Q8TDG2 (ACTT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-related protein T1
Short name=ARP-T1

Gene names

Name:	ACTRT1
Synonyms:	ARPT1
ORF Names:	HSD27

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Actin-related protein T1		PRO_0000255656
Experimental info
	Sequence conflict	13	1	I → M in AAP20055. Ref.2
	Sequence conflict	262	1	L → P in AAP20055. Ref.2
	Sequence conflict	271	1	H → R in AAM00432. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TDG2 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 4E633B7869017508	FASTA	376	41,696
	10 20 30 40 50 60 MFNPHALDVP AVIFDNGSGL CKAGLSGEIG PRHVISSVLG HCKFNVPLAR LNQKYFVGQE 70 80 90 100 110 120 ALYKYEALHL HYPIERGLVT GWDDMEKLWK HLFERELGVK PSQQPVLMTE PSLNPREIRE 130 140 150 160 170 180 KLAEMMFETF SVPGFYLSNH AVAALYASAC VTGLVVDSGD GVTCTVPIFE GYSLPHAVTK 190 200 210 220 230 240 LCMAGRDITE HLTRLLFASG FNFPCILNKA VVNNIKEKLC YIALEPEKEL RKSRGEVLGA 250 260 270 280 290 300 YRLPDGHVIH FGDELYQVPE VLFAPDQLGI HSPGLSKMVS SSIMKCDTDI QNKLYADIVL 310 320 330 340 350 360 SGGTTLLPGL EERLMKEVEQ LASKGTPIKI TASPDRCFSA WIGASIMTSM SSFKQMWVTS 370 ADFKEYGTSV VQRRCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head." Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W. Exp. Cell Res. 279:177-187(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A new spermatogenesis-related gene." Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF440739 mRNA. Translation: AAM00432.1. AY251532 mRNA. Translation: AAP20055.1. Z74696 Genomic DNA. Translation: CAI42428.1. BC014597 mRNA. Translation: AAH14597.1.
IPI	IPI00064737.
RefSeq	NP_612146.1. NM_138289.3.
UniGene	Hs.680125.
3D structure databases
ProteinModelPortal	Q8TDG2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360165.
Polymorphism databases
DMDM	118586151.
Proteomic databases
PaxDb	Q8TDG2.
PRIDE	Q8TDG2.
Protocols and materials databases
DNASU	139741.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371124; ENSP00000360165; ENSG00000123165.
GeneID	139741.
KEGG	hsa:139741.
UCSC	uc004eum.3. human.
Organism-specific databases
CTD	139741.
GeneCards	GC0XM127184.
HGNC	HGNC:24027. ACTRT1.
HPA	HPA003119.
MIM	300487. gene.
neXtProt	NX_Q8TDG2.
PharmGKB	PA142672646.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5277.
HOGENOM	HOG000233340.
HOVERGEN	HBG003771.
InParanoid	Q8TDG2.
OMA	YEALHLH.
OrthoDB	EOG4NVZKF.
PhylomeDB	Q8TDG2.
Gene expression databases
Bgee	Q8TDG2.
CleanEx	HS_ACTRT1.
Genevestigator	Q8TDG2.
Family and domain databases
InterPro	IPR004000. Actin-related. [Graphical view]
PANTHER	PTHR11937. PTHR11937. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	139741.
NextBio	84029.
SOURCE	Search...

Entry information

Entry name

ACTT1_HUMAN

Accession

Primary (citable) accession number: Q8TDG2
Secondary accession number(s): Q6X7C1, Q96L10

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.