Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease 8

Gene

RNASE8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a low ribonuclease activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton acceptorBy similarity1
Binding sitei90SubstrateBy similarity1
Active sitei149Proton donorBy similarity1

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • ribonuclease A activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciZFISH:HS10663-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 8 (EC:3.1.27.-)
Short name:
RNase 8
Gene namesi
Name:RNASE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19277. RNASE8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi122665.
OpenTargetsiENSG00000173431.
PharmGKBiPA134930162.

Polymorphism and mutation databases

BioMutaiRNASE8.
DMDMi23822095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003090228 – 154Ribonuclease 8Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 93Sequence analysis
Disulfide bondi64 ↔ 118By similarity
Disulfide bondi82 ↔ 133By similarity
Disulfide bondi89 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TDE3.
PRIDEiQ8TDE3.

PTM databases

iPTMnetiQ8TDE3.
PhosphoSitePlusiQ8TDE3.

Expressioni

Tissue specificityi

Expressed prominently in the placenta and is not detected in any other tissues examined.

Gene expression databases

CleanExiHS_RNASE8.

Organism-specific databases

HPAiHPA044765.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311398.

Structurei

3D structure databases

ProteinModelPortaliQ8TDE3.
SMRiQ8TDE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 69Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXRT. Eukaryota.
ENOG4111AZ3. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ8TDE3.
KOiK01172.
OMAiDMTSSQW.
OrthoDBiEOG091G0TF2.
PhylomeDBiQ8TDE3.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TDE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPARAGCCP LLLLLLGLWV AEVLVRAKPK DMTSSQWFKT QHVQPSPQAC
60 70 80 90 100
NSAMSIINKY TERCKDLNTF LHEPFSSVAI TCQTPNIACK NSCKNCHQSH
110 120 130 140 150
GPMSLTMGEL TSGKYPNCRY KEKHLNTPYI VACDPPQQGD PGYPLVPVHL

DKVV
Length:154
Mass (Da):17,041
Last modified:June 1, 2002 - v1
Checksum:i25E6AA09B869DC8F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05219410P → S.1 PublicationCorresponds to variant rs12437266dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF473854 Genomic DNA. Translation: AAL89644.1.
CH471078 Genomic DNA. Translation: EAW66417.1.
BC137537 mRNA. Translation: AAI37538.1.
BC137538 mRNA. Translation: AAI37539.1.
CCDSiCCDS9567.1.
RefSeqiNP_612204.1. NM_138331.2.
UniGeneiHs.553572.

Genome annotation databases

EnsembliENST00000308227; ENSP00000311398; ENSG00000173431.
GeneIDi122665.
KEGGihsa:122665.
UCSCiuc010tlm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF473854 Genomic DNA. Translation: AAL89644.1.
CH471078 Genomic DNA. Translation: EAW66417.1.
BC137537 mRNA. Translation: AAI37538.1.
BC137538 mRNA. Translation: AAI37539.1.
CCDSiCCDS9567.1.
RefSeqiNP_612204.1. NM_138331.2.
UniGeneiHs.553572.

3D structure databases

ProteinModelPortaliQ8TDE3.
SMRiQ8TDE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311398.

PTM databases

iPTMnetiQ8TDE3.
PhosphoSitePlusiQ8TDE3.

Polymorphism and mutation databases

BioMutaiRNASE8.
DMDMi23822095.

Proteomic databases

PaxDbiQ8TDE3.
PRIDEiQ8TDE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308227; ENSP00000311398; ENSG00000173431.
GeneIDi122665.
KEGGihsa:122665.
UCSCiuc010tlm.3. human.

Organism-specific databases

CTDi122665.
DisGeNETi122665.
GeneCardsiRNASE8.
HGNCiHGNC:19277. RNASE8.
HPAiHPA044765.
MIMi612485. gene.
neXtProtiNX_Q8TDE3.
OpenTargetsiENSG00000173431.
PharmGKBiPA134930162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXRT. Eukaryota.
ENOG4111AZ3. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ8TDE3.
KOiK01172.
OMAiDMTSSQW.
OrthoDBiEOG091G0TF2.
PhylomeDBiQ8TDE3.
TreeFamiTF333393.

Enzyme and pathway databases

BioCyciZFISH:HS10663-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Miscellaneous databases

GenomeRNAii122665.
PROiQ8TDE3.
SOURCEiSearch...

Gene expression databases

CleanExiHS_RNASE8.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNAS8_HUMAN
AccessioniPrimary (citable) accession number: Q8TDE3
Secondary accession number(s): B2RPP6, B2RPP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.