ID GTR14_HUMAN Reviewed; 520 AA. AC Q8TDB8; B3KVB5; B3KWW7; B7Z844; B7ZAC3; Q6UY84; Q8TDB9; DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 27-MAR-2024, entry version 170. DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 14 {ECO:0000305}; DE AltName: Full=Glucose transporter type 14 {ECO:0000303|PubMed:12504846}; DE Short=GLUT-14 {ECO:0000303|PubMed:12504846}; GN Name=SLC2A14 {ECO:0000303|PubMed:27460888, GN ECO:0000312|HGNC:HGNC:18301}; GN Synonyms=GLUT14 {ECO:0000303|PubMed:12504846}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY. RC TISSUE=Testis; RX PubMed=12504846; DOI=10.1006/geno.2002.7010; RA Wu X., Freeze H.H.; RT "GLUT14, a duplicon of GLUT3, is specifically expressed in testis as RT alternative splice forms."; RL Genomics 80:553-557(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC TISSUE=Testis; RA Fang X., Wang H., Huo R., Lu L., Xu M., Xu Y.Z., Yin L.L., Li M.J., RA Zhou M.Z., Sha H.J.; RT "Cloning of an isoform of SCL2A14 gene related to spermatogenesis."; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Fetal brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., RA Gibbs R.A.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=27460888; DOI=10.1139/bcb-2015-0089; RA Amir Shaghaghi M., Murphy B., Eck P.; RT "The SLC2A14 gene: genomic locus, tissue expression, splice variants, and RT subcellular localization of the protein."; RL Biochem. Cell Biol. 94:331-335(2016). RN [9] RP FUNCTION, AND TRANSPORTER ACTIVITY. RX PubMed=28971850; DOI=10.3945/ajcn.116.147603; RA Amir Shaghaghi M., Zhouyao H., Tu H., El-Gabalawy H., Crow G.H., Levine M., RA Bernstein C.N., Eck P.; RT "The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter RT GLUT14, is associated with inflammatory bowel disease."; RL Am. J. Clin. Nutr. 106:1508-1513(2017). CC -!- FUNCTION: Hexose transporter that can mediate the transport of glucose CC and dehydroascorbate across the cell membrane. CC {ECO:0000269|PubMed:28971850}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, CC ChEBI:CHEBI:4167; Evidence={ECO:0000269|PubMed:28971850}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-dehydroascorbate(out) = L-dehydroascorbate(in); CC Xref=Rhea:RHEA:60380, ChEBI:CHEBI:58539; CC Evidence={ECO:0000269|PubMed:28971850}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27460888}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; Synonyms=GLUT14-L {ECO:0000303|PubMed:12504846}; CC IsoId=Q8TDB8-1; Sequence=Displayed; CC Name=2; Synonyms=GLUT14-S {ECO:0000303|PubMed:12504846}; CC IsoId=Q8TDB8-2; Sequence=VSP_014450; CC Name=3; CC IsoId=Q8TDB8-3; Sequence=VSP_014449; CC Name=4; CC IsoId=Q8TDB8-4; Sequence=VSP_055253; CC Name=5; CC IsoId=Q8TDB8-5; Sequence=VSP_055254; CC -!- TISSUE SPECIFICITY: Mainly expressed in testis (PubMed:12504846, CC PubMed:27460888). Also expressed in small intestine, liver and kidney CC (PubMed:27460888). {ECO:0000269|PubMed:12504846, CC ECO:0000269|PubMed:27460888}. CC -!- MISCELLANEOUS: GLUT14 is a recent (less than 5 M year old) duplication CC of GLUT3. {ECO:0000305|PubMed:12504846}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF481878; AAL89709.1; -; mRNA. DR EMBL; AF481879; AAL89710.1; -; mRNA. DR EMBL; AY357941; AAQ63763.1; -; mRNA. DR EMBL; AK122783; BAG53727.1; -; mRNA. DR EMBL; AK126026; BAG54279.1; -; mRNA. DR EMBL; AK302881; BAH13830.1; -; mRNA. DR EMBL; AK316238; BAH14609.1; -; mRNA. DR EMBL; AL110298; CAB53739.2; -; mRNA. DR EMBL; AC006517; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC124891; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471116; EAW88652.1; -; Genomic_DNA. DR EMBL; CH471116; EAW88653.1; -; Genomic_DNA. DR EMBL; BC060766; AAH60766.1; -; mRNA. DR CCDS; CCDS66300.1; -. [Q8TDB8-4] DR CCDS; CCDS66301.1; -. [Q8TDB8-2] DR CCDS; CCDS66302.1; -. [Q8TDB8-5] DR CCDS; CCDS8585.1; -. [Q8TDB8-1] DR RefSeq; NP_001273162.1; NM_001286233.1. [Q8TDB8-1] DR RefSeq; NP_001273163.1; NM_001286234.1. [Q8TDB8-2] DR RefSeq; NP_001273164.1; NM_001286235.1. [Q8TDB8-2] DR RefSeq; NP_001273165.1; NM_001286236.1. [Q8TDB8-4] DR RefSeq; NP_001273166.1; NM_001286237.1. [Q8TDB8-5] DR RefSeq; NP_703150.1; NM_153449.3. [Q8TDB8-1] DR RefSeq; XP_005253372.1; XM_005253315.3. DR RefSeq; XP_005253374.1; XM_005253317.4. DR RefSeq; XP_011518864.1; XM_011520562.1. DR RefSeq; XP_011518865.1; XM_011520563.2. DR RefSeq; XP_011518866.1; XM_011520564.2. DR RefSeq; XP_011518867.1; XM_011520565.2. DR RefSeq; XP_016874335.1; XM_017018846.1. DR RefSeq; XP_016874336.1; XM_017018847.1. DR AlphaFoldDB; Q8TDB8; -. DR SMR; Q8TDB8; -. DR BioGRID; 126837; 28. DR IntAct; Q8TDB8; 9. DR STRING; 9606.ENSP00000445929; -. DR BindingDB; Q8TDB8; -. DR ChEMBL; CHEMBL4295906; -. DR TCDB; 2.A.1.1.90; the major facilitator superfamily (mfs). DR GlyCosmos; Q8TDB8; 1 site, No reported glycans. DR GlyGen; Q8TDB8; 1 site. DR iPTMnet; Q8TDB8; -. DR PhosphoSitePlus; Q8TDB8; -. DR BioMuta; SLC2A14; -. DR DMDM; 68565598; -. DR EPD; Q8TDB8; -. DR jPOST; Q8TDB8; -. DR MassIVE; Q8TDB8; -. DR MaxQB; Q8TDB8; -. DR PaxDb; 9606-ENSP00000445929; -. DR PeptideAtlas; Q8TDB8; -. DR ProteomicsDB; 6924; -. DR ProteomicsDB; 7059; -. DR ProteomicsDB; 74258; -. [Q8TDB8-1] DR ProteomicsDB; 74259; -. [Q8TDB8-2] DR ProteomicsDB; 74260; -. [Q8TDB8-3] DR Pumba; Q8TDB8; -. DR Antibodypedia; 53025; 56 antibodies from 6 providers. DR DNASU; 144195; -. DR Ensembl; ENST00000340749.9; ENSP00000340450.5; ENSG00000173262.12. [Q8TDB8-2] DR Ensembl; ENST00000396589.6; ENSP00000379834.2; ENSG00000173262.12. [Q8TDB8-1] DR Ensembl; ENST00000431042.7; ENSP00000407287.2; ENSG00000173262.12. [Q8TDB8-2] DR Ensembl; ENST00000535295.5; ENSP00000440492.1; ENSG00000173262.12. [Q8TDB8-4] DR Ensembl; ENST00000539924.5; ENSP00000445929.1; ENSG00000173262.12. [Q8TDB8-5] DR Ensembl; ENST00000542505.5; ENSP00000438484.1; ENSG00000173262.12. [Q8TDB8-3] DR Ensembl; ENST00000542546.5; ENSP00000443903.1; ENSG00000173262.12. [Q8TDB8-4] DR Ensembl; ENST00000543909.5; ENSP00000440480.1; ENSG00000173262.12. [Q8TDB8-1] DR Ensembl; ENST00000616981.4; ENSP00000482927.1; ENSG00000173262.12. [Q8TDB8-1] DR GeneID; 144195; -. DR KEGG; hsa:144195; -. DR MANE-Select; ENST00000431042.7; ENSP00000407287.2; NM_001286234.2; NP_001273163.1. [Q8TDB8-2] DR UCSC; uc001qtk.5; human. [Q8TDB8-1] DR AGR; HGNC:18301; -. DR CTD; 144195; -. DR DisGeNET; 144195; -. DR GeneCards; SLC2A14; -. DR HGNC; HGNC:18301; SLC2A14. DR HPA; ENSG00000173262; Tissue enriched (testis). DR MIM; 611039; gene. DR neXtProt; NX_Q8TDB8; -. DR OpenTargets; ENSG00000173262; -. DR PharmGKB; PA134885058; -. DR VEuPathDB; HostDB:ENSG00000173262; -. DR eggNOG; KOG0569; Eukaryota. DR GeneTree; ENSGT00940000162491; -. DR HOGENOM; CLU_001265_30_5_1; -. DR InParanoid; Q8TDB8; -. DR OMA; KWTVIIG; -. DR OrthoDB; 1899001at2759; -. DR PhylomeDB; Q8TDB8; -. DR TreeFam; TF313762; -. DR PathwayCommons; Q8TDB8; -. DR Reactome; R-HSA-189200; Cellular hexose transport. DR SignaLink; Q8TDB8; -. DR BioGRID-ORCS; 144195; 11 hits in 1088 CRISPR screens. DR ChiTaRS; SLC2A14; human. DR GeneWiki; SLC2A14; -. DR GenomeRNAi; 144195; -. DR Pharos; Q8TDB8; Tbio. DR PRO; PR:Q8TDB8; -. DR Proteomes; UP000005640; Chromosome 12. DR RNAct; Q8TDB8; Protein. DR Bgee; ENSG00000173262; Expressed in left testis and 100 other cell types or tissues. DR ExpressionAtlas; Q8TDB8; baseline and differential. DR GO; GO:0016235; C:aggresome; IDA:HPA. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; HDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0055056; F:D-glucose transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0033300; F:dehydroascorbic acid transmembrane transporter activity; IDA:UniProtKB. DR GO; GO:0005355; F:glucose transmembrane transporter activity; IDA:UniProtKB. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0070837; P:dehydroascorbic acid transport; IDA:UniProtKB. DR GO; GO:0046323; P:glucose import; IBA:GO_Central. DR GO; GO:1904659; P:glucose transmembrane transport; IDA:UniProtKB. DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. DR CDD; cd17431; MFS_GLUT_Class1; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1. DR InterPro; IPR002945; Glc_transpt_3. DR InterPro; IPR045263; GLUT. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR003663; Sugar/inositol_transpt. DR InterPro; IPR005829; Sugar_transporter_CS. DR NCBIfam; TIGR00879; SP; 1. DR PANTHER; PTHR23503; SOLUTE CARRIER FAMILY 2; 1. DR PANTHER; PTHR23503:SF53; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 14; 1. DR Pfam; PF00083; Sugar_tr; 1. DR PRINTS; PR01192; GLUCTRSPORT3. DR PRINTS; PR00171; SUGRTRNSPORT. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1. DR Genevisible; Q8TDB8; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Developmental protein; KW Differentiation; Glycoprotein; Membrane; Reference proteome; KW Spermatogenesis; Sugar transport; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..520 FT /note="Solute carrier family 2, facilitated glucose FT transporter member 14" FT /id="PRO_0000050381" FT TOPO_DOM 1..29 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 30..50 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 51..88 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 89..109 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 110..117 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 118..138 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 139..148 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 149..169 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 170..177 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 178..198 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 199..207 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 