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Q8TDM6 (DLG5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disks large homolog 5
Alternative name(s):
Discs large protein P-dlg
Placenta and prostate DLG
Gene names
Name:DLG5
Synonyms:KIAA0583, PDLG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1919 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton. Ref.2

Subunit structure

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex. Ref.1 Ref.7

Subcellular location

Cell junction. Cell membrane; Peripheral membrane protein. Note: Localized at sites of cell-cell contact. Ref.7

Tissue specificity

Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain. Ref.1 Ref.2 Ref.7

Sequence similarities

Belongs to the MAGUK family.

Contains 1 guanylate kinase-like domain.

Contains 4 PDZ (DHR) domains.

Contains 1 SH3 domain.

Sequence caution

The sequence AAI17696.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA25509.2 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Tgfbr1Q647293EBI-715138,EBI-2899393From a different organism.
Tgfbr2Q623123EBI-715138,EBI-2899332From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TDM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TDM6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     795-1134: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8TDM6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     130-580: Missing.
     1135-1135: E → V
     1136-1919: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8TDM6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
Isoform 5 (identifier: Q8TDM6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1245: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19191919Disks large homolog 5
PRO_0000094564

Regions

Domain620 – 71091PDZ 1
Domain705 – 79692PDZ 2
Domain1350 – 142980PDZ 3
Domain1501 – 158282PDZ 4
Domain1593 – 166169SH3
Domain1722 – 1905184Guanylate kinase-like
Compositional bias113 – 12311Poly-Ser
Compositional bias982 – 106685Pro-rich

Amino acid modifications

Modified residue2951Phosphoserine Ref.9 Ref.10

Natural variations

Alternative sequence1 – 12451245Missing in isoform 5.
VSP_027198
Alternative sequence1 – 110110Missing in isoform 4.
VSP_027197
Alternative sequence130 – 580451Missing in isoform 3.
VSP_027199
Alternative sequence795 – 1134340Missing in isoform 2.
VSP_016349
Alternative sequence11351E → V in isoform 3.
VSP_027200
Alternative sequence1136 – 1919784Missing in isoform 3.
VSP_027201
Natural variant1401Q → R. Ref.2 Ref.3 Ref.6 Ref.12
Corresponds to variant rs1248696 [ dbSNP | Ensembl ].
VAR_027897
Natural variant14811P → Q. Ref.6
Corresponds to variant rs2289310 [ dbSNP | Ensembl ].
VAR_027898
Natural variant16001A → V.
Corresponds to variant rs4979794 [ dbSNP | Ensembl ].
VAR_027899

Secondary structure

............... 1919
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 4.
Checksum: CC19273380260C92

FASTA1,919213,868
        10         20         30         40         50         60 
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG AKAELLLKLL 

        70         80         90        100        110        120 
LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG AGSTYSVLST MPSDSESSSS 

       130        140        150        160        170        180 
LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS IQLRLMTRER NELRKRLAFA THGTAFDKRP 

       190        200        210        220        230        240 
YHRLNPDYER LKIQCVRAMS DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL 

       250        260        270        280        290        300 
KDDVDMLRRE NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 

       310        320        330        340        350        360 
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK QTEMLTQQRD 

       370        380        390        400        410        420 
TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL QSELTELRTT QVKTAKESEK 

       430        440        450        460        470        480 
YREERDAVYS EYKLIMSERD QVISELDKLQ TEVELAESKL KSSTSEKKAA NEEMEALRQI 

       490        500        510        520        530        540 
KDTVTMDAGR ANKEVEILRK QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI 

       550        560        570        580        590        600 
RTLCDNLRRE RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 

       610        620        630        640        650        660 
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG DCGIFVTKVD 

       670        680        690        700        710        720 
KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG AINMVVRRRK SLGGKVVTPL 

       730        740        750        760        770        780 
HINLSGQKDS GISLENGVYA AAVLPGSPAA KEGSLAVGDR IVAINGIALD NKSLNECESL 

       790        800        810        820        830        840 
LRSCQDSLTL SLLKVFPQSS SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN 

       850        860        870        880        890        900 
STQTDIFYTD RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS 

       910        920        930        940        950        960 
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA MLSSTAVPEK 

       970        980        990       1000       1010       1020 
LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS PQPSKRAGPL TPPKPPRRSD 

      1030       1040       1050       1060       1070       1080 
SIKFQHRLET SSESEATLVG SSPSTSPPSA LPPDVDPGEP MHASPPRKAR VRIASSYYPE 

      1090       1100       1110       1120       1130       1140 
GDGDSSHLPA KKSCDEDLTS QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP 

      1150       1160       1170       1180       1190       1200 
ASGELSPELQ EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR 

      1210       1220       1230       1240       1250       1260 
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH GSNSLPSSAR 

      1270       1280       1290       1300       1310       1320 
LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS TPPQSPLNID TLSSCSQSQT 

      1330       1340       1350       1360       1370       1380 
SASTLPRIAV NPASLGERRK DRPYVEEPRH VKVQKGSEPL GISIVSGEKG GIYVSKVTVG 

      1390       1400       1410       1420       1430       1440 
SIAHQAGLEY GDQLLEFNGI NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS 

      1450       1460       1470       1480       1490       1500 
SSHLDPAGTH STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP 

      1510       1520       1530       1540       1550       1560 
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY GSLDVRNKTV 

      1570       1580       1590       1600       1610       1620 
EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA LYDRLADVEQ ELSFKKDDIL 

      1630       1640       1650       1660       1670       1680 
YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ IPSKYVMDQE FSRRLSMSEV KDDNSATKTL 

      1690       1700       1710       1720       1730       1740 
SAAARRSFFR RKHKHKRSGS KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR 

      1750       1760       1770       1780       1790       1800 
PVLILGPLLD VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV 

      1810       1820       1830       1840       1850       1860 
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE QRDPIYLRDK 

      1870       1880       1890       1900       1910 
VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI LAMVNQEQNK VLWIPACPL 

« Hide

Isoform 2 [UniParc].

Checksum: E1129566D56B6B6F
Show »

FASTA1,579176,971
Isoform 3 [UniParc].

Checksum: 9E289C42E00A3C22
Show »

FASTA68474,012
Isoform 4 [UniParc].

Checksum: B32E6DAD3F124833
Show »

FASTA1,809202,058
Isoform 5 [UniParc].

Checksum: 19F8FB067F9A400B
Show »

FASTA67474,910

References

« Hide 'large scale' references
[1]"Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55."
Nakamura H., Sudo T., Tsuiki H., Miyake H., Morisaki T., Sasaki J., Masuko N., Kochi M., Ushio Y., Saya H.
FEBS Lett. 433:63-67(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, INTERACTION WITH MPP1.
Tissue: Fetal brain.
[2]"The cloning, genomic organization and tissue expression profile of the human DLG5 gene."
Shah G., Brugada R., Gonzalez O., Czernuszewicz G., Gibbs R.A., Bachinski L., Roberts R.
BMC Genomics 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-140.
[3]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-140.
Tissue: Brain.
[4]Ohara O., Nagase T., Kikuno R., Ishikawa K.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1075-1919 (ISOFORM 3), VARIANTS ARG-140 AND GLN-1481.
Tissue: PNS.
[7]"Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact."
Wakabayashi M., Ito T., Mitsushima M., Aizawa S., Ueda K., Amachi T., Kioka N.
J. Biol. Chem. 278:21709-21714(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-1919 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SORBS3 AND CTNNB1.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Solution structure of RSGI RUH-006, the third PDZ domain of HDLG5 (KIAA0583) protein [Homo sapiens]."
RIKEN structural genomics initiative (RSGI)
Submitted (JAN-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1224-1330.
[12]"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. expand/collapse author list , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K.
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-140.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61843 mRNA. Translation: AAC61295.1.
AF352033 Genomic DNA. Translation: AAL83937.1.
AF352034 mRNA. Translation: AAL83938.1.
AB011155 mRNA. Translation: BAA25509.2. Different initiation.
AL391421, AL450306 Genomic DNA. Translation: CAI12103.1.
AL391421, AL450306 Genomic DNA. Translation: CAI12104.2.
AL450306, AL391421 Genomic DNA. Translation: CAI17323.1.
AL450306, AL391421 Genomic DNA. Translation: CAI17324.2.
BC073996 mRNA. Translation: AAH73996.1.
BC117695 mRNA. Translation: AAI17696.1. Different initiation.
BC146794 mRNA. Translation: AAI46795.1.
AB091676 mRNA. Translation: BAC65420.1.
CCDSCCDS7353.2. [Q8TDM6-1]
PIRT00346.
RefSeqNP_004738.3. NM_004747.3. [Q8TDM6-1]
XP_006718119.1. XM_006718056.1. [Q8TDM6-2]
XP_006725185.1. XM_006725122.1. [Q8TDM6-2]
UniGeneHs.652690.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UITNMR-A1336-1439[»]
ProteinModelPortalQ8TDM6.
SMRQ8TDM6. Positions 621-794, 1337-1434, 1512-1916.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114662. 10 interactions.
DIPDIP-41450N.
IntActQ8TDM6. 10 interactions.
MINTMINT-262511.

PTM databases

PhosphoSiteQ8TDM6.

Polymorphism databases

DMDM158939323.

Proteomic databases

MaxQBQ8TDM6.
PaxDbQ8TDM6.
PRIDEQ8TDM6.

Protocols and materials databases

DNASU9231.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372388; ENSP00000361464; ENSG00000151208. [Q8TDM6-2]
ENST00000372391; ENSP00000361467; ENSG00000151208. [Q8TDM6-1]
GeneID9231.
KEGGhsa:9231.
UCSCuc001jzi.3. human. [Q8TDM6-5]
uc001jzj.3. human. [Q8TDM6-2]
uc001jzk.3. human. [Q8TDM6-1]
uc001jzl.4. human. [Q8TDM6-4]

Organism-specific databases

CTD9231.
GeneCardsGC10M079550.
H-InvDBHIX0008958.
HIX0035651.
HGNCHGNC:2904. DLG5.
HPAHPA000555.
MIM604090. gene.
neXtProtNX_Q8TDM6.
PharmGKBPA27360.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316405.
HOVERGENHBG081446.
InParanoidQ8TDM6.
OMATELRTTQ.
OrthoDBEOG7VDXNB.
PhylomeDBQ8TDM6.
TreeFamTF323171.

Gene expression databases

BgeeQ8TDM6.
GenevestigatorQ8TDM6.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
2.30.42.10. 4 hits.
3.40.50.300. 2 hits.
InterProIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006907. DUF622.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 4 hits.
PF04822. Takusan. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
SM00228. PDZ. 4 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 4 hits.
SSF52540. SSF52540. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 4 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDLG5. human.
EvolutionaryTraceQ8TDM6.
GeneWikiDLG5.
GenomeRNAi9231.
NextBio34601.
PROQ8TDM6.
SOURCESearch...

Entry information

Entry nameDLG5_HUMAN
AccessionPrimary (citable) accession number: Q8TDM6
Secondary accession number(s): A6H8Y3 expand/collapse secondary AC list , Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM