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Q8TDM6

- DLG5_HUMAN

UniProt

Q8TDM6 - DLG5_HUMAN

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Protein
Disks large homolog 5
Gene
DLG5, KIAA0583, PDLG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.1 Publication

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. cytoskeletal protein binding Source: MGI
  3. protein binding Source: IntAct
  4. receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. negative regulation of cell proliferation Source: ProtInc
  3. regulation of apoptotic process Source: InterPro
  4. signal transduction Source: ProtInc
  5. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 5
Alternative name(s):
Discs large protein P-dlg
Placenta and prostate DLG
Gene namesi
Name:DLG5
Synonyms:KIAA0583, PDLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2904. DLG5.

Subcellular locationi

Cell junction. Cell membrane; Peripheral membrane protein
Note: Localized at sites of cell-cell contact.1 Publication

GO - Cellular componenti

  1. cell-cell adherens junction Source: Ensembl
  2. cytoplasm Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19191919Disks large homolog 5
PRO_0000094564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei295 – 2951Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TDM6.
PaxDbiQ8TDM6.
PRIDEiQ8TDM6.

PTM databases

PhosphoSiteiQ8TDM6.

Expressioni

Tissue specificityi

Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.3 Publications

Gene expression databases

BgeeiQ8TDM6.
GenevestigatoriQ8TDM6.

Organism-specific databases

HPAiHPA000555.

Interactioni

Subunit structurei

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tgfbr1Q647293EBI-715138,EBI-2899393From a different organism.
Tgfbr2Q623123EBI-715138,EBI-2899332From a different organism.

Protein-protein interaction databases

BioGridi114662. 9 interactions.
DIPiDIP-41450N.
IntActiQ8TDM6. 10 interactions.
MINTiMINT-262511.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1349 – 13546
Beta strandi1362 – 13665
Beta strandi1372 – 13776
Helixi1382 – 13865
Turni1402 – 14043
Helixi1407 – 14137
Beta strandi1419 – 14257

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UITNMR-A1336-1439[»]
ProteinModelPortaliQ8TDM6.
SMRiQ8TDM6. Positions 621-794, 1337-1434, 1512-1916.

Miscellaneous databases

EvolutionaryTraceiQ8TDM6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini620 – 71091PDZ 1
Add
BLAST
Domaini705 – 79692PDZ 2
Add
BLAST
Domaini1350 – 142980PDZ 3
Add
BLAST
Domaini1501 – 158282PDZ 4
Add
BLAST
Domaini1593 – 166169SH3
Add
BLAST
Domaini1722 – 1905184Guanylate kinase-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi113 – 12311Poly-Ser
Add
BLAST
Compositional biasi982 – 106685Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.
Contains 4 PDZ (DHR) domains.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG316405.
HOVERGENiHBG081446.
InParanoidiQ8TDM6.
OMAiTELRTTQ.
OrthoDBiEOG7VDXNB.
PhylomeDBiQ8TDM6.
TreeFamiTF323171.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 4 hits.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006907. DUF622.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 4 hits.
PF04822. Takusan. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 4 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 4 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 4 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TDM6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG     50
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 100
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS 150
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS 200
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE 250
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 300
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK 350
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL 400
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ 450
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK 500
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE 550
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 600
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG 650
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG 700
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA 750
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS 800
SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD 850
RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS 900
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA 950
MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS 1000
PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA 1050
LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS 1100
QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ 1150
EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR 1200
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH 1250
GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS 1300
TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH 1350
VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI 1400
NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH 1450
STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP 1500
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY 1550
GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA 1600
LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ 1650
IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS 1700
KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD 1750
VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV 1800
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE 1850
QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI 1900
LAMVNQEQNK VLWIPACPL 1919
Length:1,919
Mass (Da):213,868
Last modified:July 24, 2007 - v4
Checksum:iCC19273380260C92
GO
Isoform 2 (identifier: Q8TDM6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-1134: Missing.

Note: No experimental confirmation available.

Show »
Length:1,579
Mass (Da):176,971
Checksum:iE1129566D56B6B6F
GO
Isoform 3 (identifier: Q8TDM6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-580: Missing.
     1135-1135: E → V
     1136-1919: Missing.

Note: No experimental confirmation available.

Show »
Length:684
Mass (Da):74,012
Checksum:i9E289C42E00A3C22
GO
Isoform 4 (identifier: Q8TDM6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:1,809
Mass (Da):202,058
Checksum:iB32E6DAD3F124833
GO
Isoform 5 (identifier: Q8TDM6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1245: Missing.

Show »
Length:674
Mass (Da):74,910
Checksum:i19F8FB067F9A400B
GO

Sequence cautioni

The sequence AAI17696.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA25509.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401Q → R.4 Publications
Corresponds to variant rs1248696 [ dbSNP | Ensembl ].
VAR_027897
Natural varianti1481 – 14811P → Q.1 Publication
Corresponds to variant rs2289310 [ dbSNP | Ensembl ].
VAR_027898
Natural varianti1600 – 16001A → V.
Corresponds to variant rs4979794 [ dbSNP | Ensembl ].
VAR_027899

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12451245Missing in isoform 5.
VSP_027198Add
BLAST
Alternative sequencei1 – 110110Missing in isoform 4.
VSP_027197Add
BLAST
Alternative sequencei130 – 580451Missing in isoform 3.
VSP_027199Add
BLAST
Alternative sequencei795 – 1134340Missing in isoform 2.
VSP_016349Add
BLAST
Alternative sequencei1135 – 11351E → V in isoform 3.
VSP_027200
Alternative sequencei1136 – 1919784Missing in isoform 3.
VSP_027201Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61843 mRNA. Translation: AAC61295.1.
AF352033 Genomic DNA. Translation: AAL83937.1.
AF352034 mRNA. Translation: AAL83938.1.
AB011155 mRNA. Translation: BAA25509.2. Different initiation.
AL391421, AL450306 Genomic DNA. Translation: CAI12103.1.
AL391421, AL450306 Genomic DNA. Translation: CAI12104.2.
AL450306, AL391421 Genomic DNA. Translation: CAI17323.1.
AL450306, AL391421 Genomic DNA. Translation: CAI17324.2.
BC073996 mRNA. Translation: AAH73996.1.
BC117695 mRNA. Translation: AAI17696.1. Different initiation.
BC146794 mRNA. Translation: AAI46795.1.
AB091676 mRNA. Translation: BAC65420.1.
CCDSiCCDS7353.2. [Q8TDM6-1]
PIRiT00346.
RefSeqiNP_004738.3. NM_004747.3. [Q8TDM6-1]
XP_006718119.1. XM_006718056.1. [Q8TDM6-2]
XP_006725185.1. XM_006725122.1. [Q8TDM6-2]
UniGeneiHs.652690.

Genome annotation databases

EnsembliENST00000372388; ENSP00000361464; ENSG00000151208. [Q8TDM6-2]
ENST00000372391; ENSP00000361467; ENSG00000151208. [Q8TDM6-1]
GeneIDi9231.
KEGGihsa:9231.
UCSCiuc001jzi.3. human. [Q8TDM6-5]
uc001jzj.3. human. [Q8TDM6-2]
uc001jzk.3. human. [Q8TDM6-1]
uc001jzl.4. human. [Q8TDM6-4]

Polymorphism databases

DMDMi158939323.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61843 mRNA. Translation: AAC61295.1 .
AF352033 Genomic DNA. Translation: AAL83937.1 .
AF352034 mRNA. Translation: AAL83938.1 .
AB011155 mRNA. Translation: BAA25509.2 . Different initiation.
AL391421 , AL450306 Genomic DNA. Translation: CAI12103.1 .
AL391421 , AL450306 Genomic DNA. Translation: CAI12104.2 .
AL450306 , AL391421 Genomic DNA. Translation: CAI17323.1 .
AL450306 , AL391421 Genomic DNA. Translation: CAI17324.2 .
BC073996 mRNA. Translation: AAH73996.1 .
BC117695 mRNA. Translation: AAI17696.1 . Different initiation.
BC146794 mRNA. Translation: AAI46795.1 .
AB091676 mRNA. Translation: BAC65420.1 .
CCDSi CCDS7353.2. [Q8TDM6-1 ]
PIRi T00346.
RefSeqi NP_004738.3. NM_004747.3. [Q8TDM6-1 ]
XP_006718119.1. XM_006718056.1. [Q8TDM6-2 ]
XP_006725185.1. XM_006725122.1. [Q8TDM6-2 ]
UniGenei Hs.652690.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UIT NMR - A 1336-1439 [» ]
ProteinModelPortali Q8TDM6.
SMRi Q8TDM6. Positions 621-794, 1337-1434, 1512-1916.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114662. 9 interactions.
DIPi DIP-41450N.
IntActi Q8TDM6. 10 interactions.
MINTi MINT-262511.

PTM databases

PhosphoSitei Q8TDM6.

Polymorphism databases

DMDMi 158939323.

Proteomic databases

MaxQBi Q8TDM6.
PaxDbi Q8TDM6.
PRIDEi Q8TDM6.

Protocols and materials databases

DNASUi 9231.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372388 ; ENSP00000361464 ; ENSG00000151208 . [Q8TDM6-2 ]
ENST00000372391 ; ENSP00000361467 ; ENSG00000151208 . [Q8TDM6-1 ]
GeneIDi 9231.
KEGGi hsa:9231.
UCSCi uc001jzi.3. human. [Q8TDM6-5 ]
uc001jzj.3. human. [Q8TDM6-2 ]
uc001jzk.3. human. [Q8TDM6-1 ]
uc001jzl.4. human. [Q8TDM6-4 ]

Organism-specific databases

CTDi 9231.
GeneCardsi GC10M079550.
H-InvDB HIX0008958.
HIX0035651.
HGNCi HGNC:2904. DLG5.
HPAi HPA000555.
MIMi 604090. gene.
neXtProti NX_Q8TDM6.
PharmGKBi PA27360.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316405.
HOVERGENi HBG081446.
InParanoidi Q8TDM6.
OMAi TELRTTQ.
OrthoDBi EOG7VDXNB.
PhylomeDBi Q8TDM6.
TreeFami TF323171.

Miscellaneous databases

ChiTaRSi DLG5. human.
EvolutionaryTracei Q8TDM6.
GeneWikii DLG5.
GenomeRNAii 9231.
NextBioi 34601.
PROi Q8TDM6.
SOURCEi Search...

Gene expression databases

Bgeei Q8TDM6.
Genevestigatori Q8TDM6.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 4 hits.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006907. DUF622.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 4 hits.
PF04822. Takusan. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 4 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 4 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 4 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55."
    Nakamura H., Sudo T., Tsuiki H., Miyake H., Morisaki T., Sasaki J., Masuko N., Kochi M., Ushio Y., Saya H.
    FEBS Lett. 433:63-67(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, INTERACTION WITH MPP1.
    Tissue: Fetal brain.
  2. "The cloning, genomic organization and tissue expression profile of the human DLG5 gene."
    Shah G., Brugada R., Gonzalez O., Czernuszewicz G., Gibbs R.A., Bachinski L., Roberts R.
    BMC Genomics 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-140.
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-140.
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Ishikawa K.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1075-1919 (ISOFORM 3), VARIANTS ARG-140 AND GLN-1481.
    Tissue: PNS.
  7. "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact."
    Wakabayashi M., Ito T., Mitsushima M., Aizawa S., Ueda K., Amachi T., Kioka N.
    J. Biol. Chem. 278:21709-21714(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-1919 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SORBS3 AND CTNNB1.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Solution structure of RSGI RUH-006, the third PDZ domain of HDLG5 (KIAA0583) protein [Homo sapiens]."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1224-1330.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-140.

Entry informationi

Entry nameiDLG5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDM6
Secondary accession number(s): A6H8Y3
, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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