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Q8TDC3

- BRSK1_HUMAN

UniProt

Q8TDC3 - BRSK1_HUMAN

Protein

Serine/threonine-protein kinase BRSK1

Gene

BRSK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.4 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication
    ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by phosphorylation on Thr-189 by STK11/LKB1.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631ATPPROSITE-ProRule annotation
    Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. gamma-tubulin binding Source: UniProtKB
    3. magnesium ion binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. tau-protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. centrosome duplication Source: UniProtKB
    4. establishment of cell polarity Source: UniProtKB
    5. G2 DNA damage checkpoint Source: UniProtKB
    6. neuron differentiation Source: UniProtKB
    7. neurotransmitter secretion Source: UniProtKB
    8. protein phosphorylation Source: UniProtKB
    9. response to UV Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, DNA damage, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8TDC3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BRSK1 (EC:2.7.11.1)
    Alternative name(s):
    Brain-selective kinase 1 (EC:2.7.11.26)
    Brain-specific serine/threonine-protein kinase 1
    Short name:
    BR serine/threonine-protein kinase 1
    Serine/threonine-protein kinase SAD-B
    Synapses of Amphids Defective homolog 1
    Short name:
    SAD1 homolog
    Short name:
    hSAD1
    Gene namesi
    Name:BRSK1
    Synonyms:KIAA1811, SAD1, SADB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18994. BRSK1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell junctionsynapse By similarity
    Note: Localizes to synaptic vesicles in neurons By similarity. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.By similarity

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: HPA
    6. synaptic vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton, Nucleus, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi59 – 591K → A: Loss of kinase activity. 1 Publication
    Mutagenesisi189 – 1891T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication
    Mutagenesisi327 – 3271G → A: Abolishes activation of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134888976.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 778778Serine/threonine-protein kinase BRSK1PRO_0000085669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891Phosphothreonine; by LKB13 Publications
    Modified residuei447 – 4471Phosphoserine1 Publication
    Modified residuei508 – 5081Phosphoserine1 Publication
    Modified residuei563 – 5631Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8TDC3.
    PRIDEiQ8TDC3.

    PTM databases

    PhosphoSiteiQ8TDC3.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.1 Publication

    Gene expression databases

    ArrayExpressiQ8TDC3.
    BgeeiQ8TDC3.
    CleanExiHS_BRSK1.
    GenevestigatoriQ8TDC3.

    Organism-specific databases

    HPAiHPA021212.

    Interactioni

    Protein-protein interaction databases

    BioGridi124084. 4 interactions.
    IntActiQ8TDC3. 2 interactions.
    MINTiMINT-1651556.
    STRINGi9606.ENSP00000310649.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TDC3.
    SMRiQ8TDC3. Positions 30-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 285252Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini314 – 35643UBAPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi492 – 54049Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG007240.
    InParanoidiQ8TDC3.
    KOiK08796.
    OMAiGRHAQYV.
    OrthoDBiEOG7XSTDH.
    PhylomeDBiQ8TDC3.
    TreeFamiTF313967.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TDC3-1) [UniParc]FASTAAdd to Basket

    Also known as: SADB-Long, L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSGAKEGGG GSPAYHLPHP HPHPPQHAQY VGPYRLEKTL GKGQTGLVKL    50
    GVHCITGQKV AIKIVNREKL SESVLMKVER EIAILKLIEH PHVLKLHDVY 100
    ENKKYLYLVL EHVSGGELFD YLVKKGRLTP KEARKFFRQI VSALDFCHSY 150
    SICHRDLKPE NLLLDEKNNI RIADFGMASL QVGDSLLETS CGSPHYACPE 200
    VIKGEKYDGR RADMWSCGVI LFALLVGALP FDDDNLRQLL EKVKRGVFHM 250
    PHFIPPDCQS LLRGMIEVEP EKRLSLEQIQ KHPWYLGGKH EPDPCLEPAP 300
    GRRVAMRSLP SNGELDPDVL ESMASLGCFR DRERLHRELR SEEENQEKMI 350
    YYLLLDRKER YPSCEDQDLP PRNDVDPPRK RVDSPMLSRH GKRRPERKSM 400
    EVLSITDAGG GGSPVPTRRA LEMAQHSQRS RSVSGASTGL SSSPLSSPRS 450
    PVFSFSPEPG AGDEARGGGS PTSKTQTLPS RGPRGGGAGE QPPPPSARST 500
    PLPGPPGSPR SSGGTPLHSP LHTPRASPTG TPGTTPPPSP GGGVGGAAWR 550
    SRLNSIRNSF LGSPRFHRRK MQVPTAEEMS SLTPESSPEL AKRSWFGNFI 600
    SLDKEEQIFL VLKDKPLSSI KADIVHAFLS IPSLSHSVLS QTSFRAEYKA 650
    SGGPSVFQKP VRFQVDISSS EGPEPSPRRD GSGGGGIYSV TFTLISGPSR 700
    RFKRVVETIQ AQLLSTHDQP SVQALADEKN GAQTRPAGAP PRSLQPPPGR 750
    PDPELSSSPR RGPPKDKKLL ATNGTPLP 778
    Length:778
    Mass (Da):85,087
    Last modified:September 21, 2011 - v2
    Checksum:i8D1818D4E54398BB
    GO
    Isoform 2 (identifier: Q8TDC3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: MSSGAKEGGGGSPAYHLPHPHPHPPQ → MVAGLTLGKGPESPDGDVSVPERKDEVAGGGGEEEEAEERGR

