UniProtKB - Q8TDB4 (HUMMR_HUMAN)
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Protein
Protein MGARP
Gene
MGARP
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).By similarity
GO - Biological processi
- anterograde axonal transport Source: UniProtKB
- axonal transport of mitochondrion Source: UniProtKB
- cellular response to gonadotropin-releasing hormone Source: UniProtKB
- cellular response to hypoxia Source: UniProtKB
- cellular response to steroid hormone stimulus Source: UniProtKB
- positive regulation of mitochondrion organization Source: UniProtKB
- protein targeting to mitochondrion Source: UniProtKB
- regulation of mitochondrion organization Source: GO_Central
- retrograde axonal transport Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Protein MGARPAlternative name(s): Corneal endothelium-specific protein 1 Short name: CESP-1 Hypoxia up-regulated mitochondrial movement regulator protein Mitochondria-localized glutamic acid-rich protein Ovary-specific acidic protein |
Gene namesi | Name:MGARP Synonyms:C4orf49, CESP1, HUMMR, OSAP ORF Names:GS3582 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137463.4. |
HGNCi | HGNC:29969. MGARP. |
neXtProti | NX_Q8TDB4. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 40 | CytoplasmicBy similarityAdd BLAST | 40 | |
Transmembranei | 41 – 63 | Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST | 23 | |
Topological domaini | 64 – 240 | Mitochondrial intermembraneBy similarityAdd BLAST | 177 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84709. |
OpenTargetsi | ENSG00000137463. |
PharmGKBi | PA164717327. |
Polymorphism and mutation databases
BioMutai | MGARP. |
DMDMi | 74715889. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318764 | 1 – 240 | Protein MGARPAdd BLAST | 240 |
Proteomic databases
PaxDbi | Q8TDB4. |
PeptideAtlasi | Q8TDB4. |
PRIDEi | Q8TDB4. |
PTM databases
iPTMneti | Q8TDB4. |
PhosphoSitePlusi | Q8TDB4. |
Expressioni
Tissue specificityi
Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid-producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells.5 Publications
Gene expression databases
Bgeei | ENSG00000137463. |
Genevisiblei | Q8TDB4. HS. |
Organism-specific databases
HPAi | HPA015994. |
Interactioni
Subunit structurei
Interacts with RHOT1/Miro-1, TRAK1/OIP106 and TRAK2/GRIF1 (By similarity). Interacts with RHOT2/Miro-2.By similarity1 Publication
Protein-protein interaction databases
BioGridi | 124220. 58 interactors. |
IntActi | Q8TDB4. 3 interactors. |
MINTi | Q8TDB4. |
STRINGi | 9606.ENSP00000381928. |
Structurei
3D structure databases
ProteinModelPortali | Q8TDB4. |
SMRi | Q8TDB4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IWK1. Eukaryota. ENOG410Y7BU. LUCA. |
GeneTreei | ENSGT00440000037338. |
HOGENOMi | HOG000111473. |
InParanoidi | Q8TDB4. |
OMAi | HTEHITN. |
OrthoDBi | EOG091G0YRU. |
PhylomeDBi | Q8TDB4. |
TreeFami | TF336324. |
Family and domain databases
InterProi | View protein in InterPro IPR026093. MGARP. IPR032773. MGARP_N. |
PANTHERi | PTHR22910. PTHR22910. 1 hit. |
Pfami | View protein in Pfam PF14962. AIF-MLS. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8TDB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL
60 70 80 90 100
VVGVTVSAGG YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA
110 120 130 140 150
ETEKASSEAP EELIVEAEVV DAEESPSATV VVIKEASACP GHVEAAPETT
160 170 180 190 200
AVSAETGPEV TDAAARETTE VNPETTPEVT NAALDEAVTI DNDKDTTKNE
210 220 230 240
TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 240 | G → RANLQPVDISATNAIGCLIS AFVFLVHLV in AAG59896 (PubMed:12770732).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051256 | 128 | A → T. Corresponds to variant dbSNP:rs3208941Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF484960 mRNA. Translation: AAM09685.1. AF329088 mRNA. Translation: AAG59896.1. CH471056 Genomic DNA. Translation: EAX05122.1. BC104173 mRNA. Translation: AAI04174.1. BC104174 mRNA. Translation: AAI04175.1. |
CCDSi | CCDS43269.1. |
RefSeqi | NP_116012.2. NM_032623.3. |
UniGenei | Hs.710036. |
Genome annotation databases
Ensembli | ENST00000398955; ENSP00000381928; ENSG00000137463. |
GeneIDi | 84709. |
KEGGi | hsa:84709. |
UCSCi | uc003ihr.1. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | HUMMR_HUMAN | |
Accessioni | Q8TDB4Primary (citable) accession number: Q8TDB4 Secondary accession number(s): Q9BZC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |