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Q8TDD2

- SP7_HUMAN

UniProt

Q8TDD2 - SP7_HUMAN

Protein

Transcription factor Sp7

Gene

SP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri294 – 31825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DEAD/H-box RNA helicase binding Source: BHF-UCL
    2. DNA binding Source: BHF-UCL
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hematopoietic stem cell differentiation Source: BHF-UCL
    2. osteoblast differentiation Source: BHF-UCL
    3. positive regulation of stem cell differentiation Source: BHF-UCL
    4. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    5. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Sp7
    Alternative name(s):
    Zinc finger protein osterix
    Gene namesi
    Name:SP7
    Synonyms:OSX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17321. SP7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi58 – 581K → R: Enhances osteogenic differentiation in C2C12 cells. 1 Publication
    Mutagenesisi230 – 2301K → R: Enhances osteogenic differentiation in C2C12 cells. 1 Publication

    Keywords - Diseasei

    Osteogenesis imperfecta

    Organism-specific databases

    MIMi613849. phenotype.
    Orphaneti216820. Osteogenesis imperfecta type 4.
    PharmGKBiPA134917046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Transcription factor Sp7PRO_0000047150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki58 – 58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki230 – 230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Post-translational modificationi

    Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ8TDD2.
    PaxDbiQ8TDD2.
    PRIDEiQ8TDD2.

    PTM databases

    PhosphoSiteiQ8TDD2.

    Expressioni

    Tissue specificityi

    Restricted to bone-derived cell.1 Publication

    Gene expression databases

    BgeeiQ8TDD2.
    CleanExiHS_SP7.
    GenevestigatoriQ8TDD2.

    Organism-specific databases

    HPAiCAB005874.

    Interactioni

    Subunit structurei

    Interacts with NO66/C14orf169; the interaction is direct and inhibits transcription activator activity.By similarity

    Protein-protein interaction databases

    BioGridi125723. 1 interaction.
    STRINGi9606.ENSP00000302812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDD2.
    SMRiQ8TDD2. Positions 269-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri294 – 31825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000231067.
    HOVERGENiHBG036899.
    InParanoidiQ8TDD2.
    KOiK09197.
    OMAiPKTMGDA.
    OrthoDBiEOG73FQMR.
    PhylomeDBiQ8TDD2.
    TreeFamiTF350150.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDD2-1) [UniParc]FASTAAdd to Basket

    Also known as: alpha, long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSLLEEEV HYGSSPLAML TAACSKFGGS SPLRDSTTLG KAGTKKPYSV    50
    GSDLSASKTM GDAYPAPFTS TNGLLSPAGS PPAPTSGYAN DYPPFSHSFP 100
    GPTGTQDPGL LVPKGHSSSD CLPSVYTSLD MTHPYGSWYK AGIHAGISPG 150
    PGNTPTPWWD MHPGGNWLGG GQGQGDGLQG TLPTGPAQPP LNPQLPTYPS 200
    DFAPLNPAPY PAPHLLQPGP QHVLPQDVYK PKAVGNSGQL EGSGGAKPPR 250
    GASTGGSGGY GGSGAGRSSC DCPNCQELER LGAAAAGLRK KPIHSCHIPG 300
    CGKVYGKASH LKAHLRWHTG ERPFVCNWLF CGKRFTRSDE LERHVRTHTR 350
    EKKFTCLLCS KRFTRSDHLS KHQRTHGEPG PGPPPSGPKE LGEGRSTGEE 400
    EASQTPRPSA SPATPEKAPG GSPEQSNLLE I 431
    Length:431
    Mass (Da):44,994
    Last modified:June 1, 2002 - v1
    Checksum:i454A6FEA84309FF9
    GO
    Isoform 2 (identifier: Q8TDD2-2) [UniParc]FASTAAdd to Basket

    Also known as: beta, short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.

    Note: Generally expressed at much higher level than isoform 1.

    Show »
    Length:413
    Mass (Da):43,092
    Checksum:iFD6F791FFDCB7073
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818Missing in isoform 2. 1 PublicationVSP_047639Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466179 mRNA. Translation: AAO33377.1.
    AY150673 mRNA. Translation: AAN85556.1.
    AY150674 mRNA. Translation: AAN85557.1.
    AF477981 mRNA. Translation: AAL84281.1.
    AK128520 mRNA. Translation: BAG54688.1.
    AC073611 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96695.1.
    CH471054 Genomic DNA. Translation: EAW96697.1.
    BC101549 mRNA. Translation: AAI01550.1.
    BC113613 mRNA. Translation: AAI13614.1.
    CCDSiCCDS44897.1. [Q8TDD2-1]
    RefSeqiNP_001166938.1. NM_001173467.1. [Q8TDD2-1]
    NP_690599.1. NM_152860.1. [Q8TDD2-1]
    XP_005268700.1. XM_005268643.2. [Q8TDD2-2]
    UniGeneiHs.209402.

