Q8TDB8 (GTR14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 14

Alternative name(s):
Glucose transporter type 14
Short name=GLUT-14

Gene names

Name:	SLC2A14
Synonyms:	GLUT14, GLUT3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Facilitative glucose transporter By similarity. May have a specific function related to spermatogenesis.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed mainly in testis. Ref.1
Miscellaneous	GLUT14 is a recent (less than 5 M year old) duplication of GLUT3.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW glucose transport Inferred from electronic annotation. Source: GOC multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	glucose transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDB8-1)

Also known as: GLUT14-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDB8-2)

Also known as: GLUT14-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MEFHNGGHVSGIGGFLVSLTSRMKPHTLA → MDNRQN

Isoform 3 (identifier: Q8TDB8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-359: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Solute carrier family 2, facilitated glucose transporter member 14		PRO_0000050381
Regions
	Topological domain	1 – 29	29	Cytoplasmic Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 88	38	Extracellular Potential
	Transmembrane	89 – 109	21	Helical; Name=2; Potential
	Topological domain	110 – 117	8	Cytoplasmic Potential
	Transmembrane	118 – 138	21	Helical; Name=3; Potential
	Topological domain	139 – 148	10	Extracellular Potential
	Transmembrane	149 – 169	21	Helical; Name=4; Potential
	Topological domain	170 – 177	8	Cytoplasmic Potential
	Transmembrane	178 – 198	21	Helical; Name=5; Potential
	Topological domain	199 – 207	9	Extracellular Potential
	Transmembrane	208 – 228	21	Helical; Name=6; Potential
	Topological domain	229 – 293	65	Cytoplasmic Potential
	Transmembrane	294 – 314	21	Helical; Name=7; Potential
	Topological domain	315 – 328	14	Extracellular Potential
	Transmembrane	329 – 349	21	Helical; Name=8; Potential
	Topological domain	350 – 358	9	Cytoplasmic Potential
	Transmembrane	359 – 379	21	Helical; Name=9; Potential
	Topological domain	380 – 392	13	Extracellular Potential
	Transmembrane	393 – 413	21	Helical; Name=10; Potential
	Topological domain	414 – 423	10	Cytoplasmic Potential
	Transmembrane	424 – 444	21	Helical; Name=11; Potential
	Topological domain	445 – 451	7	Extracellular Potential
	Transmembrane	452 – 472	21	Helical; Name=12; Potential
	Topological domain	473 – 520	48	Cytoplasmic Potential
	Region	301 – 303	3	Defines substrate specificity By similarity
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 359	359	Missing in isoform 3.		VSP_014449
	Alternative sequence	1 – 29	29	MEFHN…PHTLA → MDNRQN in isoform 2.		VSP_014450
	Natural variant	506	1	G → E. Corresponds to variant rs10845981 [ dbSNP | Ensembl ].		VAR_059852
Experimental info
	Sequence conflict	369	1	C → G in AAQ63763. Ref.2
	Sequence conflict	376 – 377	2	SL → PC in AAQ63763. Ref.2
	Sequence conflict	456	1	F → L in CAB53739. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GLUT14-L) [UniParc]. Last modified June 1, 2002. Version 1. Checksum: EA304A5189087690	FASTA	520	56,320
	10 20 30 40 50 60 MEFHNGGHVS GIGGFLVSLT SRMKPHTLAV TPALIFAITV ATIGSFQFGY NTGVINAPET 70 80 90 100 110 120 IIKEFINKTL TDKANAPPSE VLLTNLWSLS VAIFSVGGMI GSFSVGLFVN RFGRRNSMLI 130 140 150 160 170 180 VNLLAATGGC LMGLCKIAES VEMLILGRLV IGLFCGLCTG FVPMYIGEIS PTALRGAFGT 190 200 210 220 230 240 LNQLGIVIGI LVAQIFGLEL ILGSEELWPV LLGFTILPAI LQSAALPCCP ESPRFLLINR 250 260 270 280 290 300 KKEENATRIL QRLWGTQDVS QDIQEMKDES ARMSQEKQVT VLELFRVSSY RQPIIISIVL 310 320 330 340 350 360 QLSQQLSGIN AVFYYSTGIF KDAGVQQPIY ATISAGVVNT IFTLLSLFLV ERAGRRTLHM 370 380 390 400 410 420 IGLGGMAFCS TLMTVSLLLK NHYNGMSFVC IGAILVFVAC FEIGPGPIPW FIVAELFSQG 430 440 450 460 470 480 PRPAAMAVAG CSNWTSNFLV GLLFPSAAYY LGAYVFIIFT GFLITFLAFT FFKVPETRGR 490 500 510 520 TFEDITRAFE GQAHGADRSG KDGVMGMNSI EPAKETTTNV
	Isoform 2 (GLUT14-S) [UniParc]. Checksum: FF6DF71A86A6E8A6	FASTA	497	54,015
	10 20 30 40 50 60 MDNRQNVTPA LIFAITVATI GSFQFGYNTG VINAPETIIK EFINKTLTDK ANAPPSEVLL 70 80 90 100 110 120 TNLWSLSVAI FSVGGMIGSF SVGLFVNRFG RRNSMLIVNL LAATGGCLMG LCKIAESVEM 130 140 150 160 170 180 LILGRLVIGL FCGLCTGFVP MYIGEISPTA LRGAFGTLNQ LGIVIGILVA QIFGLELILG 190 200 210 220 230 240 SEELWPVLLG FTILPAILQS AALPCCPESP RFLLINRKKE ENATRILQRL WGTQDVSQDI 250 260 270 280 290 300 QEMKDESARM SQEKQVTVLE LFRVSSYRQP IIISIVLQLS QQLSGINAVF YYSTGIFKDA 310 320 330 340 350 360 GVQQPIYATI SAGVVNTIFT LLSLFLVERA GRRTLHMIGL GGMAFCSTLM TVSLLLKNHY 370 380 390 400 410 420 NGMSFVCIGA ILVFVACFEI GPGPIPWFIV AELFSQGPRP AAMAVAGCSN WTSNFLVGLL 430 440 450 460 470 480 FPSAAYYLGA YVFIIFTGFL ITFLAFTFFK VPETRGRTFE DITRAFEGQA HGADRSGKDG 490 VMGMNSIEPA KETTTNV
	Isoform 3 [UniParc]. Checksum: 9C169F3D73A4F34D	FASTA	161	17,378
	10 20 30 40 50 60 MIGLGGMAFC STLMTVSLLL KNHYNGMSFV CIGAILVFVA CFEIGPGPIP WFIVAELFSQ 70 80 90 100 110 120 GPRPAAMAVA GCSNWTSNFL VGLLFPSAAY YLGAYVFIIF TGFLITFLAF TFFKVPETRG 130 140 150 160 RTFEDITRAF EGQAHGADRS GKDGVMGMNS IEPAKETTTN V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms." Wu X., Freeze H.H. Genomics 80:553-557(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Cloning of an isoform of SCL2A14 gene related to spermatogenesis." Fang X., Wang H., Huo R., Lu L., Xu M., Xu Y.Z., Yin L.L., Li M.J., Zhou M.Z., Sha H.J. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF481878 mRNA. Translation: AAL89709.1. AF481879 mRNA. Translation: AAL89710.1. AL110298 mRNA. Translation: CAB53739.2. AY357941 mRNA. Translation: AAQ63763.1. AK122783 mRNA. Translation: BAG53727.1. AK126026 mRNA. Translation: BAG54279.1. CH471116 Genomic DNA. Translation: EAW88652.1. CH471116 Genomic DNA. Translation: EAW88653.1. BC060766 mRNA. Translation: AAH60766.1.
IPI	IPI00152505. IPI00555680. IPI00607720.
RefSeq	NP_703150.1. NM_153449.2.
UniGene	Hs.655169.
3D structure databases
ProteinModelPortal	Q8TDB8.
ModBase	Search...
PTM databases
PhosphoSite	Q8TDB8.
Polymorphism databases
DMDM	68565598.
Proteomic databases
PaxDb	Q8TDB8.
PRIDE	Q8TDB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340749; ENSP00000340450; ENSG00000173262. ENST00000396589; ENSP00000379834; ENSG00000173262. ENST00000431042; ENSP00000407287; ENSG00000173262. ENST00000542505; ENSP00000438484; ENSG00000173262. ENST00000543909; ENSP00000440480; ENSG00000173262.
GeneID	144195.
KEGG	hsa:144195.
UCSC	uc001qtk.3. human. uc001qtl.3. human. uc001qto.3. human.
Organism-specific databases
CTD	144195.
GeneCards	GC12M007965.
HGNC	HGNC:18301. SLC2A14.
HPA	HPA006539.
MIM	611039. gene.
neXtProt	NX_Q8TDB8.
PharmGKB	PA134885058.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000202871.
HOVERGEN	HBG014816.
InParanoid	Q8TDB8.
PhylomeDB	Q8TDB8.
Gene expression databases
ArrayExpress	Q8TDB8.
Bgee	Q8TDB8.
CleanEx	HS_SLC2A14.
Genevestigator	Q8TDB8.
GermOnline	ENSG00000173262. Homo sapiens.
Family and domain databases
InterPro	IPR002945. Glc_transpt_3. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR01192. GLUCTRSPORT3. PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC2A14. human.
GenomeRNAi	144195.
NextBio	84858.
SOURCE	Search...

Entry information

Entry name

GTR14_HUMAN

Accession

Primary (citable) accession number: Q8TDB8
Secondary accession number(s): B3KVB5 , B3KWW7, Q6UY84, Q8TDB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.