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Protein

RAS guanyl-releasing protein 4

Gene

RASGRP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • diacylglycerol binding Source: UniProtKB
  • GTP-dependent protein binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • activation of phospholipase C activity Source: UniProtKB
  • cell growth Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • MAPK cascade Source: Reactome
  • myeloid cell differentiation Source: UniProtKB
  • positive regulation of Ras protein signal transduction Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  • response to extracellular stimulus Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171777-MONOMER.
ReactomeiR-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
RAS guanyl-releasing protein 4
Gene namesi
Name:RASGRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18958. RASGRP4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi548F → S: Loss of cell membrane targeting. 1 Publication1

Organism-specific databases

DisGeNETi115727.
OpenTargetsiENSG00000171777.
PharmGKBiPA38770.

Polymorphism and mutation databases

BioMutaiRASGRP4.
DMDMi296434529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152131 – 673RAS guanyl-releasing protein 4Add BLAST673

Proteomic databases

EPDiQ8TDF6.
PaxDbiQ8TDF6.
PeptideAtlasiQ8TDF6.
PRIDEiQ8TDF6.

PTM databases

iPTMnetiQ8TDF6.
PhosphoSitePlusiQ8TDF6.

Expressioni

Tissue specificityi

Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.2 Publications

Developmental stagei

Expressed early during development. Detected in all fetal tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000171777.
CleanExiHS_RASGRP4.
ExpressionAtlasiQ8TDF6. baseline and differential.
GenevisibleiQ8TDF6. HS.

Interactioni

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125451. 4 interactors.
IntActiQ8TDF6. 1 interactor.
STRINGi9606.ENSP00000465742.

Structurei

3D structure databases

ProteinModelPortaliQ8TDF6.
SMRiQ8TDF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 175N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST127
Domaini201 – 432Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini466 – 501EF-handPROSITE-ProRule annotationAdd BLAST36

Domaini

The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

Sequence similaritiesi

Belongs to the RASGRP family.Curated
Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ6I. Eukaryota.
ENOG410XQ12. LUCA.
GeneTreeiENSGT00850000132267.
HOGENOMiHOG000293171.
HOVERGENiHBG007513.
InParanoidiQ8TDF6.
KOiK12363.
OMAiHLVRYWL.
OrthoDBiEOG091G03RN.
PhylomeDBiQ8TDF6.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL
60 70 80 90 100
LSEGGCSEDE LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA
110 120 130 140 150
RLLTSYQKAT GDTQELRRLQ ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW
160 170 180 190 200
ATVAREGNSA QRRLGDSSDL LSPGGPGPPL PMSSPGLGKK RKVSLLFDHL
210 220 230 240 250
ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL EGSVGLSNSV
260 270 280 290 300
SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
310 320 330 340 350
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV
360 370 380 390 400
LGVHLKDLVS LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS
410 420 430 440 450
ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFNAPLVVEW
460 470 480 490 500
APGVTPKPDR VTLGRHVEQL VESVFKNYDP EGRGTISQED FERLSGNFPF
510 520 530 540 550
ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL HTFHEVTFRK
560 570 580 590 600
PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
610 620 630 640 650
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS
660 670
WETDTVPCPV MDPPSTASSK LDS
Length:673
Mass (Da):74,882
Last modified:May 18, 2010 - v2
Checksum:i3C007F595E3C7A02
GO
Isoform 2 (identifier: Q8TDF6-2) [UniParc]FASTAAdd to basket
Also known as: variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     171-184: Missing.

Note: Probably inactive.
Show »
Length:659
Mass (Da):73,607
Checksum:iAF5CEEBD186384DF
GO
Isoform 3 (identifier: Q8TDF6-3) [UniParc]FASTAAdd to basket
Also known as: variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     171-673: Missing.

Note: Probably inactive.
Show »
Length:170
Mass (Da):19,325
Checksum:i81FA75D21C6780F0
GO
Isoform 4 (identifier: Q8TDF6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-410: Missing.

