##gff-version 3 Q8TDI8 UniProtKB Chain 1 760 . . . ID=PRO_0000185380;Note=Transmembrane channel-like protein 1 Q8TDI8 UniProtKB Topological domain 1 199 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 200 220 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 221 272 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 273 293 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 294 365 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 366 386 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 387 440 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 441 461 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 462 634 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 635 655 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 656 699 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Transmembrane 700 720 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Topological domain 721 760 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TDI8 UniProtKB Region 1 80 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TDI8 UniProtKB Compositional bias 1 15 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TDI8 UniProtKB Compositional bias 27 51 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TDI8 UniProtKB Compositional bias 60 80 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8TDI8 UniProtKB Natural variant 81 81 . . . ID=VAR_052333;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850618;Dbxref=dbSNP:rs1796993,PMID:11850618 Q8TDI8 UniProtKB Natural variant 141 141 . . . ID=VAR_052334;Note=R->W;Dbxref=dbSNP:rs11143384 Q8TDI8 UniProtKB Natural variant 486 486 . . . ID=VAR_052335;Note=M->T;Dbxref=dbSNP:rs17058153 Q8TDI8 UniProtKB Natural variant 572 572 . . . ID=VAR_014125;Note=In DFNA36. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11850618,ECO:0000269|PubMed:25388789;Dbxref=dbSNP:rs121908072,PMID:11850618,PMID:25388789 Q8TDI8 UniProtKB Natural variant 654 654 . . . ID=VAR_014126;Note=In DFNB7. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850618;Dbxref=dbSNP:rs121908074,PMID:11850618 Q8TDI8 UniProtKB Sequence conflict 673 673 . . . Note=M->R;Ontology_term=ECO:0000305;evidence=ECO:0000305