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Q8TDI0

- CHD5_HUMAN

UniProt

Q8TDI0 - CHD5_HUMAN

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Protein

Chromodomain-helicase-DNA-binding protein 5

Gene
CHD5, KIAA0444
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 39048PHD-type 1Add
BLAST
Zinc fingeri416 – 46348PHD-type 2Add
BLAST
Nucleotide bindingi725 – 7328ATP Reviewed predictionBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. methylated histone binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cerebral cortex neuron differentiation Source: UniProtKB
  2. histone H3-K27 trimethylation Source: UniProtKB
  3. histone H4 acetylation Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
  5. positive regulation of signal transduction by p53 class mediator Source: UniProtKB
  6. regulation of transcription involved in cell fate commitment Source: UniProtKB
  7. spermatogenesis, exchange of chromosomal proteins Source: UniProtKB
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Differentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 5 (EC:3.6.4.12)
Short name:
CHD-5
Alternative name(s):
ATP-dependent helicase CHD5
Gene namesi
Name:CHD5
Synonyms:KIAA0444
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16816. CHD5.

Subcellular locationi

Nucleus
Note: Associates with heterochromatin By similarity.2 Publications

GO - Cellular componenti

  1. heterochromatin Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. NuRD complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in CHD5 may be a cause of the development of cancers from epithelial, neural and hematopoietic origin. CHD5 is one of the missing genes in the del(1p36), a deletion which is extremely common in this type of cancers. A decrease of its expression, results in increased susceptibility of cells to Ras-mediated transformation in vitro and in vivo (1 Publication).1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi518 – 5181L → A: Reduced affinity for trimethylated histone H3K27me3. 1 Publication
Mutagenesisi619 – 6191Y → E: Reduced affinity for trimethylated histone H3K27me3. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134969178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19541954Chromodomain-helicase-DNA-binding protein 5PRO_0000080230Add
BLAST

Proteomic databases

MaxQBiQ8TDI0.
PaxDbiQ8TDI0.
PRIDEiQ8TDI0.

PTM databases

PhosphoSiteiQ8TDI0.

Expressioni

Tissue specificityi

Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis.2 Publications

Gene expression databases

ArrayExpressiQ8TDI0.
BgeeiQ8TDI0.
CleanExiHS_CHD5.
GenevestigatoriQ8TDI0.

Organism-specific databases

HPAiHPA015809.

Interactioni

Subunit structurei

May be part of a nucleosome remodeling and histone deacetylation, NuRD-like, complex composed at least of GATAD2B, HDAC1, HDAC2 and MTA3 By similarity.

Protein-protein interaction databases

BioGridi117504. 1 interaction.
IntActiQ8TDI0. 1 interaction.
STRINGi9606.ENSP00000262450.

Structurei

3D structure databases

ProteinModelPortaliQ8TDI0.
SMRiQ8TDI0. Positions 315-468, 588-644, 943-1195.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini497 – 55458Chromo 1Add
BLAST
Domaini592 – 65362Chromo 2Add
BLAST
Domaini712 – 896185Helicase ATP-bindingAdd
BLAST
Domaini1028 – 1193166Helicase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 653311Histone-bindingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi847 – 8504DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 11668Lys-richAdd
BLAST

Domaini

The PHD domains mediate specific binding to histone H3 unmethylated at 'Lys-4' and may preferentially recruit the protein to transcriptionally inactive genes By similarity.1 Publication
The chromo domains mediate specific binding to histone H3 trimethylated at 'Lys-27' (H3K27me3) and may be required in neuron differentiation for proper gene regulation (1 Publication).1 Publication

Sequence similaritiesi

Contains 2 chromo domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0553.
HOGENOMiHOG000231124.
HOVERGENiHBG005326.
InParanoidiQ8TDI0.
KOiK14435.
OMAiKRIDDGD.
OrthoDBiEOG7C8GG7.
PhylomeDBiQ8TDI0.
TreeFamiTF106448.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR028727. CHD5.
IPR012957. CHD_C2.
IPR012958. CHD_N.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009462. DUF1086.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10799:SF583. PTHR10799:SF583. 1 hit.
PfamiPF08074. CHDCT2. 1 hit.
PF08073. CHDNT. 1 hit.
PF00385. Chromo. 2 hits.
PF06461. DUF1086. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 2 hits.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDI0-1 [UniParc]FASTAAdd to Basket

« Hide

MRGPVGTEEE LPRLFAEEME NEDEMSEEED GGLEAFDDFF PVEPVSLPKK     50
KKPKKLKENK CKGKRKKKEG SNDELSENEE DLEEKSESEG SDYSPNKKKK 100
KKLKDKKEKK AKRKKKDEDE DDNDDGCLKE PKSSGQLMAE WGLDDVDYLF 150
SEEDYHTLTN YKAFSQFLRP LIAKKNPKIP MSKMMTVLGA KWREFSANNP 200
FKGSSAAAAA AAVAAAVETV TISPPLAVSP PQVPQPVPIR KAKTKEGKGP 250
GVRKKIKGSK DGKKKGKGKK TAGLKFRFGG ISNKRKKGSS SEEDEREESD 300
FDSASIHSAS VRSECSAALG KKSKRRRKKK RIDDGDGYET DHQDYCEVCQ 350
QGGEIILCDT CPRAYHLVCL DPELEKAPEG KWSCPHCEKE GIQWEPKDDD 400
DEEEEGGCEE EEDDHMEFCR VCKDGGELLC CDACPSSYHL HCLNPPLPEI 450
PNGEWLCPRC TCPPLKGKVQ RILHWRWTEP PAPFMVGLPG PDVEPSLPPP 500
KPLEGIPERE FFVKWAGLSY WHCSWVKELQ LELYHTVMYR NYQRKNDMDE 550
PPPFDYGSGD EDGKSEKRKN KDPLYAKMEE RFYRYGIKPE WMMIHRILNH 600
SFDKKGDVHY LIKWKDLPYD QCTWEIDDID IPYYDNLKQA YWGHRELMLG 650
EDTRLPKRLL KKGKKLRDDK QEKPPDTPIV DPTVKFDKQP WYIDSTGGTL 700
HPYQLEGLNW LRFSWAQGTD TILADEMGLG KTVQTIVFLY SLYKEGHSKG 750
PYLVSAPLST IINWEREFEM WAPDFYVVTY TGDKESRSVI RENEFSFEDN 800
AIRSGKKVFR MKKEVQIKFH VLLTSYELIT IDQAILGSIE WACLVVDEAH 850
RLKNNQSKFF RVLNSYKIDY KLLLTGTPLQ NNLEELFHLL NFLTPERFNN 900
LEGFLEEFAD ISKEDQIKKL HDLLGPHMLR RLKADVFKNM PAKTELIVRV 950
ELSQMQKKYY KFILTRNFEA LNSKGGGNQV SLLNIMMDLK KCCNHPYLFP 1000
VAAVEAPVLP NGSYDGSSLV KSSGKLMLLQ KMLKKLRDEG HRVLIFSQMT 1050
KMLDLLEDFL EYEGYKYERI DGGITGGLRQ EAIDRFNAPG AQQFCFLLST 1100
RAGGLGINLA TADTVIIYDS DWNPHNDIQA FSRAHRIGQN KKVMIYRFVT 1150
RASVEERITQ VAKRKMMLTH LVVRPGLGSK SGSMTKQELD DILKFGTEEL 1200
FKDDVEGMMS QGQRPVTPIP DVQSSKGGNL AASAKKKHGS TPPGDNKDVE 1250
DSSVIHYDDA AISKLLDRNQ DATDDTELQN MNEYLSSFKV AQYVVREEDG 1300
VEEVEREIIK QEENVDPDYW EKLLRHHYEQ QQEDLARNLG KGKRIRKQVN 1350
YNDASQEDQE WQDELSDNQS EYSIGSEDED EDFEERPEGQ SGRRQSRRQL 1400
KSDRDKPLPP LLARVGGNIE VLGFNARQRK AFLNAIMRWG MPPQDAFNSH 1450
WLVRDLRGKS EKEFRAYVSL FMRHLCEPGA DGAETFADGV PREGLSRQHV 1500
LTRIGVMSLV RKKVQEFEHV NGKYSTPDLI PEGPEGKKSG EVISSDPNTP 1550
VPASPAHLLP APLGLPDKME AQLGYMDEKD PGAQKPRQPL EVQALPAALD 1600
RVESEDKHES PASKERAREE RPEETEKAPP SPEQLPREEV LPEKEKILDK 1650
LELSLIHSRG DSSELRPDDT KAEEKEPIET QQNGDKEEDD EGKKEDKKGK 1700
FKFMFNIADG GFTELHTLWQ NEERAAVSSG KIYDIWHRRH DYWLLAGIVT 1750
HGYARWQDIQ NDPRYMILNE PFKSEVHKGN YLEMKNKFLA RRFKLLEQAL 1800
VIEEQLRRAA YLNMTQDPNH PAMALNARLA EVECLAESHQ HLSKESLAGN 1850
KPANAVLHKV LNQLEELLSD MKADVTRLPS MLSRIPPVAA RLQMSERSIL 1900
SRLTNRAGDP TIQQGAFGSS QMYSNNFGPN FRGPGPGGIV NYNQMPLGPY 1950
VTDI 1954
Length:1,954
Mass (Da):223,050
Last modified:June 1, 2002 - v1
Checksum:iE333062B5B55E71F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451V → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035475
Natural varianti119 – 1191D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_035476
Natural varianti667 – 6671R → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035477
Natural varianti1253 – 12531S → I.
Corresponds to variant rs6657997 [ dbSNP | Ensembl ].
VAR_048729
Natural varianti1539 – 15391S → P.2 Publications
Corresponds to variant rs2843493 [ dbSNP | Ensembl ].
VAR_048730