    Genome annotation databases

    EnsembliENST00000303846; ENSP00000302812; ENSG00000170374. [Q8TDD2-1]
    ENST00000536324; ENSP00000443827; ENSG00000170374. [Q8TDD2-1]
    ENST00000537210; ENSP00000441367; ENSG00000170374. [Q8TDD2-2]
    GeneIDi121340.
    KEGGihsa:121340.
    UCSCiuc001sct.3. human. [Q8TDD2-1]

    Polymorphism databases

    DMDMi30913318.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466179 mRNA. Translation: AAO33377.1 .
    AY150673 mRNA. Translation: AAN85556.1 .
    AY150674 mRNA. Translation: AAN85557.1 .
    AF477981 mRNA. Translation: AAL84281.1 .
    AK128520 mRNA. Translation: BAG54688.1 .
    AC073611 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96695.1 .
    CH471054 Genomic DNA. Translation: EAW96697.1 .
    BC101549 mRNA. Translation: AAI01550.1 .
    BC113613 mRNA. Translation: AAI13614.1 .
    CCDSi CCDS44897.1. [Q8TDD2-1 ]
    RefSeqi NP_001166938.1. NM_001173467.1. [Q8TDD2-1 ]
    NP_690599.1. NM_152860.1. [Q8TDD2-1 ]
    XP_005268700.1. XM_005268643.2. [Q8TDD2-2 ]
    UniGenei Hs.209402.

    3D structure databases

    ProteinModelPortali Q8TDD2.
    SMRi Q8TDD2. Positions 269-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125723. 1 interaction.
    STRINGi 9606.ENSP00000302812.

    PTM databases

    PhosphoSitei Q8TDD2.

    Polymorphism databases

    DMDMi 30913318.

    Proteomic databases

    MaxQBi Q8TDD2.
    PaxDbi Q8TDD2.
    PRIDEi Q8TDD2.

    Protocols and materials databases

    DNASUi 121340.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303846 ; ENSP00000302812 ; ENSG00000170374 . [Q8TDD2-1 ]
    ENST00000536324 ; ENSP00000443827 ; ENSG00000170374 . [Q8TDD2-1 ]
    ENST00000537210 ; ENSP00000441367 ; ENSG00000170374 . [Q8TDD2-2 ]
    GeneIDi 121340.
    KEGGi hsa:121340.
    UCSCi uc001sct.3. human. [Q8TDD2-1 ]

    Organism-specific databases

    CTDi 121340.
    GeneCardsi GC12M053721.
    HGNCi HGNC:17321. SP7.
    HPAi CAB005874.
    MIMi 606633. gene.
    613849. phenotype.
    neXtProti NX_Q8TDD2.
    Orphaneti 216820. Osteogenesis imperfecta type 4.
    PharmGKBi PA134917046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000231067.
    HOVERGENi HBG036899.
    InParanoidi Q8TDD2.
    KOi K09197.
    OMAi PKTMGDA.
    OrthoDBi EOG73FQMR.
    PhylomeDBi Q8TDD2.
    TreeFami TF350150.

    Miscellaneous databases

    GeneWikii Sp7_transcription_factor.
    GenomeRNAii 121340.
    NextBioi 80718.
    PROi Q8TDD2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TDD2.
    CleanExi HS_SP7.
    Genevestigatori Q8TDD2.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation."
      Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., de Crombrugghe B.
      Cell 108:17-29(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells."
      Milona M.-A., Gough J.E., Edgar A.J.
      BMC Genomics 4:43-43(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene."
      Gao Y., Jheon A., Nourkeyhani H., Kobayashi H., Ganss B.
      Gene 341:101-110(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Osteosarcoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    8. "Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta."
      Lapunzina P., Aglan M., Temtamy S., Caparros-Martin J.A., Valencia M., Leton R., Martinez-Glez V., Elhossini R., Amr K., Vilaboa N., Ruiz-Perez V.L.
      Am. J. Hum. Genet. 87:110-114(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN OI12.
    9. "Characterization of Osterix protein stability and physiological role in osteoblast differentiation."
      Peng Y., Shi K., Wang L., Lu J., Li H., Pan S., Ma C.
      PLoS ONE 8:E56451-E56451(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, UBIQUITINATION AT LYS-58 AND LYS-230, MUTAGENESIS OF LYS-58 AND LYS-230.

    Entry informationi

    Entry nameiSP7_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDD2
    Secondary accession number(s): B3KY26, Q3MJ72, Q7Z718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3