Show »
Length:581
Mass (Da):64,491
Checksum:iCD8BBDAC9FA2F7A5
GO
Isoform 5 (identifier: Q8TDF6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-409: Missing.

Show »
Length:484
Mass (Da):53,910
Checksum:iFCE47E98E739BF31
GO
Isoform 6 (identifier: Q8TDF6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-318: Missing.

Note: No experimental confirmation available.
Show »
Length:576
Mass (Da):64,301
Checksum:iCF155F3D646655EE
GO
Isoform 7 (identifier: Q8TDF6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-255: Missing.

Show »
Length:639
Mass (Da):71,254
Checksum:i2E9D215E40CA9F2C
GO
Isoform 8 (identifier: Q8TDF6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-387: Missing.

Show »
Length:604
Mass (Da):66,972
Checksum:iA31300C9C32D900E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27V → A in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti73G → D in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti554C → R in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85701 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85703 (PubMed:11956218).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03814418I → T.3 PublicationsCorresponds to variant rs892055dbSNPEnsembl.1
Natural variantiVAR_038145120Q → L.1 Publication1
Natural variantiVAR_038146145V → A.1 Publication1
Natural variantiVAR_038147261R → C.1 Publication1
Natural variantiVAR_038148335R → G.1 PublicationCorresponds to variant rs202008979dbSNPEnsembl.1
Natural variantiVAR_057172620E → K.Corresponds to variant rs34377632dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030479171 – 673Missing in isoform 3. 1 PublicationAdd BLAST503
Alternative sequenceiVSP_030480171 – 184Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043176221 – 409Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_043392222 – 318Missing in isoform 6. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046907222 – 255Missing in isoform 7. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_043138319 – 410Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_046908319 – 387Missing in isoform 8. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048119 mRNA. Translation: AAK85701.1.
AY048120 mRNA. Translation: AAK85702.1.
AY048121 mRNA. Translation: AAK85703.1.
AF448437 mRNA. Translation: AAL87858.1.
FJ768677 mRNA. Translation: ACN82414.1.
FJ768678 mRNA. Translation: ACN82415.1.
FJ768679 mRNA. Translation: ACN82416.1.
FJ768680 mRNA. Translation: ACN82417.1.
FJ768682 mRNA. Translation: ACN82419.1.
AC005789 Genomic DNA. No translation available.
AC011469 Genomic DNA. No translation available.
AC093076 Genomic DNA. No translation available.
BC146669 mRNA. Translation: AAI46670.1.
BC150202 mRNA. Translation: AAI50203.1.
CCDSiCCDS46068.1. [Q8TDF6-1]
CCDS54262.1. [Q8TDF6-6]
CCDS54263.1. [Q8TDF6-7]
CCDS54264.1. [Q8TDF6-5]
CCDS59382.1. [Q8TDF6-2]
CCDS59383.1. [Q8TDF6-8]
CCDS59384.1. [Q8TDF6-9]
RefSeqiNP_001139674.1. NM_001146202.1. [Q8TDF6-2]
NP_001139675.1. NM_001146203.1. [Q8TDF6-5]
NP_001139676.1. NM_001146204.1. [Q8TDF6-9]
NP_001139677.1. NM_001146205.1. [Q8TDF6-8]
NP_001139678.1. NM_001146206.1. [Q8TDF6-6]
NP_001139679.1. NM_001146207.1. [Q8TDF6-7]
NP_733749.1. NM_170604.2. [Q8TDF6-1]
UniGeneiHs.130434.

