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Q8TD94

- KLF14_HUMAN

UniProt

Q8TD94 - KLF14_HUMAN

Protein

Krueppel-like factor 14

Gene

KLF14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 14
    Alternative name(s):
    Basic transcription element-binding protein 5
    Short name:
    BTE-binding protein 5
    Transcription factor BTEB5
    Gene namesi
    Name:KLF14
    Synonyms:BTEB5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:23025. KLF14.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Krueppel-like factor 14PRO_0000047186Add
    BLAST

    Proteomic databases

    PaxDbiQ8TD94.
    PRIDEiQ8TD94.

    PTM databases

    PhosphoSiteiQ8TD94.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TD94.
    BgeeiQ8TD94.
    CleanExiHS_KLF14.
    GenevestigatoriQ8TD94.

    Organism-specific databases

    HPAiHPA044729.

    Interactioni

    Protein-protein interaction databases

    BioGridi126450. 1 interaction.
    STRINGi9606.ENSP00000310878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TD94.
    SMRiQ8TD94. Positions 169-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000233575.
    HOVERGENiHBG050746.
    InParanoidiQ8TD94.
    OMAiNSEDAVP.
    OrthoDBiEOG7FJH0Q.
    PhylomeDBiQ8TD94.
    TreeFamiTF351003.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TD94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAHPES    50
    ALPGPGPSGP ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS 100
    WENSGEAPRA SSGFSDPIPC SVQTPCSELA PASGAAAVCA PESSSDAPAV 150
    PSAPAAPGAP AASGGFSGGA LGAGPAPAAD QAPRRRSVTP AAKRHQCPFP 200
    GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT 250
    GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL 300
    TSEVESSASG SGPGPAPSFT TCL 323
    Length:323
    Mass (Da):33,124
    Last modified:June 1, 2002 - v1
    Checksum:iD9129E7968E598A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471H → Q in ABF82392. 1 PublicationCurated
    Sequence conflicti47 – 471H → Q in ABF82393. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti173 – 1731A → P.
    Corresponds to variant rs35770036 [ dbSNP | Ensembl ].
    VAR_052718

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF490374 mRNA. Translation: AAM08349.1.
    DQ534756 Genomic DNA. Translation: ABF82392.1.
    DQ534757 mRNA. Translation: ABF82393.1.
    CCDSiCCDS5825.1.
    UniGeneiHs.125240.

    Genome annotation databases

    UCSCiuc003vqk.2. human.

    Polymorphism databases

    DMDMi32129442.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF490374 mRNA. Translation: AAM08349.1 .
    DQ534756 Genomic DNA. Translation: ABF82392.1 .
    DQ534757 mRNA. Translation: ABF82393.1 .
    CCDSi CCDS5825.1.
    UniGenei Hs.125240.

    3D structure databases

    ProteinModelPortali Q8TD94.
    SMRi Q8TD94. Positions 169-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126450. 1 interaction.
    STRINGi 9606.ENSP00000310878.

    PTM databases

    PhosphoSitei Q8TD94.

    Polymorphism databases

    DMDMi 32129442.

    Proteomic databases

    PaxDbi Q8TD94.
    PRIDEi Q8TD94.

    Protocols and materials databases

    DNASUi 136259.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc003vqk.2. human.

    Organism-specific databases

    GeneCardsi GC07M130417.
    HGNCi HGNC:23025. KLF14.
    HPAi HPA044729.
    MIMi 609393. gene.
    neXtProti NX_Q8TD94.
    PharmGKBi PA134868089.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000233575.
    HOVERGENi HBG050746.
    InParanoidi Q8TD94.
    OMAi NSEDAVP.
    OrthoDBi EOG7FJH0Q.
    PhylomeDBi Q8TD94.
    TreeFami TF351003.

    Miscellaneous databases

    NextBioi 83560.
    PROi Q8TD94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TD94.
    Bgeei Q8TD94.
    CleanExi HS_KLF14.
    Genevestigatori Q8TD94.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of BTEB5, a new member of the BTEB subfamily of Sp1-like proteins."
      Kaczynski J.A., Urrutia R.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The centre for applied genomics genome annotation project."
      Parker-Katiraee L., Scherer S.W.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiKLF14_HUMAN
    AccessioniPrimary (citable) accession number: Q8TD94
    Secondary accession number(s): Q19A42, Q19A43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3