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Q8TDG2

- ACTT1_HUMAN

UniProt

Q8TDG2 - ACTT1_HUMAN

Protein

Actin-related protein T1

Gene

ACTRT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ8TDG2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein T1
    Short name:
    ARP-T1
    Gene namesi
    Name:ACTRT1
    Synonyms:ARPT1
    ORF Names:HSD27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24027. ACTRT1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672646.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Actin-related protein T1PRO_0000255656Add
    BLAST

    Proteomic databases

    PaxDbiQ8TDG2.
    PRIDEiQ8TDG2.

    Expressioni

    Gene expression databases

    BgeeiQ8TDG2.
    CleanExiHS_ACTRT1.
    GenevestigatoriQ8TDG2.

    Organism-specific databases

    HPAiHPA003119.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000360165.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDG2.
    SMRiQ8TDG2. Positions 11-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233340.
    HOVERGENiHBG003771.
    InParanoidiQ8TDG2.
    OMAiLYKYEAL.
    OrthoDBiEOG7QRQV3.
    PhylomeDBiQ8TDG2.
    TreeFamiTF354237.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TDG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNPHALDVP AVIFDNGSGL CKAGLSGEIG PRHVISSVLG HCKFNVPLAR    50
    LNQKYFVGQE ALYKYEALHL HYPIERGLVT GWDDMEKLWK HLFERELGVK 100
    PSQQPVLMTE PSLNPREIRE KLAEMMFETF SVPGFYLSNH AVAALYASAC 150
    VTGLVVDSGD GVTCTVPIFE GYSLPHAVTK LCMAGRDITE HLTRLLFASG 200
    FNFPCILNKA VVNNIKEKLC YIALEPEKEL RKSRGEVLGA YRLPDGHVIH 250
    FGDELYQVPE VLFAPDQLGI HSPGLSKMVS SSIMKCDTDI QNKLYADIVL 300
    SGGTTLLPGL EERLMKEVEQ LASKGTPIKI TASPDRCFSA WIGASIMTSM 350
    SSFKQMWVTS ADFKEYGTSV VQRRCF 376
    Length:376
    Mass (Da):41,696
    Last modified:October 31, 2006 - v2
    Checksum:i4E633B7869017508
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131I → M in AAP20055. 1 PublicationCurated
    Sequence conflicti262 – 2621L → P in AAP20055. 1 PublicationCurated
    Sequence conflicti271 – 2711H → R in AAM00432. (PubMed:12243744)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF440739 mRNA. Translation: AAM00432.1.
    AY251532 mRNA. Translation: AAP20055.1.
    Z74696 Genomic DNA. Translation: CAI42428.1.
    BC014597 mRNA. Translation: AAH14597.1.
    CCDSiCCDS14611.1.
    RefSeqiNP_612146.1. NM_138289.3.
    UniGeneiHs.680125.

    Genome annotation databases

    EnsembliENST00000371124; ENSP00000360165; ENSG00000123165.
    GeneIDi139741.
    KEGGihsa:139741.
    UCSCiuc004eum.3. human.

    Polymorphism databases

    DMDMi118586151.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF440739 mRNA. Translation: AAM00432.1 .
    AY251532 mRNA. Translation: AAP20055.1 .
    Z74696 Genomic DNA. Translation: CAI42428.1 .
    BC014597 mRNA. Translation: AAH14597.1 .
    CCDSi CCDS14611.1.
    RefSeqi NP_612146.1. NM_138289.3.
    UniGenei Hs.680125.

    3D structure databases

    ProteinModelPortali Q8TDG2.
    SMRi Q8TDG2. Positions 11-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000360165.

    Polymorphism databases

    DMDMi 118586151.

    Proteomic databases

    PaxDbi Q8TDG2.
    PRIDEi Q8TDG2.

    Protocols and materials databases

    DNASUi 139741.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371124 ; ENSP00000360165 ; ENSG00000123165 .
    GeneIDi 139741.
    KEGGi hsa:139741.
    UCSCi uc004eum.3. human.

    Organism-specific databases

    CTDi 139741.
    GeneCardsi GC0XM127184.
    HGNCi HGNC:24027. ACTRT1.
    HPAi HPA003119.
    MIMi 300487. gene.
    neXtProti NX_Q8TDG2.
    PharmGKBi PA142672646.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233340.
    HOVERGENi HBG003771.
    InParanoidi Q8TDG2.
    OMAi LYKYEAL.
    OrthoDBi EOG7QRQV3.
    PhylomeDBi Q8TDG2.
    TreeFami TF354237.

    Enzyme and pathway databases

    SignaLinki Q8TDG2.

    Miscellaneous databases

    GenomeRNAii 139741.
    NextBioi 84029.
    PROi Q8TDG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDG2.
    CleanExi HS_ACTRT1.
    Genevestigatori Q8TDG2.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head."
      Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.
      Exp. Cell Res. 279:177-187(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A new spermatogenesis-related gene."
      Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiACTT1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDG2
    Secondary accession number(s): Q6X7C1, Q96L10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3