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Protein

Disks large homolog 5

Gene

DLG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.1 Publication

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • cytoskeletal protein binding Source: MGI
  • receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 5
Alternative name(s):
Discs large protein P-dlg
Placenta and prostate DLG
Gene namesi
Name:DLG5
Synonyms:KIAA0583, PDLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2904. DLG5.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: Ensembl
  • cytoplasm Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9231.
OpenTargetsiENSG00000151208.
ENSG00000274429.
PharmGKBiPA27360.

Polymorphism and mutation databases

BioMutaiDLG5.
DMDMi158939323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945641 – 1919Disks large homolog 5Add BLAST1919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei984PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1011PhosphothreonineCombined sources1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1183PhosphothreonineCombined sources1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1263PhosphoserineCombined sources1
Modified residuei1334PhosphoserineCombined sources1
Modified residuei1666PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDM6.
MaxQBiQ8TDM6.
PaxDbiQ8TDM6.
PeptideAtlasiQ8TDM6.
PRIDEiQ8TDM6.

PTM databases

iPTMnetiQ8TDM6.
PhosphoSitePlusiQ8TDM6.

Expressioni

Tissue specificityi

Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.3 Publications

Gene expression databases

BgeeiENSG00000151208.
ExpressionAtlasiQ8TDM6. baseline and differential.
GenevisibleiQ8TDM6. HS.

Organism-specific databases

HPAiHPA000555.

Interactioni

Subunit structurei

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tgfbr1Q647293EBI-715138,EBI-2899393From a different organism.
Tgfbr2Q623123EBI-715138,EBI-2899332From a different organism.

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • cytoskeletal protein binding Source: MGI
  • receptor signaling complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114662. 31 interactors.
DIPiDIP-41450N.
IntActiQ8TDM6. 29 interactors.
MINTiMINT-262511.
STRINGi9606.ENSP00000361467.

Structurei

Secondary structure

11919
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1349 – 1354Combined sources6
Beta strandi1362 – 1366Combined sources5
Beta strandi1372 – 1377Combined sources6
Helixi1382 – 1386Combined sources5
Turni1402 – 1404Combined sources3
Helixi1407 – 1413Combined sources7
Beta strandi1419 – 1425Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UITNMR-A1336-1439[»]
ProteinModelPortaliQ8TDM6.
SMRiQ8TDM6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDM6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini620 – 710PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini705 – 796PDZ 2PROSITE-ProRule annotationAdd BLAST92
Domaini1350 – 1429PDZ 3PROSITE-ProRule annotationAdd BLAST80
Domaini1501 – 1582PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini1593 – 1661SH3PROSITE-ProRule annotationAdd BLAST69
Domaini1722 – 1905Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili383 – 599Sequence analysisAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 123Poly-SerAdd BLAST11
Compositional biasi982 – 1066Pro-richAdd BLAST85

