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Protein

Breast carcinoma-amplified sequence 4

Gene

BCAS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Breast carcinoma-amplified sequence 4
Gene namesi
Name:BCAS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14367. BCAS4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei60 – 612Breakpoint for translocation to form BCAS4-BCAS3

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA25287.

Polymorphism and mutation databases

BioMutaiBCAS4.
DMDMi33301030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Breast carcinoma-amplified sequence 4PRO_0000064865Add
BLAST

Proteomic databases

MaxQBiQ8TDM0.
PaxDbiQ8TDM0.
PRIDEiQ8TDM0.

PTM databases

iPTMnetiQ8TDM0.

Expressioni

Tissue specificityi

Brain, thymus, spleen, kidney and placenta. Overexpressed in most breast cancer cell lines.1 Publication

Gene expression databases

BgeeiQ8TDM0.
ExpressionAtlasiQ8TDM0. baseline and differential.
GenevisibleiQ8TDM0. HS.

Organism-specific databases

HPAiHPA038812.

Interactioni

Protein-protein interaction databases

BioGridi120785. 11 interactions.
STRINGi9606.ENSP00000351642.

Structurei

3D structure databases

ProteinModelPortaliQ8TDM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cappuccino family.Curated

Phylogenomic databases

eggNOGiENOG410IX4H. Eukaryota.
ENOG410XVQ5. LUCA.
GeneTreeiENSGT00390000006790.
HOVERGENiHBG099298.
InParanoidiQ8TDM0.
OMAiCSLADMI.
OrthoDBiEOG7RRF93.
PhylomeDBiQ8TDM0.
TreeFamiTF326629.

Family and domain databases

InterProiIPR024857. Cappuccino.
[Graphical view]
PANTHERiPTHR16230. PTHR16230. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDM0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRTGGGAPR PGRNHGLPGS LRQPDPVALL MLLVDADQPE PMRSGARELA
60 70 80 90 100
LFLTPEPGAE AKEVEETIEG MLLRLEEFCS LADLIRSDTS QILEENIPVL
110 120 130 140 150
KAKLTEMRGI YAKVDRLEAF VKMVGHHVAF LEADVLQAER DHGAFPQALR
160 170 180 190 200
RWLGSAGLPS FRNVECSGTI PARCNLRLPG SSDSPASASQ VAGITEVTCT
210
GARDVRAAHT V
Length:211
Mass (Da):22,758
Last modified:June 1, 2002 - v1
Checksum:iD16930DBC982AF5B
GO
Isoform 2 (identifier: Q8TDM0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-147: AFVKMVGHHVAFLEADVLQAERDHGAFPQ → KSPAPVPVTYELPTLYRTEDYFPVDAGEA
     148-211: Missing.

Show »
Length:147
Mass (Da):16,186
Checksum:i7F1A29A2869E676C
GO
Isoform 3 (identifier: Q8TDM0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-203: VECSGTIPAR...ITEVTCTGAR → KSPAPVPVTY...HHPRTCPRPL
     204-211: Missing.

Show »
Length:203
Mass (Da):22,495
Checksum:iDC143F9B565EEC45
GO

Sequence cautioni

The sequence AAH38381.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91209.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD53579.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561E → D.
Corresponds to variant rs2272962 [ dbSNP | Ensembl ].
VAR_016031
Natural varianti173 – 1731R → H.
Corresponds to variant rs7273412 [ dbSNP | Ensembl ].
VAR_059590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 14729AFVKM…GAFPQ → KSPAPVPVTYELPTLYRTED YFPVDAGEA in isoform 2. 1 PublicationVSP_007854Add
BLAST
Alternative sequencei148 – 21164Missing in isoform 2. 1 PublicationVSP_007855Add
BLAST
Alternative sequencei164 – 20340VECSG…CTGAR → KSPAPVPVTYELPTLYRTED YFPVDAGEAQHHPRTCPRPL in isoform 3. 1 PublicationVSP_015289Add
BLAST
Alternative sequencei204 – 2118Missing in isoform 3. 1 PublicationVSP_015290

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361220 mRNA. Translation: AAL99633.1.
AF361221 mRNA. Translation: AAL99634.1. Different termination.
AL031680, AL133228 Genomic DNA. Translation: CAI23006.1.
AL031680, AL133228 Genomic DNA. Translation: CAI23007.2.
AL031680, AL133228 Genomic DNA. Translation: CAI23008.1.
AL133228, AL031680 Genomic DNA. Translation: CAI19061.1.
AL133228, AL031680 Genomic DNA. Translation: CAI19062.2.
AL133228, AL031680 Genomic DNA. Translation: CAI19063.1.
AK000502 mRNA. Translation: BAA91209.1. Different initiation.
BC038381 mRNA. Translation: AAH38381.1. Different initiation.
BC047337 mRNA. Translation: AAH47337.1.
AJ511266 mRNA. Translation: CAD53579.1. Different initiation.
CCDSiCCDS13432.2. [Q8TDM0-3]
CCDS33487.1. [Q8TDM0-1]
RefSeqiNP_001010974.1. NM_001010974.2.
NP_060313.3. NM_017843.4. [Q8TDM0-1]
NP_942094.2. NM_198799.3. [Q8TDM0-3]
XP_011527189.1. XM_011528887.1. [Q8TDM0-3]
UniGeneiHs.381178.

Genome annotation databases

EnsembliENST00000358791; ENSP00000351642; ENSG00000124243. [Q8TDM0-1]
ENST00000371608; ENSP00000360669; ENSG00000124243. [Q8TDM0-3]
GeneIDi55653.
KEGGihsa:55653.
UCSCiuc002xvq.4. human. [Q8TDM0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361220 mRNA. Translation: AAL99633.1.
AF361221 mRNA. Translation: AAL99634.1. Different termination.
AL031680, AL133228 Genomic DNA. Translation: CAI23006.1.
AL031680, AL133228 Genomic DNA. Translation: CAI23007.2.
AL031680, AL133228 Genomic DNA. Translation: CAI23008.1.
AL133228, AL031680 Genomic DNA. Translation: CAI19061.1.
AL133228, AL031680 Genomic DNA. Translation: CAI19062.2.
AL133228, AL031680 Genomic DNA. Translation: CAI19063.1.
AK000502 mRNA. Translation: BAA91209.1. Different initiation.
BC038381 mRNA. Translation: AAH38381.1. Different initiation.
BC047337 mRNA. Translation: AAH47337.1.
AJ511266 mRNA. Translation: CAD53579.1. Different initiation.
CCDSiCCDS13432.2. [Q8TDM0-3]
CCDS33487.1. [Q8TDM0-1]
RefSeqiNP_001010974.1. NM_001010974.2.
NP_060313.3. NM_017843.4. [Q8TDM0-1]
NP_942094.2. NM_198799.3. [Q8TDM0-3]
XP_011527189.1. XM_011528887.1. [Q8TDM0-3]
UniGeneiHs.381178.

3D structure databases

ProteinModelPortaliQ8TDM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120785. 11 interactions.
STRINGi9606.ENSP00000351642.

PTM databases

iPTMnetiQ8TDM0.

Polymorphism and mutation databases

BioMutaiBCAS4.
DMDMi33301030.

Proteomic databases

MaxQBiQ8TDM0.
PaxDbiQ8TDM0.
PRIDEiQ8TDM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358791; ENSP00000351642; ENSG00000124243. [Q8TDM0-1]
ENST00000371608; ENSP00000360669; ENSG00000124243. [Q8TDM0-3]
GeneIDi55653.
KEGGihsa:55653.
UCSCiuc002xvq.4. human. [Q8TDM0-1]

Organism-specific databases

CTDi55653.
GeneCardsiBCAS4.
HGNCiHGNC:14367. BCAS4.
HPAiHPA038812.
MIMi607471. gene.
neXtProtiNX_Q8TDM0.
PharmGKBiPA25287.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX4H. Eukaryota.
ENOG410XVQ5. LUCA.
GeneTreeiENSGT00390000006790.
HOVERGENiHBG099298.
InParanoidiQ8TDM0.
OMAiCSLADMI.
OrthoDBiEOG7RRF93.
PhylomeDBiQ8TDM0.
TreeFamiTF326629.

Miscellaneous databases

ChiTaRSiBCAS4. human.
GenomeRNAii55653.
PROiQ8TDM0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TDM0.
ExpressionAtlasiQ8TDM0. baseline and differential.
GenevisibleiQ8TDM0. HS.

Family and domain databases

InterProiIPR024857. Cappuccino.
[Graphical view]
PANTHERiPTHR16230. PTHR16230. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer."
    Baerlund M., Monni O., Weaver J.D., Kauraniemi P., Sauter G., Heiskanen M., Kallioniemi O.-P., Kallioniemi A.
    Genes Chromosomes Cancer 35:311-317(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH BCAS3.
    Tissue: Liver.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-211 (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-211 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-211 (ISOFORM 3).
    Tissue: Lymph.
  5. "Cloning and sequencing of a new BCAS4 isoform (BCAS4 isoform 1)."
    Bauer M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-211 (ISOFORM 2).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCAS4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDM0
Secondary accession number(s): Q5TD52
, Q5TD53, Q5TD54, Q5U5K7, Q5XKE8, Q8IXI7, Q8NEZ6, Q8TDL9, Q9NX13, Q9Y511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.