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Q8TD94

- KLF14_HUMAN

UniProt

Q8TD94 - KLF14_HUMAN

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Protein

Krueppel-like factor 14

Gene

KLF14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 14
Alternative name(s):
Basic transcription element-binding protein 5
Short name:
BTE-binding protein 5
Transcription factor BTEB5
Gene namesi
Name:KLF14
Synonyms:BTEB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:23025. KLF14.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Krueppel-like factor 14PRO_0000047186Add
BLAST

Proteomic databases

PaxDbiQ8TD94.
PRIDEiQ8TD94.

PTM databases

PhosphoSiteiQ8TD94.

Expressioni

Gene expression databases

BgeeiQ8TD94.
CleanExiHS_KLF14.
GenevestigatoriQ8TD94.

Organism-specific databases

HPAiHPA044729.

Interactioni

Protein-protein interaction databases

BioGridi126450. 1 interaction.
STRINGi9606.ENSP00000310878.

Structurei

3D structure databases

ProteinModelPortaliQ8TD94.
SMRiQ8TD94. Positions 193-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ8TD94.
OMAiNSEDAVP.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ8TD94.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAHPES
60 70 80 90 100
ALPGPGPSGP ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS
110 120 130 140 150
WENSGEAPRA SSGFSDPIPC SVQTPCSELA PASGAAAVCA PESSSDAPAV
160 170 180 190 200
PSAPAAPGAP AASGGFSGGA LGAGPAPAAD QAPRRRSVTP AAKRHQCPFP
210 220 230 240 250
GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL
310 320
TSEVESSASG SGPGPAPSFT TCL
Length:323
Mass (Da):33,124
Last modified:June 1, 2002 - v1
Checksum:iD9129E7968E598A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471H → Q in ABF82392. 1 PublicationCurated
Sequence conflicti47 – 471H → Q in ABF82393. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731A → P.
Corresponds to variant rs35770036 [ dbSNP | Ensembl ].
VAR_052718

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA. Translation: AAM08349.1.
DQ534756 Genomic DNA. Translation: ABF82392.1.
DQ534757 mRNA. Translation: ABF82393.1.
CCDSiCCDS5825.1.
UniGeneiHs.125240.

Genome annotation databases

UCSCiuc003vqk.2. human.

Polymorphism databases

DMDMi32129442.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA. Translation: AAM08349.1 .
DQ534756 Genomic DNA. Translation: ABF82392.1 .
DQ534757 mRNA. Translation: ABF82393.1 .
CCDSi CCDS5825.1.
UniGenei Hs.125240.

3D structure databases

ProteinModelPortali Q8TD94.
SMRi Q8TD94. Positions 193-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126450. 1 interaction.
STRINGi 9606.ENSP00000310878.

PTM databases

PhosphoSitei Q8TD94.

Polymorphism databases

DMDMi 32129442.

Proteomic databases

PaxDbi Q8TD94.
PRIDEi Q8TD94.

Protocols and materials databases

DNASUi 136259.
Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc003vqk.2. human.

Organism-specific databases

GeneCardsi GC07M130417.
HGNCi HGNC:23025. KLF14.
HPAi HPA044729.
MIMi 609393. gene.
neXtProti NX_Q8TD94.
PharmGKBi PA134868089.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000233575.
HOVERGENi HBG050746.
InParanoidi Q8TD94.
OMAi NSEDAVP.
OrthoDBi EOG7FJH0Q.
PhylomeDBi Q8TD94.
TreeFami TF351003.

Miscellaneous databases

NextBioi 83560.
PROi Q8TD94.
SOURCEi Search...

Gene expression databases

Bgeei Q8TD94.
CleanExi HS_KLF14.
Genevestigatori Q8TD94.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of BTEB5, a new member of the BTEB subfamily of Sp1-like proteins."
    Kaczynski J.A., Urrutia R.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The centre for applied genomics genome annotation project."
    Parker-Katiraee L., Scherer S.W.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiKLF14_HUMAN
AccessioniPrimary (citable) accession number: Q8TD94
Secondary accession number(s): Q19A42, Q19A43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3