208..228 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 229..293 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 294..314 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 315..328 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 329..349 FT /note="Helical; Name=8" FT /evidence="ECO:0000255" FT TOPO_DOM 350..358 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 359..379 FT /note="Helical; Name=9" FT /evidence="ECO:0000255" FT TOPO_DOM 380..392 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 393..413 FT /note="Helical; Name=10" FT /evidence="ECO:0000255" FT TOPO_DOM 414..423 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 424..444 FT /note="Helical; Name=11" FT /evidence="ECO:0000255" FT TOPO_DOM 445..451 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 452..472 FT /note="Helical; Name=12" FT /evidence="ECO:0000255" FT TOPO_DOM 473..520 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 493..520 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 183 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT BINDING 304..305 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT BINDING 310 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT BINDING 339 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT BINDING 402 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT BINDING 410 FT /ligand="D-glucose" FT /ligand_id="ChEBI:CHEBI:4167" FT /evidence="ECO:0000250|UniProtKB:P11169" FT CARBOHYD 67 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1..359 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_014449" FT VAR_SEQ 1..113 FT /note="MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNT FT GVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNR FT FG -> MLLR (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_055253" FT VAR_SEQ 1..29 FT /note="MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MDNRQN (in isoform FT 2)" FT /evidence="ECO:0000303|PubMed:12504846, FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334, FT ECO:0000303|Ref.2" FT /id="VSP_014450" FT VAR_SEQ 1..29 FT /note="MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MQRLQLLRVEVLLGVKQGD FT EMRHFFFSSQTSTLEKSQNGGVGEE (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_055254" FT VARIANT 506 FT /note="G -> E (in dbSNP:rs10845981)" FT /id="VAR_059852" FT CONFLICT 369 FT /note="C -> G (in Ref. 2; AAQ63763)" FT /evidence="ECO:0000305" FT CONFLICT 376..377 FT /note="SL -> PC (in Ref. 2; AAQ63763)" FT /evidence="ECO:0000305" FT CONFLICT 456 FT /note="F -> L (in Ref. 4; CAB53739)" FT /evidence="ECO:0000305" SQ SEQUENCE 520 AA; 56320 MW; EA304A5189087690 CRC64; MEFHNGGHVS GIGGFLVSLT SRMKPHTLAV TPALIFAITV ATIGSFQFGY NTGVINAPET IIKEFINKTL TDKANAPPSE VLLTNLWSLS VAIFSVGGMI GSFSVGLFVN RFGRRNSMLI VNLLAATGGC LMGLCKIAES VEMLILGRLV IGLFCGLCTG FVPMYIGEIS PTALRGAFGT LNQLGIVIGI LVAQIFGLEL ILGSEELWPV LLGFTILPAI LQSAALPCCP ESPRFLLINR KKEENATRIL QRLWGTQDVS QDIQEMKDES ARMSQEKQVT VLELFRVSSY RQPIIISIVL QLSQQLSGIN AVFYYSTGIF KDAGVQQPIY ATISAGVVNT IFTLLSLFLV ERAGRRTLHM IGLGGMAFCS TLMTVSLLLK NHYNGMSFVC IGAILVFVAC FEIGPGPIPW FIVAELFSQG PRPAAMAVAG CSNWTSNFLV GLLFPSAAYY LGAYVFIIFT GFLITFLAFT FFKVPETRGR TFEDITRAFE GQAHGADRSG KDGVMGMNSI EPAKETTTNV //