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Q8TDL5

- BPIB1_HUMAN

UniProt

Q8TDL5 - BPIB1_HUMAN

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Protein

BPI fold-containing family B member 1

Gene

BPIFB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.1 Publication

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. innate immune response in mucosa Source: UniProt
  2. negative regulation of toll-like receptor 4 signaling pathway Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
Von Ebner minor salivary gland protein
Short name:
VEMSGP
Gene namesi
Name:BPIFB1
Synonyms:C20orf114, LPLUNC1
ORF Names:UNQ706/PRO1357
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16108. BPIFB1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProt
  2. extracellular space Source: InterPro
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 484463BPI fold-containing family B member 1PRO_0000017180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 201By similarity
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDL5.
PRIDEiQ8TDL5.

PTM databases

PhosphoSiteiQ8TDL5.

Expressioni

Tissue specificityi

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.1 Publication

Gene expression databases

BgeeiQ8TDL5.
CleanExiHS_C20orf114.
ExpressionAtlasiQ8TDL5. baseline and differential.
GenevestigatoriQ8TDL5.

Organism-specific databases

HPAiHPA024256.

Interactioni

Protein-protein interaction databases

BioGridi124975. 2 interactions.
IntActiQ8TDL5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TDL5.
SMRiQ8TDL5. Positions 54-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG302127.
GeneTreeiENSGT00720000108893.
HOVERGENiHBG052339.
InParanoidiQ8TDL5.
OMAiDRIHLMN.
OrthoDBiEOG7VB2FG.
PhylomeDBiQ8TDL5.
TreeFamiTF338541.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
IPR021193. PLUNC_long_form.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037186. PLUNC_long_form. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TDL5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT
60 70 80 90 100
SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK
110 120 130 140 150
PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP
160 170 180 190 200
TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL
210 220 230 240 250
CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA
260 270 280 290 300
KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE
310 320 330 340 350
EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI
360 370 380 390 400
DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN
410 420 430 440 450
NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL
460 470 480
VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
Length:484
Mass (Da):52,442
Last modified:June 1, 2002 - v1
Checksum:iA32A85F74D544E81
GO
Isoform 2 (identifier: Q8TDL5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.

Note: No experimental confirmation available.

Show »
Length:160
Mass (Da):17,695
Checksum:i235B7A2830539689
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711H → Y in AAQ88958. (PubMed:12975309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841I → V.1 Publication
Corresponds to variant rs1078761 [ dbSNP | Ensembl ].
VAR_016756
Natural varianti140 – 1401T → A.
Corresponds to variant rs34578060 [ dbSNP | Ensembl ].
VAR_049747
Natural varianti284 – 2841V → M.
Corresponds to variant rs6141383 [ dbSNP | Ensembl ].
VAR_049748
Natural varianti287 – 2871D → H.
Corresponds to variant rs34548457 [ dbSNP | Ensembl ].
VAR_049749
Natural varianti298 – 2981S → P.
Corresponds to variant rs6120221 [ dbSNP | Ensembl ].
VAR_023361
Natural varianti313 – 3131S → I.
Corresponds to variant rs6120222 [ dbSNP | Ensembl ].
VAR_023362
Natural varianti464 – 4641T → S.1 Publication
Corresponds to variant rs17856249 [ dbSNP | Ensembl ].
VAR_049750
Natural varianti479 – 4791S → T.2 Publications
Corresponds to variant rs1999663 [ dbSNP | Ensembl ].
VAR_016757

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 169169Missing in isoform 2. 1 PublicationVSP_015285Add
BLAST
Alternative sequencei170 – 22051LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2. 1 PublicationVSP_015286Add
BLAST
Alternative sequencei328 – 3292AA → LQ in isoform 2. 1 PublicationVSP_015287
Alternative sequencei330 – 484155Missing in isoform 2. 1 PublicationVSP_015288Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364078 mRNA. Translation: AAM00283.1.
AY358595 mRNA. Translation: AAQ88958.1.
AK127971 mRNA. Translation: BAC87212.1.
AK290243 mRNA. Translation: BAF82932.1.
AL121901, AL355392 Genomic DNA. Translation: CAI14743.1.
AL355392, AL121901 Genomic DNA. Translation: CAI19398.1.
BC008429 mRNA. Translation: AAH08429.1.
CCDSiCCDS13218.1. [Q8TDL5-1]
RefSeqiNP_149974.2. NM_033197.2. [Q8TDL5-1]
UniGeneiHs.65551.

Genome annotation databases

EnsembliENST00000253354; ENSP00000253354; ENSG00000125999. [Q8TDL5-1]
GeneIDi92747.
KEGGihsa:92747.
UCSCiuc002wyw.1. human. [Q8TDL5-1]
uc031rst.1. human. [Q8TDL5-2]

Polymorphism databases

DMDMi34395685.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364078 mRNA. Translation: AAM00283.1 .
AY358595 mRNA. Translation: AAQ88958.1 .
AK127971 mRNA. Translation: BAC87212.1 .
AK290243 mRNA. Translation: BAF82932.1 .
AL121901 , AL355392 Genomic DNA. Translation: CAI14743.1 .
AL355392 , AL121901 Genomic DNA. Translation: CAI19398.1 .
BC008429 mRNA. Translation: AAH08429.1 .
CCDSi CCDS13218.1. [Q8TDL5-1 ]
RefSeqi NP_149974.2. NM_033197.2. [Q8TDL5-1 ]
UniGenei Hs.65551.

3D structure databases

ProteinModelPortali Q8TDL5.
SMRi Q8TDL5. Positions 54-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124975. 2 interactions.
IntActi Q8TDL5. 1 interaction.

PTM databases

PhosphoSitei Q8TDL5.

Polymorphism databases

DMDMi 34395685.

Proteomic databases

PaxDbi Q8TDL5.
PRIDEi Q8TDL5.

Protocols and materials databases

DNASUi 92747.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253354 ; ENSP00000253354 ; ENSG00000125999 . [Q8TDL5-1 ]
GeneIDi 92747.
KEGGi hsa:92747.
UCSCi uc002wyw.1. human. [Q8TDL5-1 ]
uc031rst.1. human. [Q8TDL5-2 ]

Organism-specific databases

CTDi 92747.
GeneCardsi GC20P031864.
HGNCi HGNC:16108. BPIFB1.
HPAi HPA024256.
neXtProti NX_Q8TDL5.
PharmGKBi PA25654.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302127.
GeneTreei ENSGT00720000108893.
HOVERGENi HBG052339.
InParanoidi Q8TDL5.
OMAi DRIHLMN.
OrthoDBi EOG7VB2FG.
PhylomeDBi Q8TDL5.
TreeFami TF338541.

Miscellaneous databases

GenomeRNAii 92747.
NextBioi 77869.
PROi Q8TDL5.

Gene expression databases

Bgeei Q8TDL5.
CleanExi HS_C20orf114.
ExpressionAtlasi Q8TDL5. baseline and differential.
Genevestigatori Q8TDL5.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
IPR021193. PLUNC_long_form.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF037186. PLUNC_long_form. 1 hit.
SMARTi SM00328. BPI1. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
    Bingle C.D., Craven C.J.
    Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung, Nasal epithelium and Submandibular gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-479.
    Tissue: Cervix and Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-84; SER-464 AND THR-479.
    Tissue: Skeletal muscle.
  6. Cited for: LIPOPOLYSACCHARIDE-BINDING, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiBPIB1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8
, Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3