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Q8TDM6

- DLG5_HUMAN

UniProt

Q8TDM6 - DLG5_HUMAN

Protein

Disks large homolog 5

Gene

DLG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 4 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.1 Publication

    GO - Molecular functioni

    1. beta-catenin binding Source: MGI
    2. cytoskeletal protein binding Source: MGI
    3. protein binding Source: IntAct
    4. receptor signaling complex scaffold activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. negative regulation of cell proliferation Source: ProtInc
    3. regulation of apoptotic process Source: InterPro
    4. signal transduction Source: ProtInc
    5. single organismal cell-cell adhesion Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large homolog 5
    Alternative name(s):
    Discs large protein P-dlg
    Placenta and prostate DLG
    Gene namesi
    Name:DLG5
    Synonyms:KIAA0583, PDLG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2904. DLG5.

    Subcellular locationi

    Cell junction 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Localized at sites of cell-cell contact.

    GO - Cellular componenti

    1. cell-cell adherens junction Source: Ensembl
    2. cytoplasm Source: ProtInc
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27360.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19191919Disks large homolog 5PRO_0000094564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei295 – 2951Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TDM6.
    PaxDbiQ8TDM6.
    PRIDEiQ8TDM6.

    PTM databases

    PhosphoSiteiQ8TDM6.

    Expressioni

    Tissue specificityi

    Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.3 Publications

    Gene expression databases

    BgeeiQ8TDM6.
    GenevestigatoriQ8TDM6.

    Organism-specific databases

    HPAiHPA000555.

    Interactioni

    Subunit structurei

    Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tgfbr1Q647293EBI-715138,EBI-2899393From a different organism.
    Tgfbr2Q623123EBI-715138,EBI-2899332From a different organism.

    Protein-protein interaction databases

    BioGridi114662. 9 interactions.
    DIPiDIP-41450N.
    IntActiQ8TDM6. 12 interactions.
    MINTiMINT-262511.

    Structurei

    Secondary structure

    1
    1919
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1349 – 13546
    Beta strandi1362 – 13665
    Beta strandi1372 – 13776
    Helixi1382 – 13865
    Turni1402 – 14043
    Helixi1407 – 14137
    Beta strandi1419 – 14257

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UITNMR-A1336-1439[»]
    ProteinModelPortaliQ8TDM6.
    SMRiQ8TDM6. Positions 621-794, 1337-1434, 1512-1916.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TDM6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini620 – 71091PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini705 – 79692PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1350 – 142980PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1501 – 158282PDZ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1593 – 166169SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1722 – 1905184Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi113 – 12311Poly-SerAdd
    BLAST
    Compositional biasi982 – 106685Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG316405.
    HOVERGENiHBG081446.
    InParanoidiQ8TDM6.
    OMAiTELRTTQ.
    OrthoDBiEOG7VDXNB.
    PhylomeDBiQ8TDM6.
    TreeFamiTF323171.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.30.42.10. 4 hits.
    3.40.50.300. 2 hits.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR006907. DUF622.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 4 hits.
    PF04822. Takusan. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 4 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 4 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 4 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG     50
    AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 100
    AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS 150
    IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS 200
    DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE 250
    NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 300
    KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK 350
    QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL 400
    QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ 450
    TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK 500
    QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE 550
    RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 600
    AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG 650
    DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG 700
    AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA 750
    KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS 800
    SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD 850
    RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS 900
    GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA 950
    MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS 1000
    PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA 1050
    LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS 1100
    QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ 1150
    EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR 1200
    SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH 1250
    GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS 1300
    TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH 1350
    VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI 1400
    NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH 1450
    STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP 1500
    RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY 1550
    GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA 1600
    LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ 1650
    IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS 1700
    KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD 1750
    VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV 1800
    TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE 1850
    QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI 1900
    LAMVNQEQNK VLWIPACPL 1919
    Length:1,919
    Mass (Da):213,868
    Last modified:July 24, 2007 - v4
    Checksum:iCC19273380260C92
    GO
    Isoform 2 (identifier: Q8TDM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         795-1134: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,579
    Mass (Da):176,971
    Checksum:iE1129566D56B6B6F
    GO
    Isoform 3 (identifier: Q8TDM6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         130-580: Missing.
         1135-1135: E → V
         1136-1919: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:684
    Mass (Da):74,012
    Checksum:i9E289C42E00A3C22
    GO
    Isoform 4 (identifier: Q8TDM6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Show »
    Length:1,809
    Mass (Da):202,058
    Checksum:iB32E6DAD3F124833
    GO
    Isoform 5 (identifier: Q8TDM6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1245: Missing.

