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Q8TDL5 (BPIB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
Von Ebner minor salivary gland protein
Short name=VEMSGP
Gene names
Name:BPIFB1
Synonyms:C20orf114, LPLUNC1
ORF Names:UNQ706/PRO1357
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. Ref.6

Subcellular location

Secreted By similarity.

Tissue specificity

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung. Ref.6

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TDL5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TDL5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 484463BPI fold-containing family B member 1
PRO_0000017180

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 201 By similarity

Natural variations

Alternative sequence1 – 169169Missing in isoform 2.
VSP_015285
Alternative sequence170 – 22051LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2.
VSP_015286
Alternative sequence328 – 3292AA → LQ in isoform 2.
VSP_015287
Alternative sequence330 – 484155Missing in isoform 2.
VSP_015288
Natural variant841I → V. Ref.5
Corresponds to variant rs1078761 [ dbSNP | Ensembl ].
VAR_016756
Natural variant1401T → A.
Corresponds to variant rs34578060 [ dbSNP | Ensembl ].
VAR_049747
Natural variant2841V → M.
Corresponds to variant rs6141383 [ dbSNP | Ensembl ].
VAR_049748
Natural variant2871D → H.
Corresponds to variant rs34548457 [ dbSNP | Ensembl ].
VAR_049749
Natural variant2981S → P.
Corresponds to variant rs6120221 [ dbSNP | Ensembl ].
VAR_023361
Natural variant3131S → I.
Corresponds to variant rs6120222 [ dbSNP | Ensembl ].
VAR_023362
Natural variant4641T → S. Ref.5
Corresponds to variant rs17856249 [ dbSNP | Ensembl ].
VAR_049750
Natural variant4791S → T. Ref.3 Ref.5
Corresponds to variant rs1999663 [ dbSNP | Ensembl ].
VAR_016757

Experimental info

Sequence conflict1711H → Y in AAQ88958. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A32A85F74D544E81

FASTA48452,442
        10         20         30         40         50         60 
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS 

        70         80         90        100        110        120 
AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF 

       130        140        150        160        170        180 
NTPLVKTIVE FHMTTEAQAT IRMDTSASGP TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL 

       190        200        210        220        230        240 
AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK 

       250        260        270        280        290        300 
GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE 

       310        320        330        340        350        360 
EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGHAKVAQL 

       370        380        390        400        410        420 
IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD 

       430        440        450        460        470        480 
VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPSS 


PVSQ 

« Hide

Isoform 2 [UniParc].

Checksum: 235B7A2830539689
Show »

FASTA16017,695

References

« Hide 'large scale' references
[1]"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
Bingle C.D., Craven C.J.
Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lung, Nasal epithelium and Submandibular gland.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-479.
Tissue: Cervix and Testis.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-84; SER-464 AND THR-479.
Tissue: Skeletal muscle.
[6]"LPLUNC1 modulates innate immune responses to Vibrio cholerae."
Shin O.S., Uddin T., Citorik R., Wang J.P., Della Pelle P., Kradin R.L., Bingle C.D., Bingle L., Camilli A., Bhuiyan T.R., Shirin T., Ryan E.T., Calderwood S.B., Finberg R.W., Qadri F., Larocque R.C., Harris J.B.
J. Infect. Dis. 204:1349-1357(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: LIPOPOLYSACCHARIDE-BINDING, TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF364078 mRNA. Translation: AAM00283.1.
AY358595 mRNA. Translation: AAQ88958.1.
AK127971 mRNA. Translation: BAC87212.1.
AK290243 mRNA. Translation: BAF82932.1.
AL121901, AL355392 Genomic DNA. Translation: CAI14743.1.
AL355392, AL121901 Genomic DNA. Translation: CAI19398.1.
BC008429 mRNA. Translation: AAH08429.1.
CCDSCCDS13218.1. [Q8TDL5-1]
RefSeqNP_149974.2. NM_033197.2. [Q8TDL5-1]
UniGeneHs.65551.

3D structure databases

ProteinModelPortalQ8TDL5.
SMRQ8TDL5. Positions 54-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124975. 1 interaction.
IntActQ8TDL5. 1 interaction.

PTM databases

PhosphoSiteQ8TDL5.

Polymorphism databases

DMDM34395685.

Proteomic databases

PaxDbQ8TDL5.
PRIDEQ8TDL5.

Protocols and materials databases

DNASU92747.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253354; ENSP00000253354; ENSG00000125999. [Q8TDL5-1]
GeneID92747.
KEGGhsa:92747.
UCSCuc002wyw.1. human. [Q8TDL5-1]
uc031rst.1. human. [Q8TDL5-2]

Organism-specific databases

CTD92747.
GeneCardsGC20P031864.
HGNCHGNC:16108. BPIFB1.
HPAHPA024256.
neXtProtNX_Q8TDL5.
PharmGKBPA25654.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302127.
HOVERGENHBG052339.
InParanoidQ8TDL5.
OMADRIHLMN.
OrthoDBEOG7VB2FG.
PhylomeDBQ8TDL5.
TreeFamTF338541.

Gene expression databases

BgeeQ8TDL5.
CleanExHS_C20orf114.
GenevestigatorQ8TDL5.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
IPR021193. PLUNC_long_form.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFPIRSF037186. PLUNC_long_form. 1 hit.
SMARTSM00328. BPI1. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi92747.
NextBio77869.
PROQ8TDL5.

Entry information

Entry nameBPIB1_HUMAN
AccessionPrimary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8 expand/collapse secondary AC list , Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM