Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DmX-like protein 2

Gene

DMXL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).By similarity1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104093-MONOMER.
SignaLinkiQ8TDJ6.

Names & Taxonomyi

Protein namesi
Recommended name:
DmX-like protein 2
Alternative name(s):
Rabconnectin-3
Gene namesi
Name:DMXL2
Synonyms:KIAA0856
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2938. DMXL2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular space Source: UniProtKB
  • RAVE complex Source: GO_Central
  • synaptic vesicle Source: MGI
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Polyendocrine-polyneuropathy syndrome (PEPNS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA progressive endocrine and neurodevelopmental disorder manifesting early in childhood with growth retardation and recurrent episodes of profound asymptomatic hypoglycemia. PEPNS is characterized by central hypothyroidism, hypogonadotropic hypogonadism, incomplete puberty, progressive non-autoimmune insulin-dependent diabetes mellitus, peripheral demyelinating sensorimotor polyneuropathy, and cerebellar and pyramidal signs.
See also OMIM:616113
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0726421942 – 1946Missing in PEPNS. 1 Publication5

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Hypogonadotropic hypogonadism, Neuropathy

Organism-specific databases

DisGeNETi23312.
MalaCardsiDMXL2.
MIMi616113. phenotype.
OpenTargetsiENSG00000104093.
PharmGKBiPA27392.

Polymorphism and mutation databases

BioMutaiDMXL2.
DMDMi296434481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233241 – 3036DmX-like protein 2Add BLAST3036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei326PhosphoserineBy similarity1
Modified residuei473PhosphoserineCombined sources1
Modified residuei588PhosphoserineBy similarity1
Modified residuei944PhosphoserineCombined sources1
Modified residuei945PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1143PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1287PhosphoserineBy similarity1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1417PhosphothreonineBy similarity1
Modified residuei1857PhosphoserineCombined sources1
Modified residuei1984PhosphoserineCombined sources1
Modified residuei2022PhosphothreonineBy similarity1
Modified residuei2399PhosphoserineCombined sources1
Modified residuei2640PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDJ6.
MaxQBiQ8TDJ6.
PaxDbiQ8TDJ6.
PeptideAtlasiQ8TDJ6.
PRIDEiQ8TDJ6.

PTM databases

iPTMnetiQ8TDJ6.
PhosphoSitePlusiQ8TDJ6.

Expressioni

Gene expression databases

BgeeiENSG00000104093.
CleanExiHS_DMXL2.
ExpressionAtlasiQ8TDJ6. baseline and differential.
GenevisibleiQ8TDJ6. HS.

Organism-specific databases

HPAiHPA039375.

Interactioni

Subunit structurei

Interacts with MADD and RAB3GAP.1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi116903. 13 interactors.
IntActiQ8TDJ6. 2 interactors.
STRINGi9606.ENSP00000441858.

Structurei

3D structure databases

ProteinModelPortaliQ8TDJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati108 – 145WD 1Add BLAST38
Repeati167 – 207WD 2Add BLAST41
Repeati230 – 278WD 3Add BLAST49
Repeati492 – 532WD 4Add BLAST41
Repeati595 – 634WD 5Add BLAST40
Repeati751 – 803WD 6Add BLAST53
Repeati878 – 920WD 7Add BLAST43
Repeati1000 – 1037WD 8Add BLAST38
Repeati1163 – 1204WD 9Add BLAST42
Repeati1244 – 1281WD 10Add BLAST38
Repeati2761 – 2800WD 11Add BLAST40
Repeati2804 – 2843WD 12Add BLAST40
Repeati2850 – 2892WD 13Add BLAST43
Repeati2898 – 2937WD 14Add BLAST40
Repeati2940 – 2979WD 15Add BLAST40
Repeati2992 – 3030WD 16Add BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2122 – 2153Sequence analysisAdd BLAST32

Sequence similaritiesi

Contains 16 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1064. Eukaryota.
ENOG410XPUM. LUCA.
GeneTreeiENSGT00390000000096.
HOGENOMiHOG000018348.
HOVERGENiHBG079593.
InParanoidiQ8TDJ6.
OMAiHPLAFRD.
OrthoDBiEOG091G002O.
PhylomeDBiQ8TDJ6.
TreeFamiTF312896.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR022033. Rav1p_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12234. Rav1p_C. 2 hits.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLHQVLTGA VNPGDNCYSV GSVGDVPFTA YGSGCDIVIL ANDFECVQII
60 70 80 90 100
PGAKHGNIQV SCVECSNQQG RIAASYGNAV CIFEPLGINS HKRNCQLKCQ
110 120 130 140 150
WLKTGQFFLS SVTYNLAWDP QDNRLLTATD SIQLWAPPGD DILEEEEEID
160 170 180 190 200
NTVPPVLNDW KCVWQCKTSV SVHLMEWSPD GEYFATAGKD DCLLKVWYPM
210 220 230 240 250
TGWKSSIIPQ DHHEVKRRQS STQFSFVYLA HPRAVTGFSW RKTSKYMPRG
260 270 280 290 300
SVCNVLLTSC HDGVCRLWAE TLLPEDCLLG EQICETTTSS IASSLSHAGR
310 320 330 340 350
HKDRIQHALE TIHHLKNLRK GQRRSSVLVT HAELMPDQTA MHEVQRHISH
360 370 380 390 400
HANALCHFHI AASINPATDI PNVLVGTAFN VDDGNGGFVV HWLNNKEFHF
410 420 430 440 450
TSSTEVFMHQ LRKLSDKQVD HENDDADRED EEHSQEDRER GLHMKLDHDL
460 470 480 490 500
SLDRESEAGT GSSEHEDGER EGSPRTYSRL SVPMPLPTVL LDRKIETLLT
510 520 530 540 550
EWNKNPDMLF TIHPVDGTFL VWHVKYLDEY NPGIFRQVQV SFSSRIPVAF
560 570 580 590 600
PSGDASSLSK NIMMYACINA TKDSHHTLLH QEGMSVGSPH GSQPHSRSHS
610 620 630 640 650
THMNILAPTV MMISKHIDGS LNQWAVTFAD KSAFTTVLTV SHKFRYCGHR
660 670 680 690 700
FHLNDLACHS VLPLLLTSSH HNALLTPELD CQWDSDNKLS RLMDPVKHIK
710 720 730 740 750
GSSKQPLRNA ATRTFHDPNA IYSELILWRV DPIGPLSYTG GVSELARINS
760 770 780 790 800
LHTSAFSNVA WLPTLIPSYC LGTYCNSASA CFVASDGKNL RLYQAVVDAR
810 820 830 840 850
KLLDELSDPE SSKLIGEVFN IVSQQSTARP GCIIELDAIT NQCGSNTQLL
860 870 880 890 900
HVFQEDFIIG YKPHKEDMEK KETEIFFQPS QGYRPPPFSE KFFLVVIEKD
910 920 930 940 950
SNNNSILHMW HLHLKSVQAC LAKASEGASS ESLLSVPGQK NVDSSPETSP
960 970 980 990 1000
SVSPMPHSSS IANLQTASKL ILSSRLVYSQ PLDLPESVEV IRATPSAGHL
1010 1020 1030 1040 1050
SSSSIYPVCL APYLVVTTCS DNKVRFWKCC MEANPECNKS DEKEIYHWKR
1060 1070 1080 1090 1100
WPLMNDEGED NSSTVSIVGR PVAVSCSYTG RLAVAYKQPI HHNGFVSKEF
1110 1120 1130 1140 1150
SMHVCIFECE STGGSEWVLE QTIHLDDLVK VGSVLDSRVS VDSNLFVYSK
1160 1170 1180 1190 1200
SDALLSKDRY LIPNIKHLVH LDWVSKEDGS HILTVGVGAN IFMYGRLSGI
1210 1220 1230 1240 1250
VTEQTNSKDG VAVITLPLGG SIKQGVKSRW VLLRSIDLVS SVDGTPSLPV
1260 1270 1280 1290 1300
SLSWVRDGIL VVGMDCEMHV YAQWKHAVKF GDTEADSSNA EEAAMQDHST
1310 1320 1330 1340 1350
FKSNMLARKS VVEGTAISDD VFCSPTVIQD GGLFEAAHVL SPTLPQYHPT
1360 1370 1380 1390 1400
QLLELMDLGK VRRAKAILSH LVKCIAGEVA IVRDPDAGEG TKRHLSRTIS
1410 1420 1430 1440 1450
VSGSTAKETV TVGKDGTRDY TEIDSIPPLP LYALLAADQD TSYRISEEST
1460 1470 1480 1490 1500
KIPQSYEDQT VSQPEDQYSE LFQIQDIPTD DIDLEPEKRE NKSKVINLSQ
1510 1520 1530 1540 1550
YGPAYFGQEH ARVLSSHLMH SSLPGLTRLE QMFLVALADT VATTSTELDE
1560 1570 1580 1590 1600
SRDKSCSGRD TLDECGLRYL LAMRLHTCLL TSLPPLYRVQ LLHQGVSTCH
1610 1620 1630 1640 1650
FAWAFHSEAE EELINMIPAI QRGDPQWSEL RAMGIGWWVR NINTLRRCIE
1660 1670 1680 1690 1700
KVAKASFQRN NDALDAALFY LSMKKKAVVW GLFRSQHDEK MTTFFSHNFN
1710 1720 1730 1740 1750
EDRWRKAALK NAFSLLGKQR FEQSAAFFLL AGSLKDAIEV CLEKMEDIQL
1760 1770 1780 1790 1800
AMVIARLYES EFETSSTYIS ILNQKILGCQ KDGSGFSCKR LHPDPFLRSL
1810 1820 1830 1840 1850
AYWVMKDYTR ALDTLLEQTP KEDDEHQVII KSCNPVAFSF YNYLRTHPLL
1860 1870 1880 1890 1900
IRRNLASPEG TLATLGLKTE KNFVDKINLI ERKLFFTTAN AHFKVGCPVL
1910 1920 1930 1940 1950
ALEVLSKIPK VTKTSALSAK KDQPDFISHR MDDVPSHSKA LSDGNGSSGI
1960 1970 1980 1990 2000
EWSNVTSSQY DWSQPIVKVD EEPLNLDWGE DHDSALDEEE DDAVGLVMKS
2010 2020 2030 2040 2050
TDAREKDKQS DQKASDPNML LTPQEEDDPE GDTEVDVIAE QLKFRACLKI
2060 2070 2080 2090 2100
LMTELRTLAT GYEVDGGKLR FQLYNWLEKE IAALHEICNH ESVIKEYSSK
2110 2120 2130 2140 2150
TYSKVESDLL DQEEMVDKPD IGSYERHQIE RRRLQAKREH AERRKSWLQK
2160 2170 2180 2190 2200
NQDLLRVFLS YCSLHGAQGG GLASVRMELK FLLQESQQET TVKQLQSPLP
2210 2220 2230 2240 2250
LPTTLPLLSA SIASTKTVIA NPVLYLNNHI HDILYTIVQM KTPPHPSIED
2260 2270 2280 2290 2300
VKVHTLHSLA ASLSASIYQA LCDSHSYSQT EGNQFTGMAY QGLLLSDRRR
2310 2320 2330 2340 2350
LRTESIEEHA TPNSSPAQWP GVSSLINLLS SAQDEDQPKL NILLCEAVVA
2360 2370 2380 2390 2400
VYLSLLIHAL ATNSSSELFR LAAHPLNNRM WAAVFGGGVK LVVKPRRQSE
2410 2420 2430 2440 2450
NISAPPVLSE DIDKHRRRFN MRMLVPGRPV KDATPPPVPA ERPSYKEKFI
2460 2470 2480 2490 2500
PPELSMWDYF VAKPFLPLSD SGVIYDSDES IHSDEEDDAF FSDTQIQEHQ
2510 2520 2530 2540 2550
DPNSYSWALL HLTMVKLALH NVKNFFPIAG LEFSELPVTS PLGIAVIKNL
2560 2570 2580 2590 2600
ENWEQILQEK MDQFEGPPPN YINTYPTDLS VGAGPAILRN KAMLEPENTP
2610 2620 2630 2640 2650
FKSRDSSAFP VKRLWHFLVK QEVLQETFIR YIFTKKRKQS EVEADLGYPG
2660 2670 2680 2690 2700
GKAKVIHKES DMIMAFSVNK ANCNEIVLAS THDVQELDVT SLLACQSYIW
2710 2720 2730 2740 2750
IGEEYDRESK SSDDVDYRGS TTTLYQPSAT SYSASQVHPP SSLPWLGTGQ
2760 2770 2780 2790 2800
TSTGASVLMK RNLHNVKRMT SHPVHQYYLT GAQDGSVRMF EWTRPQQLVC
2810 2820 2830 2840 2850
FRQAGNARVT RLYFNSQGNK CGVADGEGFL SIWQVNQTAS NPKPYMSWQC
2860 2870 2880 2890 2900
HSKATSDFAF ITSSSLVATS GHSNDNRNVC LWDTLISPGN SLIHGFTCHD
2910 2920 2930 2940 2950
HGATVLQYAP KQQLLISGGR KGHVCIFDIR QRQLIHTFQA HDSAIKALAL
2960 2970 2980 2990 3000
DPYEEYFTTG SAEGNIKVWR LTGHGLIHSF KSEHAKQSIF RNIGAGVMQI
3010 3020 3030
DIIQGNRLFS CGADGTLKTR VLPNAFNIPN RILDIL
Length:3,036
Mass (Da):339,641
Last modified:May 18, 2010 - v2
Checksum:i25E9B1D05C69882C
GO
Isoform 2 (identifier: Q8TDJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     922-1557: Missing.

Note: No experimental confirmation available.
Show »
Length:2,400
Mass (Da):270,148
Checksum:iB068FEAABF9030D4
GO
Isoform 3 (identifier: Q8TDJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2278-2278: S → SS

Note: No experimental confirmation available.
Show »
Length:3,037
Mass (Da):339,729
Checksum:i8FB825BB044FAC82
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128A → T in AAL93215 (PubMed:11809763).Curated1
Sequence conflicti974S → F in AAL93215 (PubMed:11809763).Curated1
Sequence conflicti2984H → Y in AAL93215 (PubMed:11809763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062094144E → Q.Corresponds to variant rs35097381dbSNPEnsembl.1
Natural variantiVAR_057593497T → M.Corresponds to variant rs17524906dbSNPEnsembl.1
Natural variantiVAR_057594903N → D.Corresponds to variant rs16953073dbSNPEnsembl.1
Natural variantiVAR_0575951288S → P.2 PublicationsCorresponds to variant rs12102203dbSNPEnsembl.1
Natural variantiVAR_0575961481D → G.Corresponds to variant rs35349640dbSNPEnsembl.1
Natural variantiVAR_0690281698N → S.1 PublicationCorresponds to variant rs149028181dbSNPEnsembl.1
Natural variantiVAR_0726421942 – 1946Missing in PEPNS. 1 Publication5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043015922 – 1557Missing in isoform 2. 1 PublicationAdd BLAST636
Alternative sequenceiVSP_0449772278S → SS in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389880 mRNA. Translation: AAL93215.1.
AB020663 mRNA. Translation: BAA74879.2.
AC020892 Genomic DNA. No translation available.
AC066613 Genomic DNA. No translation available.
BC140781 mRNA. Translation: AAI40782.1.
BC144539 mRNA. Translation: AAI44540.1.
CCDSiCCDS10141.1. [Q8TDJ6-1]
CCDS53945.1. [Q8TDJ6-2]
CCDS53946.1. [Q8TDJ6-3]
RefSeqiNP_001167587.1. NM_001174116.1. [Q8TDJ6-3]
NP_001167588.1. NM_001174117.1. [Q8TDJ6-2]
NP_056078.2. NM_015263.3. [Q8TDJ6-1]
UniGeneiHs.511386.

Genome annotation databases

EnsembliENST00000251076; ENSP00000251076; ENSG00000104093. [Q8TDJ6-1]
ENST00000449909; ENSP00000400855; ENSG00000104093. [Q8TDJ6-2]
ENST00000543779; ENSP00000441858; ENSG00000104093. [Q8TDJ6-3]
GeneIDi23312.
KEGGihsa:23312.
UCSCiuc002abf.4. human. [Q8TDJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389880 mRNA. Translation: AAL93215.1.
AB020663 mRNA. Translation: BAA74879.2.
AC020892 Genomic DNA. No translation available.
AC066613 Genomic DNA. No translation available.
BC140781 mRNA. Translation: AAI40782.1.
BC144539 mRNA. Translation: AAI44540.1.
CCDSiCCDS10141.1. [Q8TDJ6-1]
CCDS53945.1. [Q8TDJ6-2]
CCDS53946.1. [Q8TDJ6-3]
RefSeqiNP_001167587.1. NM_001174116.1. [Q8TDJ6-3]
NP_001167588.1. NM_001174117.1. [Q8TDJ6-2]
NP_056078.2. NM_015263.3. [Q8TDJ6-1]
UniGeneiHs.511386.

3D structure databases

ProteinModelPortaliQ8TDJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116903. 13 interactors.
IntActiQ8TDJ6. 2 interactors.
STRINGi9606.ENSP00000441858.

PTM databases

iPTMnetiQ8TDJ6.
PhosphoSitePlusiQ8TDJ6.

Polymorphism and mutation databases

BioMutaiDMXL2.
DMDMi296434481.

Proteomic databases

EPDiQ8TDJ6.
MaxQBiQ8TDJ6.
PaxDbiQ8TDJ6.
PeptideAtlasiQ8TDJ6.
PRIDEiQ8TDJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251076; ENSP00000251076; ENSG00000104093. [Q8TDJ6-1]
ENST00000449909; ENSP00000400855; ENSG00000104093. [Q8TDJ6-2]
ENST00000543779; ENSP00000441858; ENSG00000104093. [Q8TDJ6-3]
GeneIDi23312.
KEGGihsa:23312.
UCSCiuc002abf.4. human. [Q8TDJ6-1]

Organism-specific databases

CTDi23312.
DisGeNETi23312.
GeneCardsiDMXL2.
H-InvDBHIX0012246.
HIX0172819.
HGNCiHGNC:2938. DMXL2.
HPAiHPA039375.
MalaCardsiDMXL2.
MIMi612186. gene.
616113. phenotype.
neXtProtiNX_Q8TDJ6.
OpenTargetsiENSG00000104093.
PharmGKBiPA27392.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1064. Eukaryota.
ENOG410XPUM. LUCA.
GeneTreeiENSGT00390000000096.
HOGENOMiHOG000018348.
HOVERGENiHBG079593.
InParanoidiQ8TDJ6.
OMAiHPLAFRD.
OrthoDBiEOG091G002O.
PhylomeDBiQ8TDJ6.
TreeFamiTF312896.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104093-MONOMER.
SignaLinkiQ8TDJ6.

Miscellaneous databases

ChiTaRSiDMXL2. human.
GenomeRNAii23312.
PROiQ8TDJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104093.
CleanExiHS_DMXL2.
ExpressionAtlasiQ8TDJ6. baseline and differential.
GenevisibleiQ8TDJ6. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR022033. Rav1p_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12234. Rav1p_C. 2 hits.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMXL2_HUMAN
AccessioniPrimary (citable) accession number: Q8TDJ6
Secondary accession number(s): B2RTR3
, B7ZMH3, F5GWF1, O94938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.