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Q8TDG2

- ACTT1_HUMAN

UniProt

Q8TDG2 - ACTT1_HUMAN

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Protein
Actin-related protein T1
Gene
ACTRT1, ARPT1, HSD27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TDG2.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein T1
Short name:
ARP-T1
Gene namesi
Name:ACTRT1
Synonyms:ARPT1
ORF Names:HSD27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24027. ACTRT1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Actin-related protein T1
PRO_0000255656Add
BLAST

Proteomic databases

PaxDbiQ8TDG2.
PRIDEiQ8TDG2.

Expressioni

Gene expression databases

BgeeiQ8TDG2.
CleanExiHS_ACTRT1.
GenevestigatoriQ8TDG2.

Organism-specific databases

HPAiHPA003119.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360165.

Structurei

3D structure databases

ProteinModelPortaliQ8TDG2.
SMRiQ8TDG2. Positions 11-376.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.

Phylogenomic databases

eggNOGiCOG5277.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ8TDG2.
OMAiLYKYEAL.
OrthoDBiEOG7QRQV3.
PhylomeDBiQ8TDG2.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin-related.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TDG2-1 [UniParc]FASTAAdd to Basket

« Hide

MFNPHALDVP AVIFDNGSGL CKAGLSGEIG PRHVISSVLG HCKFNVPLAR    50
LNQKYFVGQE ALYKYEALHL HYPIERGLVT GWDDMEKLWK HLFERELGVK 100
PSQQPVLMTE PSLNPREIRE KLAEMMFETF SVPGFYLSNH AVAALYASAC 150
VTGLVVDSGD GVTCTVPIFE GYSLPHAVTK LCMAGRDITE HLTRLLFASG 200
FNFPCILNKA VVNNIKEKLC YIALEPEKEL RKSRGEVLGA YRLPDGHVIH 250
FGDELYQVPE VLFAPDQLGI HSPGLSKMVS SSIMKCDTDI QNKLYADIVL 300
SGGTTLLPGL EERLMKEVEQ LASKGTPIKI TASPDRCFSA WIGASIMTSM 350
SSFKQMWVTS ADFKEYGTSV VQRRCF 376
Length:376
Mass (Da):41,696
Last modified:October 31, 2006 - v2
Checksum:i4E633B7869017508
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131I → M in AAP20055. 1 Publication
Sequence conflicti262 – 2621L → P in AAP20055. 1 Publication
Sequence conflicti271 – 2711H → R in AAM00432. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF440739 mRNA. Translation: AAM00432.1.
AY251532 mRNA. Translation: AAP20055.1.
Z74696 Genomic DNA. Translation: CAI42428.1.
BC014597 mRNA. Translation: AAH14597.1.
CCDSiCCDS14611.1.
RefSeqiNP_612146.1. NM_138289.3.
UniGeneiHs.680125.

Genome annotation databases

EnsembliENST00000371124; ENSP00000360165; ENSG00000123165.
GeneIDi139741.
KEGGihsa:139741.
UCSCiuc004eum.3. human.

Polymorphism databases

DMDMi118586151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF440739 mRNA. Translation: AAM00432.1 .
AY251532 mRNA. Translation: AAP20055.1 .
Z74696 Genomic DNA. Translation: CAI42428.1 .
BC014597 mRNA. Translation: AAH14597.1 .
CCDSi CCDS14611.1.
RefSeqi NP_612146.1. NM_138289.3.
UniGenei Hs.680125.

3D structure databases

ProteinModelPortali Q8TDG2.
SMRi Q8TDG2. Positions 11-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000360165.

Polymorphism databases

DMDMi 118586151.

Proteomic databases

PaxDbi Q8TDG2.
PRIDEi Q8TDG2.

Protocols and materials databases

DNASUi 139741.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371124 ; ENSP00000360165 ; ENSG00000123165 .
GeneIDi 139741.
KEGGi hsa:139741.
UCSCi uc004eum.3. human.

Organism-specific databases

CTDi 139741.
GeneCardsi GC0XM127184.
HGNCi HGNC:24027. ACTRT1.
HPAi HPA003119.
MIMi 300487. gene.
neXtProti NX_Q8TDG2.
PharmGKBi PA142672646.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5277.
HOGENOMi HOG000233340.
HOVERGENi HBG003771.
InParanoidi Q8TDG2.
OMAi LYKYEAL.
OrthoDBi EOG7QRQV3.
PhylomeDBi Q8TDG2.
TreeFami TF354237.

Enzyme and pathway databases

SignaLinki Q8TDG2.

Miscellaneous databases

GenomeRNAii 139741.
NextBioi 84029.
PROi Q8TDG2.
SOURCEi Search...

Gene expression databases

Bgeei Q8TDG2.
CleanExi HS_ACTRT1.
Genevestigatori Q8TDG2.

Family and domain databases

InterProi IPR004000. Actin-related.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head."
    Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.
    Exp. Cell Res. 279:177-187(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A new spermatogenesis-related gene."
    Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACTT1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDG2
Secondary accession number(s): Q6X7C1, Q96L10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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