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Q8TDD1

- DDX54_HUMAN

UniProt

Q8TDD1 - DDX54_HUMAN

Protein

ATP-dependent RNA helicase DDX54

Gene

DDX54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi140 – 1478ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent RNA helicase activity Source: UniProtKB
    3. estrogen receptor binding Source: UniProtKB
    4. poly(A) RNA binding Source: UniProtKB
    5. receptor binding Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. intracellular estrogen receptor signaling pathway Source: UniProtKB
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. RNA metabolic process Source: UniProtKB
    5. RNA processing Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase DDX54 (EC:3.6.4.13)
    Alternative name(s):
    ATP-dependent RNA helicase DP97
    DEAD box RNA helicase 97 kDa
    DEAD box protein 54
    Gene namesi
    Name:DDX54
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:20084. DDX54.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleolus Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134992026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 881881ATP-dependent RNA helicase DDX54PRO_0000055056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Phosphoserine2 Publications
    Modified residuei39 – 391Phosphoserine2 Publications
    Modified residuei41 – 411Phosphoserine2 Publications
    Modified residuei75 – 751Phosphoserine1 Publication
    Modified residuei644 – 6441Phosphoserine1 Publication
    Modified residuei696 – 6961Phosphoserine1 Publication
    Modified residuei698 – 6981Phosphoserine1 Publication
    Modified residuei782 – 7821Phosphoserine5 Publications
    Modified residuei788 – 7881Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TDD1.
    PaxDbiQ8TDD1.
    PRIDEiQ8TDD1.

    2D gel databases

    SWISS-2DPAGEQ8TDD1.

    PTM databases

    PhosphoSiteiQ8TDD1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TDD1.
    BgeeiQ8TDD1.
    CleanExiHS_DDX54.
    GenevestigatoriQ8TDD1.

    Organism-specific databases

    HPAiHPA028244.

    Interactioni

    Subunit structurei

    Interacts in a hormone-dependent manner with nuclear receptors.

    Protein-protein interaction databases

    BioGridi122503. 18 interactions.
    IntActiQ8TDD1. 6 interactions.
    MINTiMINT-3045390.
    STRINGi9606.ENSP00000323858.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDD1.
    SMRiQ8TDD1. Positions 98-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 299173Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini326 – 473148Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni605 – 64743Interaction with nuclear receptorsAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi96 – 12429Q motifAdd
    BLAST
    Motifi247 – 2504DEAD box

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    HOGENOMiHOG000246455.
    HOVERGENiHBG051333.
    InParanoidiQ8TDD1.
    KOiK14808.
    OMAiENVVNYD.
    OrthoDBiEOG786H2W.
    PhylomeDBiQ8TDD1.
    TreeFamiTF105707.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR012541. DBP10CT.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF08147. DBP10CT. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    ProDomiPD024971. DBP10CT. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDD1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADKGPAAG PRSRAAMAQW RKKKGLRKRR GAASQARGSD SEDGEFEIQA    50
    EDDARARKLG PGRPLPTFPT SECTSDVEPD TREMVRAQNK KKKKSGGFQS 100
    MGLSYPVFKG IMKKGYKVPT PIQRKTIPVI LDGKDVVAMA RTGSGKTACF 150
    LLPMFERLKT HSAQTGARAL ILSPTRELAL QTLKFTKELG KFTGLKTALI 200
    LGGDRMEDQF AALHENPDII IATPGRLVHV AVEMSLKLQS VEYVVFDEAD 250
    RLFEMGFAEQ LQEIIARLPG GHQTVLFSAT LPKLLVEFAR AGLTEPVLIR 300
    LDVDTKLNEQ LKTSFFLVRE DTKAAVLLHL LHNVVRPQDQ TVVFVATKHH 350
    AEYLTELLTT QRVSCAHIYS ALDPTARKIN LAKFTLGKCS TLIVTDLAAR 400
    GLDIPLLDNV INYSFPAKGK LFLHRVGRVA RAGRSGTAYS LVAPDEIPYL 450
    LDLHLFLGRS LTLARPLKEP SGVAGVDGML GRVPQSVVDE EDSGLQSTLE 500
    ASLELRGLAR VADNAQQQYV RSRPAPSPES IKRAKEMDLV GLGLHPLFSS 550
    RFEEEELQRL RLVDSIKNYR SRATIFEINA SSRDLCSQVM RAKRQKDRKA 600
    IARFQQGQQG RQEQQEGPVG PAPSRPALQE KQPEKEEEEE AGESVEDIFS 650
    EVVGRKRQRS GPNRGAKRRR EEARQRDQEF YIPYRPKDFD SERGLSISGE 700
    GGAFEQQAAG AVLDLMGDEA QNLTRGRQQL KWDRKKKRFV GQSGQEDKKK 750
    IKTESGRYIS SSYKRDLYQK WKQKQKIDDR DSDEEGASDR RGPERRGGKR 800
    DRGQGASRPH APGTPAGRVR PELKTKQQIL KQRRRAQKLH FLQRGGLKQL 850
    SARNRRRVQE LQQGAFGRGA RSKKGKMRKR M 881
    Length:881
    Mass (Da):98,595
    Last modified:April 26, 2004 - v2
    Checksum:i9823C75156D998C4
    GO
    Isoform 2 (identifier: Q8TDD1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         804-804: Q → QA

    Show »
    Length:882
    Mass (Da):98,666
    Checksum:i947F50470F865F96
    GO

    Sequence cautioni

    The sequence AAN59978.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti570 – 5701R → H.
    Corresponds to variant rs35519289 [ dbSNP | Ensembl ].
    VAR_052171
    Natural varianti693 – 6931R → Q.
    Corresponds to variant rs11564 [ dbSNP | Ensembl ].
    VAR_052172
    Natural varianti712 – 7121V → A.
    Corresponds to variant rs10354 [ dbSNP | Ensembl ].
    VAR_052173
    Natural varianti821 – 8211P → L.
    Corresponds to variant rs1048889 [ dbSNP | Ensembl ].
    VAR_033860

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei804 – 8041Q → QA in isoform 2. 1 PublicationVSP_040135

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF478457 mRNA. Translation: AAL85336.1.
    AC089999 Genomic DNA. No translation available.
    AY148094 mRNA. Translation: AAN59978.1. Sequence problems.
    BC005848 mRNA. Translation: AAH05848.2.
    CCDSiCCDS31907.1. [Q8TDD1-1]
    CCDS44984.1. [Q8TDD1-2]
    RefSeqiNP_001104792.1. NM_001111322.1. [Q8TDD1-2]
    NP_076977.3. NM_024072.3. [Q8TDD1-1]
    UniGeneiHs.506861.

    Genome annotation databases

    EnsembliENST00000306014; ENSP00000304072; ENSG00000123064. [Q8TDD1-1]
    ENST00000314045; ENSP00000323858; ENSG00000123064. [Q8TDD1-2]
    GeneIDi79039.
    KEGGihsa:79039.
    UCSCiuc001tup.3. human. [Q8TDD1-1]
    uc001tuq.4. human. [Q8TDD1-2]

    Polymorphism databases

    DMDMi46576615.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF478457 mRNA. Translation: AAL85336.1 .
    AC089999 Genomic DNA. No translation available.
    AY148094 mRNA. Translation: AAN59978.1 . Sequence problems.
    BC005848 mRNA. Translation: AAH05848.2 .
    CCDSi CCDS31907.1. [Q8TDD1-1 ]
    CCDS44984.1. [Q8TDD1-2 ]
    RefSeqi NP_001104792.1. NM_001111322.1. [Q8TDD1-2 ]
    NP_076977.3. NM_024072.3. [Q8TDD1-1 ]
    UniGenei Hs.506861.

    3D structure databases

    ProteinModelPortali Q8TDD1.
    SMRi Q8TDD1. Positions 98-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122503. 18 interactions.
    IntActi Q8TDD1. 6 interactions.
    MINTi MINT-3045390.
    STRINGi 9606.ENSP00000323858.

    PTM databases

    PhosphoSitei Q8TDD1.

    Polymorphism databases

    DMDMi 46576615.

    2D gel databases

    SWISS-2DPAGE Q8TDD1.

    Proteomic databases

    MaxQBi Q8TDD1.
    PaxDbi Q8TDD1.
    PRIDEi Q8TDD1.

    Protocols and materials databases

    DNASUi 79039.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306014 ; ENSP00000304072 ; ENSG00000123064 . [Q8TDD1-1 ]
    ENST00000314045 ; ENSP00000323858 ; ENSG00000123064 . [Q8TDD1-2 ]
    GeneIDi 79039.
    KEGGi hsa:79039.
    UCSCi uc001tup.3. human. [Q8TDD1-1 ]
    uc001tuq.4. human. [Q8TDD1-2 ]

    Organism-specific databases

    CTDi 79039.
    GeneCardsi GC12M113598.
    HGNCi HGNC:20084. DDX54.
    HPAi HPA028244.
    MIMi 611665. gene.
    neXtProti NX_Q8TDD1.
    PharmGKBi PA134992026.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0513.
    HOGENOMi HOG000246455.
    HOVERGENi HBG051333.
    InParanoidi Q8TDD1.
    KOi K14808.
    OMAi ENVVNYD.
    OrthoDBi EOG786H2W.
    PhylomeDBi Q8TDD1.
    TreeFami TF105707.

    Miscellaneous databases

    ChiTaRSi DDX54. human.
    GenomeRNAii 79039.
    NextBioi 67773.
    PROi Q8TDD1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDD1.
    Bgeei Q8TDD1.
    CleanExi HS_DDX54.
    Genevestigatori Q8TDD1.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR012541. DBP10CT.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF08147. DBP10CT. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    ProDomi PD024971. DBP10CT. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positional cloning of the Flv gene."
      Perelygin A.A.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Placenta.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)."
      Rajendran R.R., Nye A.C., Frasor J., Balsara R.D., Martini P.G., Katzenellenbogen B.S.
      J. Biol. Chem. 278:4628-4638(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-881 (ISOFORM 1), FUNCTION.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-881 (ISOFORM 1).
      Tissue: Kidney.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-75; SER-644; SER-782 AND SER-788, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-39; SER-41 AND SER-782, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696; SER-698 AND SER-782, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-41 AND SER-782, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDDX54_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDD1
    Secondary accession number(s): Q86YT8, Q9BRZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3