQ8TDN1. baseline and differential.
GenevisibleiQ8TDN1. HS.

Organism-specific databases

HPAiHPA039161.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 (PubMed:19074135).1 Publication

GO - Molecular functioni

  • ion channel binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125002. 5 interactors.
STRINGi9606.ENSP00000312129.

Structurei

3D structure databases

ProteinModelPortaliQ8TDN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi418 – 423Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8TDN1.
KOiK04903.
OMAiCCLRKLL.
OrthoDBiEOG091G05DD.
PhylomeDBiQ8TDN1.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL
60 70 80 90 100
DASPVDLKKE ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL
110 120 130 140 150
CDDYDEDSQE FFFDRSPSAF GVIVSFLAAG KLVLLQEMCA LSFQEELAYW
160 170 180 190 200
GIEEAHLERC CLRKLLRKLE ELEELAKLHR EDVLRQQRET RRPASHSSRW
210 220 230 240 250
GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV STMPDLRAEE
260 270 280 290 300
DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI
310 320 330 340 350
LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL
360 370 380 390 400
ARHSLGLQTL GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL
410 420 430 440 450
EFTSIPASYW WAIISMTTVG YGDMVPRSVP GQMVALSSIL SGILIMAFPA
460 470 480 490 500
TSIFHTFSHS YLELKKEQEQ LQARLRHLQN TGPASECELL DPHVASEHEL
510
MNDVNDLILE GPALPIMHM
Length:519
Mass (Da):58,979
Last modified:June 1, 2002 - v1
Checksum:iE5BBA354931AB0A4
GO
Isoform 2 (identifier: Q8TDN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-256: GECS → VSGL
     257-519: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):29,334
Checksum:i5A48EFC68637F8B8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0538618G → W.Corresponds to variant rs35379218dbSNPEnsembl.1
Natural variantiVAR_053862206R → W.Corresponds to variant rs11646443dbSNPEnsembl.1
Natural variantiVAR_053863255C → Y.Corresponds to variant rs17736370dbSNPEnsembl.1
Natural variantiVAR_053864321E → K.Corresponds to variant rs4782905dbSNPEnsembl.1
Natural variantiVAR_053865325G → R.Corresponds to variant rs7196482dbSNPEnsembl.1
Natural variantiVAR_053866427R → H.Corresponds to variant rs35649980dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001029253 – 256GECS → VSGL in isoform 2. 1 Publication4
Alternative sequenceiVSP_001030257 – 519Missing in isoform 2. 1 PublicationAdd BLAST263

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348984 mRNA. Translation: AAL83911.1.
BC008969 mRNA. Translation: AAH08969.1.
CCDSiCCDS10945.1. [Q8TDN1-1]
RefSeqiNP_758857.1. NM_172347.2. [Q8TDN1-1]
UniGeneiHs.335877.
Hs.560407.
Hs.737415.

Genome annotation databases

EnsembliENST00000308251; ENSP00000312129; ENSG00000168418. [Q8TDN1-1]
ENST00000568181; ENSP00000457897; ENSG00000168418. [Q8TDN1-2]
GeneIDi93107.
KEGGihsa:93107.
UCSCiuc002fhu.1. human. [Q8TDN1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348984 mRNA. Translation: AAL83911.1.
BC008969 mRNA. Translation: AAH08969.1.
CCDSiCCDS10945.1. [Q8TDN1-1]
RefSeqiNP_758857.1. NM_172347.2. [Q8TDN1-1]
UniGeneiHs.335877.
Hs.560407.
Hs.737415.

3D structure databases

ProteinModelPortaliQ8TDN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125002. 5 interactors.
STRINGi9606.ENSP00000312129.

Chemistry databases

ChEMBLiCHEMBL2362996.

PTM databases

PhosphoSitePlusiQ8TDN1.
SwissPalmiQ8TDN1.

Polymorphism and mutation databases

BioMutaiKCNG4.
DMDMi26006803.

Proteomic databases

PaxDbiQ8TDN1.
PeptideAtlasiQ8TDN1.
PRIDEiQ8TDN1.

Protocols and materials databases

DNASUi93107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308251; ENSP00000312129; ENSG00000168418. [Q8TDN1-1]
ENST00000568181; ENSP00000457897; ENSG00000168418. [Q8TDN1-2]
GeneIDi93107.
KEGGihsa:93107.
UCSCiuc002fhu.1. human. [Q8TDN1-1]

Organism-specific databases

CTDi93107.
DisGeNETi93107.
GeneCardsiKCNG4.
HGNCiHGNC:19697. KCNG4.
HPAiHPA039161.
MIMi607603. gene.
neXtProtiNX_Q8TDN1.
OpenTargetsiENSG00000168418.
PharmGKBiPA134989953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8TDN1.
KOiK04903.
OMAiCCLRKLL.
OrthoDBiEOG091G05DD.
PhylomeDBiQ8TDN1.
TreeFamiTF313103.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168418-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNG4.
GenomeRNAii93107.
PROiQ8TDN1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168418.
CleanExiHS_KCNG3.
HS_KCNG4.
ExpressionAtlasiQ8TDN1. baseline and differential.
GenevisibleiQ8TDN1. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDN1
Secondary accession number(s): Q96H24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.