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Q8TDN1

- KCNG4_HUMAN

UniProt

Q8TDN1 - KCNG4_HUMAN

Protein

Potassium voltage-gated channel subfamily G member 4

Gene

KCNG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 4
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv6.4
    Gene namesi
    Name:KCNG4
    Synonyms:KCNG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19697. KCNG4.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134989953.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Potassium voltage-gated channel subfamily G member 4PRO_0000054080Add
    BLAST

    Proteomic databases

    PaxDbiQ8TDN1.
    PRIDEiQ8TDN1.

    PTM databases

    PhosphoSiteiQ8TDN1.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, and at lower levels in liver, small intestine and colon.

    Gene expression databases

    ArrayExpressiQ8TDN1.
    BgeeiQ8TDN1.
    CleanExiHS_KCNG3.
    HS_KCNG4.
    GenevestigatoriQ8TDN1.

    Organism-specific databases

    HPAiHPA039161.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.

    Protein-protein interaction databases

    BioGridi125002. 2 interactions.
    STRINGi9606.ENSP00000312129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDN1.
    SMRiQ8TDN1. Positions 58-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 221221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 28910CytoplasmicSequence Analysis
    Topological domaini356 – 37015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini455 – 51965CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei406 – 42621Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei222 – 24221Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi418 – 4236Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ8TDN1.
    KOiK04903.
    OMAiEMVENPQ.
    OrthoDBiEOG7K9K2K.
    PhylomeDBiQ8TDN1.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDN1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL    50
    DASPVDLKKE ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL 100
    CDDYDEDSQE FFFDRSPSAF GVIVSFLAAG KLVLLQEMCA LSFQEELAYW 150
    GIEEAHLERC CLRKLLRKLE ELEELAKLHR EDVLRQQRET RRPASHSSRW 200
    GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV STMPDLRAEE 250
    DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI 300
    LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL 350
    ARHSLGLQTL GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL 400
    EFTSIPASYW WAIISMTTVG YGDMVPRSVP GQMVALSSIL SGILIMAFPA 450
    TSIFHTFSHS YLELKKEQEQ LQARLRHLQN TGPASECELL DPHVASEHEL 500
    MNDVNDLILE GPALPIMHM 519
    Length:519
    Mass (Da):58,979
    Last modified:June 1, 2002 - v1
    Checksum:iE5BBA354931AB0A4
    GO
    Isoform 2 (identifier: Q8TDN1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         253-256: GECS → VSGL
         257-519: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):29,334
    Checksum:i5A48EFC68637F8B8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81G → W.
    Corresponds to variant rs35379218 [ dbSNP | Ensembl ].
    VAR_053861
    Natural varianti206 – 2061R → W.
    Corresponds to variant rs11646443 [ dbSNP | Ensembl ].
    VAR_053862
    Natural varianti255 – 2551C → Y.
    Corresponds to variant rs17736370 [ dbSNP | Ensembl ].
    VAR_053863
    Natural varianti321 – 3211E → K.
    Corresponds to variant rs4782905 [ dbSNP | Ensembl ].
    VAR_053864
    Natural varianti325 – 3251G → R.
    Corresponds to variant rs7196482 [ dbSNP | Ensembl ].
    VAR_053865
    Natural varianti427 – 4271R → H.
    Corresponds to variant rs35649980 [ dbSNP | Ensembl ].
    VAR_053866

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei253 – 2564GECS → VSGL in isoform 2. 1 PublicationVSP_001029
    Alternative sequencei257 – 519263Missing in isoform 2. 1 PublicationVSP_001030Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348984 mRNA. Translation: AAL83911.1.
    BC008969 mRNA. Translation: AAH08969.1.
    CCDSiCCDS10945.1. [Q8TDN1-1]
    RefSeqiNP_758857.1. NM_172347.2. [Q8TDN1-1]
    UniGeneiHs.335877.
    Hs.560407.
    Hs.737415.

    Genome annotation databases

    EnsembliENST00000308251; ENSP00000312129; ENSG00000168418. [Q8TDN1-1]
    ENST00000568181; ENSP00000457897; ENSG00000168418. [Q8TDN1-2]
    GeneIDi93107.
    KEGGihsa:93107.
    UCSCiuc002fhu.1. human. [Q8TDN1-2]
    uc010voc.2. human. [Q8TDN1-1]

    Polymorphism databases

    DMDMi26006803.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348984 mRNA. Translation: AAL83911.1 .
    BC008969 mRNA. Translation: AAH08969.1 .
    CCDSi CCDS10945.1. [Q8TDN1-1 ]
    RefSeqi NP_758857.1. NM_172347.2. [Q8TDN1-1 ]
    UniGenei Hs.335877.
    Hs.560407.
    Hs.737415.

    3D structure databases

    ProteinModelPortali Q8TDN1.
    SMRi Q8TDN1. Positions 58-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125002. 2 interactions.
    STRINGi 9606.ENSP00000312129.

    Chemistry

    ChEMBLi CHEMBL2362996.

    PTM databases

    PhosphoSitei Q8TDN1.

    Polymorphism databases

    DMDMi 26006803.

    Proteomic databases

    PaxDbi Q8TDN1.
    PRIDEi Q8TDN1.

    Protocols and materials databases

    DNASUi 93107.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308251 ; ENSP00000312129 ; ENSG00000168418 . [Q8TDN1-1 ]
    ENST00000568181 ; ENSP00000457897 ; ENSG00000168418 . [Q8TDN1-2 ]
    GeneIDi 93107.
    KEGGi hsa:93107.
    UCSCi uc002fhu.1. human. [Q8TDN1-2 ]
    uc010voc.2. human. [Q8TDN1-1 ]

    Organism-specific databases

    CTDi 93107.
    GeneCardsi GC16M084255.
    HGNCi HGNC:19697. KCNG4.
    HPAi HPA039161.
    MIMi 607603. gene.
    neXtProti NX_Q8TDN1.
    PharmGKBi PA134989953.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q8TDN1.
    KOi K04903.
    OMAi EMVENPQ.
    OrthoDBi EOG7K9K2K.
    PhylomeDBi Q8TDN1.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNG4.
    GenomeRNAii 93107.
    NextBioi 77984.
    PROi Q8TDN1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDN1.
    Bgeei Q8TDN1.
    CleanExi HS_KCNG3.
    HS_KCNG4.
    Genevestigatori Q8TDN1.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome."
      Ottschytsch N., Raes A., Van Hoorick D., Snyders D.J.
      Proc. Natl. Acad. Sci. U.S.A. 99:7986-7991(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.

    Entry informationi

    Entry nameiKCNG4_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDN1
    Secondary accession number(s): Q96H24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3