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Protein

Ribonuclease 8

Gene

RNASE8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a low ribonuclease activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Proton acceptorBy similarity
Binding sitei90 – 901SubstrateBy similarity
Active sitei149 – 1491Proton donorBy similarity

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • ribonuclease A activity Source: UniProtKB

GO - Biological processi

  • RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 8 (EC:3.1.27.-)
Short name:
RNase 8
Gene namesi
Name:RNASE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19277. RNASE8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930162.

Polymorphism and mutation databases

BioMutaiRNASE8.
DMDMi23822095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 154127Ribonuclease 8PRO_0000030902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 93Sequence analysis
Disulfide bondi64 ↔ 118By similarity
Disulfide bondi82 ↔ 133By similarity
Disulfide bondi89 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TDE3.
PRIDEiQ8TDE3.

PTM databases

iPTMnetiQ8TDE3.

Expressioni

Tissue specificityi

Expressed prominently in the placenta and is not detected in any other tissues examined.

Gene expression databases

CleanExiHS_RNASE8.

Organism-specific databases

HPAiHPA044765.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311398.

Structurei

3D structure databases

ProteinModelPortaliQ8TDE3.
SMRiQ8TDE3. Positions 28-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 695Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXRT. Eukaryota.
ENOG4111AZ3. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ8TDE3.
KOiK01172.
OMAiDMTSSQW.
OrthoDBiEOG7J1826.
PhylomeDBiQ8TDE3.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TDE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPARAGCCP LLLLLLGLWV AEVLVRAKPK DMTSSQWFKT QHVQPSPQAC
60 70 80 90 100
NSAMSIINKY TERCKDLNTF LHEPFSSVAI TCQTPNIACK NSCKNCHQSH
110 120 130 140 150
GPMSLTMGEL TSGKYPNCRY KEKHLNTPYI VACDPPQQGD PGYPLVPVHL

DKVV
Length:154
Mass (Da):17,041
Last modified:June 1, 2002 - v1
Checksum:i25E6AA09B869DC8F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101P → S.1 Publication
Corresponds to variant rs12437266 [ dbSNP | Ensembl ].
VAR_052194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF473854 Genomic DNA. Translation: AAL89644.1.
CH471078 Genomic DNA. Translation: EAW66417.1.
BC137537 mRNA. Translation: AAI37538.1.
BC137538 mRNA. Translation: AAI37539.1.
CCDSiCCDS9567.1.
RefSeqiNP_612204.1. NM_138331.2.
UniGeneiHs.553572.

Genome annotation databases

EnsembliENST00000308227; ENSP00000311398; ENSG00000173431.
GeneIDi122665.
KEGGihsa:122665.
UCSCiuc010tlm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF473854 Genomic DNA. Translation: AAL89644.1.
CH471078 Genomic DNA. Translation: EAW66417.1.
BC137537 mRNA. Translation: AAI37538.1.
BC137538 mRNA. Translation: AAI37539.1.
CCDSiCCDS9567.1.
RefSeqiNP_612204.1. NM_138331.2.
UniGeneiHs.553572.

3D structure databases

ProteinModelPortaliQ8TDE3.
SMRiQ8TDE3. Positions 28-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311398.

PTM databases

iPTMnetiQ8TDE3.

Polymorphism and mutation databases

BioMutaiRNASE8.
DMDMi23822095.

Proteomic databases

PaxDbiQ8TDE3.
PRIDEiQ8TDE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308227; ENSP00000311398; ENSG00000173431.
GeneIDi122665.
KEGGihsa:122665.
UCSCiuc010tlm.3. human.

Organism-specific databases

CTDi122665.
GeneCardsiRNASE8.
HGNCiHGNC:19277. RNASE8.
HPAiHPA044765.
MIMi612485. gene.
neXtProtiNX_Q8TDE3.
PharmGKBiPA134930162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXRT. Eukaryota.
ENOG4111AZ3. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ8TDE3.
KOiK01172.
OMAiDMTSSQW.
OrthoDBiEOG7J1826.
PhylomeDBiQ8TDE3.
TreeFamiTF333393.

Miscellaneous databases

GenomeRNAii122665.
PROiQ8TDE3.
SOURCEiSearch...

Gene expression databases

CleanExiHS_RNASE8.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta."
    Zhang J., Dyer K.D., Rosenberg H.F.
    Nucleic Acids Res. 30:1169-1175(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-10.

Entry informationi

Entry nameiRNAS8_HUMAN
AccessioniPrimary (citable) accession number: Q8TDE3
Secondary accession number(s): B2RPP6, B2RPP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.