Q8TDN1 (KCNG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily G member 4

Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4

Gene names

Name:	KCNG4
Synonyms:	KCNG3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Subunit structure	Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
Tissue specificity	Highly expressed in brain, and at lower levels in liver, small intestine and colon.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	plasma membrane Traceable author statement. Source: Reactome voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     253-256: GECS → VSGL
     257-519: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Potassium voltage-gated channel subfamily G member 4		PRO_0000054080
Regions
	Topological domain	1 – 118	118	Cytoplasmic Potential
	Transmembrane	119 – 139	21	Helical; Name=Segment S1; Potential
	Transmembrane	259 – 279	21	Helical; Name=Segment S2; Potential
	Topological domain	280 – 289	10	Cytoplasmic Potential
	Transmembrane	290 – 310	21	Helical; Name=Segment S3; Potential
	Transmembrane	335 – 355	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	356 – 370	15	Cytoplasmic Potential
	Transmembrane	371 – 391	21	Helical; Name=Segment S5; Potential
	Intramembrane	406 – 426	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	434 – 454	21	Helical; Name=Segment S6; Potential
	Topological domain	455 – 519	65	Cytoplasmic Potential
	Motif	418 – 423	6	Selectivity filter By similarity
Natural variations
	Alternative sequence	253 – 256	4	GECS → VSGL in isoform 2.		VSP_001029
	Alternative sequence	257 – 519	263	Missing in isoform 2.		VSP_001030
	Natural variant	8	1	G → W. Corresponds to variant rs35379218 [ dbSNP | Ensembl ].		VAR_053861
	Natural variant	206	1	R → W. Corresponds to variant rs11646443 [ dbSNP | Ensembl ].		VAR_053862
	Natural variant	255	1	C → Y. Corresponds to variant rs17736370 [ dbSNP | Ensembl ].		VAR_053863
	Natural variant	321	1	E → K. Corresponds to variant rs4782905 [ dbSNP | Ensembl ].		VAR_053864
	Natural variant	325	1	G → R. Corresponds to variant rs7196482 [ dbSNP | Ensembl ].		VAR_053865
	Natural variant	427	1	R → H. Corresponds to variant rs35649980 [ dbSNP | Ensembl ].		VAR_053866

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E5BBA354931AB0A4	FASTA	519	58,979
	10 20 30 40 50 60 MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL DASPVDLKKE 70 80 90 100 110 120 ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL CDDYDEDSQE FFFDRSPSAF 130 140 150 160 170 180 GVIVSFLAAG KLVLLQEMCA LSFQEELAYW GIEEAHLERC CLRKLLRKLE ELEELAKLHR 190 200 210 220 230 240 EDVLRQQRET RRPASHSSRW GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV 250 260 270 280 290 300 STMPDLRAEE DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI 310 320 330 340 350 360 LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL ARHSLGLQTL 370 380 390 400 410 420 GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL EFTSIPASYW WAIISMTTVG 430 440 450 460 470 480 YGDMVPRSVP GQMVALSSIL SGILIMAFPA TSIFHTFSHS YLELKKEQEQ LQARLRHLQN 490 500 510 TGPASECELL DPHVASEHEL MNDVNDLILE GPALPIMHM
	Isoform 2 [UniParc]. Checksum: 5A48EFC68637F8B8	FASTA	256	29,334
	10 20 30 40 50 60 MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL DASPVDLKKE 70 80 90 100 110 120 ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL CDDYDEDSQE FFFDRSPSAF 130 140 150 160 170 180 GVIVSFLAAG KLVLLQEMCA LSFQEELAYW GIEEAHLERC CLRKLLRKLE ELEELAKLHR 190 200 210 220 230 240 EDVLRQQRET RRPASHSSRW GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV 250 STMPDLRAEE DQVSGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome." Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J. Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF348984 mRNA. Translation: AAL83911.1. BC008969 mRNA. Translation: AAH08969.1.
IPI	IPI00152565. IPI00215662.
RefSeq	NP_758857.1. NM_172347.2.
UniGene	Hs.335877. Hs.560407. Hs.737415.
3D structure databases
ProteinModelPortal	Q8TDN1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000312129.
PTM databases
PhosphoSite	Q8TDN1.
Polymorphism databases
DMDM	26006803.
Proteomic databases
PaxDb	Q8TDN1.
PRIDE	Q8TDN1.
Protocols and materials databases
DNASU	93107.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308251; ENSP00000312129; ENSG00000168418. ENST00000568181; ENSP00000457897; ENSG00000168418.
GeneID	93107.
KEGG	hsa:93107.
UCSC	uc002fhu.1. human. uc010voc.2. human.
Organism-specific databases
CTD	93107.
GeneCards	GC16M084255.
HGNC	HGNC:19697. KCNG4.
HPA	HPA039161.
MIM	607603. gene.
neXtProt	NX_Q8TDN1.
PharmGKB	PA134989953.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231014.
HOVERGEN	HBG100172.
InParanoid	Q8TDN1.
KO	K04903.
OMA	EMVENPQ.
OrthoDB	EOG4HT8S4.
PhylomeDB	Q8TDN1.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q8TDN1.
Bgee	Q8TDN1.
CleanEx	HS_KCNG3. HS_KCNG4.
Genevestigator	Q8TDN1.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003971. K_chnl_volt-dep_Kv9. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01494. KV9CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	93107.
NextBio	77984.
SOURCE	Search...

Entry information

Entry name

KCNG4_HUMAN

Accession

Primary (citable) accession number: Q8TDN1
Secondary accession number(s): Q96H24

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.