    Show »
    Length:674
    Mass (Da):74,910
    Checksum:i19F8FB067F9A400B
    GO

    Sequence cautioni

    The sequence AAI17696.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA25509.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401Q → R.4 Publications
    Corresponds to variant rs1248696 [ dbSNP | Ensembl ].
    VAR_027897
    Natural varianti1481 – 14811P → Q.1 Publication
    Corresponds to variant rs2289310 [ dbSNP | Ensembl ].
    VAR_027898
    Natural varianti1600 – 16001A → V.
    Corresponds to variant rs4979794 [ dbSNP | Ensembl ].
    VAR_027899

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12451245Missing in isoform 5. 1 PublicationVSP_027198Add
    BLAST
    Alternative sequencei1 – 110110Missing in isoform 4. 1 PublicationVSP_027197Add
    BLAST
    Alternative sequencei130 – 580451Missing in isoform 3. 1 PublicationVSP_027199Add
    BLAST
    Alternative sequencei795 – 1134340Missing in isoform 2. CuratedVSP_016349Add
    BLAST
    Alternative sequencei1135 – 11351E → V in isoform 3. 1 PublicationVSP_027200
    Alternative sequencei1136 – 1919784Missing in isoform 3. 1 PublicationVSP_027201Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61843 mRNA. Translation: AAC61295.1.
    AF352033 Genomic DNA. Translation: AAL83937.1.
    AF352034 mRNA. Translation: AAL83938.1.
    AB011155 mRNA. Translation: BAA25509.2. Different initiation.
    AL391421, AL450306 Genomic DNA. Translation: CAI12103.1.
    AL391421, AL450306 Genomic DNA. Translation: CAI12104.2.
    AL450306, AL391421 Genomic DNA. Translation: CAI17323.1.
    AL450306, AL391421 Genomic DNA. Translation: CAI17324.2.
    BC073996 mRNA. Translation: AAH73996.1.
    BC117695 mRNA. Translation: AAI17696.1. Different initiation.
    BC146794 mRNA. Translation: AAI46795.1.
    AB091676 mRNA. Translation: BAC65420.1.
    CCDSiCCDS7353.2. [Q8TDM6-1]
    PIRiT00346.
    RefSeqiNP_004738.3. NM_004747.3. [Q8TDM6-1]
    XP_006718119.1. XM_006718056.1. [Q8TDM6-2]
    XP_006725185.1. XM_006725122.1. [Q8TDM6-2]
    UniGeneiHs.652690.

    Genome annotation databases

    EnsembliENST00000372391; ENSP00000361467; ENSG00000151208. [Q8TDM6-1]
    GeneIDi9231.
    KEGGihsa:9231.
    UCSCiuc001jzi.3. human. [Q8TDM6-5]
    uc001jzj.3. human. [Q8TDM6-2]
    uc001jzk.3. human. [Q8TDM6-1]
    uc001jzl.4. human. [Q8TDM6-4]

    Polymorphism databases

    DMDMi158939323.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61843 mRNA. Translation: AAC61295.1 .
    AF352033 Genomic DNA. Translation: AAL83937.1 .
    AF352034 mRNA. Translation: AAL83938.1 .
    AB011155 mRNA. Translation: BAA25509.2 . Different initiation.
    AL391421 , AL450306 Genomic DNA. Translation: CAI12103.1 .
    AL391421 , AL450306 Genomic DNA. Translation: CAI12104.2 .
    AL450306 , AL391421 Genomic DNA. Translation: CAI17323.1 .
    AL450306 , AL391421 Genomic DNA. Translation: CAI17324.2 .
    BC073996 mRNA. Translation: AAH73996.1 .
    BC117695 mRNA. Translation: AAI17696.1 . Different initiation.
    BC146794 mRNA. Translation: AAI46795.1 .
    AB091676 mRNA. Translation: BAC65420.1 .
    CCDSi CCDS7353.2. [Q8TDM6-1 ]
    PIRi T00346.
    RefSeqi NP_004738.3. NM_004747.3. [Q8TDM6-1 ]
    XP_006718119.1. XM_006718056.1. [Q8TDM6-2 ]
    XP_006725185.1. XM_006725122.1. [Q8TDM6-2 ]
    UniGenei Hs.652690.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UIT NMR - A 1336-1439 [» ]
    ProteinModelPortali Q8TDM6.
    SMRi Q8TDM6. Positions 621-794, 1337-1434, 1512-1916.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114662. 9 interactions.
    DIPi DIP-41450N.
    IntActi Q8TDM6. 12 interactions.
    MINTi MINT-262511.

    PTM databases

    PhosphoSitei Q8TDM6.

    Polymorphism databases

    DMDMi 158939323.

    Proteomic databases

    MaxQBi Q8TDM6.
    PaxDbi Q8TDM6.
    PRIDEi Q8TDM6.

    Protocols and materials databases

    DNASUi 9231.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372391 ; ENSP00000361467 ; ENSG00000151208 . [Q8TDM6-1 ]
    GeneIDi 9231.
    KEGGi hsa:9231.
    UCSCi uc001jzi.3. human. [Q8TDM6-5 ]
    uc001jzj.3. human. [Q8TDM6-2 ]
    uc001jzk.3. human. [Q8TDM6-1 ]
    uc001jzl.4. human. [Q8TDM6-4 ]

    Organism-specific databases

    CTDi 9231.
    GeneCardsi GC10M079550.
    H-InvDB HIX0008958.
    HIX0035651.
    HGNCi HGNC:2904. DLG5.
    HPAi HPA000555.
    MIMi 604090. gene.
    neXtProti NX_Q8TDM6.
    PharmGKBi PA27360.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316405.
    HOVERGENi HBG081446.
    InParanoidi Q8TDM6.
    OMAi TELRTTQ.
    OrthoDBi EOG7VDXNB.
    PhylomeDBi Q8TDM6.
    TreeFami TF323171.

    Miscellaneous databases

    ChiTaRSi DLG5. human.
    EvolutionaryTracei Q8TDM6.
    GeneWikii DLG5.
    GenomeRNAii 9231.
    NextBioi 34601.
    PROi Q8TDM6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDM6.
    Genevestigatori Q8TDM6.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.30.42.10. 4 hits.
    3.40.50.300. 2 hits.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR006907. DUF622.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 4 hits.
    PF04822. Takusan. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 4 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 4 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 4 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55."
      Nakamura H., Sudo T., Tsuiki H., Miyake H., Morisaki T., Sasaki J., Masuko N., Kochi M., Ushio Y., Saya H.
      FEBS Lett. 433:63-67(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, INTERACTION WITH MPP1.
      Tissue: Fetal brain.
    2. "The cloning, genomic organization and tissue expression profile of the human DLG5 gene."
      Shah G., Brugada R., Gonzalez O., Czernuszewicz G., Gibbs R.A., Bachinski L., Roberts R.
      BMC Genomics 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-140.
    3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-140.
      Tissue: Brain.
    4. Ohara O., Nagase T., Kikuno R., Ishikawa K.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1075-1919 (ISOFORM 3), VARIANTS ARG-140 AND GLN-1481.
      Tissue: PNS.
    7. "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact."
      Wakabayashi M., Ito T., Mitsushima M., Aizawa S., Ueda K., Amachi T., Kioka N.
      J. Biol. Chem. 278:21709-21714(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-1919 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SORBS3 AND CTNNB1.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Solution structure of RSGI RUH-006, the third PDZ domain of HDLG5 (KIAA0583) protein [Homo sapiens]."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JAN-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1224-1330.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-140.

    Entry informationi

    Entry nameiDLG5_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDM6
    Secondary accession number(s): A6H8Y3
    , Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 139 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3