ID   TMC2_HUMAN     STANDARD;      PRT;   906 AA.
AC   Q8TDI7; Q9BYN2; Q9BYN3; Q9BYN4; Q9BYN5;
DT   28-FEB-2003 (Rel. 41, Created)
DT   15-MAR-2004 (Rel. 43, Last sequence update)
DT   15-MAR-2004 (Rel. 43, Last annotation update)
DE   Transmembrane cochlear-expressed protein 2.
GN   TMC2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain, Inner ear, and Testis;
RX   MEDLINE=21918583; PubMed=11850618;
RA   Kurima K., Peters L.M., Yang Y., Riazuddin S., Ahmed Z.M., Naz S.,
RA   Arnaud D., Drury S., Mo J., Makishima T., Ghosh M., Menon P.S.N.,
RA   Deshmukh D., Oddoux C., Ostrer H., Khan S., Raizuddin S.,
RA   Deininger P.L., Hampton L.L., Sullivan S.L., Battey J.F.,
RA   Keats B.J.B., Wilcox E.R., Friedman T.B., Griffith A.J.;
RT   "Dominant and recessive deafness caused by mutations of a novel gene,
RT   TMC1, required for cochlear hair-cell function.";
RL   Nat. Genet. 30:277-284(2002).
RN   [2]
RP   REVISIONS.
RA   Kurima K., Griffith A.J., Friedman T.B.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21638749; PubMed=11780052;
RA   Deloukas P., Matthews L.H., Ashurst J., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
CC   -!- FUNCTION: May be required for the normal function of cochlear hair
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (Potential).
CC   -!- TISSUE SPECIFICITY: Detected in fetal cochlea.
CC   -!- SIMILARITY: Belongs to the TMC family.
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DR   EMBL; AF417580; AAL86401.2; -.
DR   EMBL; AL049712; CAC29096.1; -.
DR   EMBL; AL049712; CAC29097.1; -.
DR   EMBL; AL049712; CAC29098.1; -.
DR   EMBL; AL049712; CAC29099.1; -.
DR   Genew; HGNC:16527; TMC2.
DR   MIM; 606707; -.
KW   Transmembrane.
FT   DOMAIN        1    263       Cytoplasmic (Potential).
FT   TRANSMEM    264    284       Potential.
FT   DOMAIN      285    336       Extracellular (Potential).
FT   TRANSMEM    337    357       Potential.
FT   DOMAIN      358    431       Cytoplasmic (Potential).
FT   TRANSMEM    432    452       Potential.
FT   DOMAIN      453    508       Extracellular (Potential).
FT   TRANSMEM    509    529       Potential.
FT   DOMAIN      530    693       Cytoplasmic (Potential).
FT   TRANSMEM    694    714       Potential.
FT   DOMAIN      715    750       Extracellular (Potential).
FT   TRANSMEM    751    771       Potential.
FT   DOMAIN      772    906       Cytoplasmic (Potential).
FT   DOMAIN        6    242       GLU/ASP/LYS/ARG-RICH (HIGHLY CHARGED).
SQ   SEQUENCE   906 AA;  102581 MW;  792C552E4F2FCA32 CRC64;
     MSHQVKGLKE EARGGVKGRV KSGSPHTGDR LGRRSSSKRA LKAEGTPGRR GAQRSQKERA
     GGSPSPGSPR RKQTGRRRHR EELGEQERGE AERTCEGRRK RDERASFQER TAAPKREKEI
     PRKEEKSKRQ KKPRSSSLAS SASGGESLSE EELAQILEQV EEKKKLIATM RSKPWPMAKK
     LTELREAQEF VEKYEGALGK GKGKQLYAYK MLMAKKWVKF KRDFDNFKTQ CIPWEMKIKD
     IESHFGSSVA SYFIFLRWMY GVNLVLFGLI FGLVIIPEVL MGMPYGSIPR KTVPRAEEEK
     AMDFSVLWDF EGYIKYSALF YGYYNNQRTI GWLRYRLPMA YFMVGVSVFG YSLIIVIRSM
     ASNTQGSTGE GESDNFTFSF KMFTSWDYLI GNSETADNKY ASITTSFKES IVDEQESNKE
     ENIHLTRFLR VLANFLIICC LCGSGYLIYF VVKRSQQFSK MQNVSWYERN EVEIVMSLLG
     MFCPPLFETI AALENYHPRT GLKWQLGRIF ALFLGNLYTF LLALMDDVHL KLANEETIKN
     ITHWTLFNYY NSSGWNESVP RPPLHPADVP RGSCWETAVG IEFMRLTVSD MLVTYITILL
     GDFLRACFVR FMNYCWCWDL EAGFPSYAEF DISGNVLGLI FNQGMIWMGS FYAPGLVGIN
     VLRLLTSMYF QCWAVMSSNV PHERVFKASR SNNFYMGLLL LVLFLSLLPV AYTIMSLPPS
     FDCGPFSGKN RMYDVLQETI ENDFPTFLGK IFAFLANPGL IIPAILLMFL AIYYLNSVSK
     SLSRANAQLR KKIQVLREVE KSHKSVKGKA TARDSEDTPK SSSKNATQLQ LTKEETTPPS
     ASQSQAMDKK AQGPGTSNSA SRTTLPASGH LPISRPPGIG PDSGHAPSQT HPWRSASGKS
     AQRPPH
//