MGARP

Functionⁱ

Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).By similarity

GO - Biological processⁱ

anterograde axonal transport Source: UniProtKB
axonal transport of mitochondrion Source: UniProtKB
cellular response to gonadotropin-releasing hormone Source: UniProtKB
cellular response to hypoxia Source: UniProtKB
cellular response to steroid hormone stimulus Source: UniProtKB
positive regulation of mitochondrion organization Source: UniProtKB
protein targeting to mitochondrion Source: UniProtKB
regulation of mitochondrion organization Source: GO_Central
retrograde axonal transport Source: UniProtKB

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein MGARP Alternative name(s): Corneal endothelium-specific protein 1 Short name: CESP-1 Hypoxia up-regulated mitochondrial movement regulator protein Mitochondria-localized glutamic acid-rich protein Ovary-specific acidic protein
Gene namesⁱ	Name:MGARP Synonyms:C4orf49, CESP1, HUMMR, OSAP ORF Names:GS3582
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29969. MGARP.

HGNCⁱ

HGNC:29969. MGARP.

Subcellular locationⁱ

Note:

Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion.By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 40	CytoplasmicBy similarityAdd BLAST	40
Transmembraneⁱ	41 – 63	Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST	23
Topological domainⁱ	64 – 240	Mitochondrial intermembraneBy similarityAdd BLAST	177

GO - Cellular componentⁱ

axon cytoplasm Source: GOC
integral component of mitochondrial outer membrane Source: UniProtKB
mitochondrion
Source: UniProtKB
Inferred from direct assayⁱ
- 16565373
- 21447634

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84709.
Open Targets More...OpenTargetsⁱ	ENSG00000137463.
PharmGKBⁱ	PA164717327.

Polymorphism and mutation databases

BioMutaⁱ	MGARP.
DMDMⁱ	74715889.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000318764	1 – 240	Protein MGARPAdd BLAST		240

Proteomic databases

EPDⁱ	Q8TDB4.
PaxDbⁱ	Q8TDB4.
PeptideAtlas More...PeptideAtlasⁱ	Q8TDB4.
PRIDEⁱ	Q8TDB4.

PTM databases

iPTMnetⁱ	Q8TDB4.
PhosphoSitePlusⁱ	Q8TDB4.

Expressionⁱ

Tissue specificityⁱ

Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid-producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells.5 Publications

Gene expression databases

Bgeeⁱ	ENSG00000137463.
Genevisibleⁱ	Q8TDB4. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015994.

HPAⁱ

HPA015994.

Interactionⁱ

Subunit structureⁱ

Interacts with RHOT1/Miro-1, TRAK1/OIP106 and TRAK2/GRIF1 (By similarity). Interacts with RHOT2/Miro-2.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	124220. 2 interactors.
IntActⁱ	Q8TDB4. 3 interactors.
STRINGⁱ	9606.ENSP00000381928.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TDB4.
SMRⁱ	Q8TDB4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWK1. Eukaryota. ENOG410Y7BU. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000037338.
HOGENOMⁱ	HOG000111473.
InParanoidⁱ	Q8TDB4.
OMAⁱ	HTEHITN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YRU.
PhylomeDBⁱ	Q8TDB4.
TreeFamⁱ	TF336324.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026093. MGARP. IPR032773. MGARP_N.
PANTHERⁱ	PTHR22910. PTHR22910. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14962. AIF-MLS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TDB4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL 
        60         70         80         90        100
VVGVTVSAGG YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA 
       110        120        130        140        150
ETEKASSEAP EELIVEAEVV DAEESPSATV VVIKEASACP GHVEAAPETT 
       160        170        180        190        200
AVSAETGPEV TDAAARETTE VNPETTPEVT NAALDEAVTI DNDKDTTKNE 
       210        220        230        240
TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG

Length:240

Mass (Da):25,390

Last modified:June 1, 2002 - v1

Checksum:ⁱ6E210FA627635CEC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	240	G → RANLQPVDISATNAIGCLIS AFVFLVHLV in AAG59896 (PubMed:12770732).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051256	128	A → T. Corresponds to variant dbSNP:rs3208941Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF484960 mRNA. Translation: AAM09685.1. AF329088 mRNA. Translation: AAG59896.1. CH471056 Genomic DNA. Translation: EAX05122.1. BC104173 mRNA. Translation: AAI04174.1. BC104174 mRNA. Translation: AAI04175.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43269.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_116012.2. NM_032623.3.
UniGeneⁱ	Hs.710036.

Genome annotation databases

Ensemblⁱ	ENST00000398955; ENSP00000381928; ENSG00000137463.
GeneIDⁱ	84709.
KEGGⁱ	hsa:84709.
UCSC genome browser More...UCSCⁱ	uc003ihr.1. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF484960 mRNA. Translation: AAM09685.1. AF329088 mRNA. Translation: AAG59896.1. CH471056 Genomic DNA. Translation: EAX05122.1. BC104173 mRNA. Translation: AAI04174.1. BC104174 mRNA. Translation: AAI04175.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43269.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_116012.2. NM_032623.3.
UniGeneⁱ	Hs.710036.

3D structure databases

ProteinModelPortalⁱ	Q8TDB4.
SMRⁱ	Q8TDB4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124220. 2 interactors.
IntActⁱ	Q8TDB4. 3 interactors.
STRINGⁱ	9606.ENSP00000381928.

PTM databases

iPTMnetⁱ	Q8TDB4.
PhosphoSitePlusⁱ	Q8TDB4.

Polymorphism and mutation databases

BioMutaⁱ	MGARP.
DMDMⁱ	74715889.

Proteomic databases

EPDⁱ	Q8TDB4.
PaxDbⁱ	Q8TDB4.
PeptideAtlas More...PeptideAtlasⁱ	Q8TDB4.
PRIDEⁱ	Q8TDB4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000398955; ENSP00000381928; ENSG00000137463.
GeneIDⁱ	84709.
KEGGⁱ	hsa:84709.
UCSC genome browser More...UCSCⁱ	uc003ihr.1. human.

Organism-specific databases

CTDⁱ	84709.
DisGeNET More...DisGeNETⁱ	84709.
GeneCardsⁱ	MGARP.
H-InvDBⁱ	HIX0200666.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29969. MGARP.
Human Protein Atlas More...HPAⁱ	HPA015994.
neXtProtⁱ	NX_Q8TDB4.
Open Targets More...OpenTargetsⁱ	ENSG00000137463.
PharmGKBⁱ	PA164717327.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWK1. Eukaryota. ENOG410Y7BU. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000037338.
HOGENOMⁱ	HOG000111473.
InParanoidⁱ	Q8TDB4.
OMAⁱ	HTEHITN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YRU.
PhylomeDBⁱ	Q8TDB4.
TreeFamⁱ	TF336324.

Miscellaneous databases

GenomeRNAiⁱ	84709.
Protein Ontology More...PROⁱ	PR:Q8TDB4.

Gene expression databases

Bgeeⁱ	ENSG00000137463.
Genevisibleⁱ	Q8TDB4. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026093. MGARP. IPR032773. MGARP_N.
PANTHERⁱ	PTHR22910. PTHR22910. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14962. AIF-MLS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HUMMR_HUMAN
Accessionⁱ	Q8TDB4Primary (citable) accession number: Q8TDB4 Secondary accession number(s): Q9BZC3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	June 1, 2002
	Last modified:	March 15, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TDB4 (HUMMR_HUMAN)

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Protein MGARP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