Q8TDL5 (BPIB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family B member 1

Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
Von Ebner minor salivary gland protein
Short name=VEMSGP

Gene names

Name:	BPIFB1
Synonyms:	C20orf114, LPLUNC1
ORF Names:	UNQ706/PRO1357

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in innate immunity in mouth, nose and lungs.
Subcellular location	Secreted By similarity.
Tissue specificity	Detected in trachea, nasal septal epithelium and lung.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDL5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDL5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 484	463	BPI fold-containing family B member 1		PRO_0000017180
Amino acid modifications
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 169	169	Missing in isoform 2.		VSP_015285
	Alternative sequence	170 – 220	51	LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2.		VSP_015286
	Alternative sequence	328 – 329	2	AA → LQ in isoform 2.		VSP_015287
	Alternative sequence	330 – 484	155	Missing in isoform 2.		VSP_015288
	Natural variant	84	1	I → V. Ref.5 Corresponds to variant rs1078761 [ dbSNP | Ensembl ].		VAR_016756
	Natural variant	140	1	T → A. Corresponds to variant rs34578060 [ dbSNP | Ensembl ].		VAR_049747
	Natural variant	284	1	V → M. Corresponds to variant rs6141383 [ dbSNP | Ensembl ].		VAR_049748
	Natural variant	287	1	D → H. Corresponds to variant rs34548457 [ dbSNP | Ensembl ].		VAR_049749
	Natural variant	298	1	S → P. Corresponds to variant rs6120221 [ dbSNP | Ensembl ].		VAR_023361
	Natural variant	313	1	S → I. Corresponds to variant rs6120222 [ dbSNP | Ensembl ].		VAR_023362
	Natural variant	464	1	T → S. Ref.5 Corresponds to variant rs17856249 [ dbSNP | Ensembl ].		VAR_049750
	Natural variant	479	1	S → T. Ref.3 Ref.5 Corresponds to variant rs1999663 [ dbSNP | Ensembl ].		VAR_016757
Experimental info
	Sequence conflict	171	1	H → Y in AAQ88958. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A32A85F74D544E81	FASTA	484	52,442
	10 20 30 40 50 60 MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS 70 80 90 100 110 120 AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF 130 140 150 160 170 180 NTPLVKTIVE FHMTTEAQAT IRMDTSASGP TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL 190 200 210 220 230 240 AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK 250 260 270 280 290 300 GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE 310 320 330 340 350 360 EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGHAKVAQL 370 380 390 400 410 420 IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD 430 440 450 460 470 480 VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
	Isoform 2 [UniParc]. Checksum: 235B7A2830539689	FASTA	160	17,695
	10 20 30 40 50 60 MCCPGGHYTL ILRRGNRFRR EKRPAKVTGA QTEVQLAPPL PRGRARRSPW SVPISLSIDR 70 80 90 100 110 120 LEFDLLYPAI KGDTIQLYLG AKLLDSQGKV TKWFNNSAAS LTMPTLDNIP FSLIVSQDVV 130 140 150 160 KAAVAAVLSP EEFMVLLDSV LPESAHRLKS SIGLINEKLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx." Bingle C.D., Craven C.J. Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lung, Nasal epithelium and Submandibular gland.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-479. Tissue: Cervix and Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-84; SER-464 AND THR-479. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF364078 mRNA. Translation: AAM00283.1. AY358595 mRNA. Translation: AAQ88958.1. AK127971 mRNA. Translation: BAC87212.1. AK290243 mRNA. Translation: BAF82932.1. AL121901, AL355392 Genomic DNA. Translation: CAI14743.1. AL355392, AL121901 Genomic DNA. Translation: CAI19398.1. BC008429 mRNA. Translation: AAH08429.1.
IPI	IPI00291410. IPI00444116.
RefSeq	NP_149974.2. NM_033197.2.
UniGene	Hs.65551.
3D structure databases
ProteinModelPortal	Q8TDL5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TDL5. 1 interaction.
PTM databases
PhosphoSite	Q8TDL5.
Polymorphism databases
DMDM	34395685.
Proteomic databases
PaxDb	Q8TDL5.
PRIDE	Q8TDL5.
Protocols and materials databases
DNASU	92747.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253354; ENSP00000253354; ENSG00000125999.
GeneID	92747.
KEGG	hsa:92747.
UCSC	uc002wyw.1. human.
Organism-specific databases
CTD	92747.
GeneCards	GC20P031864.
HGNC	HGNC:16108. BPIFB1.
HPA	HPA024256.
neXtProt	NX_Q8TDL5.
PharmGKB	PA25654.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302127.
HOVERGEN	HBG052339.
InParanoid	Q8TDL5.
OMA	FFTLGIE.
PhylomeDB	Q8TDL5.
Gene expression databases
ArrayExpress	Q8TDL5.
Bgee	Q8TDL5.
CleanEx	HS_C20orf114.
Genevestigator	Q8TDL5.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017942. Lipid-bd_serum_glycop_N. IPR021193. PLUNC_long_form. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
PIRSF	PIRSF037186. PLUNC_long_form. 1 hit.
SMART	SM00328. BPI1. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
ProtoNet	Search...
Other
GenomeRNAi	92747.
NextBio	77869.

Entry information

Entry name

BPIB1_HUMAN

Accession

Primary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8 , Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.