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Protein

Krueppel-like factor 14

Gene

KLF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 14
Alternative name(s):
Basic transcription element-binding protein 5
Short name:
BTE-binding protein 5
Transcription factor BTEB5
Gene namesi
Name:KLF14
Synonyms:BTEB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23025. KLF14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi136259.
PharmGKBiPA134868089.

Polymorphism and mutation databases

DMDMi32129442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471861 – 323Krueppel-like factor 14Add BLAST323

Proteomic databases

PaxDbiQ8TD94.
PRIDEiQ8TD94.

PTM databases

iPTMnetiQ8TD94.
PhosphoSitePlusiQ8TD94.

Expressioni

Gene expression databases

BgeeiENSG00000174595.
CleanExiHS_KLF14.

Organism-specific databases

HPAiHPA044729.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310878.

Structurei

3D structure databases

ProteinModelPortaliQ8TD94.
SMRiQ8TD94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ8TD94.
PhylomeDBiQ8TD94.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAHPES
60 70 80 90 100
ALPGPGPSGP ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS
110 120 130 140 150
WENSGEAPRA SSGFSDPIPC SVQTPCSELA PASGAAAVCA PESSSDAPAV
160 170 180 190 200
PSAPAAPGAP AASGGFSGGA LGAGPAPAAD QAPRRRSVTP AAKRHQCPFP
210 220 230 240 250
GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL
310 320
TSEVESSASG SGPGPAPSFT TCL
Length:323
Mass (Da):33,124
Last modified:June 1, 2002 - v1
Checksum:iD9129E7968E598A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47H → Q in ABF82392 (Ref. 2) Curated1
Sequence conflicti47H → Q in ABF82393 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052718173A → P.Corresponds to variant rs35770036dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA. Translation: AAM08349.1.
DQ534756 Genomic DNA. Translation: ABF82392.1.
DQ534757 mRNA. Translation: ABF82393.1.
CCDSiCCDS5825.1.
UniGeneiHs.125240.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA. Translation: AAM08349.1.
DQ534756 Genomic DNA. Translation: ABF82392.1.
DQ534757 mRNA. Translation: ABF82393.1.
CCDSiCCDS5825.1.
UniGeneiHs.125240.

3D structure databases

ProteinModelPortaliQ8TD94.
SMRiQ8TD94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310878.

PTM databases

iPTMnetiQ8TD94.
PhosphoSitePlusiQ8TD94.

Polymorphism and mutation databases

DMDMi32129442.

Proteomic databases

PaxDbiQ8TD94.
PRIDEiQ8TD94.

Protocols and materials databases

DNASUi136259.
Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi136259.
GeneCardsiKLF14.
HGNCiHGNC:23025. KLF14.
HPAiHPA044729.
MIMi609393. gene.
neXtProtiNX_Q8TD94.
PharmGKBiPA134868089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ8TD94.
PhylomeDBiQ8TD94.
TreeFamiTF351003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174595-MONOMER.

Miscellaneous databases

PROiQ8TD94.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174595.
CleanExiHS_KLF14.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF14_HUMAN
AccessioniPrimary (citable) accession number: Q8TD94
Secondary accession number(s): Q19A42, Q19A43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.