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Q8TDG2 (ACTT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein T1

Short name=ARP-T1
Gene names
Name:ACTRT1
Synonyms:ARPT1
ORF Names:HSD27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the actin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Actin-related protein T1
PRO_0000255656

Experimental info

Sequence conflict131I → M in AAP20055. Ref.2
Sequence conflict2621L → P in AAP20055. Ref.2
Sequence conflict2711H → R in AAM00432. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TDG2 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 4E633B7869017508

FASTA37641,696
        10         20         30         40         50         60 
MFNPHALDVP AVIFDNGSGL CKAGLSGEIG PRHVISSVLG HCKFNVPLAR LNQKYFVGQE 

        70         80         90        100        110        120 
ALYKYEALHL HYPIERGLVT GWDDMEKLWK HLFERELGVK PSQQPVLMTE PSLNPREIRE 

       130        140        150        160        170        180 
KLAEMMFETF SVPGFYLSNH AVAALYASAC VTGLVVDSGD GVTCTVPIFE GYSLPHAVTK 

       190        200        210        220        230        240 
LCMAGRDITE HLTRLLFASG FNFPCILNKA VVNNIKEKLC YIALEPEKEL RKSRGEVLGA 

       250        260        270        280        290        300 
YRLPDGHVIH FGDELYQVPE VLFAPDQLGI HSPGLSKMVS SSIMKCDTDI QNKLYADIVL 

       310        320        330        340        350        360 
SGGTTLLPGL EERLMKEVEQ LASKGTPIKI TASPDRCFSA WIGASIMTSM SSFKQMWVTS 

       370 
ADFKEYGTSV VQRRCF 

« Hide

References

« Hide 'large scale' references
[1]"Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head."
Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.
Exp. Cell Res. 279:177-187(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A new spermatogenesis-related gene."
Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF440739 mRNA. Translation: AAM00432.1.
AY251532 mRNA. Translation: AAP20055.1.
Z74696 Genomic DNA. Translation: CAI42428.1.
BC014597 mRNA. Translation: AAH14597.1.
RefSeqNP_612146.1. NM_138289.3.
UniGeneHs.680125.

3D structure databases

ProteinModelPortalQ8TDG2.
SMRQ8TDG2. Positions 11-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360165.

Polymorphism databases

DMDM118586151.

Proteomic databases

PaxDbQ8TDG2.
PRIDEQ8TDG2.

Protocols and materials databases

DNASU139741.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371124; ENSP00000360165; ENSG00000123165.
GeneID139741.
KEGGhsa:139741.
UCSCuc004eum.3. human.

Organism-specific databases

CTD139741.
GeneCardsGC0XM127184.
HGNCHGNC:24027. ACTRT1.
HPAHPA003119.
MIM300487. gene.
neXtProtNX_Q8TDG2.
PharmGKBPA142672646.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5277.
HOGENOMHOG000233340.
HOVERGENHBG003771.
InParanoidQ8TDG2.
OMALYKYEAL.
OrthoDBEOG7QRQV3.
PhylomeDBQ8TDG2.
TreeFamTF354237.

Enzyme and pathway databases

SignaLinkQ8TDG2.

Gene expression databases

BgeeQ8TDG2.
CleanExHS_ACTRT1.
GenevestigatorQ8TDG2.

Family and domain databases

InterProIPR004000. Actin-related.
IPR027666. ACTRT1/ACTRT2.
[Graphical view]
PANTHERPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF38. PTHR11937:SF38. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi139741.
NextBio84029.
PROQ8TDG2.
SOURCESearch...

Entry information

Entry nameACTT1_HUMAN
AccessionPrimary (citable) accession number: Q8TDG2
Secondary accession number(s): Q6X7C1, Q96L10
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: February 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM