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Protein

BPI fold-containing family B member 1

Gene

BPIFB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.1 Publication

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral response Source: Reactome
  • innate immune response in mucosa Source: UniProtKB
  • negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
von Ebner minor salivary gland protein
Short name:
VEMSGP
Gene namesi
Name:BPIFB1
Synonyms:C20orf114, LPLUNC1
ORF Names:UNQ706/PRO1357
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125999.10
HGNCiHGNC:16108 BPIFB1
neXtProtiNX_Q8TDL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi92747
OpenTargetsiENSG00000125999
PharmGKBiPA25654

Polymorphism and mutation databases

BioMutaiBPIFB1
DMDMi34395685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001718022 – 484BPI fold-containing family B member 1Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 201By similarity
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDL5
PeptideAtlasiQ8TDL5
PRIDEiQ8TDL5
TopDownProteomicsiQ8TDL5-1 [Q8TDL5-1]

PTM databases

iPTMnetiQ8TDL5
PhosphoSitePlusiQ8TDL5

Expressioni

Tissue specificityi

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.1 Publication

Gene expression databases

BgeeiENSG00000125999
CleanExiHS_C20orf114
ExpressionAtlasiQ8TDL5 baseline and differential
GenevisibleiQ8TDL5 HS

Organism-specific databases

HPAiHPA024256

Interactioni

Protein-protein interaction databases

BioGridi124975, 17 interactors
IntActiQ8TDL5, 2 interactors
MINTiQ8TDL5
STRINGi9606.ENSP00000253354

Structurei

3D structure databases

ProteinModelPortaliQ8TDL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00840000130012
HOVERGENiHBG052339
InParanoidiQ8TDL5
OMAiKNQLCPV
OrthoDBiEOG091G0CAE
PhylomeDBiQ8TDL5
TreeFamiTF338541

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR021193 Bpifb1
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037186 PLUNC_long_form, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT
60 70 80 90 100
SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK
110 120 130 140 150
PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP
160 170 180 190 200
TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL
210 220 230 240 250
CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA
260 270 280 290 300
KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE
310 320 330 340 350
EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI
360 370 380 390 400
DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN
410 420 430 440 450
NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL
460 470 480
VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
Length:484
Mass (Da):52,442
Last modified:June 1, 2002 - v1
Checksum:iA32A85F74D544E81
GO
Isoform 2 (identifier: Q8TDL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,695
Checksum:i235B7A2830539689
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171H → Y in AAQ88958 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01675684I → V1 PublicationCorresponds to variant dbSNP:rs1078761Ensembl.1
Natural variantiVAR_049747140T → A. Corresponds to variant dbSNP:rs34578060Ensembl.1
Natural variantiVAR_049748284V → M. Corresponds to variant dbSNP:rs6141383Ensembl.1
Natural variantiVAR_049749287D → H. Corresponds to variant dbSNP:rs34548457Ensembl.1
Natural variantiVAR_023361298S → P. Corresponds to variant dbSNP:rs6120221Ensembl.1
Natural variantiVAR_023362313S → I. Corresponds to variant dbSNP:rs6120222Ensembl.1
Natural variantiVAR_049750464T → S1 PublicationCorresponds to variant dbSNP:rs17856249Ensembl.1
Natural variantiVAR_016757479S → T2 PublicationsCorresponds to variant dbSNP:rs1999663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152851 – 169Missing in isoform 2. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_015286170 – 220LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_015287328 – 329AA → LQ in isoform 2. 1 Publication2
Alternative sequenceiVSP_015288330 – 484Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364078 mRNA Translation: AAM00283.1
AY358595 mRNA Translation: AAQ88958.1
AK127971 mRNA Translation: BAC87212.1
AK290243 mRNA Translation: BAF82932.1
AL121901 Genomic DNA No translation available.
AL355392 Genomic DNA No translation available.
BC008429 mRNA Translation: AAH08429.1
CCDSiCCDS13218.1 [Q8TDL5-1]
RefSeqiNP_149974.2, NM_033197.2 [Q8TDL5-1]
UniGeneiHs.65551

Genome annotation databases

EnsembliENST00000253354; ENSP00000253354; ENSG00000125999 [Q8TDL5-1]
GeneIDi92747
KEGGihsa:92747
UCSCiuc002wyw.1 human [Q8TDL5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBPIB1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8
, Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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