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Q8TD94 (KLF14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 14
Alternative name(s):
Basic transcription element-binding protein 5
Short name=BTE-binding protein 5
Transcription factor BTEB5
Gene names
Name:KLF14
Synonyms:BTEB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Krueppel-like factor 14
PRO_0000047186

Regions

Zinc finger195 – 22430C2H2-type 1
Zinc finger225 – 25430C2H2-type 2
Zinc finger255 – 28228C2H2-type 3

Natural variations

Natural variant1731A → P.
Corresponds to variant rs35770036 [ dbSNP | Ensembl ].
VAR_052718

Experimental info

Sequence conflict471H → Q in ABF82392. Ref.2
Sequence conflict471H → Q in ABF82393. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8TD94 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D9129E7968E598A3

FASTA32333,124
        10         20         30         40         50         60 
MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAHPES ALPGPGPSGP 

        70         80         90        100        110        120 
ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS WENSGEAPRA SSGFSDPIPC 

       130        140        150        160        170        180 
SVQTPCSELA PASGAAAVCA PESSSDAPAV PSAPAAPGAP AASGGFSGGA LGAGPAPAAD 

       190        200        210        220        230        240 
QAPRRRSVTP AAKRHQCPFP GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD 

       250        260        270        280        290        300 
ELARHYRTHT GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL 

       310        320 
TSEVESSASG SGPGPAPSFT TCL 

« Hide

References

[1]"Identification of BTEB5, a new member of the BTEB subfamily of Sp1-like proteins."
Kaczynski J.A., Urrutia R.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The centre for applied genomics genome annotation project."
Parker-Katiraee L., Scherer S.W.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF490374 mRNA. Translation: AAM08349.1.
DQ534756 Genomic DNA. Translation: ABF82392.1.
DQ534757 mRNA. Translation: ABF82393.1.
CCDSCCDS5825.1.
UniGeneHs.125240.

3D structure databases

ProteinModelPortalQ8TD94.
SMRQ8TD94. Positions 169-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126450. 1 interaction.
STRING9606.ENSP00000310878.

PTM databases

PhosphoSiteQ8TD94.

Polymorphism databases

DMDM32129442.

Proteomic databases

PaxDbQ8TD94.
PRIDEQ8TD94.

Protocols and materials databases

DNASU136259.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310992; ENSP00000310878; ENSG00000174595.
UCSCuc003vqk.2. human.

Organism-specific databases

GeneCardsGC07M130417.
HGNCHGNC:23025. KLF14.
HPAHPA044729.
MIM609393. gene.
neXtProtNX_Q8TD94.
PharmGKBPA134868089.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000233575.
HOVERGENHBG050746.
InParanoidQ8TD94.
OMANSEDAVP.
OrthoDBEOG7FJH0Q.
PhylomeDBQ8TD94.
TreeFamTF351003.

Gene expression databases

ArrayExpressQ8TD94.
BgeeQ8TD94.
CleanExHS_KLF14.
GenevestigatorQ8TD94.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio83560.
PROQ8TD94.
SOURCESearch...

Entry information

Entry nameKLF14_HUMAN
AccessionPrimary (citable) accession number: Q8TD94
Secondary accession number(s): Q19A42, Q19A43
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM