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Protein

Sperm acrosome membrane-associated protein 4

Gene

SPACA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome membrane-associated protein 4
Alternative name(s):
Sperm acrosomal membrane-associated protein 14
Gene namesi
Name:SPACA4
Synonyms:SAMP14
ORF Names:UNQ3046/PRO9862
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16441. SPACA4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38141.

Polymorphism and mutation databases

BioMutaiSPACA4.
DMDMi74730606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 9778Sperm acrosome membrane-associated protein 4PRO_0000252450Add
BLAST
Propeptidei98 – 12427Removed in mature formSequence analysisPRO_0000252451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 47By similarity
Disulfide bondi26 ↔ 41By similarity
Disulfide bondi34 ↔ 65By similarity
Disulfide bondi71 ↔ 90By similarity
Disulfide bondi91 ↔ 96By similarity
Lipidationi97 – 971GPI-anchor amidated asparagineCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8TDM5.
PeptideAtlasiQ8TDM5.
PRIDEiQ8TDM5.

Expressioni

Tissue specificityi

Testis specific. Expressed in spermatozoa.1 Publication

Gene expression databases

BgeeiQ8TDM5.
CleanExiHS_SPACA4.
GenevisibleiQ8TDM5. HS.

Organism-specific databases

HPAiHPA041927.
HPA061302.

Interactioni

Protein-protein interaction databases

BioGridi128108. 7 interactions.
STRINGi9606.ENSP00000312774.

Structurei

3D structure databases

ProteinModelPortaliQ8TDM5.
SMRiQ8TDM5. Positions 35-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9775UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ6H. Eukaryota.
ENOG410Z1I7. LUCA.
GeneTreeiENSGT00510000049347.
HOGENOMiHOG000154243.
HOVERGENiHBG093928.
InParanoidiQ8TDM5.
KOiK19894.
OMAiMRCGDDE.
OrthoDBiEOG7TMZV5.
PhylomeDBiQ8TDM5.
TreeFamiTF338445.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TDM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLCWLLLLV MALPPGTTGV KDCVFCELTD SMQCPGTYMH CGDDEDCFTG
60 70 80 90 100
HGVAPGTGPV INKGCLRATS CGLEEPVSYR GVTYSLTTNC CTGRLCNRAP
110 120
SSQTVGATTS LALGLGMLLP PRLL
Length:124
Mass (Da):13,004
Last modified:June 1, 2002 - v1
Checksum:i53407C5CCD8FC8BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353721 mRNA. Translation: AAL83950.1.
AY358387 mRNA. Translation: AAQ88753.1.
BC047334 mRNA. Translation: AAH47334.1.
CCDSiCCDS12725.1.
RefSeqiNP_598005.1. NM_133498.2.
UniGeneiHs.122599.

Genome annotation databases

EnsembliENST00000321762; ENSP00000312774; ENSG00000177202.
GeneIDi171169.
KEGGihsa:171169.
UCSCiuc002pjo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353721 mRNA. Translation: AAL83950.1.
AY358387 mRNA. Translation: AAQ88753.1.
BC047334 mRNA. Translation: AAH47334.1.
CCDSiCCDS12725.1.
RefSeqiNP_598005.1. NM_133498.2.
UniGeneiHs.122599.

3D structure databases

ProteinModelPortaliQ8TDM5.
SMRiQ8TDM5. Positions 35-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128108. 7 interactions.
STRINGi9606.ENSP00000312774.

Polymorphism and mutation databases

BioMutaiSPACA4.
DMDMi74730606.

Proteomic databases

PaxDbiQ8TDM5.
PeptideAtlasiQ8TDM5.
PRIDEiQ8TDM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321762; ENSP00000312774; ENSG00000177202.
GeneIDi171169.
KEGGihsa:171169.
UCSCiuc002pjo.3. human.

Organism-specific databases

CTDi171169.
GeneCardsiSPACA4.
HGNCiHGNC:16441. SPACA4.
HPAiHPA041927.
HPA061302.
MIMi609932. gene.
neXtProtiNX_Q8TDM5.
PharmGKBiPA38141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ6H. Eukaryota.
ENOG410Z1I7. LUCA.
GeneTreeiENSGT00510000049347.
HOGENOMiHOG000154243.
HOVERGENiHBG093928.
InParanoidiQ8TDM5.
KOiK19894.
OMAiMRCGDDE.
OrthoDBiEOG7TMZV5.
PhylomeDBiQ8TDM5.
TreeFamiTF338445.

Miscellaneous databases

GenomeRNAii171169.
PROiQ8TDM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDM5.
CleanExiHS_SPACA4.
GenevisibleiQ8TDM5. HS.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction."
    Shetty J., Wolkowicz M.J., Digilio L.C., Klotz K.L., Jayes F.L., Diekman A.B., Westbrook V.A., Farris E.M., Hao Z., Coonrod S.A., Flickinger C.J., Herr J.C.
    J. Biol. Chem. 278:30506-30515(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 68-80, POSSIBLE FUNCTION IN GAMETE INTERACTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSACA4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.