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF425231 mRNA. Translation: AAL98962.1.
AL031847, AL035406 Genomic DNA. Translation: CAI19450.1.
AL035406, AL031847 Genomic DNA. Translation: CAI19891.1.
AL117491 mRNA. Translation: CAB55959.1.
AB007913 mRNA. Translation: BAA32289.1.
CCDSiCCDS57.1.
PIRiT17269.
RefSeqiNP_056372.1. NM_015557.2.
UniGeneiHs.522898.

Genome annotation databases

EnsembliENST00000262450; ENSP00000262450; ENSG00000116254.
GeneIDi26038.
KEGGihsa:26038.
UCSCiuc001amb.2. human.

Polymorphism databases

DMDMi51701343.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF425231 mRNA. Translation: AAL98962.1 .
AL031847 , AL035406 Genomic DNA. Translation: CAI19450.1 .
AL035406 , AL031847 Genomic DNA. Translation: CAI19891.1 .
AL117491 mRNA. Translation: CAB55959.1 .
AB007913 mRNA. Translation: BAA32289.1 .
CCDSi CCDS57.1.
PIRi T17269.
RefSeqi NP_056372.1. NM_015557.2.
UniGenei Hs.522898.

3D structure databases

ProteinModelPortali Q8TDI0.
SMRi Q8TDI0. Positions 315-468, 588-644, 943-1195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117504. 1 interaction.
IntActi Q8TDI0. 1 interaction.
STRINGi 9606.ENSP00000262450.

PTM databases

PhosphoSitei Q8TDI0.

Polymorphism databases

DMDMi 51701343.

Proteomic databases

MaxQBi Q8TDI0.
PaxDbi Q8TDI0.
PRIDEi Q8TDI0.

Protocols and materials databases

DNASUi 26038.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262450 ; ENSP00000262450 ; ENSG00000116254 .
GeneIDi 26038.
KEGGi hsa:26038.
UCSCi uc001amb.2. human.

Organism-specific databases

CTDi 26038.
GeneCardsi GC01M006161.
HGNCi HGNC:16816. CHD5.
HPAi HPA015809.
MIMi 610771. gene.
neXtProti NX_Q8TDI0.
PharmGKBi PA134969178.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0553.
HOGENOMi HOG000231124.
HOVERGENi HBG005326.
InParanoidi Q8TDI0.
KOi K14435.
OMAi KRIDDGD.
OrthoDBi EOG7C8GG7.
PhylomeDBi Q8TDI0.
TreeFami TF106448.

Miscellaneous databases

ChiTaRSi CHD5. human.
GeneWikii CHD5.
GenomeRNAii 26038.
NextBioi 47863.
PROi Q8TDI0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TDI0.
Bgeei Q8TDI0.
CleanExi HS_CHD5.
Genevestigatori Q8TDI0.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR028727. CHD5.
IPR012957. CHD_C2.
IPR012958. CHD_N.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009462. DUF1086.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10799:SF583. PTHR10799:SF583. 1 hit.
Pfami PF08074. CHDCT2. 1 hit.
PF08073. CHDNT. 1 hit.
PF00385. Chromo. 2 hits.
PF06461. DUF1086. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 2 hits.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 2 hits.
SM00184. RING. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system."
    Thompson P.M., Gotoh T., Kok M., White P.S., Brodeur G.M.
    Oncogene 22:1002-1011(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 567-1954, VARIANT PRO-1539.
    Tissue: Testis.
  4. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 977-1954, VARIANT PRO-1539.
    Tissue: Brain.
  5. Cited for: DISEASE.
  6. "CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes."
    Potts R.C., Zhang P., Wurster A.L., Precht P., Mughal M.R., Wood W.H., Zhang Y., Becker K.G., Mattson M.P., Pazin M.J.
    PLoS ONE 6:E24515-E24515(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression."
    Egan C.M., Nyman U., Skotte J., Streubel G., Turner S., O'Connell D.J., Rraklli V., Dolan M.J., Chadderton N., Hansen K., Farrar G.J., Helin K., Holmberg J., Bracken A.P.
    Dev. Cell 26:223-236(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REGULATOR, FUNCTION IN NEURON DIFFERENTIATION, INTERACTION WITH HISTONE H3K27ME3, SUBCELLULAR LOCATION, CHROMO DOMAINS, MUTAGENESIS OF LEU-518 AND TYR-619.
  8. Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-45; ASN-119 AND GLY-667.

Entry informationi

Entry nameiCHD5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDI0
Secondary accession number(s): O75032
, Q5TG89, Q7LGH2, Q9UFR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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