    Show »
    Length:794
    Mass (Da):86,753
    Checksum:i5DD395B0E61AEF77
    GO
    Isoform 3 (identifier: Q8TDC3-3) [UniParc]FASTAAdd to Basket

    Also known as: SADB-short, S

    The sequence of this isoform differs from the canonical sequence as follows:
         344-778: Missing.

    Show »
    Length:343
    Mass (Da):38,782
    Checksum:i225C16D92E18BD8C
    GO

    Sequence cautioni

    The sequence AAH16681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti762 – 7621G → A in AAH16681. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031R → W in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040394
    Natural varianti319 – 3191V → I in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040395
    Natural varianti391 – 3911G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_040396
    Natural varianti531 – 5311T → N.1 Publication
    Corresponds to variant rs55892637 [ dbSNP | Ensembl ].
    VAR_040397
    Natural varianti749 – 7491G → S.1 Publication
    Corresponds to variant rs12978445 [ dbSNP | Ensembl ].
    VAR_040398
    Natural varianti764 – 7641P → A.1 Publication
    Corresponds to variant rs55796422 [ dbSNP | Ensembl ].
    VAR_040399

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626MSSGA…PHPPQ → MVAGLTLGKGPESPDGDVSV PERKDEVAGGGGEEEEAEER GR in isoform 2. 2 PublicationsVSP_008158Add
    BLAST
    Alternative sequencei344 – 778435Missing in isoform 3. 1 PublicationVSP_041742Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY458602 mRNA. Translation: AAS10354.1.
    AY505124 mRNA. Translation: AAS86442.1.
    HQ830199 mRNA. Translation: ADX95745.1.
    AF479826 mRNA. Translation: AAL87697.1.
    AF479827 mRNA. Translation: AAL87698.1.
    AC008974 Genomic DNA. No translation available.
    AC020922 Genomic DNA. No translation available.
    AL831945 mRNA. Translation: CAD38595.1.
    AL834275 mRNA. Translation: CAD38950.2.
    AB058714 mRNA. Translation: BAB47440.1.
    BC016681 mRNA. Translation: AAH16681.1. Different initiation.
    CCDSiCCDS12921.1. [Q8TDC3-1]
    RefSeqiNP_115806.1. NM_032430.1. [Q8TDC3-1]
    UniGeneiHs.182081.

    Genome annotation databases

    EnsembliENST00000309383; ENSP00000310649; ENSG00000160469. [Q8TDC3-1]
    ENST00000585418; ENSP00000467357; ENSG00000160469. [Q8TDC3-3]
    ENST00000590333; ENSP00000468190; ENSG00000160469. [Q8TDC3-2]
    GeneIDi84446.
    KEGGihsa:84446.
    UCSCiuc002qkf.3. human. [Q8TDC3-2]
    uc002qkg.3. human. [Q8TDC3-1]
    uc021vbs.1. human. [Q8TDC3-3]

    Polymorphism databases

    DMDMi347595639.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY458602 mRNA. Translation: AAS10354.1 .
    AY505124 mRNA. Translation: AAS86442.1 .
    HQ830199 mRNA. Translation: ADX95745.1 .
    AF479826 mRNA. Translation: AAL87697.1 .
    AF479827 mRNA. Translation: AAL87698.1 .
    AC008974 Genomic DNA. No translation available.
    AC020922 Genomic DNA. No translation available.
    AL831945 mRNA. Translation: CAD38595.1 .
    AL834275 mRNA. Translation: CAD38950.2 .
    AB058714 mRNA. Translation: BAB47440.1 .
    BC016681 mRNA. Translation: AAH16681.1 . Different initiation.
    CCDSi CCDS12921.1. [Q8TDC3-1 ]
    RefSeqi NP_115806.1. NM_032430.1. [Q8TDC3-1 ]
    UniGenei Hs.182081.

    3D structure databases

    ProteinModelPortali Q8TDC3.
    SMRi Q8TDC3. Positions 30-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124084. 4 interactions.
    IntActi Q8TDC3. 2 interactions.
    MINTi MINT-1651556.
    STRINGi 9606.ENSP00000310649.

    Chemistry

    BindingDBi Q8TDC3.
    ChEMBLi CHEMBL5650.
    GuidetoPHARMACOLOGYi 1946.

    PTM databases

    PhosphoSitei Q8TDC3.

    Polymorphism databases

    DMDMi 347595639.

    Proteomic databases

    PaxDbi Q8TDC3.
    PRIDEi Q8TDC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309383 ; ENSP00000310649 ; ENSG00000160469 . [Q8TDC3-1 ]
    ENST00000585418 ; ENSP00000467357 ; ENSG00000160469 . [Q8TDC3-3 ]
    ENST00000590333 ; ENSP00000468190 ; ENSG00000160469 . [Q8TDC3-2 ]
    GeneIDi 84446.
    KEGGi hsa:84446.
    UCSCi uc002qkf.3. human. [Q8TDC3-2 ]
    uc002qkg.3. human. [Q8TDC3-1 ]
    uc021vbs.1. human. [Q8TDC3-3 ]

    Organism-specific databases

    CTDi 84446.
    GeneCardsi GC19P055795.
    H-InvDB HIX0015461.
    HGNCi HGNC:18994. BRSK1.
    HPAi HPA021212.
    MIMi 609235. gene.
    neXtProti NX_Q8TDC3.
    PharmGKBi PA134888976.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG007240.
    InParanoidi Q8TDC3.
    KOi K08796.
    OMAi GRHAQYV.
    OrthoDBi EOG7XSTDH.
    PhylomeDBi Q8TDC3.
    TreeFami TF313967.

    Enzyme and pathway databases

    SignaLinki Q8TDC3.

    Miscellaneous databases

    ChiTaRSi BRSK1. human.
    GeneWikii BRSK1.
    GenomeRNAii 84446.
    NextBioi 74213.
    PROi Q8TDC3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TDC3.
    Bgeei Q8TDC3.
    CleanExi HS_BRSK1.
    Genevestigatori Q8TDC3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
      Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.
      EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-189, MUTAGENESIS OF THR-189.
    2. "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."
      Lu R., Niida H., Nakanishi M.
      J. Biol. Chem. 279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-59.
      Tissue: Testis.
    3. "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release."
      Inoue E., Mochida S., Takagi H., Higa S., Deguchi-Tawarada M., Takao-Rikitsu E., Inoue M., Yao I., Takeuchi K., Kitajima I., Setou M., Ohtsuka T., Takai Y.
      Neuron 50:261-275(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "SADB phosphorylation of gamma-tubulin regulates centrosome duplication."
      Alvarado-Kristensson M., Rodriguez M.J., Silio V., Valpuesta J.M., Carrera A.C.
      Nat. Cell Biol. 11:1081-1092(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. She X.Y., Yu L., Guo J.H.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-778.
      Tissue: Brain.
    8. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-778.
      Tissue: Brain.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 287-778.
      Tissue: Lymph.
    10. "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation."
      Bright N.J., Carling D., Thornton C.
      J. Biol. Chem. 283:14946-14954(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-189, MUTAGENESIS OF GLY-327.
    11. "Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP."
      Fogarty S., Hawley S.A., Green K.A., Saner N., Mustard K.J., Hardie D.G.
      Biochem. J. 426:109-118(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    12. "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity."
      Muller M., Lutter D., Puschel A.W.
      J. Cell Sci. 123:286-294(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Phosphorylation of microtubule-associated protein tau by AMPK-related kinases."
      Yoshida H., Goedert M.
      J. Neurochem. 120:165-176(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, FUNCTION IN MAPT PHOSPHORYLATION.
    14. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-303; ILE-319; GLU-391; ASN-531; SER-749 AND ALA-764.

    Entry informationi

    Entry nameiBRSK1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDC3
    Secondary accession number(s): F1DG44
    , Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3