Genome annotation databases

EnsembliENST00000293062; ENSP00000293062; ENSG00000171777. [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777. [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777. [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777. [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777. [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777. [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777. [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777. [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777. [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777. [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777. [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777. [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777. [Q8TDF6-6]
GeneIDi115727.
KEGGihsa:115727.
UCSCiuc010efz.4. human. [Q8TDF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048119 mRNA. Translation: AAK85701.1.
AY048120 mRNA. Translation: AAK85702.1.
AY048121 mRNA. Translation: AAK85703.1.
AF448437 mRNA. Translation: AAL87858.1.
FJ768677 mRNA. Translation: ACN82414.1.
FJ768678 mRNA. Translation: ACN82415.1.
FJ768679 mRNA. Translation: ACN82416.1.
FJ768680 mRNA. Translation: ACN82417.1.
FJ768682 mRNA. Translation: ACN82419.1.
AC005789 Genomic DNA. No translation available.
AC011469 Genomic DNA. No translation available.
AC093076 Genomic DNA. No translation available.
BC146669 mRNA. Translation: AAI46670.1.
BC150202 mRNA. Translation: AAI50203.1.
CCDSiCCDS46068.1. [Q8TDF6-1]
CCDS54262.1. [Q8TDF6-6]
CCDS54263.1. [Q8TDF6-7]
CCDS54264.1. [Q8TDF6-5]
CCDS59382.1. [Q8TDF6-2]
CCDS59383.1. [Q8TDF6-8]
CCDS59384.1. [Q8TDF6-9]
RefSeqiNP_001139674.1. NM_001146202.1. [Q8TDF6-2]
NP_001139675.1. NM_001146203.1. [Q8TDF6-5]
NP_001139676.1. NM_001146204.1. [Q8TDF6-9]
NP_001139677.1. NM_001146205.1. [Q8TDF6-8]
NP_001139678.1. NM_001146206.1. [Q8TDF6-6]
NP_001139679.1. NM_001146207.1. [Q8TDF6-7]
NP_733749.1. NM_170604.2. [Q8TDF6-1]
UniGeneiHs.130434.

3D structure databases

ProteinModelPortaliQ8TDF6.
SMRiQ8TDF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125451. 4 interactors.
IntActiQ8TDF6. 1 interactor.
STRINGi9606.ENSP00000465742.

PTM databases

iPTMnetiQ8TDF6.
PhosphoSitePlusiQ8TDF6.

Polymorphism and mutation databases

BioMutaiRASGRP4.
DMDMi296434529.

Proteomic databases

EPDiQ8TDF6.
PaxDbiQ8TDF6.
PeptideAtlasiQ8TDF6.
PRIDEiQ8TDF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293062; ENSP00000293062; ENSG00000171777. [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777. [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777. [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777. [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777. [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777. [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777. [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777. [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777. [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777. [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777. [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777. [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777. [Q8TDF6-6]
GeneIDi115727.
KEGGihsa:115727.
UCSCiuc010efz.4. human. [Q8TDF6-1]

Organism-specific databases

CTDi115727.
DisGeNETi115727.
GeneCardsiRASGRP4.
H-InvDBHIX0015095.
HGNCiHGNC:18958. RASGRP4.
MIMi607320. gene.
neXtProtiNX_Q8TDF6.
OpenTargetsiENSG00000171777.
PharmGKBiPA38770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6I. Eukaryota.
ENOG410XQ12. LUCA.
GeneTreeiENSGT00850000132267.
HOGENOMiHOG000293171.
HOVERGENiHBG007513.
InParanoidiQ8TDF6.
KOiK12363.
OMAiHLVRYWL.
OrthoDBiEOG091G03RN.
PhylomeDBiQ8TDF6.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171777-MONOMER.
ReactomeiR-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

GenomeRNAii115727.
PROiQ8TDF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171777.
CleanExiHS_RASGRP4.
ExpressionAtlasiQ8TDF6. baseline and differential.
GenevisibleiQ8TDF6. HS.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRP4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDF6
Secondary accession number(s): A6H8M4
, C0LTP2, C0LTP3, C0LTP4, C0LTP5, C0LTP7, C9J416, C9JHZ1, Q8N858, Q96QN5, Q96QN6, Q96QN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.