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
KOG3528. Eukaryota.
ENOG410XP9M. LUCA.
GeneTreeiENSGT00760000118866.
HOVERGENiHBG081446.
InParanoidiQ8TDM6.
OMAiQTDIFYT.
OrthoDBiEOG091G00NF.
PhylomeDBiQ8TDM6.
TreeFamiTF323171.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 4 hits.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006907. DUF622.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF04822. Takusan. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 4 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 4 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 4 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG
60 70 80 90 100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG
110 120 130 140 150
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS
160 170 180 190 200
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS
210 220 230 240 250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE
260 270 280 290 300
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN
310 320 330 340 350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK
360 370 380 390 400
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL
410 420 430 440 450
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ
460 470 480 490 500
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK
510 520 530 540 550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE
560 570 580 590 600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM
610 620 630 640 650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG
660 670 680 690 700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG
710 720 730 740 750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA
760 770 780 790 800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS
810 820 830 840 850
SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD
860 870 880 890 900
RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS
910 920 930 940 950
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA
960 970 980 990 1000
MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS
1010 1020 1030 1040 1050
PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA
1060 1070 1080 1090 1100
LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS
1110 1120 1130 1140 1150
QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ
1160 1170 1180 1190 1200
EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR
1210 1220 1230 1240 1250
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH
1260 1270 1280 1290 1300
GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS
1310 1320 1330 1340 1350
TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH
1360 1370 1380 1390 1400
VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI
1410 1420 1430 1440 1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH
1460 1470 1480 1490 1500
STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP
1510 1520 1530 1540 1550
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY
1560 1570 1580 1590 1600
GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA
1610 1620 1630 1640 1650
LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ
1660 1670 1680 1690 1700
IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS
1710 1720 1730 1740 1750
KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD
1760 1770 1780 1790 1800
VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV
1810 1820 1830 1840 1850
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE
1860 1870 1880 1890 1900
QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI
1910
LAMVNQEQNK VLWIPACPL
Length:1,919
Mass (Da):213,868
Last modified:July 24, 2007 - v4
Checksum:iCC19273380260C92
GO
Isoform 2 (identifier: Q8TDM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-1134: Missing.

Note: No experimental confirmation available.
Show »
Length:1,579
Mass (Da):176,971
Checksum:iE1129566D56B6B6F
GO
Isoform 3 (identifier: Q8TDM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-580: Missing.
     1135-1135: E → V
     1136-1919: Missing.

Note: No experimental confirmation available.
Show »
Length:684
Mass (Da):74,012
Checksum:i9E289C42E00A3C22
GO
Isoform 4 (identifier: Q8TDM6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:1,809
Mass (Da):202,058
Checksum:iB32E6DAD3F124833
GO
Isoform 5 (identifier: Q8TDM6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1245: Missing.

Show »
Length:674
Mass (Da):74,910
Checksum:i19F8FB067F9A400B
GO

Sequence cautioni

The sequence AAI17696 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25509 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027897140Q → R.4 PublicationsCorresponds to variant rs1248696dbSNPEnsembl.1
Natural variantiVAR_0278981481P → Q.1 PublicationCorresponds to variant rs2289310dbSNPEnsembl.1
Natural variantiVAR_0278991600A → V.Corresponds to variant rs4979794dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271981 – 1245Missing in isoform 5. 1 PublicationAdd BLAST1245
Alternative sequenceiVSP_0271971 – 110Missing in isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_027199130 – 580Missing in isoform 3. 1 PublicationAdd BLAST451
Alternative sequenceiVSP_016349795 – 1134Missing in isoform 2. CuratedAdd BLAST340
Alternative sequenceiVSP_0272001135E → V in isoform 3. 1 Publication1
Alternative sequenceiVSP_0272011136 – 1919Missing in isoform 3. 1 PublicationAdd BLAST784

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61843 mRNA. Translation: AAC61295.1.
AF352033 Genomic DNA. Translation: AAL83937.1.
AF352034 mRNA. Translation: AAL83938.1.
AB011155 mRNA. Translation: BAA25509.2. Different initiation.
AL391421, AL450306 Genomic DNA. Translation: CAI12103.1.
AL391421, AL450306 Genomic DNA. Translation: CAI12104.2.
AL450306, AL391421 Genomic DNA. Translation: CAI17323.1.
AL450306, AL391421 Genomic DNA. Translation: CAI17324.2.
BC073996 mRNA. Translation: AAH73996.1.
BC117695 mRNA. Translation: AAI17696.1. Different initiation.
BC146794 mRNA. Translation: AAI46795.1.
AB091676 mRNA. Translation: BAC65420.1.
CCDSiCCDS7353.2. [Q8TDM6-1]
PIRiT00346.
RefSeqiNP_004738.3. NM_004747.3. [Q8TDM6-1]
XP_006718119.1. XM_006718056.3. [Q8TDM6-2]
XP_011538647.1. XM_011540345.1.
XP_016872403.1. XM_017016914.1. [Q8TDM6-4]
UniGeneiHs.652690.

Genome annotation databases

EnsembliENST00000372391; ENSP00000361467; ENSG00000151208. [Q8TDM6-1]
ENST00000614211; ENSP00000484894; ENSG00000274429. [Q8TDM6-1]
GeneIDi9231.
KEGGihsa:9231.
UCSCiuc001jzk.4. human. [Q8TDM6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61843 mRNA. Translation: AAC61295.1.
AF352033 Genomic DNA. Translation: AAL83937.1.
AF352034 mRNA. Translation: AAL83938.1.
AB011155 mRNA. Translation: BAA25509.2. Different initiation.
AL391421, AL450306 Genomic DNA. Translation: CAI12103.1.
AL391421, AL450306 Genomic DNA. Translation: CAI12104.2.
AL450306, AL391421 Genomic DNA. Translation: CAI17323.1.
AL450306, AL391421 Genomic DNA. Translation: CAI17324.2.
BC073996 mRNA. Translation: AAH73996.1.
BC117695 mRNA. Translation: AAI17696.1. Different initiation.
BC146794 mRNA. Translation: AAI46795.1.
AB091676 mRNA. Translation: BAC65420.1.
CCDSiCCDS7353.2. [Q8TDM6-1]
PIRiT00346.
RefSeqiNP_004738.3. NM_004747.3. [Q8TDM6-1]
XP_006718119.1. XM_006718056.3. [Q8TDM6-2]
XP_011538647.1. XM_011540345.1.
XP_016872403.1. XM_017016914.1. [Q8TDM6-4]
UniGeneiHs.652690.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UITNMR-A1336-1439[»]
ProteinModelPortaliQ8TDM6.
SMRiQ8TDM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114662. 31 interactors.
DIPiDIP-41450N.
IntActiQ8TDM6. 29 interactors.
MINTiMINT-262511.
STRINGi9606.ENSP00000361467.

PTM databases

iPTMnetiQ8TDM6.
PhosphoSitePlusiQ8TDM6.

Polymorphism and mutation databases

BioMutaiDLG5.
DMDMi158939323.

Proteomic databases

EPDiQ8TDM6.
MaxQBiQ8TDM6.
PaxDbiQ8TDM6.
PeptideAtlasiQ8TDM6.
PRIDEiQ8TDM6.

Protocols and materials databases

DNASUi9231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372391; ENSP00000361467; ENSG00000151208. [Q8TDM6-1]
ENST00000614211; ENSP00000484894; ENSG00000274429. [Q8TDM6-1]
GeneIDi9231.
KEGGihsa:9231.
UCSCiuc001jzk.4. human. [Q8TDM6-1]

Organism-specific databases

CTDi9231.
DisGeNETi9231.
GeneCardsiDLG5.
H-InvDBHIX0008958.
HIX0035651.
HGNCiHGNC:2904. DLG5.
HPAiHPA000555.
MIMi604090. gene.
neXtProtiNX_Q8TDM6.
OpenTargetsiENSG00000151208.
ENSG00000274429.
PharmGKBiPA27360.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
KOG3528. Eukaryota.
ENOG410XP9M. LUCA.
GeneTreeiENSGT00760000118866.
HOVERGENiHBG081446.
InParanoidiQ8TDM6.
OMAiQTDIFYT.
OrthoDBiEOG091G00NF.
PhylomeDBiQ8TDM6.
TreeFamiTF323171.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151208-MONOMER.

Miscellaneous databases

ChiTaRSiDLG5. human.
EvolutionaryTraceiQ8TDM6.
GeneWikiiDLG5.
GenomeRNAii9231.
PROiQ8TDM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151208.
ExpressionAtlasiQ8TDM6. baseline and differential.
GenevisibleiQ8TDM6. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 4 hits.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006907. DUF622.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF04822. Takusan. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 4 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 4 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 4 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLG5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDM6
Secondary accession number(s): A6H8Y3
, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 161 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.